KEGG ORTHOLOGY: K05901

ORTHOLOGY: K05901

Entry

K05901                      KO

Symbol

BLVRB

Name

biliverdin reductase / flavin reductase [EC:1.3.1.24 1.5.1.30]

Pathway

map00740

Riboflavin metabolism

map00860

Porphyrin metabolism

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Reaction

R02391

bilirubin:NAD+ oxidoreductase

R02393

bilirubin:NADP+ oxidoreductase

R05707

reduced-riboflavin:NADP+ oxidoreductase

R09520

FADH2:NADP+ oxidoreductase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00740 Riboflavin metabolism
    K05901  BLVRB; biliverdin reductase / flavin reductase
   00860 Porphyrin metabolism
    K05901  BLVRB; biliverdin reductase / flavin reductase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.24  biliverdin reductase
     K05901  BLVRB; biliverdin reductase / flavin reductase
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.30  flavin reductase (NADPH)
     K05901  BLVRB; biliverdin reductase / flavin reductase

Other DBs

GO:	0004074 0042602

Genes

HSA:	645(BLVRB)

PTR:	456039(BLVRB)

PPS:	100989093(BLVRB)

GGO:	101142015(BLVRB)

PON:	100446184(BLVRB)

NLE:	100587172(BLVRB)

HMH:	116480674(BLVRB)

MCC:	703020(BLVRB)

MCF:	102142962(BLVRB)

MTHB:

126942092

MNI:	105495336(BLVRB)

CSAB:

103234707(BLVRB)

CATY:

105597983(BLVRB)

PANU:

101021963(BLVRB)

TGE:	112613110(BLVRB)

MLEU:

105542622(BLVRB)

RRO:	104676113(BLVRB)

RBB:	108539085(BLVRB)

TFN:	117091948(BLVRB) 117092438

PTEH:

111553962(BLVRB)

CANG:

105519183(BLVRB)

CJC:	100391206(BLVRB)

SBQ:	101043206(BLVRB)

CIMI:

108285782(BLVRB)

CSYR:

103272286(BLVRB)

MMUR:

105876763(BLVRB)

LCAT:

123624314(BLVRB)

PCOQ:

105820481(BLVRB)

OGA:	100956880(BLVRB)

MMU:	233016(Blvrb)

MCAL:

110297893(Blvrb)

MPAH:

110331802(Blvrb)

RNO:	292737(Blvrb)

MCOC:

116101881(Blvrb)

ANU:	117698969(Blvrb)

MUN:	110556744(Blvrb)

CGE:	100768929(Blvrb)

MAUA:

101844617(Blvrb)

PROB:

127238361(Blvrb)

PLEU:

114681553(Blvrb)

MORG:

121449703(Blvrb) 121453592

MFOT:

126492547

AAMP:

119821315 119821342(Blvrb)

NGI:	103750766(Blvrb)

HGL:	101697384(Blvrb)

CPOC:

100723970(Blvrb)

CCAN:

109688540(Blvrb)

DORD:

105998024(Blvrb)

DSP:	122097439(Blvrb)

PLOP:

125368345(Blvrb)

NCAR:

124966872

MMMA:

107151453(Blvrb)

OCU:

100340115

OPI:	101535891(BLVRB)

TUP:	102490802(BLVRB)

GVR:	103598605(BLVRB)

CFA:	476456(BLVRB)

CLUD:

112645456(BLVRB)

VVP:	112928368(BLVRB)

VLG:	121485710(BLVRB)

NPO:	129500870(BLVRB)

AML:	100467254(BLVRB)

UMR:	103661047(BLVRB)

UAH:	113243564(BLVRB)

UAR:	123784022(BLVRB)

ELK:

111161593

LLV:	125088933 125098045

MPUF:

101682683(BLVRB)

MNP:	132005993(BLVRB)

MLK:	131818594(BLVRB)

NVS:	122912043(BLVRB)

ORO:	101371765(BLVRB)

EJU:	114202467(BLVRB)

ZCA:	113936395(BLVRB)

