KEGG ORTHOLOGY: K06270

ORTHOLOGY: K06270

Entry

K06270                      KO

Symbol

PPP1R12A, MYPT1

Name

protein phosphatase 1 regulatory subunit 12A

Pathway

map04022

cGMP-PKG signaling pathway

map04024

cAMP signaling pathway

map04270

Vascular smooth muscle contraction

map04510

Focal adhesion

map04611

Platelet activation

map04810

Regulation of actin cytoskeleton

map04921

Oxytocin signaling pathway

map05205

Proteoglycans in cancer

Disease

H02523

Genitourinary and/or brain malformation syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
   04022 cGMP-PKG signaling pathway
    K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
Protein phosphatases and associated proteins [BR:ko01009]
Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A

Genes

HSA:	4659(PPP1R12A)

PTR:	452095(PPP1R12A)

PPS:	100989468(PPP1R12A)

GGO:	101139376(PPP1R12A)

PON:	100172617(PPP1R12A)

NLE:	100602476(PPP1R12A)

HMH:	116479049(PPP1R12A)

MCC:	695735(PPP1R12A)

MCF:	101864805(PPP1R12A)

MTHB:

126931234

MNI:	105473304(PPP1R12A)

CSAB:

103238782(PPP1R12A)

CATY:

105581076(PPP1R12A)

PANU:

101021299(PPP1R12A)

TGE:	112633984(PPP1R12A)

MLEU:

105540701(PPP1R12A)

RRO:	104675773(PPP1R12A)

RBB:	108528527(PPP1R12A)

TFN:	117089688(PPP1R12A)

PTEH:

111547177(PPP1R12A)

CANG:

105515197(PPP1R12A)

CJC:	100393191(PPP1R12A)

SBQ:	101034840(PPP1R12A)

CIMI:

108314544(PPP1R12A)

CSYR:

103258562(PPP1R12A)

MMUR:

105863369(PPP1R12A)

LCAT:

123639486(PPP1R12A)

PCOQ:

105819944(PPP1R12A)

OGA:	100955707(PPP1R12A)

MMU:	17931(Ppp1r12a)

MCAL:

110302933(Ppp1r12a)

MPAH:

110326185(Ppp1r12a)

RNO:	116670(Ppp1r12a)

MCOC:

116076104(Ppp1r12a)

ANU:	117696193(Ppp1r12a)

MUN:	110558205(Ppp1r12a)

CGE:	100754718(Ppp1r12a)

MAUA:

101822552(Ppp1r12a)

PROB:

127237990(Ppp1r12a)

PLEU:

114695636(Ppp1r12a)

MORG:

121464440(Ppp1r12a)

MFOT:

126497496

AAMP:

119803249(Ppp1r12a)

NGI:	103749250(Ppp1r12a)

HGL:	101700150(Ppp1r12a)

CPOC:

100727982(Ppp1r12a)

CCAN:

109697808(Ppp1r12a)

DORD:

105987486(Ppp1r12a)

DSP:	122124417(Ppp1r12a)

PLOP:

125360886(Ppp1r12a)

NCAR:

124982345

MMMA:

107140034(Ppp1r12a)

OCU:

100350558

OPI:	101529033(PPP1R12A)

TUP:	102473894(PPP1R12A)

GVR:	103585507(PPP1R12A)

CFA:	475411(PPP1R12A)

CLUD:

112654323(PPP1R12A)

VVP:	112914878(PPP1R12A)

VLG:	121480949(PPP1R12A)

NPO:	129520637(PPP1R12A)

AML:	100483995(PPP1R12A)

UMR:	103680852(PPP1R12A)

UAH:	113256222(PPP1R12A)

UAR:	123780848(PPP1R12A)

ELK:

111141992

LLV:

125106141

MPUF:

101684983(PPP1R12A)

MNP:	132019394(PPP1R12A)

MLK:	131839209(PPP1R12A)

NVS:	122891698(PPP1R12A)

ORO:	101384536(PPP1R12A)

EJU:	114211055(PPP1R12A)

ZCA:	113921641(PPP1R12A)

MLX:	118008531(PPP1R12A)

NSU:	110570596(PPP1R12A)

LWW:	102737077(PPP1R12A)

FCA:	101089624(PPP1R12A)

PYU:	121040701(PPP1R12A)

