KEGG ORTHOLOGY: K07207

ORTHOLOGY: K07207

Entry

K07207                      KO

Symbol

TSC2

Name

tuberous sclerosis 2

Pathway

map04072

Phospholipase D signaling pathway

map04115

p53 signaling pathway

map04140

Autophagy - animal

map04150

mTOR signaling pathway

map04151

PI3K-Akt signaling pathway

map04152

AMPK signaling pathway

map04211

Longevity regulating pathway

map04218

Cellular senescence

map04714

Thermogenesis

map04910

Insulin signaling pathway

map04919

Thyroid hormone signaling pathway

map05163

Human cytomegalovirus infection

map05165

Human papillomavirus infection

map05168

Herpes simplex virus 1 infection

map05231

Choline metabolism in cancer

Disease

H00896

Lymphangioleiomyomatosis

H00915

Tuberous sclerosis complex

H01251

Focal cortical dysplasia of Taylor

H01691

Renal angiomyolipoma

H01692

Subependymal giant cell astrocytoma

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    K07207  TSC2; tuberous sclerosis 2
   04151 PI3K-Akt signaling pathway
    K07207  TSC2; tuberous sclerosis 2
   04152 AMPK signaling pathway
    K07207  TSC2; tuberous sclerosis 2
   04150 mTOR signaling pathway
    K07207  TSC2; tuberous sclerosis 2
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K07207  TSC2; tuberous sclerosis 2
  09143 Cell growth and death
   04115 p53 signaling pathway
    K07207  TSC2; tuberous sclerosis 2
   04218 Cellular senescence
    K07207  TSC2; tuberous sclerosis 2
09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K07207  TSC2; tuberous sclerosis 2
   04919 Thyroid hormone signaling pathway
    K07207  TSC2; tuberous sclerosis 2
  09149 Aging
   04211 Longevity regulating pathway
    K07207  TSC2; tuberous sclerosis 2
  09159 Environmental adaptation
   04714 Thermogenesis
    K07207  TSC2; tuberous sclerosis 2
09160 Human Diseases
  09161 Cancer: overview
   05231 Choline metabolism in cancer
    K07207  TSC2; tuberous sclerosis 2
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    K07207  TSC2; tuberous sclerosis 2
   05163 Human cytomegalovirus infection
    K07207  TSC2; tuberous sclerosis 2
   05165 Human papillomavirus infection
    K07207  TSC2; tuberous sclerosis 2
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K07207  TSC2; tuberous sclerosis 2
Protein phosphatases and associated proteins [BR:ko01009]
Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K07207  TSC2; tuberous sclerosis 2

Genes

HSA:	7249(TSC2)

PTR:	468086(TSC2)

PPS:	100971050(TSC2)

GGO:	101137934(TSC2)

PON:	100441126(TSC2)

NLE:	100604902 115831278

HMH:	116462653(TSC2)

MCC:	694965(TSC2)

MCF:	102140628(TSC2)

MTHB:

126944570

MNI:	105485816(TSC2)

CSAB:

103226584(TSC2)

CATY:

105573530(TSC2)

PANU:

101025020(TSC2)

TGE:	112614277(TSC2)

MLEU:

105529748(TSC2)

RRO:	104681538(TSC2)

RBB:	108519399(TSC2)

TFN:	117097810(TSC2)

PTEH:

111524144(TSC2)

CANG:

105526466(TSC2)

CJC:	100390664(TSC2)

SBQ:	101031475(TSC2)

CIMI:

108290925(TSC2)

CSYR:

103250119(TSC2)

MMUR:

105859584(TSC2)

LCAT:

123631484(TSC2)

PCOQ:

105813061(TSC2)

OGA:	100956811(TSC2)

MMU:	22084(Tsc2)

MCAL:

110284338(Tsc2)

MPAH:

110338315(Tsc2)

RNO:	24855(Tsc2)

MCOC:

116078562(Tsc2)

ANU:	117710404(Tsc2)

MUN:	110553023(Tsc2)

CGE:	100755849(Tsc2)

MAUA:

101837089(Tsc2)

PROB:

127219556(Tsc2)

PLEU:

114680760(Tsc2)

MORG:

121463682(Tsc2)

MFOT:

126498654

AAMP:

119811857(Tsc2)

NGI:	103752451(Tsc2)

HGL:	101713968(Tsc2)

CPOC:

100731690(Tsc2)

CCAN:

109690162(Tsc2)

DORD:

105982089(Tsc2)

DSP:	122123834(Tsc2)

PLOP:

125340703(Tsc2)

NCAR:

124970035

MMMA:

107146721(Tsc2)

OCU:

100351640

OPI:	101519464(TSC2)

TUP:	102484276(TSC2)

GVR:	103597845(TSC2)

CFA:	479883(TSC2)

CLUD:

112640546(TSC2)

VVP:	112909041(TSC2)

VLG:	121487228(TSC2)

NPO:	129519340(TSC2)

AML:	100465690(TSC2)

UMR:	103668779(TSC2)

UAH:	113245080(TSC2)

UAR:	123783731(TSC2)

ELK:

111156259

LLV:

125090843

MPUF:

101672308(TSC2)

MNP:	132027018(TSC2)

MLK:	131819373(TSC2)

NVS:	122896129(TSC2)

ORO:	101371494(TSC2)

EJU:	114215501(TSC2)

ZCA:	113933431(TSC2)

MLX:	118021717(TSC2)

NSU:	110588066 123323688

LWW:	102736702(TSC2)

FCA:	101082969(TSC2)

PYU:	121019674(TSC2)

PCOO:

112853203(TSC2)

PBG:	122471824(TSC2)

PVIV:

125154230(TSC2)

LRUF:

124525459

PTG:	102956176(TSC2)

PPAD:

109278145(TSC2)

PUC:

125926191

AJU:

106982748

HHV:	120241477(TSC2)

BTA:	504985(TSC2)

BOM:	102267343(TSC2)

BIU:	109578279(TSC2)

BBUB:

102389973(TSC2)

BBIS:

104985533

CHX:	100860943(TSC2)

OAS:	101115088(TSC2)

BTAX:

128043920(TSC2)

ODA:	120873306(TSC2)

CCAD:

122433316(TSC2)

MBEZ:

129545260(TSC2)

SSC:	100505408(TSC2)

CFR:	102523349(TSC2)

CBAI:

105064853(TSC2)

CDK:	105099714(TSC2)

VPC:	102524933(TSC2)

BACU:

103008177(TSC2)

BMUS:

118880802(TSC2)

LVE:	103075350(TSC2)

OOR:	101276336(TSC2)

DLE:	111185176(TSC2)

PCAD:

102985473(TSC2)

PSIU:

116740928(TSC2)

NASI:

112409519(TSC2)

ECB:	100065679(TSC2)

EPZ:	103566788(TSC2)

EAI:	106836234(TSC2)

MYB:	102253389(TSC2)

MYD:	102770093(TSC2)

MMYO:

118656215(TSC2)

MLF:	102422720(TSC2)

PKL:	118702780(TSC2)

EFUS:

103290502(TSC2)

MNA:	107533380(TSC2)

DRO:	112298303(TSC2)

SHON:

118978897(TSC2)

AJM:	119058207(TSC2)

PDIC:

114509258(TSC2)

PHAS:

123807207(TSC2)

MMF:	118642250(TSC2)

PPAM:

129083598(TSC2)

HAI:	109385868(TSC2)

RFQ:	117019487(TSC2)

PALE:

102898762(TSC2)

PGIG:

120620251(TSC2)

PVP:	105303335(TSC2)

RAY:	107506056(TSC2)

MJV:	108410254(TSC2)

TOD:	119242027(TSC2)

