KEGG   ORTHOLOGY: K08691
Entry
K08691                      KO                                     
Symbol
mcl
Name
malyl-CoA/(S)-citramalyl-CoA lyase [EC:4.1.3.24 4.1.3.25]
Pathway
map00630  Glyoxylate and dicarboxylate metabolism
map00660  C5-Branched dibasic acid metabolism
map00680  Methane metabolism
map00720  Carbon fixation pathways in prokaryotes
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01200  Carbon metabolism
Module
M00346  Formaldehyde assimilation, serine pathway
M00373  Ethylmalonyl pathway
M00376  3-Hydroxypropionate bi-cycle
Reaction
R00237  (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
R00473  L-malyl-CoA glyoxylate-lyase (acetyl-CoA-forming)
R00934  L-erythro-3-methylmalyl-CoA glyoxylate-lyase (propanoyl-CoA-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00630 Glyoxylate and dicarboxylate metabolism
    K08691  mcl; malyl-CoA/(S)-citramalyl-CoA lyase
   00660 C5-Branched dibasic acid metabolism
    K08691  mcl; malyl-CoA/(S)-citramalyl-CoA lyase
  09102 Energy metabolism
   00720 Carbon fixation pathways in prokaryotes
    K08691  mcl; malyl-CoA/(S)-citramalyl-CoA lyase
   00680 Methane metabolism
    K08691  mcl; malyl-CoA/(S)-citramalyl-CoA lyase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.3  Oxo-acid-lyases
    4.1.3.24  malyl-CoA lyase
     K08691  mcl; malyl-CoA/(S)-citramalyl-CoA lyase
    4.1.3.25  (S)-citramalyl-CoA lyase
     K08691  mcl; malyl-CoA/(S)-citramalyl-CoA lyase
Other DBs
COG: COG2301
GO: 0050083 0047777
Genes
SACZ: AOT14_23590(mcl1)
LLG: 44548918_02118(mcl1)
MCA: MCA1739
METU: GNH96_10430
MMEO: OOT43_04275
MMT: Metme_2695
MDN: JT25_000155
MDH: AYM39_08385
MKO: MKLM6_1752
METL: U737_10260
MPAD: KEF85_03350
MELL: IVG45_03090
MRP: NM686_005355
MMOT: QZJ86_13270
MAH: MEALZ_3217(mclA1)
MBUR: EQU24_04630
MPSY: CEK71_18035
MMAI: sS8_2223
MSZE: MSZNOR_4946(mcl)
MMOB: F6R98_20170
MEIN: methR_P0949
MOZ: MoryE10_14040
MISZ: MishRS11D_11830
MESL: KKZ03_00260
MEIY: MIN45_P1852
MCAU: MIT9_P1453
BLEP: AL038_08990
THIP: N838_00825
TSN: W908_06430
RPJ: N234_12055
CNC: CNE_BB1p10140(mcl)
BGP: BGL_2c16890
BPLA: bpln_2g17560
BPH: Bphy_5924
BFN: OI25_5771 OI25_7353
BCAI: K788_0001579
PHS: C2L64_21705
PTER: C2L65_26290
PTRO: G5S35_34875
PACS: FAZ98_23740
PSAA: QEN71_12140 QEN71_33975
PKF: RW095_22000
PPAI: E1956_20570
BBRO: BAU06_24990
BFZ: BAU07_25025
BOH: AKI39_23800
APES: FOC84_30065
HYN: F9K07_00140
CBAB: SMCB_1586
MPT: Mpe_A3254
METP: C1M51_05895
XYK: GT347_12545
NEU: NE1809
NET: Neut_0607
NIT: NAL212_0420
NII: Nit79A3_0103
NCO: AAW31_08285
NUR: ATY38_03755
NST: Nstercoris_01831
NLC: EBAPG3_012580
NIZ: NNRS527_01104
METR: BSY238_253
NIM: W01_13780
NARC: NTG6680_0561(mcl)
URU: DSM104443_00577(mcl1_1)
FMY: HO273_03895
APP: CAP2UW1_2508
MLN: A9174_19865
MOP: Mesop_3793
MAM: Mesau_03584