PCOO:

112863593(PPP1R12A)

PBG:	122472249(PPP1R12A)

PVIV:

125169821(PPP1R12A)

LRUF:

124501034

PTG:	102951696(PPP1R12A)

PPAD:

109270552(PPP1R12A)

PUC:

125919358

AJU:

106967400

HHV:	120233963(PPP1R12A)

BTA:	538606(PPP1R12A)

BOM:	102268036(PPP1R12A)

BIU:	109558936(PPP1R12A)

BBUB:

102395084(PPP1R12A)

BBIS:

104982594(PPP1R12A)

CHX:	102183294(PPP1R12A)

OAS:	641303(PPP1R12A)

BTAX:

128047405(PPP1R12A)

ODA:	120858445(PPP1R12A)

CCAD:

122427569(PPP1R12A)

MBEZ:

129536404(PPP1R12A)

SSC:	397190(PPP1R12A)

CFR:	102511361(PPP1R12A)

CBAI:

105072021(PPP1R12A)

CDK:	105084895(PPP1R12A)

VPC:	102539445(PPP1R12A)

BACU:

103020020(PPP1R12A)

BMUS:

118901861(PPP1R12A)

LVE:	103071997(PPP1R12A)

OOR:	101279306(PPP1R12A) 125962845

DLE:	111167253(PPP1R12A)

PCAD:

102992707(PPP1R12A)

PSIU:

116760401(PPP1R12A)

NASI:

112394349(PPP1R12A)

ECB:	100060501(PPP1R12A)

EPZ:	103549928(PPP1R12A)

EAI:	106831522(PPP1R12A)

MYB:	102251394(PPP1R12A)

MYD:	102765262(PPP1R12A)

MMYO:

118650077(PPP1R12A)

MLF:	102429955(PPP1R12A)

PKL:	118730887(PPP1R12A)

EFUS:

103288089(PPP1R12A)

MNA:	107526828(PPP1R12A)

DRO:	112322163(PPP1R12A)

SHON:

118984712(PPP1R12A)

AJM:	119058981(PPP1R12A)

PDIC:

114513386(PPP1R12A)

PHAS:

123822821(PPP1R12A)

MMF:	118623369(PPP1R12A)

PPAM:

129075912(PPP1R12A)

HAI:	109375211(PPP1R12A)

RFQ:	117028313(PPP1R12A)

PALE:

102898474(PPP1R12A)

PGIG:

120583373(PPP1R12A)

PVP:	105301889(PPP1R12A)

RAY:	107503696(PPP1R12A)

MJV:	108408094(PPP1R12A)

TOD:	119247473(PPP1R12A)

SARA:

101556321(PPP1R12A)

SETR:

126022461(PPP1R12A)

LAV:	100673922(PPP1R12A)

TMU:

101341352

ETF:	101646224(PPP1R12A)

DNM:	101447857(PPP1R12A)

MDO:	100019488(PPP1R12A)

GAS:	123250694(PPP1R12A)

SHR:	100926931(PPP1R12A)

AFZ:

127564078

PCW:	110213174(PPP1R12A)

OAA:	100077235(PPP1R12A)

GGA:	396020(PPP1R12A)

PCOC:

116226728(PPP1R12A)

MGP:	100539276(PPP1R12A)

CJO:	107311018(PPP1R12A)

TPAI:

128074109(PPP1R12A)

LMUT:

125688062(PPP1R12A)

NMEL:

110392872(PPP1R12A)

APLA:

101800288(PPP1R12A)

ACYG:

106046454(PPP1R12A)

CATA:

118246795(PPP1R12A)

AFUL:

116497380(PPP1R12A)

TGU:	100220857(PPP1R12A)

LSR:	110469380(PPP1R12A)

SCAN:

103813426(PPP1R12A)

PMOA:

120499763(PPP1R12A)

OTC:	121338585(PPP1R12A)

PRUF:

121352505(PPP1R12A)

GFR:	102037308(PPP1R12A)

FAB:	101822232(PPP1R12A)

OMA:	130248439(PPP1R12A)

PHI:	102107346(PPP1R12A)

PMAJ:

107204392(PPP1R12A)

CCAE:

111933170(PPP1R12A)

CCW:	104698411(PPP1R12A)

CBRC:

103614837(PPP1R12A)

