KEGG ORTHOLOGY: K07508

ORTHOLOGY: K07508

Entry

K07508                      KO

Symbol

ACAA2

Name

acetyl-CoA acyltransferase 2 [EC:2.3.1.16]

Pathway

map00062

Fatty acid elongation

map00071

Fatty acid degradation

map00280

Valine, leucine and isoleucine degradation

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map01212

Fatty acid metabolism

Module

M00085

Fatty acid elongation in mitochondria

M00087

beta-Oxidation

Reaction

R00238

acetyl-CoA:acetyl-CoA C-acetyltransferase

R00391

acyl-CoA:acetyl-CoA C-acyltransferase

R00927

acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase

R01177

butanoyl-CoA:acetyl-CoA C-butanoyltransferase

R03778

octanoyl-CoA:acetyl-CoA C-acyltransferase

R03858

lauroyl-CoA:acetyl-CoA C-acyltransferase

R03991

myristoyl-CoA:acetylCoA C-myristoyltransferase

R04546

R04742

decanoyl-CoA:acetyl-CoA C-acyltransferase

R04747

hexanoyl-CoA:acetyl-CoA C-acyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00062 Fatty acid elongation
    K07508  ACAA2; acetyl-CoA acyltransferase 2
   00071 Fatty acid degradation
    K07508  ACAA2; acetyl-CoA acyltransferase 2
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K07508  ACAA2; acetyl-CoA acyltransferase 2
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.16  acetyl-CoA C-acyltransferase
     K07508  ACAA2; acetyl-CoA acyltransferase 2

Other DBs

GO:

0003988

Genes

HSA:	10449(ACAA2)

PTR:	455414(ACAA2)

PPS:	100986504(ACAA2)

GGO:	101146857(ACAA2)

PON:	100171644(ACAA2)

NLE:	100595632(ACAA2)

HMH:	116468550(ACAA2)

MCC:	709350(ACAA2)

MCF:	101865671(ACAA2)

MTHB:

126941317

MNI:	105489396(ACAA2)

CSAB:

103222430(ACAA2)

CATY:

105592504(ACAA2)

PANU:

101012951(ACAA2)

TGE:	112611277(ACAA2)

MLEU:

105531185(ACAA2)

RRO:	104656838(ACAA2)

RBB:	108539750(ACAA2)

TFN:	117063912(ACAA2) 117083992

PTEH:

111539668(ACAA2)

CANG:

105502358(ACAA2)

CJC:	100402284(ACAA2)

SBQ:	101036389(ACAA2)

CIMI:

108305099(ACAA2)

CSYR:

103266899(ACAA2)

MMUR:

105874245(ACAA2)

LCAT:

123621943(ACAA2)

PCOQ:

105808881(ACAA2)

OGA:	100958557(ACAA2)

MMU:	52538(Acaa2)

MCAL:

110284792(Acaa2)

MPAH:

110333199(Acaa2)

RNO:	170465(Acaa2)

MCOC:

116087353(Acaa2)

ANU:	117720173(Acaa2)

MUN:	110561488(Acaa2)

CGE:	100765829(Acaa2)

MAUA:

101828915(Acaa2)

PROB:

127234357(Acaa2)

PLEU:

114694872(Acaa2)

MORG:

121438798(Acaa2)

MFOT:

126507317

AAMP:

119814212(Acaa2)

NGI:	103724572(Acaa2)

HGL:	101721744(Acaa2)

CPOC:

100715434(Acaa2)

CCAN:

109698177(Acaa2)

DORD:

105987579(Acaa2)

DSP:	122104322(Acaa2)

PLOP:

125364172(Acaa2)

NCAR:

124965793

MMMA:

107139510(Acaa2)

OCU:

100339733

OPI:	101529594(ACAA2)

TUP:	102473069(ACAA2)

GVR:	103609291(ACAA2)

CFA:	490568(ACAA2)

CLUD:

112648122(ACAA2)

VVP:	112925318(ACAA2)

VLG:	121489297(ACAA2)

NPO:	129508696(ACAA2)

AML:	100476344(ACAA2)

UMR:	103664100(ACAA2)

UAH:	113253408(ACAA2)

UAR:	123787380(ACAA2)

ELK:

111142457

LLV:

125081701

MPUF:

101687319(ACAA2)

MNP:	132023620(ACAA2)

MLK:	131810871(ACAA2)

NVS:	122902889(ACAA2)

ORO:	101378384(ACAA2)

EJU:	114205018(ACAA2)

ZCA:	113913091(ACAA2)

MLX:	118004702(ACAA2)

NSU:	110577100(ACAA2)

LWW:	102733309(ACAA2)

FCA:	101089302(ACAA2)

PYU:	121032937(ACAA2)

PCOO:

112868251(ACAA2)

PBG:	122470761(ACAA2)

PVIV:

125149408(ACAA2)

LRUF:

124517051

PTG:	102967396(ACAA2)

PPAD:

109275723(ACAA2)

PUC:

125914608

AJU:

106974956

HHV:	120229676(ACAA2)

BTA:	522006(ACAA2)

BOM:	102270140(ACAA2)

BBUB:

102391006(ACAA2)

BBIS:

104995804(ACAA2)

CHX:	102183474(ACAA2)

OAS:	101111925(ACAA2)

BTAX:

128067415(ACAA2)

ODA:	120880995(ACAA2)

CCAD:

122425461(ACAA2)

MBEZ:

129549844(ACAA2)

SSC:	100312959(ACAA2)

CFR:	102510739(ACAA2)

CBAI:

105073958(ACAA2)

CDK:	105103279(ACAA2)

VPC:	102536826(ACAA2)

BACU:

103010085(ACAA2)

BMUS:

118880084(ACAA2)

LVE:	103089821(ACAA2)

OOR:	101280546(ACAA2)

DLE:	111180263(ACAA2)

PCAD:

102982675(ACAA2)

PSIU:

116739273(ACAA2)

NASI:

112407470(ACAA2)

ECB:	100069345(ACAA2)

EPZ:	103547459(ACAA2)

EAI:	106834604(ACAA2)

MYB:	102258815(ACAA2)

MYD:	102756865(ACAA2)

MMYO:

118663396(ACAA2)

MLF:	102423649(ACAA2)

PKL:	118708032(ACAA2)

EFUS:

103292168(ACAA2)

MNA:	107546630(ACAA2)

DRO:	112322907(ACAA2)

SHON:

118978584(ACAA2)

AJM:	119063650(ACAA2)

PDIC:

114506451(ACAA2)

PHAS:

123826347(ACAA2)

MMF:	118619001(ACAA2)

PPAM:

129078713(ACAA2)

HAI:	109376904(ACAA2)

RFQ:	117011944(ACAA2)

PALE:

102895865(ACAA2)

PGIG:

120585516(ACAA2)

PVP:	105292509(ACAA2)

MJV:	108400223(ACAA2)

TOD:	119243044(ACAA2)

SARA:

101550180(ACAA2)

SETR:

126020085(ACAA2)

LAV:	100669834(ACAA2)

ETF:	101645394(ACAA2)

DNM:	101414975(ACAA2)

MDO:	100020101(ACAA2)

GAS:	123252209(ACAA2)

SHR:	100919041(ACAA2)

AFZ:

127543507

PCW:	110198152(ACAA2)

OAA:	100077748(ACAA2)

GGA:	426847(ACAA2)

PCOC:

116231380(ACAA2)

MGP:	100543276(ACAA2)

CJO:	107305710(ACAA2)

TPAI:

128074326(ACAA2)

LMUT:

125686959(ACAA2)

NMEL:

110390054(ACAA2)

APLA:

101791052(ACAA2)

ACYG:

106037343(ACAA2)

CATA:

118254586(ACAA2)

AFUL:

116500921(ACAA2)

TGU:	100231849(ACAA2)

LSR:	110478717(ACAA2)

SCAN:

103820669(ACAA2)

PMOA:

120513688(ACAA2)

OTC:	121346103(ACAA2)

PRUF:

121350379(ACAA2)

GFR:	102031671(ACAA2)

FAB:	101820899(ACAA2)

OMA:	130265225(ACAA2)

PHI:	102099098(ACAA2)

PMAJ:

107198381(ACAA2)

CCAE:

111940954(ACAA2)

CCW:	104686724(ACAA2)

CBRC:

103615659(ACAA2)

ETL:	114064115(ACAA2)

