KEGG ORTHOLOGY: K07431

ORTHOLOGY: K07431

Entry

K07431                      KO

Symbol

CYP8B1

Name

sterol 12-alpha-hydroxylase [EC:1.14.14.139]

Pathway

map00120

Primary bile acid biosynthesis

map01100

Metabolic pathways

map03320

PPAR signaling pathway

Module

M00104

Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate

Reaction

R04826

7alpha-hydroxycholest-4-en-3-one,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (12alpha-hydroxylating)

R07204

5beta-cholestane-3alpha,7alpha-diol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (12alpha-hydroxylating)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00120 Primary bile acid biosynthesis
    K07431  CYP8B1; sterol 12-alpha-hydroxylase
09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    K07431  CYP8B1; sterol 12-alpha-hydroxylase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07431  CYP8B1; sterol 12-alpha-hydroxylase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.139  5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase
     K07431  CYP8B1; sterol 12-alpha-hydroxylase
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP8 family
   K07431  CYP8B1; sterol 12-alpha-hydroxylase

Other DBs

GO:

0008397

Genes

HSA:	1582(CYP8B1)

PTR:	736962(CYP8B1)

PPS:	100969929(CYP8B1)

GGO:

PON:

NLE:

HMH:

MCC:

MCF:	102132602(CYP8B1)

MTHB:

126948519

MNI:

105480287

CSAB:

103227471(CYP8B1)

CATY:

PANU:

TGE:

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

CJC:	100402181(CYP8B1)

SBQ:

101037790

CIMI:

108300032(CYP8B1)

CSYR:

MMUR:

PCOQ:

OGA:

MMU:	13124(Cyp8b1)

MCAL:

110302470

MPAH:

110327161

RNO:	81924(Cyp8b1)

MCOC:

ANU:

MUN:

CGE:

MAUA:

PROB:

PLEU:

MORG:

MFOT:

AAMP:

NGI:

CPOC:

CCAN:

DORD:

DSP:

PLOP:

NCAR:

MMMA:

OCU:	100009301(CYP8B1)

OPI:

101531078

TUP:

102479742

GVR:

103588225

CFA:	485619(CYP8B1)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

NSU:

LWW:

FCA:	101082004(CYP8B1)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

PTG:

PPAD:

PUC:

AJU:

HHV:	120243596 120243597

BTA:	538964(CYP8B1)

BIU:

BBUB:

BBIS:

CHX:

OAS:

BTAX:

ODA:

CCAD:

MBEZ:

SSC:	403328(CYP8B1)

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

DLE:

PCAD:

PSIU:

NASI:

ECB:

EPZ:

EAI:

MYB:

MYD:

MMYO:

MLF:

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:

MJV:

TOD:

SARA:

SETR:

LAV:

TMU:

ETF:

DNM:

MDO:	100026525 100026549(CYP8B)

GAS:	123230807 123254771

SHR:	100918099 100919664 100926550 105749568

PCW:

110217059

OAA:

103166427

GGA:	425055(CYP8B1)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

ACYG:

CATA:

AFUL:

TGU:

LSR:

SCAN:

PMOA:

OTC:

PRUF:

GFR:

FAB:

OMA:

PHI:

PMAJ:

CCAE:

CCW:

CBRC:

ETL:

ZAB:

ACHL:

SVG:

MMEA:

HRT:

FPG:

FCH:

CLV:

EGZ:

NNI:

PCRI:

PLET:

EHS:

PCAO:

ACUN:

TALA:

PADL:

AFOR:

ACHC:

HALD:

HLE:

AGEN:

GCL:

CCRI:

CSTI:

CMAC:

MUI:

BREG:

FGA:

GSTE:

LDI:

MNB:

OHA:

NNT:

SHAB:

DPUB:

PGUU:

ACAR:

CPEA:

AVIT:

CVF:

RTD:

CUCA:

TEO:

BRHI:

NPD:

TGT:

DNE:

SCAM:

ASN:

AMJ:	102573091(CYP8B1)

CPOO:

GGN:

PSS:

CMY:

CCAY:

DCC:	119850697 119851812

CPIC:

TST:

CABI:

MRV:

ACS:	100551676 100551876 100562756 100562953 100565509 100565705 100565905 100566106

ASAO:

132779804 132779808 132779809 132779810

PVT:	110091568 110091574 110091575

SUND:

121932425 121934688 121935162 121935580 121935581

PBI:	103051222 103065731

PMUR:

107284342 107284343 107284344 107284346 107284348 107284362

CTIG:

120296691 120318053 120318058 120318065 120319285

TSR:	106538485 106538492

PGUT:

117680087 117680089

APRI:

131196734 131196735

PTEX:

113449276 113449277

NSS:	113422182 113422190

VKO:	123020905 123020984

PMUA:

114607583 114607705 114607796 114607915

PRAF:

128398296 128398297 128398298

ZVI:	118091758 118091759 118091944

HCG:	128330313 128330314 128330315 128331371 128331373 128331374 128331751 128331752

GJA:	107106985 107106986 107110695 107112093 107125164

STOW:

125440698 125441151

EMC:	129337237 129337817 129337819 129337820 129337853 129337869 129337928

XLA:	108718630(cyp8b1.2.L) 379482(cyp8b1.1.S)

XTR:	100488015(cyp8b1.2) 100488168(cyp8b1.1)

NPR:

RTEM:

BBUF:

BGAR:

MUO:	115466283 115466290 115466320 115466327 115466341 115466365

GSH:

117355598

DRE:	100004274(cyp8b1.2) 445281(cyp8b1.1) 447848(cyp8b1.3)

SRX:	107711691 107727542

SANH:

107661909 107671665

SGH:	107558014 107580338 107593879

CCAR:

109056773 109056779 109056788

CAUA:

113038725 113038733 113046101

CGIB:

127950969 128024980 128024994

PTET:

LROH:

OMC:

PPRM:

RKG:

MAMB:

CIDE:

MASI:

TROS:

TDW:

MANU:

129442789 129442794 129442795

IPU:	108261592 108268189 108268197

IFU:	128610594 128610595 128610596 128610597 128610598 128610762

PHYP:

SMEO:

TFD:

TVC:

TRN:	134311801 134311802 134311803

AMEX:

103039627

CMAO:

118826322 118826323

EEE:	113582944 113590803

CHAR:

105900586

TRU:	101070868 101071841 101080232 115248012 115248013

TFS:	130538329 130538331 130538332 130539269

TNG:	GSTEN00016125G001 GSTEN00016134G001

LCO:	104917693 104924020

NCC:	104940932 104941058

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

ELY:	117269563 117272242 117272243

EFO:	125898267 125901748

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

GAT:

PPUG:

AFB:

CLUM:

PSWI:

MSAM:

SCHU:

CUD:

ALAT:

MZE:	101474730 106675939 106676194

ONL:	100693750 109195682 109195683 109195699

OAU:	116316201 116316225 120434437

OLA:

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:

KMR:	108241650 108241654

ALIM:

NWH:

AOCE:

MCEP:

CSEM:

POV:	109625444 109637167 109638123

SSEN:

122767875 122767883 122767892 122767898 122767900 122768649 122768658 122779511

HHIP:

117777688 117777689

HSP:	118117221 118118273

PPLT:

128453984 128454860 128454863 128454869 128454883 128455003

SMAU:

118310554 118311576

LCF:	108883349 108893535

SDU:

111231161

SLAL:

111653251

XGL:	120798539 120802087

HCQ:

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

BSPL:

114843905 114845031 114845073

SJO:

128368941

SASA:

106569335 106599887 106599889

STRU:

115157201 115169574 115169575

OTW:	112226785 112226786 112260644

OMY:	110508572 110530492

OGO:	124010151 124040889 124041735

ONE:	115102943 115102944 115114571

OKI:	109872203 109872381 109875004

OKE:	118394819 118401954 127907637

SALP:

111956862

SNH:	120019994 120020264 120055983

CCLU:

121535363 121581051 121581540

ELS:	105019795 105019804 106024913

SFM:	108919335 108937621 114910968 114910986

PKI:	111845862 111845867

AANG:

118232872

LOC:	102682983 102694619 102694818

PSPA:

121311421 121311422 121312642 121312643 121312849 121314286 121314287 121314288 121314311 121314312

ARUT:

117394306 117394549 117394961 117399933

PSEX:

120529851 120529852 120529853

LCM:	102357417 102361952

CMK:

RTP:

CPLA:

HOC:

LERI:

PMRN:

116946580 116946581 116946582 116946700

LRJ:	133353068 133353069 133353070

MMER:

RPHI:

Reference

PMID:10051404

Authors

Gafvels M, Olin M, Chowdhary BP, Raudsepp T, Andersson U, Persson B, Jansson M, Bjorkhem I, Eggertsen G

Title

Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns.

Journal

Genomics 56:184-96 (1999)
DOI:10.1006/geno.1998.5606

Sequence

[hsa:1582] [mmu:13124]

Reference

PMID:12543708

Authors

Russell DW

Title

The enzymes, regulation, and genetics of bile acid synthesis.

Journal

Annu Rev Biochem 72:137-74 (2003)
DOI:10.1146/annurev.biochem.72.121801.161712

LinkDB

DBGET integrated database retrieval system