ETL:	114063665(PPP1R12A)

ZAB:	102071992(PPP1R12A)

ZLE:	135442317(PPP1R12A)

ACHL:

103810897(PPP1R12A)

SVG:	106860690(PPP1R12A)

MMEA:

130580119(PPP1R12A)

HRT:	120752392(PPP1R12A)

FPG:	101914871(PPP1R12A)

FCH:	102052384(PPP1R12A)

CLV:	102098984(PPP1R12A)

EGZ:	104132935(PPP1R12A)

NNI:	104010975(PPP1R12A)

PCRI:

104029467(PPP1R12A)

PLET:

104622247(PPP1R12A)

EHS:	104510260(PPP1R12A)

PCAO:

104045553

ACUN:

113488441(PPP1R12A)

TALA:

104368605(PPP1R12A)

PADL:

103919928(PPP1R12A)

AFOR:

103903676(PPP1R12A)

ACHC:

115336095(PPP1R12A)

HALD:

104317487(PPP1R12A)

HLE:	104828256(PPP1R12A)

AGEN:

126034582

GCL:

127013257

CCRI:

104164446(PPP1R12A)

CSTI:

104562965(PPP1R12A)

CMAC:

104476702(PPP1R12A)

MUI:	104540034(PPP1R12A)

BREG:

104642045(PPP1R12A)

FGA:	104084417(PPP1R12A)

GSTE:

104250675(PPP1R12A)

LDI:	104345846(PPP1R12A)

MNB:	103771501(PPP1R12A)

OHA:	104333566(PPP1R12A)

NNT:	104408102(PPP1R12A)

SHAB:

115605709(PPP1R12A)

DPUB:

104309212(PPP1R12A)

PGUU:

104467507

ACAR:

104523546

CPEA:

104397964(PPP1R12A)

AVIT:

104280872(PPP1R12A)

CVF:	104284306(PPP1R12A)

RTD:	128904367(PPP1R12A)

CUCA:

104061152(PPP1R12A)

TEO:	104374455(PPP1R12A)

BRHI:

104501752(PPP1R12A)

AAM:	106488611(PPP1R12A)

AROW:

112963277(PPP1R12A)

NPD:	112956239(PPP1R12A)

TGT:	104576377(PPP1R12A)

DNE:	112983349(PPP1R12A)

SCAM:

104140657(PPP1R12A)

ASN:	102381466(PPP1R12A)

AMJ:	102562278(PPP1R12A)

CPOO:

109315966(PPP1R12A)

GGN:	109295752(PPP1R12A)

PSS:	102460329(PPP1R12A)

CMY:	102930708(PPP1R12A)

DCC:	119853857(PPP1R12A)

CPIC:

101949705(PPP1R12A)

TST:	117878110(PPP1R12A)

CABI:

116835801(PPP1R12A)

MRV:	120380171(PPP1R12A)

ACS:	100560455(ppp1r12a)

ASAO:

132776135(PPP1R12A)

PVT:	110084990(PPP1R12A)

SUND:

121930949(PPP1R12A)

PBI:	103053749(PPP1R12A)

PMUR:

107284036(PPP1R12A)

CTIG:

120316844(PPP1R12A)

TSR:	106547769(PPP1R12A)

PGUT:

117655359(PPP1R12A)

APRI:

131202682(PPP1R12A)

PTEX:

113435424(PPP1R12A)

NSS:	113412228(PPP1R12A)

VKO:	123036395(PPP1R12A)

PRAF:

128422625(PPP1R12A)

ZVI:	118091493(PPP1R12A)

HCG:	128325998(PPP1R12A)

GJA:	107113829(PPP1R12A)

STOW:

125434445(PPP1R12A)

EMC:	129336225(PPP1R12A)

XLA:	108711109(ppp1r12a.L) 108713841 108715193 733200(ppp1r12a.S)

XTR:	100487727 100493563(ppp1r12a)

NPR:	108799788(PPP1R12A)

RTEM:

120917244 120931940(PPP1R12A)

BBUF:

120980976(PPP1R12A) 120981057

BGAR:

122920592 122927987(PPP1R12A)

MUO:	115468956 115477272(PPP1R12A) 115477441

GSH:	117352014 117363551(PPP1R12A)

DRE:	445393(ppp1r12a) 571837(zmp:0000001167)