ZAB:	102063959(ACAA2)

ACHL:

103802382(ACAA2)

SVG:	106865053(ACAA2)

MMEA:

130580744(ACAA2)

HRT:	120765692(ACAA2)

FPG:	101917832(ACAA2)

FCH:	102058082(ACAA2)

CLV:	102090854(ACAA2)

EGZ:	104134191(ACAA2)

NNI:	104010858(ACAA2)

PCRI:

104025677(ACAA2)

PLET:

104627658(ACAA2)

EHS:	104512621(ACAA2)

PCAO:

104041008

ACUN:

113489837(ACAA2)

TALA:

104357364(ACAA2)

PADL:

103919461(ACAA2)

AFOR:

103894446(ACAA2)

ACHC:

115337441(ACAA2)

HALD:

104317092(ACAA2)

HLE:	104841385(ACAA2)

AGEN:

126035605

GCL:

127027230

CCRI:

104161533

CSTI:

104555521(ACAA2)

CMAC:

104479179(ACAA2)

MUI:	104540605(ACAA2)

BREG:

104633145(ACAA2)

FGA:	104070464(ACAA2)

GSTE:

104263982(ACAA2)

LDI:	104354115(ACAA2)

MNB:	103777496(ACAA2)

OHA:	104335613(ACAA2)

NNT:	104413091(ACAA2)

SHAB:

115601130(ACAA2)

PGUU:

104463522(ACAA2)

ACAR:

104525372(ACAA2)

CPEA:

104392324 104398396(ACAA2)

AVIT:

104270496(ACAA2)

CVF:	104282855(ACAA2)

RTD:	128902111 128902953

CUCA:

104063574(ACAA2)

TEO:	104383357(ACAA2)

BRHI:

104488940 104496984(ACAA2)

AAM:	106487890(ACAA2)

AROW:

112978618(ACAA2)

NPD:	112947775(ACAA2)

TGT:	104570727(ACAA2) 104577213

DNE:	112994469(ACAA2)

SCAM:

104138525(ACAA2)

ASN:	102376718(ACAA2)

AMJ:	102568981(ACAA2)

CPOO:

109307727(ACAA2)

GGN:	109298024(ACAA2)

PSS:	102446655(ACAA2)

CMY:	102938453(ACAA2)

CCAY:

125637026(ACAA2)

DCC:	119855505(ACAA2)

CPIC:

101948785(ACAA2)

TST:	117879173(ACAA2)

CABI:

116817764(ACAA2)

MRV:	120407484(ACAA2)

ACS:	100554020(acaa2)

ASAO:

132766870(ACAA2)

PVT:	110090044(ACAA2)

SUND:

121922842(ACAA2)

PBI:	103049409(ACAA2)

PMUR:

107284131(ACAA2)

CTIG:

120317454(ACAA2)

TSR:	106545855(ACAA2)

PGUT:

117654831(ACAA2)

APRI:

131192113(ACAA2)

PTEX:

113445657(ACAA2)

NSS:	113411342(ACAA2)

VKO:	123023993(ACAA2)

PMUA:

114606439(ACAA2)

PRAF:

128423395(ACAA2)

ZVI:	118077071(ACAA2)

HCG:	128347967(ACAA2)

GJA:	107109968(ACAA2)

STOW:

125436609(ACAA2)

EMC:	129334603(ACAA2)

XLA:	108705465(acaa2.S) 380424(acaa2.L)

XTR:	779631(acaa2)

NPR:	108790694(ACAA2)

RTEM:

120926716(ACAA2) 120943975

BBUF:

120992249(ACAA2)

BGAR:

122937233(ACAA2)

MUO:

115462877

GSH:	117355703(ACAA2)

DRE:	406325(acaa2)

SRX:	107752996 107754401(acaa2)

SANH:

107671002

SGH:	107559599(acaa2)

CAUA:

113106963(acaa2)

CGIB:

127964058

PTET:

122350830(acaa2)

LROH:

127170258(acaa2)

OMC:	131545485(acaa2)

PPRM:

120489722(acaa2)

MAMB:

125279346(acaa2)

CIDE:

127517686

MASI:

127414512

TROS:

130568146(acaa2)

TDW:	130406868(acaa2)

MANU:

129413496(acaa2)