SARA:

101543551(TSC2)

SETR:

126000897(TSC2)

LAV:	100670924(TSC2)

TMU:

101358131

ETF:	101663717(TSC2)

DNM:	101413281(TSC2)

MDO:	100011431(TSC2)

GAS:	123231037(TSC2)

SHR:	100918445(TSC2)

AFZ:

127543419

PCW:	110221953(TSC2)

OAA:	100086661(TSC2)

GGA:	416552(TSC2)

PCOC:

116237652(TSC2)

MGP:	100542960(TSC2)

CJO:	107320601(TSC2)

TPAI:

128079396(TSC2)

LMUT:

125700990(TSC2)

NMEL:

110406041(TSC2)

APLA:

101804966(TSC2)

ACYG:

106032149(TSC2)

CATA:

118256451(TSC2)

AFUL:

116495290(TSC2)

TGU:	100222231(TSC2)

LSR:	110480669(TSC2)

SCAN:

103817576(TSC2)

PMOA:

120513021(TSC2)

OTC:	121334348(TSC2)

PRUF:

121365816(TSC2)

GFR:	102039715(TSC2)

FAB:	101818727(TSC2)

OMA:	130259507(TSC2)

PHI:	102110699(TSC2)

PMAJ:

107211281(TSC2)

CCAE:

111936184(TSC2)

CCW:	104684745(TSC2)

ETL:	114064312(TSC2)

ZAB:	102062324(TSC2)

ZLE:	135454394(TSC2)

ACHL:

103805908

SVG:	106859288(TSC2)

MMEA:

130576502(TSC2)

HRT:	120759865(TSC2)

FPG:	101919684(TSC2)

FCH:	102055452(TSC2)

CLV:	102098310(TSC2)

EGZ:	104127720(TSC2)

NNI:	104015144(TSC2)

PCRI:

104027225(TSC2)

PLET:

104624805(TSC2)

EHS:	104507359(TSC2)

PCAO:

104048872(TSC2)

ACUN:

113485670(TSC2)

TALA:

104357357(TSC2)

PADL:

103921410(TSC2)

AFOR:

103904934(TSC2)

ACHC:

115335525(TSC2)

HALD:

104322514(TSC2)

HLE:	104833651(TSC2)

AGEN:

126034317

GCL:

127022241

CCRI:

104161623(TSC2)

CSTI:

104561655(TSC2)

CMAC:

104478259(TSC2)

MUI:	104540982(TSC2)

BREG:

104629116(TSC2)

FGA:	104069209(TSC2)

GSTE:

104257503(TSC2)

LDI:	104352218(TSC2)

MNB:	103768547(TSC2)

OHA:	104336140(TSC2)

NNT:	104409203(TSC2)

SHAB:

115607606(TSC2)

DPUB:

104296683(TSC2)

PGUU:

104460800

ACAR:

104528615(TSC2)

CPEA:

104393110(TSC2)

AVIT:

104267029(TSC2)

CVF:	104294989(TSC2)

RTD:	128913277(TSC2)

CUCA:

104060377(TSC2)

TEO:	104374782(TSC2)

BRHI:

104493029(TSC2)

AAM:	106492227(TSC2)

AROW:

112975465(TSC2)

NPD:	112959892(TSC2)

TGT:

104571035

DNE:	112985370(TSC2)

SCAM:

104138420(TSC2)

ASN:	102387523(TSC2)

AMJ:	102558178(TSC2)

CPOO:

109314619(TSC2)

GGN:	109294404(TSC2)

PSS:	102448020(TSC2)

CMY:	102946461(TSC2)

CCAY:

125643570(TSC2)

DCC:	119862521(TSC2)

CPIC:

101934665(TSC2)

TST:	117883582(TSC2)

CABI:

116814839(TSC2)

MRV:	120373814(TSC2)

ACS:	100552562(tsc2)

ASAO:

132781932(TSC2)

PVT:	110085051(TSC2)

SUND:

121914529(TSC2)

PBI:	103048571(TSC2)

PMUR:

107302611(TSC2)

CTIG:

120313548(TSC2)

TSR:	106549890(TSC2)

PGUT:

117667350(TSC2)

APRI:

131185165(TSC2)

PTEX:

113438575(TSC2)

NSS:	113422575(TSC2)

VKO:	123034871(TSC2)

PMUA:

114584836(TSC2)

PRAF:

128401959(TSC2)

ZVI:	118092654(TSC2)

HCG:	128336398(TSC2)

GJA:	107114161(TSC2)

STOW:

125431771(TSC2)

EMC:	129340080(TSC2)

XLA:	108701656(tsc2.L) 108703213(tsc2.S)

XTR:	100170546(tsc2)

NPR:	108791228(TSC2)

RTEM:

120943277(TSC2)

BBUF:

121008869(TSC2)

BGAR:

122945224(TSC2)

MUO:	115477003(TSC2)

GSH:	117369055(TSC2)

DRE:	567524(tsc2)

SRX:	107709598(tsc2) 107729879

SANH:

107700795 107703706

SGH:	107594329 107598529

CCAR:

109106409

CAUA:

113057450 113076699 113097610

CGIB:

127949105 127957193 127957194 127958752 128019916

PTET:

122346357(tsc2)

LROH:

127170175(tsc2)

OMC:	131541038(tsc2)

PPRM:

120488524(tsc2)

RKG:	130070041(tsc2)

MAMB:

125271746(tsc2)

CIDE:

127520890

MASI:

127443978 127445592

TROS:

130553344(tsc2)

TDW:	130433910(tsc2)

MANU:

129443972(tsc2)

IPU:

108258582

IFU:	128601858(tsc2)

PHYP:

113537702(tsc2)

SMEO:

124378329(tsc2)

TFD:	113663584(tsc2)

TVC:	132839274(tsc2)

TRN:	134328631(tsc2)

AMEX:

103033522(tsc2)

CMAO:

118798267(tsc2)

EEE:	113591344(tsc2)

CHAR:

105896278(tsc2)

TRU:	101078033(tsc2)

TFS:	130527850(tsc2)

TNG:	GSTEN00026281G001

LCO:	104927875(tsc2)

NCC:

104946556

TBEN:

117474659(tsc2)

CGOB:

115015359(tsc2)

PGEO:

117460959(tsc2)

GACU:

117561619(tsc2)

EMAC:

134864423(tsc2)

ELY:	117254935(tsc2)

EFO:	125886310(tsc2)

PLEP:

121941791(tsc2)

SLUC:

116042780(tsc2)

ECRA:

117958819(tsc2)

ESP:	116704311(tsc2)

PFLV:

114545904(tsc2)

GAT:	120824746(tsc2)

PPUG:

119217409(tsc2)

AFB:	129095966(tsc2)

CLUM:

117729575(tsc2)

PSWI:

130190568(tsc2)

MSAM:

119899493(tsc2)

SCHU:

122873522(tsc2)

CUD:	121508350(tsc2)

ALAT:

119024301(tsc2)

MZE:	101468908(tsc2)

ONL:	100696216(tsc2)

OAU:	116330594(tsc2)

OLA:	101168435(tsc2)

OML:	112137256(tsc2)

CSAI:

133443224(tsc2)

XMA:	102219500(tsc2)

XCO:	114144594(tsc2)

XHE:	116719927(tsc2)

PRET:

103465672(tsc2)

PFOR:

103150546(tsc2)

PLAI:

106939438(tsc2)

PMEI:

106917577(tsc2)

GAF:	122829597(tsc2)

PPRL:

129367134(tsc2)

CVG:	107098599(tsc2)

CTUL:

119774330(tsc2)

GMU:	124867678(tsc2)

NFU:	107390291(tsc2)