SRX:	107726853 107749073 107755884

SANH:

107655150 107674811 107680011 107694147

SGH:	107551438 107560300(ppp1r12a) 107561184 107591124

CCAR:

109076480

CAUA:

113042896 113043027 113048194 113060311 113062096 113066529

CGIB:

127947324 127956609 127973335 128014167(zmp:0000001167)

PTET:

122330628(zmp:0000001167) 122342724(ppp1r12a)

LROH:

127156342(zmp:0000001167) 127163965(ppp1r12a)

OMC:	131534253(zmp:0000001167) 131538640(ppp1r12a)

PPRM:

120473478(ppp1r12a) 120474043(zmp:0000001167)

RKG:	130082647(ppp1r12a) 130106485(zmp:0000001167)

MAMB:

125246147(ppp1r12a) 125246847(zmp:0000001167)

CIDE:

127506683(zmp:0000001167) 127510961

MASI:

127435398 127435746(zmp:0000001167) 127436784 127437189

TROS:

130547691(ppp1r12a) 130551781(zmp:0000001167)

TDW:	130413960(zmp:0000001167) 130420517(ppp1r12a)

MANU:

129432377(ppp1r12a) 129434290(zmp:0000001167)

IPU:

108279475

IFU:	128618037(zmp:0000001167) 128622997(ppp1r12a)

SMEO:

124392160(zmp:0000001167) 124400916(ppp1r12a)

TFD:	113648169 113654009(zmp:0000001167) 125139542

TVC:	132856664(zmp:0000001167) 132859149(ppp1r12a)

TRN:	134311718(zmp:0000001167) 134316693(ppp1r12a)

AMEX:

103046804(ppp1r12a)

CMAO:

118811910(zmp:0000001167) 118812308(ppp1r12a)

EEE:	113582642(ppp1r12a)

CHAR:

105889597(ppp1r12a) 105912025(zmp:0000001167)

TRU:	101079088(ppp1r12a)

TFS:	130519018(ppp1r12a)

LCO:	104924035(ppp1r12a) 104928858

NCC:	104949170(ppp1r12a) 104956193

TBEN:

117484918(ppp1r12a)

CGOB:

115028155(ppp1r12a)

PGEO:

117468356(ppp1r12a)

GACU:

117552449(ppp1r12a)

EMAC:

134879172(ppp1r12a)

ELY:	117249219(ppp1r12a) 117262461(zmp:0000001167)

EFO:	125882873(ppp1r12a)

PLEP:

121950090(zmp:0000001167) 121961097(ppp1r12a)

SLUC:

116038311(zmp:0000001167) 116060013(ppp1r12a)

ECRA:

117938723(ppp1r12a)

ESP:	116673322(ppp1r12a)

PFLV:

114549886(ppp1r12a)

GAT:	120808673(zmp:0000001167) 120817575(ppp1r12a)

PPUG:

119195724(zmp:0000001167) 119210250(ppp1r12a)

AFB:	129112252(ppp1r12a)

CLUM:

117725929(ppp1r12a)

PSWI:

130200763(ppp1r12a)

MSAM:

119893300(zmp:0000001167) 119918120(ppp1r12a)

SCHU:

122871502(ppp1r12a)

CUD:	121505651(ppp1r12a) 121515748(zmp:0000001167)

ALAT:

119032431(ppp1r12a)

MZE:	101469187 101484034(ppp1r12a)

ONL:	100691168 100701481(ppp1r12a)

OAU:	116325451(ppp1r12a) 116326292(zmp:0000001167)

OLA:	101161524(ppp1r12a)

OML:	112155122(ppp1r12a)

CSAI:

133424408(ppp1r12a)

XMA:	102218333(ppp1r12a)

XCO:	114160902(ppp1r12a)

XHE:	116736685(ppp1r12a)

PRET:

103459134(ppp1r12a)

PFOR:

103140246(ppp1r12a)

PLAI:

106945351(ppp1r12a)

PMEI:

106918559(ppp1r12a)

GAF:	122826603(ppp1r12a)

PPRL:

129351513(ppp1r12a)

CVG:	107085644(ppp1r12a)

CTUL:

119781029(ppp1r12a)

GMU:	124882879(ppp1r12a)

NFU:	107386601(ppp1r12a)