MAMO: A6B35_22110
MESP: C1M53_18670
MHUA: MCHK_2942
MJR: EB229_19625
MERD: EB233_16970
AAK: AA2016_5786
AMIH: CO731_05425(mcl1)
AMIS: Amn_pa02870
ANJ: AMD1_PA0303(mcl)
PHT: BLM14_27150
PLA: Plav_3098
PMOB: HG718_00970
KMN: HW532_00815
PECT: BN1012_Phect939
RBS: RHODOSMS8_01011(mcl)
RHI: NGR_c26230
SFH: SFHH103_02474(cite1)
SFD: USDA257_c22030(mcl1)
SAME: SAMCFNEI73_pC0656(mcl)
SINO: SS05631_b61290
ESJ: SJ05684_b48780
EAK: EKH55_4315
ENU: PYH37_000576
EGI: PZN02_002069
STEG: QA637_13125
BRC: BCCGELA001_06950
BRAD: BF49_2901
BOT: CIT37_18285
BRQ: CIT40_04560
BGQ: X265_31260
BSYM: CIT39_02900
BEL: BE61_53460(citE)
BDG: LPJ38_11055
BCAN: BcanWSM471_32370
BAUT: QA635_20755
BBRA: QA636_21300
BPAH: QA639_24260
BVV: BHK69_20015
BVES: QO058_01020
BOP: AXW83_07320
BOS: BSY19_2901
BOI: BLM15_06415
BOF: FQV39_02445
BOW: NWE53_06435
XAU: Xaut_3870
XDI: EZH22_19265
AZC: AZC_1227
LNE: FZC33_08695
MEA: Mex_1p1733(mcl) Mex_1p4295
MDI: METDI2485(mcl) METDI4906
MEX: Mext_1802 Mext_3917
MCH: Mchl_2138 Mchl_4285
MPO: Mpop_1754 Mpop_4390
MZA: B2G69_01480 B2G69_16670
MRD: Mrad2831_1650 Mrad2831_3663
MET: M446_6315 M446_6559
MNO: Mnod_7119 Mnod_7178
MOR: MOC_2043 MOC_4185
META: Y590_08615 Y590_19480
MAQU: Maq22A_c18385(citE) Maq22A_c19250(mcl)
MPHY: MCBMB27_01298 MCBMB27_03145
MEE: DA075_20140 DA075_27160
METD: C0214_10380 C0214_21595
METX: A3862_13170 A3862_22625
METS: DK389_15360 DK389_27325
METI: DK427_15555 DK427_17480
MMES: MMSR116_01155 MMSR116_21315
MTEA: DK419_14290 DK419_26925
MIND: mvi_25720 mvi_28860
MOG: MMB17_01150 MMB17_19730
MTAD: M6G65_09600 M6G65_20420
MSL: Msil_1719
MTUN: MTUNDRAET4_3402(mcl)
MLG: CWB41_04715
MEDK: QEV83_04540
BBAR: RHAL1_03825(mcl_2)
RHJ: HZY79_12425
CHEL: AL346_17425
CDQ: BOQ54_08925
HDN: Hden_1659 Hden_3153
HDT: HYPDE_30183 HYPDE_38943
HMC: HYPMC_1941 HYPMC_4395(mcl)
HNI: W911_10365 W911_15805
RVA: Rvan_1682
RLAC: QMO75_10135
FIL: BN1229_v1_1240(mcl) BN1229_v1_2672
FIY: BN1229_v1_1238(mcl) BN1229_v1_3242
RHZ: RHPLAN_35810
MCG: GL4_3371
METG: HT051_02845
BVR: BVIR_1803
BLAG: BLTE_09690(mclA)
MSC: BN69_1171 BN69_2035
MBRY: B1812_00060 B1812_17545
MROS: EHO51_12185 EHO51_15075
MHEY: H2LOC_011805 H2LOC_014625
MPAR: F7D14_06360 F7D14_09175
MIWA: SS37A_01470 SS37A_07190
MTW: CQW49_12235 CQW49_16215
MECQ: MSC49_04610 MSC49_35030(mclA)
CMET: K6K41_15080 K6K41_22170
PLEO: OHA_1_00681(mcl) OHA_1_00777(citE)
HDI: HDIA_2217(mcl1_1) HDIA_2467(mcl1_2)
BRN: D1F64_11585
PSIN: CAK95_23545
NOH: G5V57_13010
RBM: TEF_05695
PSF: PSE_3192
PPHR: APZ00_18415
LAP: ACP90_14745
LABR: CHH27_05755
LABP: FJ695_18280
LABT: FIU93_20440(mcl2)
LAGG: B0E33_26575
RPOP: K1718_15345
SIW: GH266_00855
PHR: C6569_07730
PSTG: E8M01_31685
PAQT: E8L99_17855
CCR: CC_2999
CCS: CCNA_03094
CAK: Caul_0731
CSE: Cseg_3490
CHQ: AQ619_14395
CMB: CSW64_04970
