KEGG ORTHOLOGY: K08573

ORTHOLOGY: K08573

Entry

K08573                      KO

Symbol

CAPN3

Name

calpain-3 [EC:3.4.22.54]

Pathway

map04820

Cytoskeleton in muscle cells

Disease

H00592

Calpainopathy

H00593

Limb-girdle muscular dystrophy

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09142 Cell motility
   04820 Cytoskeleton in muscle cells
    K08573  CAPN3; calpain-3
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K08573  CAPN3; calpain-3
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.54  calpain-3
     K08573  CAPN3; calpain-3
Peptidases and inhibitors [BR:ko01002]
Cysteine peptidases
  Family C2: calpain family
   K08573  CAPN3; calpain-3

Other DBs

GO:

0004198

Genes

HSA:	825(CAPN3)

PPS:

100984344

PON:	100449804(CAPN3)

HMH:	116482515(CAPN3)

MCC:	707913(CAPN3)

MCF:	102115794(CAPN3)

MTHB:

126959809

MNI:	105491693(CAPN3)

CSAB:

103245772(CAPN3)

CATY:

105574217(CAPN3)

PANU:

101003739(CAPN3)

TGE:	112627441(CAPN3)

MLEU:

105546143(CAPN3)

RRO:	104665262(CAPN3)

RBB:	108521152(CAPN3)

TFN:	117070804(CAPN3)

PTEH:

111529157

CANG:

105511067(CAPN3)

CJC:	100389438(CAPN3)

SBQ:	101035050(CAPN3)

CIMI:

108294422(CAPN3)

CSYR:

103261776(CAPN3)

MMUR:

105872501(CAPN3)

LCAT:

123630188(CAPN3)

PCOQ:

105814391(CAPN3)

OGA:	100964370(CAPN3)

MMU:	12335(Capn3)

MCAL:

110309710(Capn3)

MPAH:

110318292(Capn3)

RNO:	29155(Capn3)

MCOC:

116090761(Capn3)

ANU:	117702858(Capn3)

MUN:	110549916(Capn3)

CGE:	100758723(Capn3)

MAUA:

101822522(Capn3)

PROB:

127221592(Capn3)

PLEU:

114681123(Capn3)

MORG:

121465595(Capn3)

MFOT:

126494432

AAMP:

119814387(Capn3)

NGI:	103744953(Capn3)

HGL:	101707543(Capn3)

CPOC:

100735679(Capn3)

CCAN:

109690734(Capn3)

DORD:

105981170(Capn3)

DSP:	122114613(Capn3)

PLOP:

125340953(Capn3)

NCAR:

124977436

MMMA:

107138183(Capn3)

OCU:	100008726(CAPN3)

OPI:	101533222(CAPN3)

TUP:	102468105(CAPN3)

GVR:	103600898(CAPN3)

CFA:	100856545(CAPN3)

CLUD:

112676067(CAPN3)

VVP:	112919983(CAPN3)

VLG:	121485770(CAPN3)

NPO:	129504162(CAPN3)

AML:	100478387(CAPN3)

UMR:	103673424(CAPN3)

UAH:	113241990(CAPN3)

UAR:	123775845(CAPN3)

ELK:

111160918

LLV:

125105494

MPUF:

101675191(CAPN3)

MLK:	131836166(CAPN3)

NVS:	122892893(CAPN3)

ORO:	101384331(CAPN3)

EJU:	114201673(CAPN3)

ZCA:	113910306(CAPN3)

MLX:	118003460(CAPN3)

NSU:	110585421(CAPN3)

LWW:	102746966(CAPN3)

FCA:	101081304(CAPN3)

PYU:	121041570(CAPN3)

PCOO:

112856247(CAPN3)

PBG:	122467655(CAPN3)

PVIV:

125167938(CAPN3)

LRUF:

124508078

PTG:	102962051(CAPN3)

PPAD:

109263103(CAPN3)

PUC:

125909904

AJU:

106968505

HHV:	120232213(CAPN3)

BTA:	281663(CAPN3)

BOM:	102284625(CAPN3)

BIU:	109564987(CAPN3)

BBUB:

102393431(CAPN3)

BBIS:

104994443(CAPN3)

CHX:	102189762(CAPN3)

OAS:	443038(CAPN3)

BTAX:

128053913(CAPN3)

ODA:	120853162(CAPN3)

CCAD:

122443440(CAPN3)

MBEZ:

129562575(CAPN3)

SSC:	397349(CAPN3)

CFR:	102518250(CAPN3)

CBAI:

105076938(CAPN3)

CDK:	105101740(CAPN3)

VPC:	102530952(CAPN3)

LVE:	103088026(CAPN3)

OOR:	101289409(CAPN3)

DLE:	111181696(CAPN3)

PCAD:

102985687(CAPN3)

PSIU:

116749382(CAPN3)

NASI:

112391183(CAPN3)

ECB:	100056798(CAPN3)

EPZ:	103549943(CAPN3)

EAI:	106841338(CAPN3)

MYB:	102245181(CAPN3)

MYD:	102768421(CAPN3)

MMYO:

118650353(CAPN3)

MLF:	102423101(CAPN3)

PKL:	118722897(CAPN3)

EFUS:

103287348(CAPN3)

MNA:	107536546(CAPN3)

DRO:	112311921(CAPN3)

AJM:	119061279(CAPN3)

PDIC:

114492273(CAPN3)

PHAS:

123808805(CAPN3)

MMF:	118641423(CAPN3)

PPAM:

129064324(CAPN3)

RFQ:	117024234(CAPN3)

PALE:

102886269(CAPN3)

PGIG:

120622749(CAPN3)

PVP:	105288790(CAPN3)

RAY:	107510930(CAPN3)

MJV:	108386637(CAPN3)

TOD:	119238530(CAPN3)

SARA:

101558331(CAPN3)

SETR:

126020066(CAPN3)

LAV:	100667912(CAPN3)

TMU:

101356561

ETF:	101638394(CAPN3)

DNM:	101428782(CAPN3)

MDO:	100010062(CAPN3)

GAS:	123237897(CAPN3)

SHR:	100916328(CAPN3)

AFZ:

127549283

PCW:	110223679(CAPN3)

OAA:	100084116(CAPN3)

GGA:	423233(CAPN3)

MGP:	100546035(CAPN3)

CJO:	107314753(CAPN3)

TPAI:

128085680(CAPN3)

LMUT:

125694509(CAPN3)

NMEL:

110401942(CAPN3)

APLA:

101792647(CAPN3)

ACYG:

106042918(CAPN3)

CATA:

118244573(CAPN3)

AFUL:

116489626(CAPN3)

TGU:	100225837(CAPN3)

LSR:	110472120(CAPN3)

SCAN:

103826645(CAPN3)

PMOA:

120500534(CAPN3)

OTC:	121335792(CAPN3)

PRUF:

121349554(CAPN3)

GFR:	102042342(CAPN3)

FAB:	101814350(CAPN3)

OMA:	130254444(CAPN3)

PHI:	102107172(CAPN3)

PMAJ:

107205589(CAPN3)

CCAE:

111930233(CAPN3)

CCW:	104698659(CAPN3)

CBRC:

103620775(CAPN3)

ETL:	114056480(CAPN3)

ZAB:	102071927(CAPN3)

ZLE:	135448184(CAPN3)

ACHL:

103801729(CAPN3)

SVG:	106848997(CAPN3)

MMEA:

130573546(CAPN3)

HRT:	120753965(CAPN3)

FPG:	101924532(CAPN3)

FCH:	102055944(CAPN3)

CLV:	102094715(CAPN3)

EGZ:	104127554(CAPN3)

NNI:	104020344(CAPN3)

PCRI:

104024917(CAPN3)

PLET:

104625460(CAPN3)

EHS:	104515389(CAPN3)

PCAO:

104043793(CAPN3)

ACUN:

113480542(CAPN3)

TALA:

104359490(CAPN3)

PADL:

103912804(CAPN3)

AFOR:

103897520(CAPN3)

ACHC:

115349507(CAPN3)

HALD:

104325215(CAPN3)

HLE:	104839649(CAPN3)

AGEN:

126049193

GCL:

127016432

CCRI:

104162432(CAPN3)

CSTI:

104555939

CMAC:

104474015(CAPN3)

BREG:

104638113(CAPN3)

FGA:

104080460

GSTE:

104263026(CAPN3)

LDI:	104340731(CAPN3)

MNB:

103775218

OHA:	104328119(CAPN3)

NNT:	104410103(CAPN3)

SHAB:

115606495(CAPN3)

DPUB:

104298852(CAPN3)

PGUU:

104458993(CAPN3)

ACAR:

104532886(CAPN3)

CPEA:

104388443(CAPN3)

AVIT:

104273019(CAPN3)

CVF:	104289069(CAPN3)

RTD:	128908873(CAPN3)

CUCA:

104067323(CAPN3)

TEO:	104380706(CAPN3)

BRHI:

104492893(CAPN3)

AROW:

112964040(CAPN3)

NPD:	112942521(CAPN3)

DNE:	112980626(CAPN3)

SCAM:

104150406(CAPN3)

ASN:	102379878(CAPN3)

AMJ:	102577345(CAPN3)

CPOO:

109321300(CAPN3)

GGN:	109298795(CAPN3)

PSS:	102450185(CAPN3)

CMY:	102936637(CAPN3)

CCAY:

125638798(CAPN3)

DCC:	119856903(CAPN3)

CPIC:

101952809(CAPN3)

TST:	117876784(CAPN3)

CABI:

116825465(CAPN3)

MRV:	120403813(CAPN3)

ACS:	100559629(capn3)

ASAO:

132766589(CAPN3)

PVT:	110079031(CAPN3)

SUND:

121919140(CAPN3)

PBI:	103066997(CAPN3)

PMUR:

107295757(CAPN3)

CTIG:

120300708(CAPN3)

TSR:	106547747(CAPN3)

PGUT:

117665635(CAPN3)

APRI:

131187587(CAPN3)

PTEX:

113442185(CAPN3)

NSS:	113414257(CAPN3)

VKO:	123026806(CAPN3)

PMUA:

114594341(CAPN3)

PRAF:

128411373(CAPN3)

ZVI:	118083644(CAPN3)

HCG:	128340139(CAPN3)

GJA:	107117895(CAPN3)

STOW:

125427212(CAPN3)

EMC:	129324117(CAPN3)

XLA:	100125665(capn3.L) 108700461

XTR:	100497532(capn3)

NPR:	108797818(CAPN3)

RTEM:

120920795(CAPN3)

BBUF:

120981853(CAPN3)

BGAR:

122921245(CAPN3)

MUO:	115478040(CAPN3)

GSH:	117364048(CAPN3)

DRE:	447832(capn3a)

SRX:	107732302 107739229

SANH:

107664429(capn3)

SGH:

107586853

CAUA:

113060520 113117063

CGIB:

127976709

PTET:

122362108(capn3a)

LROH:

127180254(capn3a)

OMC:	131522870(capn3a)

PPRM:

120464073(capn3a)

RKG:	130080204(capn3a)

MAMB:

125269025(capn3a)

CIDE:

127498978

MASI:

127411246 127454769

TROS:

130560049(capn3a)

TDW:	130436767(capn3a)

MANU:

129418082(capn3a)

IPU:	108269768(capn3a)

IFU:	128613021(capn3a)

PHYP:

113538734

SMEO:

124390085(capn3a)

TFD:	113659539(capn3a)

TVC:	132852566(capn3a)

TRN:	134325767(capn3a)

CMAO:

118823930(capn3a)

EEE:

113587020

CHAR:

105899114(capn3a)

TRU:	101075691 101077986(capn3)

TFS:	130513329(capn3a) 130515702(capn3b)

TNG:	GSTEN00019931G001

LCO:

104936553

NCC:	104945865(capn3)

TBEN:

117486936(capn3b) 117493771(capn3a)

CGOB:

115027228(capn3) 115028992

PGEO:

117439943(capn3b) 117467960(capn3a)

GACU:

117542903 117549038(capn3a) 117555691(capn3b)

EMAC:

134876635(capn3b) 134881072(capn3a)

ELY:	117267460(capn3a) 117270774(capn3b)

EFO:	125897620(capn3b) 125901103(capn3a)

PLEP:

121953730(capn3a) 121955200(capn3b)

SLUC:

116057697(capn3a) 116066425(capn3b)

ECRA:

117936309(capn3a) 117961699(capn3b)

ESP:	116686083(capn3) 116705817

PFLV:

114546330(capn3) 114573031

GAT:	120808321(capn3b) 120833187(capn3a)

PPUG:

119194637(capn3b) 119227420(capn3a)

AFB:	129102973(capn3a) 129107456(capn3b)

CLUM:

117727050(capn3b) 117751379(capn3a)

PSWI:

130201752(capn3a) 130202117(capn3b)

