KEGG ORTHOLOGY: K07430

KEGG

ORTHOLOGY: K07430

Entry

K07430                      KO

Symbol

CYP7B

Name

25/26-hydroxycholesterol 7alpha-hydroxylase [EC:1.14.14.29]

Pathway

Primary bile acid biosynthesis

Steroid hormone biosynthesis

Reaction

cholest-5-ene-3beta,25-diol,[NADPH---hemoprotein reductase]:oxygen oxidoreductase (7alpha-hydroxylating)

cholest-5-ene-3beta,26-diol,[NADPH---hemoprotein reductase]:oxygen oxidoreductase (7alpha-hydroxylating)

3beta-hydroxy-5-cholestenoate,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)

pregnenolone,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)

Disease

Hereditary spastic paraplegia

Congenital bile acid synthesis defect

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00120 Primary bile acid biosynthesis
    K07430  CYP7B; 25/26-hydroxycholesterol 7alpha-hydroxylase
   00140 Steroid hormone biosynthesis
    K07430  CYP7B; 25/26-hydroxycholesterol 7alpha-hydroxylase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07430  CYP7B; 25/26-hydroxycholesterol 7alpha-hydroxylase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.29  25/26-hydroxycholesterol 7alpha-hydroxylase
     K07430  CYP7B; 25/26-hydroxycholesterol 7alpha-hydroxylase
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP7 family
   K07430  CYP7B; 25/26-hydroxycholesterol 7alpha-hydroxylase

Other DBs

GO:

Genes

HSA:	9420(CYP7B1)

PTR:	743817(CYP7B1)

PPS:	100995737(CYP7B1)

GGO:

PON:

NLE:

HMH:

MCC:

MCF:	102132453(CYP7B1)

MTHB:

MNI:

CSAB:

CATY:

PANU:

TGE:

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

CJC:	100385287(CYP7B1)

SBQ:

CIMI:

108317172(CYP7B1)

CSYR:

MMUR:

LCAT:

PCOQ:

OGA:

MMU:	13123(Cyp7b1)

MCAL:

MPAH:

RNO:	25429(Cyp7b1)

MCOC:

ANU:

MUN:

CGE:

MAUA:

PROB:

PLEU:

MORG:

MFOT:

AAMP:

NGI:

HGL:

CPOC:

CCAN:

DORD:

DSP:

PLOP:

NCAR:

MMMA:

OCU:

OPI:

TUP:

GVR:

CFA:	486973(CYP7B1)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

NSU:

LWW:

FCA:	101086873(CYP7B1)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

PTG:

PPAD:

PUC:

AJU:

HHV:

BTA:	529552(CYP7B1)

BOM:

BIU:

BBUB:

BBIS:

CHX:

OAS:

BTAX:

ODA:

CCAD:

MBEZ:

SSC:

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

DLE:

PCAD:

PSIU:

NASI:

ECB:

EPZ:

EAI:

MYB:

MYD:

MMYO:

MLF:

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:

MJV:

TOD:

SARA:

SETR:

LAV:

TMU:

ETF:

DNM:

MDO:	100029487(CYP7B1)

GAS:

SHR:

AFZ:

PCW:

OAA:

GGA:	420164(CYP7B1)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

ACYG:

CATA:

AFUL:

TGU:

LSR:

SCAN:

PMOA:

OTC:

PRUF:

GFR:

FAB:

OMA:

PHI:

PMAJ:

CCAE:

CCW:

CBRC:

ETL:

ZAB:

ZLE:

ACHL:

SVG:

MMEA:

HRT:

FPG:

FCH:

CLV:

EGZ:

NNI:

PCRI:

PLET:

EHS:

PCAO:

ACUN:

TALA:

PADL:

AFOR:

ACHC:

HALD:

HLE:

AGEN:

GCL:

CCRI:

CSTI:

CMAC:

MUI:

BREG:

FGA:

GSTE:

LDI:

MNB:

OHA:

NNT:

SHAB:

DPUB:

PGUU:

ACAR:

CPEA:

AVIT:

CVF:

RTD:

CUCA:

TEO:

BRHI:

AAM:

AROW:

NPD:

TGT:

DNE:

SCAM:

ASN:

AMJ:	102562782(CYP7B1)

CPOO:

GGN:

PSS:

CMY:

CCAY:

DCC:

CPIC:

TST:

CABI:

MRV:

ACS:

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

APRI:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

ZVI:

HCG:

GJA:

STOW:

EMC:

XLA:	108719274(cyp7b1.L)

XTR:	100145642(cyp7b1)

NPR:

RTEM:

BBUF:

BGAR:

MUO:

GSH:

DRE:	570455(cyp7b1)

SRX:	107721742 107749124

SANH:

107659553 107690180

SGH:	107566988 107602637

CCAR:

109070086 109073141

CAUA:

113045069 113120109 113120636

CGIB:

127934243 127950509

PTET:

LROH:

OMC:

PPRM:

RKG:

MAMB:

CIDE:

MASI:

127440311 127442099

TROS:

TDW:

MANU:

IPU:

IFU:

PHYP:

SMEO:

TFD:

TVC:

TRN:

AMEX:

CMAO:

EEE:

CHAR:

TRU:

TFS:

TNG:	GSTEN00005656G001 GSTEN00010553G001

LCO:

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

116056359 116056373

ECRA:

PFLV:

GAT:

PPUG:

AFB:

CLUM:

MSAM:

119896733 119902807

SCHU:

CUD:

ALAT:

MZE:

ONL:

OAU:

OLA:

OML:

CSAI:

XMA:

XCO:	114146856 114146857

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

129351715 129356708

CVG:

CTUL:

GMU:

NFU:

KMR:

ALIM:

NWH:

AOCE:

MCEP:

CSEM:

SSEN:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:

SLAL:

XGL:

HCQ:

SSCV:

SBIA:

PEE:

PTAO:

MALB:

BSPL:

SJO:

SASA:

106569045 106599438(CP7B1)

STRU:

115156926 115169796

OTW:	112226969 112260443

OMY:	110508760 110530280

OGO:	124009594 124041887

ONE:	115103117 115114379

OKI:	109871991 109874863

OKE:	118394623 118402137

SALP:

111956752 111979270

SNH:	120020376 120055909

CCLU:

ELS:

SFM:

PKI:

LOC:

PSPA:

ARUT:

LCM:

CMK:

RTP:

CPLA:

HOC:

LERI:

PMRN:

116951257 116951268

LRJ:	133347460 133347943

BFO:	118409866 118419007

BBEL:

109463792 109465379 109468210 109472486

Reference

PMID:10588945 (CYP7B1)

Authors

Wu Z, Martin KO, Javitt NB, Chiang JY

Title

Structure and functions of human oxysterol 7alpha-hydroxylase cDNAs and gene CYP7B1.

Journal

J Lipid Res 40:2195-203 (1999)

Sequence

[hsa:9420]

Reference

PMID:12759897 (CYP7B1)

Authors

Ren S, Marques D, Redford K, Hylemon PB, Gil G, Vlahcevic ZR, Pandak WM

Title

Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in the rat.

Journal

Metabolism 52:636-42 (2003)
DOI:10.1053/meta.2003.50106

Sequence

[rno:25429]

LinkDB

DBGET integrated database retrieval system