CFH: C1707_10190
CAUF: CSW63_06460
BALB: M8231_03195
TSV: DSM104635_00778(mcl1)
SIL: SPO1565 SPO3608(mclA)
SIT: TM1040_3165
RUA: D1823_18170 D1823_20490
RUT: FIU92_13270(mcl2) FIU92_19865(mcl3)
RCON: K3740_00765 K3740_20040
JAN: Jann_0471
RDE: RD1_1001(citE) RD1_1160(mclA) RD1_4242(mclA)
RLI: RLO149_c002070(mcl1) RLO149_c036850(mcl2)
RPON: G3256_17055
DSH: Dshi_3050(citE2)
PGA: PGA1_c30490
PGL: PGA2_c28380
PGD: Gal_00369
PHP: PhaeoP97_00458
PPIC: PhaeoP14_02820
PHQ: D1820_09925
OAT: OAN307_c02220
OAR: OA238_c37200
OTM: OSB_28710(mcl1)
OCT: FTO60_14185
LMD: METH_02340 METH_18390
LEJ: ETW24_03080 ETW24_17910
LAQU: R2C4_14570 R2C4_19790
LEV: ETW23_00250 ETW23_17075
LCAE: K3721_02490 K3721_16185
RED: roselon_01454 roselon_02260
CID: P73_3958 P73_4243
CMAR: IMCC12053_1300
CEH: CEW89_10920
MALG: MALG_03008
CON: TQ29_15155
YPAC: CEW88_13335
YAN: AYJ57_18165
TPRO: Ga0080559_TMP1541
PABY: Ga0080574_TMP2641
SUAM: BOO69_01375
SULZ: C1J03_02230
SULI: C1J05_00980
SULD: B5M07_15575
SPOT: G6548_03345
SMED: JNX03_11790
SINL: DSM14862_03056(mcl1)
SFAV: PL335_14640
SUAL: KDD17_13110
SDUB: R1T39_09450
SPSE: SULPSESMR1_03496(mcl1)
TOM: BWR18_14535
RMM: ROSMUCSMR3_02149(mcl1) ROSMUCSMR3_03455(mcl1)
ROK: RAK1035_1037 RAK1035_2340
RID: RIdsm_02779(mcl1_1) RIdsm_05011(mcl1_2)
ROM: EI983_00710 EI983_08270
ROH: FIU89_19925(mcl2)
RPEL: N7U68_03480 N7U68_09695
AHT: ANTHELSMS3_00280(mcl1)
SAGU: CDO87_13335 CDO87_15505
THAA: CFI11_04070
OCD: FHY55_18010
ROT: FIV09_13785(mcl2)
RMH: LVO79_03465
MALU: KU6B_08980(mcl1) KU6B_14460 KU6B_40050
TGL: HFZ77_14905
TMD: KUV46_04605
HAT: RC74_08495
PALX: GQA70_15345 GQA70_23220
LSAL: KBK07_02450
LALG: LentiSH36_02533
TRY: QF118_05630
MARU: FIU81_14310(mcl3)
RMAI: MACH21_17090 MACH21_30420(mcl1)
RSP: RSP_1771
RSH: Rsph17029_0417
RSQ: Rsph17025_2481
RSK: RSKD131_0071
CAZT: LV780_11350
RCP: RCAP_rcc03164(citE2)
RHP: LPB142_02980
RBL: B6K69_09750
FYT: QF092_14495 QF092_14520
PDE: Pden_0799
PAMI: JCM7686_2763 JCM7686_3168
PYE: A6J80_07835
PCON: B0A89_03920
PZH: CX676_04845 CX676_15565
PARO: CUV01_10870
PAMN: JCM7685_2683 pAMV1p0135(mcl) pAMV3p0611(mcal)
PMUT: DPM13_05940
PARR: EOJ32_05825
PAAK: FIU66_06855
PKD: F8A10_08855
PPAN: ESD82_17880
PLIA: E4191_12750
PSAN: HGN31_05715
PMAU: CP157_02398(mcl1)
PMEH: JWJ88_07325
PSEW: JHW44_10240
PSAP: JHX88_01975 JHX88_17895 JHX88_20315
PFIS: JHX87_05090
PAEX: JHW48_04005
PSTL: JHW45_12805
PALP: JHW40_15150 JHW40_18530
PVER: E3U25_16380
PFEO: E3U26_05025
PTP: RCA23_c05980(mclA)
RSU: NHU_02809
RHM: B5V46_11900
RHC: RGUI_3145
RMB: K529_018960
TSCO: R1T40_18500
DAA: AKL17_3598
DON: BSK21_02035
RBZ: B9057_11515
THW: BMG03_17130
TEC: AKL02_016915
LVS: LOKVESSMR4R_02838(mcl1)
RBG: BG454_02060 BG454_05615
GEH: HYN69_16130 HYN69_16155
GFU: KM031_08955 KM031_11830
TAW: EI545_00080 EI545_09215
SALO: EF888_18940