MSAM:

119909041(capn3b) 119909908(capn3a)

SCHU:

122861776(capn3a) 122863461(capn3b)

CUD:	121521109(capn3b) 121526230(capn3a)

ALAT:

119005030(capn3a) 119012575(capn3b)

MZE:	101463601 101466182(capn3)

ONL:	100691885(capn3) 100699569

OAU:	116318066(capn3a) 116324143(capn3b)

OLA:	101157263 101169329

OML:	112144429(capn3a) 112158058(capn3b)

CSAI:

133418611(capn3b) 133462927(capn3a)

XMA:	102221680(capn3) 102222528

XCO:	114134598(capn3) 114158499

XHE:	116708429(capn3) 116733763

PRET:

103457431 103458212(capn3)

PFOR:

103133981 103150049(capn3)

PLAI:

106952040 106953715

PMEI:

106919034(capn3) 106924031

GAF:	122825756(capn3b) 122846114(capn3a)

PPRL:

129375248(capn3b) 129377228(capn3a)

CVG:	107093158 107096801(capn3)

CTUL:

119779718(capn3a)

GMU:	124856039(capn3a) 124882084(capn3b)

NFU:	107377674 107391866(capn3)

KMR:	108233461(capn3b) 108234555(capn3a)

ALIM:

106524302(capn3) 106537237

NWH:	119418575(capn3b) 119426946(capn3a)

AOCE:

111574533 111587838

MCEP:

124998693(capn3b) 125023329(capn3a)

CSEM:

103380923 103381555

POV:	109636052 109644862

SSEN:

122783338(capn3a) 122784464(capn3b)

HHIP:

117755906(capn3a) 117757990(capn3b)

HSP:	118099302(capn3b) 118117058(capn3a)

PPLT:

128450708(capn3a) 128460677(capn3b)

SMAU:

118285806(capn3a) 118290255(capn3b)

LCF:	108876634(capn3a) 108895964

SDU:	111225368(capn3) 111237184

SLAL:

111646798(capn3) 111661373

XGL:	120788896(capn3b) 120795487(capn3a)

HCQ:	109508050(capn8) 109517476(capn3)

SSCV:

125981134 125990290

SBIA:

133497039(capn3b) 133513735(capn3a)

PEE:	133412495(capn3a) 133416781(capn3b)

PTAO:

133468094(capn3b) 133487602(capn3a)

BPEC:

110157545(capn3) 110173943

MALB:

109953348 109962461(capn3)

BSPL:

114849042(capn3a) 114849713(capn3b)

SASA:

100306869(can3) 106568467(capn3) 106611143

STRU:

115161830 115173034 115175025

OTW:	112241717 112249945(capn3b) 112255824(capn3a)

OMY:	110498417 110505915(capn3a) 110529398(capn3b)

OGO:	123990572(capn3b) 124002235 124046822(capn3a)

ONE:	115107570 115138850

OKI:	109880971 109883062 109900562

OKE:

118380901

SALP:

111954339(capn3)

SNH:	120024248(capn3b) 120035919(capn3a)

CCLU:

121539129 121544526(capn3a) 121552620(capn3b)

ELS:	105015344 105015896(capn3)

SFM:

108924080

PKI:	111859952(capn3)

AANG:

118223800(capn3a) 118229185

LOC:	102695785(capn3)

PSPA:

121324768

ARUT:

117422311(capn3a)

PSEX:

120518426(capn3a)

LCM:	102358118(CAPN3)

CMK:

103190049

RTP:	109927910(capn3a)

CPLA:

122553855(capn3a)

HOC:	132818086 132836295

LERI:

129714207

PMRN:

116939632 116943170 116947735 116947736

LRJ:	133341426 133341428 133342411 133347253 133352610

BFO:

BBEL:

CIN:

SCLV:

NLU:

HAME:

ESN:

EAF:

PVUL:

BGT:

Reference

PMID:7720071

Authors

Richard I, Broux O, Allamand V, Fougerousse F, Chiannilkulchai N, Bourg N, Brenguier L, Devaud C, Pasturaud P, Roudaut C, et al.

Title

Mutations in the proteolytic enzyme calpain 3 cause limb-girdle muscular dystrophy type 2A.

Journal

Cell 81:27-40 (1995)
DOI:10.1016/0092-8674(95)90368-2

Sequence

[hsa:825]

LinkDB

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