MLX:	118022653(BLVRB)

NSU:	110590243(BLVRB)

LWW:	102749984(BLVRB)

FCA:	101092315(BLVRB)

PYU:	121011436(BLVRB)

PBG:	122494035(BLVRB)

PVIV:

125152916(BLVRB)

LRUF:

124511113

PTG:	102957700(BLVRB)

PPAD:

109256587(BLVRB)

PUC:

125915658

AJU:

106979604

HHV:	120240932(BLVRB)

BTA:	281650(BLVRB)

BOM:	102277747(BLVRB)

BIU:	109572681(BLVRB)

BBUB:

102402107(BLVRB)

BBIS:

104995362(BLVRB)

CHX:	102187796(BLVRB)

OAS:	101119750(BLVRB)

BTAX:

128063605(BLVRB)

ODA:	120872449(BLVRB)

CCAD:

122420884(BLVRB) 122443458

MBEZ:

129546807(BLVRB)

SSC:	100625219(BLVRB)

CFR:	102522968(BLVRB)

CBAI:

105062862(BLVRB)

CDK:	105093394(BLVRB)

VPC:	102543677(BLVRB)

BACU:

103014515(BLVRB)

BMUS:

118885044(BLVRB)

LVE:	103082225(BLVRB)

OOR:	101269881(BLVRB)

DLE:	111180848(BLVRB)

PCAD:

102992855(BLVRB)

PSIU:

116743687(BLVRB)

NASI:

112415632(BLVRB)

ECB:	100068145(BLVRB)

EPZ:	103560493(BLVRB)

EAI:	106843297(BLVRB)

MYB:	102251416(BLVRB)

MYD:	102759928(BLVRB)

MMYO:

118674559(BLVRB)

MLF:	102432652(BLVRB)

PKL:	118702235(BLVRB)

EFUS:

103284696(BLVRB) 103290292

MNA:	107534172(BLVRB)

DRO:	112320111(BLVRB)

SHON:

118988083(BLVRB)

AJM:	119040590(BLVRB)

PDIC:

114511105(BLVRB)

PHAS:

123823786(BLVRB)

MMF:	118639318(BLVRB)

PPAM:

129076686(BLVRB)

HAI:	109374869(BLVRB)

RFQ:	117035103(BLVRB)

PALE:

102879551(BLVRB)

PGIG:

120595620(BLVRB)

PVP:	105300209(BLVRB)

RAY:	107521823(BLVRB)

MJV:	108404844(BLVRB)

TOD:	119249327(BLVRB)

SARA:

101557111(BLVRB)

SETR:

126028163(BLVRB)

LAV:	100665167(BLVRB)

TMU:

101354315

ETF:	101645971(BLVRB)

DNM:	101437673(BLVRB)

MDO:	100017892(BLVRB)

GAS:	123255652(BLVRB)

SHR:	100930351(BLVRB)

AFZ:

127556203

PCW:	110202810(BLVRB)

OAA:	100073853(BLVRB)

MGP:	100303679(BLVRB)

APLA:

113841036(BLVRB)

CATA:

118261579(BLVRB)

PHI:	102113532(BLVRB)

CCAE:

111943368(BLVRB)

ACHC:

115337712

HALD:

104321959(BLVRB)

AGEN:

126036625 126037224

BREG:

104641217(BLVRB)

SHAB:

115603330(BLVRB)

RTD:	128903851(BLVRB)

AAM:	106493723(BLVRB)

AROW:

112960997(BLVRB)

NPD:	112955489(BLVRB)

TGT:	104572768(BLVRB)

DNE:	112996331(BLVRB)

ASN:	102387963(BLVRB)

AMJ:	102574563(BLVRB)

CMY:	114022374(BLVRB)

CCAY:

125628119(BLVRB)

DCC:	119847368(BLVRB)

CPIC:

101948417(BLVRB)

TST:	117888630(BLVRB)

CABI:

116833857(BLVRB)

MRV:	120388171(BLVRB)

ACS:	100564796(blvrb)

ASAO:

132780135(BLVRB)