KMR:	108236362(tsc2)

ALIM:

106532497(tsc2)

NWH:	119422323(tsc2)

AOCE:

111571907(tsc2)

MCEP:

125004240(tsc2)

CSEM:

103383928(tsc2)

POV:	109627333 109627588

SSEN:

122770774(tsc2)

HHIP:

117768487(tsc2)

HSP:	118118306(tsc2)

PPLT:

128437265(tsc2)

SMAU:

118311969(tsc2)

LCF:

108875623

SDU:	111229195(tsc2)

SLAL:

111659043 111666666(tsc2)

XGL:	120799938(tsc2)

HCQ:	109527351(tsc2)

SSCV:

125969583

SBIA:

133506475(tsc2)

PEE:	133404591(tsc2)

PTAO:

133476343(tsc2)

BPEC:

110165184 110166137

MALB:

109957851(tsc2)

BSPL:

114860476(tsc2)

SJO:	128381140(tsc2)

SASA:

106564303

STRU:

115147613(tsc2)

OTW:

112242265

OMY:	110495049(tsc2) 110510382 118951919 118959021

OGO:	124020654 124020660

OKI:	109878903(tsc2)

OKE:

118380360

SNH:	120018258(tsc2)

CCLU:

121533065(tsc2)

ELS:	105031540(tsc2)

SFM:	108939799(tsc2)

PKI:	111858859(tsc2)

AANG:

118220763(tsc2)

LOC:	102698706(tsc2)

PSPA:

121300741(tsc2) 121330994

ARUT:

117418002 117431069

PSEX:

120542319(tsc2)

LCM:	102365821(TSC2)

CMK:	103189890(tsc2)

RTP:	109913050(tsc2)

CPLA:

122560514(tsc2)

HOC:	132825367(tsc2)

LERI:

129706968(tsc2)

PMRN:

116952897(TSC2)

LRJ:	133347575(TSC2)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

SKO:

DME:	Dmel_CG6975(gig)

DER:

6545890

DSE:

6616239

DSI:	Dsimw501_GD14854(Dsim_GD14854)

DYA:	Dyak_GE19646 Dyak_GE22756

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI11523

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ007912

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:	660002(TSC2)

DPA:

SOY:

AGRG:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_209357

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PGW:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

NLU:

HVI:	124354304 124370904

MQU:

128991934

PHU:	Phum_PHUM422030

FOC:

TPAL:

ZNE:

CSEC:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_228923(TSC2)

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

ABRU:

UDV:

SDM:

NAI:	NECAME_10602

LOA:	LOAG_16626

TSP:

Tsp_05666

LGI:	LOTGIDRAFT_61259

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MMER:

RPHI:

MAEA:

OBI:

OSN:

LJP:

LAK:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:	114541799 114543475

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_60832

AQU:

100640651

TVS:	TRAVEDRAFT_65744

ABP:	AGABI1DRAFT131561(AGABI1DRAFT_131561)

ABV:	AGABI2DRAFT121761(AGABI2DRAFT_121761)

E1B28_010237

MBR:	MONBRDRAFT_39243

DDI:	DDB_G0280527

DPP:	DICPUDRAFT_156510

DFA:

DFA_11640

ACAN:

ACA1_061610

PIF:	PITG_03732

PSOJ:

PHYSODRAFT_437914

SPAR:

SPRG_10646

GTT:	GUITHDRAFT_113795

» show all

Reference

PMID:8269512

Title

Identification and characterization of the tuberous sclerosis gene on chromosome 16.

Journal

Cell 75:1305-15 (1993)
DOI:10.1016/0092-8674(93)90618-Z

Sequence

[hsa:7249]

Reference

PMID:12271141

Authors

Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J

Title

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling.

Journal

Proc Natl Acad Sci U S A 99:13571-6 (2002)
DOI:10.1073/pnas.202476899

Sequence

[hsa:7249]

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