IPU:

100304819

IFU:	128607699(acaa2)

PHYP:

113533324(acaa2)

SMEO:

124400027(acaa2)

TFD:	113658509(acaa2)

TVC:	132853200(acaa2)

TRN:	134317546(acaa2)

AMEX:

103039096(acaa2)

CMAO:

118813505(acaa2)

EEE:	113590681(acaa2)

CHAR:

105898472(acaa2)

TRU:	101062577(acaa2)

TFS:	130526095(acaa2)

TNG:	GSTEN00029578G001

LCO:	104921655(acaa2)

NCC:	104956691(acaa2)

TBEN:

117473064(acaa2)

CGOB:

115013918(acaa2)

PGEO:

117451965(acaa2)

GACU:

117560526(acaa2)

EMAC:

134874070(acaa2)

ELY:	117252366(acaa2)

EFO:	125890570(acaa2)

PLEP:

121944348(acaa2)

SLUC:

116054451(acaa2)

ECRA:

117945493(acaa2)

ESP:	116689740(acaa2)

PFLV:

114555635(acaa2)

GAT:	120831083(acaa2)

PPUG:

119225245(acaa2)

AFB:	129101325(acaa2)

CLUM:

117736793(acaa2)

PSWI:

130196995(acaa2)

MSAM:

119891199(acaa2)

SCHU:

122875680(acaa2)

CUD:	121510452(acaa2)

ALAT:

119019518(acaa2)

MZE:	101475921(acaa2)

ONL:	100699406(acaa2)

OAU:	116311007(acaa2)

OLA:	101171672(acaa2)

OML:	112148074(acaa2)

CSAI:

133451127(acaa2)

XMA:	102225065(acaa2)

XCO:	114154595(acaa2)

XHE:	116729793(acaa2)

PRET:

103470032(acaa2)

PFOR:

103145834(acaa2)

PLAI:

106956800(acaa2)

PMEI:

106921746(acaa2)

GAF:	122826529(acaa2)

PPRL:

129366003(acaa2)

CVG:	107089652(acaa2)

CTUL:

119778132(acaa2)

GMU:	124877320(acaa2)

NFU:	107394253(acaa2)

KMR:	108233695(acaa2)

NWH:	119413240(acaa2)

AOCE:

111577286(acaa2)

MCEP:

125012240(acaa2)

CSEM:

103397146 103397771(acaa2)

POV:	109637054(acaa2)

SSEN:

122769394(acaa2)

HHIP:

117768157(acaa2)

HSP:	118115012(acaa2)

PPLT:

128438202(acaa2)

SMAU:

118313372(acaa2)

LCF:

108881684

SDU:	111236472(acaa2)

SLAL:

111665974(acaa2)

XGL:	120805072(acaa2)

HCQ:	109527328(acaa2)

SSCV:

125994108

SBIA:

133499457(acaa2)

PEE:	133399968(acaa2)

PTAO:

133475144(acaa2)

BPEC:

110155754(acaa2)

MALB:

109956563(acaa2)

BSPL:

114863021(acaa2)

SJO:	128364519(acaa2)

SASA:

106580430(THIM) 106585052(THIM)

STRU:

115164358 115200294

OTW:	112248600 112262751(acaa2)

OMY:	110525808 110536192(acaa2)

OGO:	124034212 124035238(acaa2)

ONE:	115111718 115140188

OKI:	109881322 109896036

OKE:	118371612 118393337

SALP:

111957767 111974321

SNH:	120039009(acaa2) 120054931

CCLU:

121573178(acaa2) 121584970

ELS:	105014304(acaa2)

SFM:	108920128(acaa2)

PKI:	111854352(acaa2)

AANG:

118237582(acaa2)

LOC:	102693198(acaa2)

PSPA:

121317725(acaa2) 121327200

ARUT:

117409644(acaa2)

PSEX:

120527222(acaa2)

LCM:	102358248(ACAA2)

CMK:	103187341(acaa2)

CPLA:

122564480(acaa2)

HOC:	132832136(acaa2)

LERI:

129711954(acaa2)

PMRN:

116953611(ACAA2)

LRJ:	133355141(ACAA2)

BFO:

BBEL:

CIN:

SCLV:

SPU:	115927202 588288

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG4600(yip2)