PVT:	110075662(BLVRB)

SUND:

121916153(BLVRB)

PBI:	103053858(BLVRB)

PMUR:

107285666(BLVRB)

CTIG:

120316372(BLVRB)

TSR:	106541075(BLVRB)

PGUT:

117677851(BLVRB)

APRI:

131204274(BLVRB)

PTEX:

113450296(BLVRB)

NSS:	113425551(BLVRB)

VKO:	123021032(BLVRB)

PMUA:

114603071(BLVRB)

PRAF:

128418178(BLVRB)

ZVI:	118078075 118086651(BLVRB)

HCG:	128332650(BLVRB)

GJA:	107107369(BLVRB)

STOW:

125430722(BLVRB)

EMC:	129343090(BLVRB)

XLA:	443881(blvrb.L)

XTR:	100124834(blvrb) 116406791

NPR:	108791950(BLVRB)

RTEM:

120913299(BLVRB)

BBUF:

120977966(BLVRB)

BGAR:

122923946(BLVRB)

MUO:	115480591(BLVRB)

GSH:	117364657(BLVRB)

DRE:	436959(blvrb)

SRX:	107717620(blvrb)

SANH:

107670601 107692505

SGH:	107602119(blvrb)

CCAR:

109109302 109109306

CAUA:

113061728 113082608 113118645

CGIB:

127934336 127977858

PTET:

122323140(blvrb)

LROH:

127180549(blvrb)

OMC:	131523974(blvrb)

PPRM:

120460021 120460038

RKG:	130069968(blvrb)

MAMB:

125254500(blvrb)

CIDE:

127499299

MASI:

127455779

TROS:

130562861(blvrb)

TDW:	130435551(blvrb)

MANU:

129419592(blvrb)

IPU:

124626957

IFU:	128606874(blvrb)

PHYP:

113526426(blvrb)

SMEO:

124396010(blvrb)

TFD:	113638812(blvrb)

TVC:	132851041(blvrb)

TRN:	134322999(blvrb)

AMEX:

103040962(blvrb)

CMAO:

118818247(blvrb)

EEE:	113580124(blvrb)

CHAR:

105909718(blvrb)

TRU:	101061122(blvrb)

TFS:	130534656(blvrb)

TNG:	GSTEN00035152G001

LCO:	104927805(blvrb)

NCC:	104965039(blvrb)

TBEN:

117471124(blvrb)

CGOB:

115018241(blvrb)

PGEO:

117457425(blvrb)

GACU:

117555581(blvrb)

EMAC:

134880858(blvrb)

ELY:	117259444(blvrb)

EFO:	125888677(blvrb)

PLEP:

121943190(blvrb)

SLUC:

116053283(blvrb)

ECRA:

117942519(blvrb)

ESP:	116687001(blvrb)

PFLV:

114552606(blvrb)

GAT:	120829425(blvrb)

PPUG:

119222042(blvrb)

AFB:	129090654(blvrb)

CLUM:

117741131(blvrb)

PSWI:

130210565(blvrb)

MSAM:

119882831(blvrb)

SCHU:

122879513(blvrb)

CUD:	121526977(blvrb)

ALAT:

119033096(blvrb)

MZE:	101484658(blvrb)

ONL:	100702669(blvrb)

OAU:	116320348(blvrb)

OLA:	101163919(blvrb)

OML:	112149783(blvrb)

CSAI:

133442247(blvrb)

XMA:	102228591(blvrb)

XCO:	114133538(blvrb)

XHE:	116707592 116707593

PRET:

103475161(blvrb)

PFOR:

103138303(blvrb)

PLAI:

106947919(blvrb)

PMEI:

106921476(blvrb)

GAF:	122832913(blvrb)

PPRL:

129358719(blvrb)

CVG:	107094869(blvrb)

CTUL:

119796633(blvrb)

GMU:	124883659(blvrb)

NFU:	107379787(blvrb)

KMR:	108247879(blvrb)

ALIM:

106522783(blvrb)

NWH:	119411413(blvrb)