KMR:	108233296(ppp1r12a)

ALIM:

106521272(ppp1r12a)

AOCE:

111568454(ppp1r12a) 111577267

MCEP:

124999912(ppp1r12a)

CSEM:

103380280 103382552(ppp1r12a)

POV:	109641125(ppp1r12a)

SSEN:

122766043(ppp1r12a) 122776008(zmp:0000001167)

HHIP:

117756962(ppp1r12a) 117763329(zmp:0000001167)

HSP:	118101276(ppp1r12a) 118109588(zmp:0000001167)

PPLT:

128428411(ppp1r12a) 128443910(zmp:0000001167)

SMAU:

118292242(ppp1r12a) 118316000(zmp:0000001167)

LCF:	108873647 108886890(zmp:0000001167)

SDU:	111224778(ppp1r12a) 111229837

SLAL:

111660032(ppp1r12a) 111666970

XGL:	120793526(zmp:0000001167) 120801257(ppp1r12a)

HCQ:	109507600 109530079(ppp1r12a)

SSCV:

125992475

SBIA:

133493170(ppp1r12a)

PEE:	133397124(ppp1r12a)

PTAO:

133471666(ppp1r12a)

BPEC:

110161521(ppp1r12a) 110169303

MALB:

109967812(ppp1r12a) 109972924

BSPL:

114857076(zmp:0000001167) 114862499(ppp1r12a)

SJO:	128353072(ppp1r12a)

SASA:

106584787 106609419

STRU:

115193074 115197721 115198972

OTW:	112214179 112219159(zmp:0000001167) 112238870

OMY:	110490454 110500010 110501253 110521175

OGO:	124014555 124037460(zmp:0000001167) 124038538

ONE:

115107095

OKI:	109881399 109882082 109896632 109910297

OKE:	118366359 118381918 118392497 127912147

SALP:

111951439 111955769 112070264

SNH:	120031751 120049962

CCLU:

121540099(zmp:0000001167)

ELS:	105018059 105020291(ppp1r12a)

SFM:

108942353

PKI:	111843391(ppp1r12a)

AANG:

118218693 118231698(ppp1r12a)

PSPA:

121294632 121318051 121320035 121330033

ARUT:

117415287 117419536(ppp1r12a)

PSEX:

120534272(ppp1r12a)

LCM:	102356119(PPP1R12A)

CPLA:

122557924 122559350(ppp1r12a)

HOC:	132824378(zmp:0000001167) 132824834(ppp1r12a)

LERI:

129706329(ppp1r12a)

PMRN:

116952022(PPP1R12A)

LRJ:

BFO:

BBEL:

CIN:

SCLV:

SPU:	580387 591869

DGR:

ACOZ:

AARA:

ASTE:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ006926

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:	105286756 113561443

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

TCA:

SOY:

CSET:

DVV:

NVL:

APLN:

PPYR:

OTU:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM561400 Phum_PHUM561410

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

DSV:

RSAN:

RMP:

VDE:

VJA:

ABRU:

UDV:

CEL:	CELE_C06C3.1(mel-11)

CBR:	CBG_00870(Cbr-mel-11)

CRQ:	GCK72_004351

BMY:	BM_BM2006(Bma-mel-11)

LOA:	LOAG_01053

PVUL:

BGT:

GAE:

HRF:

HRJ:

CRG:

PMAX:

OSN:

LJP:

SMM:	Smp_143370

NVE:

ATEN:

XEN:

Reference

PMID:7982954

Authors

Shimizu H, Ito M, Miyahara M, Ichikawa K, Okubo S, Konishi T, Naka M, Tanaka T, Hirano K, Hartshorne DJ, et al.

Title

Characterization of the myosin-binding subunit of smooth muscle myosin phosphatase.

Journal

J Biol Chem 269:30407-11 (1994)

Sequence

[gga:396020]

Reference

PMID:21291858

Authors

Grassie ME, Moffat LD, Walsh MP, MacDonald JA

Title

The myosin phosphatase targeting protein (MYPT) family: a regulated mechanism for achieving substrate specificity of the catalytic subunit of protein phosphatase type 1delta.

Journal

Arch Biochem Biophys 510:147-59 (2011)
DOI:10.1016/j.abb.2011.01.018

LinkDB

DBGET integrated database retrieval system