DER:

6541725

DSE:

6611877

DSI:	Dsimw501_GD23636(Dsim_GD23636)

DYA:	Dyak_GE18877(Dyak_yip2)

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI17721

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:	108374170 108375335 108379974

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ002342

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:	114871649 114871657

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105669845 105669846

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:	115881821 115888029

AGRG:

126744431

ATD:

109599494

CSET:

123306918

AGB:	108914001 108916293

LDC:	111504790 111504795

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

100500748(at1) 101738252 105841738

BMAN:

114244590 114244618 114244619

MSEX:

115451051 115451052 115451054 115451059

DPL:	KGM_206001 KGM_206002

BANY:

112047648 112047649 112047650

MJU:

123875923

NIQ:	126774993 126774994 126774995 126774996

VCD:	124537495 124537496 124537498

MCIX:

123661630 123661631 123661632

PMAC:

106716645 106716779 106716780

PPOT:

106102070 106102197 106102490

PXU:	106114431 106114531

PRAP:

111000172 111000181 111000183

PBX:	123714932 123714933 123715610

PNAP:

125057069 125057070 125057410

ZCE:	119831596 119831597 119831950

CCRC:

123699090 123699091 123699095

LSIN:

126972088 126972089 126972091

AAGE:

121737055 121737056

HAW:	110379955 110379956 110379969 110379979

HZE:	124637957 124638209 124638371

TNL:	113502219 113502224 113502233 113502255

SLIU:

111347791 111348340 111349030 111350202 111350624 111350638

OFU:	114364375 114364376 114364383

PXY:	105384038 105384039 105384060 105394710 105394722 105394723 105394725 105396785 105396788

PGW:	126374723 126374724 126374725

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:	124354687 124372051

MQU:	128996283 128996329

PHU:	Phum_PHUM043260

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:	110860027 110860110

DPX:	DAPPUDRAFT_58917

DMK:	116923473 123472519

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_F53A2.7(acaa-2)

CBR:

CBG_24278

CRQ:	GCK72_008370

NAI:	NECAME_09686

HRO:	HELRODRAFT_186335

LGI:	LOTGIDRAFT_219437

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

TAD:	TRIADDRAFT_19473

AQU:

100636926

CNE:

CNA05060

CNB:

CNBA4880

CNG:	CNAG_00524

CGI:	CGB_A5350W

CDEU:

CNBG_1392

TMS:	TREMEDRAFT_24275

TASA:

A1Q1_00430

CCAC:

CcaHIS019_0401110(CcaverHIS019_0401110)

RSX:	RhiXN_09637

UMA:	UMAG_03298

PFP:	PFL1_05545

SGRA:

MGL:

MRT:

MSYM:

PGR:	PGTG_00588

PTRC:

PtA15_2A784

PSTR:

Pst134EA_000707

MLR:	MELLADRAFT_47555

MBR:	MONBRDRAFT_38241

SRE:	PTSG_00975

PTI:	PHATRDRAFT_45947

FCY:	FRACYDRAFT_268162(ACAT2)

TPS:	THAPSDRAFT_34809(KCT1)

NGD:	NGA_0450401(KCT2)

PIF:	PITG_07197

PSOJ:

PHYSODRAFT_480767

SPAR:

SPRG_15243

» show all

Reference

PMID:8241273

Authors

Abe H, Ohtake A, Yamamoto S, Satoh Y, Takayanagi M, Amaya Y, Takiguchi M, Sakuraba H, Suzuki Y, Mori M, et al.

Title

Cloning and sequence analysis of a full length cDNA encoding human mitochondrial 3-oxoacyl-CoA thiolase.

Journal

Biochim Biophys Acta 1216:304-6 (1993)
DOI:10.1016/0167-4781(93)90160-f

Sequence

[hsa:10449]

Reference

PMID:25478839

Authors

Kiema TR, Harijan RK, Strozyk M, Fukao T, Alexson SE, Wierenga RK.

Title

The crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase (T1): insight into the reaction mechanism of its thiolase and thioesterase activities.

Journal

Acta Crystallogr D Biol Crystallogr 70:3212-25 (2014)
DOI:10.1107/S1399004714023827

Sequence

[hsa:10449]

LinkDB

DBGET integrated database retrieval system