AOCE:

111586211(blvrb)

MCEP:

125012958(blvrb)

CSEM:

103377891(blvrb)

POV:	109630121(blvrb)

SSEN:

122773296(blvrb)

HHIP:

117773323(blvrb)

HSP:	118105862(blvrb)

PPLT:

128439617(blvrb)

SMAU:

118294571(blvrb)

LCF:

108876241

SDU:	111216890(blvrb)

SLAL:

111662215(blvrb)

XGL:	120792571(blvrb)

HCQ:	109529422(blvrb)

SSCV:

125972512

SBIA:

133504585(blvrb)

PEE:	133405512(blvrb)

PTAO:

133482614(blvrb)

BPEC:

110172712(blvrb)

MALB:

109963258(blvrb)

BSPL:

114867627(blvrb)

SJO:	128360742(blvrb)

SASA:

106580739(blvrb) 106612705(BLVRB)

STRU:

115163034(blvrb) 115205994

OTW:	112265119 112266772

OMY:	110503591 110507468

OGO:	123993025 124005618

ONE:	115137042 115141548

OKI:	109905459 109908908

OKE:	118385438 118397176

SALP:

111982788 111982809

SNH:	120018812 120028367

CCLU:

121562566 121568255

ELS:	105023068(blvrb)

SFM:	108928749(blvrb)

PKI:	111844029(blvrb)

AANG:

118209415(blvrb)

LOC:	102698532(blvrb)

PSPA:

121303818 121304996(blvrb)

ARUT:

117397815 117415212

PSEX:

120538736(blvrb)

LCM:	102358034(BLVRB)

CMK:	103173572(blvrb)

RTP:	109926910(blvrb)

CPLA:

122542852(blvrb)

HOC:	132836604(blvrb)

LERI:

129714249(blvrb)

PMRN:

116953899(BLVRB)

LRJ:

133356338

BFO:	118410084 118414353 118424422

CIN:

100185152

SCLV:

120347803 120347819 120347831 120347846 120347854 120347866

SPU:	100889296 578603

APLC:

110978883 110978939

SKO:

100374763

DER:

6552273

DSI:	Dsimw501_GD20759(Dsim_GD20759)

DYA:	Dyak_GE24730

DSR:

DPO:

DPE:

DMN:

DWI:

DMO:	Dmoj_GI24882

DAZ:

DNV:

DHE:

DVI:

MDE:

LCQ:

ACOZ:

AAG:

AALB:

109405306 109406365 115258289

CQU:	CpipJ_CPIJ011826

CPII:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

SOC:	105203443 105203453 105204185

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VVE:

NVI:

CSOL:

MDL:

TCA:

DPA:

ATD:

DVV:

NVL:

BMOR:

BMAN:

DPL:	KGM_212873

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

API:	100168586(Blvrb) 100574136

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

NLU:

HVI:	124353097 124353098 124373554

PHU:	Phum_PHUM514080

ZNE:

110828593

CSEC:

111868350

BROR:

134535992

DPX:	DAPPUDRAFT_230602

DMK:

DPZ:

PVM:

PMOO:

CQD:

MNZ:

HAZT:

DSV:

RSAN:

RMP:

TUT:	107359695 107367634

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

LGI:	LOTGIDRAFT_113739 LOTGIDRAFT_145414

PCAN:

112555334

HRJ:

124291888

MYI:	110441547 110448057

LAK:	106151286 106161246 106163455 106163456 106163458

NVE:

5503663

EPA:	110232712 110232713

ADF:

107351009

AMIL:

114961956

PDAM:

113669019 113669042 113678890 113678891

SPIS:

111322492 111322494 111325275 111325299

» show all

Reference

PMID:10620517

Authors

Cunningham O, Gore MG, Mantle TJ

Title

Initial-rate kinetics of the flavin reductase reaction catalysed by human biliverdin-IXbeta reductase (BVR-B).

Journal

Biochem J 345 Pt 2:393-9 (2000)
DOI:10.1042/bj3450393

Sequence

[hsa:645]

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