SEDI: EBB79_18450 EBB79_24155
PPSO: QPJ95_09700
BOO: E2K80_13755
PSEB: EOK75_09010
PPRU: FDP22_10475
PAED: G5B38_01665 G5B38_14245
MON: G8E03_06220
PAMO: BAR1_02110
POZ: I0K15_04605
PALW: PSAL_024060(mcl1)
PSHQ: F3W81_17090
PGV: SL003B_2239
CACT: HZ995_04375
THAS: C6Y53_06905
HDH: G5B40_08975
CMAG: CBW24_04620
GCE: KYE46_00395
NSM: JO391_00315 JO391_12675
ACRO: K3J57_12105
SINR: O5O51_01720
AALK: LGT41_0000610
AMYL: QBD29_03580 QBD29_08415
AMAQ: GO499_03725 GO499_18685
RHOC: QTA57_06920
PBAE: P8S53_01310
FAQ: G5B39_01155
RBX: I3V23_08345
HNE: HNE_0078(mclA)
HBA: Hbal_0778
CBOT: ATE48_06115
HBC: AEM38_14745
RDI: CMV14_07525
TFV: IDJ81_06845
GBE: GbCGDNIH1_0055
GBH: GbCGDNIH2_0055
GBC: GbCGDNIH3_0055
GBS: GbCGDNIH4_0055
RAP: RHOA_5783(mcl)
SKT: IGS68_03250
SMUC: JL100_003365
SROE: JL101_003125
RRU: Rru_A0217
RRF: F11_01090
RPM: RSPPHO_00107
MGY: MGMSRv2__3257
MGRY: MSR1_29830(mcl1)
MAGX: XM1_1373
MAGN: WV31_14965
FER: FNB15_09270
DEX: HWD60_03940
DVN: HQ394_01635
MAG: amb3977
HTQ: FRZ44_44960
HADH: FRZ61_42590 FRZ61_45950
TXI: TH3_02680
THAC: CSC3H3_02980
TII: DY252_18625
THAI: IT893_02795
TLU: R1T41_11295
TTB: MACH01_05680
MAGQ: MGMAQ_0659
VSU: P3M64_12025
TMO: TMO_0350(citE)
ECOG: FIV45_00610
SNEA: NBZ79_03900
DEO: CAY53_08885
DML: Dmul_11170
DAX: FDQ92_06220
EUZ: DVS28_a0494
RANT: RHODO2019_08890
STRE: GZL_04819
SLD: T261_4311
SLC: SL103_17980
SNR: SNOUR_21930
SALU: DC74_4078
SALL: SAZ_21750
SGV: B1H19_20540
STRO: STRMOE7_00865
SPLA: CP981_36035
SDW: K7C20_34930
SAUH: SU9_032330
SANU: K7396_01540
SINE: KI385_01365
SNIG: HEK616_29400(citE_1)
STUD: STRTU_000263
SYUN: MOV08_22140
SCT: SCAT_4364
SCY: SCATT_43520
ABRY: NYE86_27165
AGLA: OIE69_13955
ICA: Intca_2587
ARS: ADJ73_02415
JTE: ASJ30_03525
JLI: EXU32_11365
JME: EEW87_011295
JAY: H7A72_03525
JCR: O9K63_16190
TEH: GKE56_09880
PEI: H9L10_09525
TED: U5C87_20770
AUS: IPK37_13860
NCA: Noca_4393
NDK: I601_0974(mcl1)
NOY: EXE57_13540
NOI: FCL41_01330
NOO: FE634_19600
NSN: EXE58_09730
NBE: Back2_15770(citE_1)
NANO: G5V58_24335
NARO: CFH99_21490
NPI: G7071_06375
NAQU: ENKNEFLB_04247(mcl)
NRO: K8W59_01590
NOQ: LN652_11495
NCQ: K6T13_15930
NPC: KUV85_11405
NMAR: HPC71_19405
NFC: KG111_16475
PSIM: KR76_23920
AER: AERYTH_05645
AEZ: C3E78_04975
AEB: C6I20_10755
AEF: GEV26_04810
ASEZ: H9L21_04165
ADB: NP095_04110
AWN: NQV15_05020
NBT: KLP28_00560
FRA: Francci3_2805
FSY: FsymDg_0509
AMD: AMED_0079(citE)
AMN: RAM_00395
AMM: AMES_0076(citE)
AMZ: B737_0077(citE)
AOI: AORI_0068(mcl)
AJA: AJAP_00370
AMQ: AMETH_0090(citE)
AMYC: CU254_39710
AMYB: BKN51_34375
AAB: A4R43_28985
AMYY: YIM_00345(mcl2)
AORI: SD37_41460
AACD: LWP59_00255
APRT: MUY14_36265
AROO: NQK81_25995
ATHM: L1857_02835
KAL: KALB_2473
KUT: JJ691_99900(citE_1)
KPHY: AOZ06_42935
ALO: CRK61727
PMAD: BAY61_00315
ACTU: Actkin_00833(mcl1)
EKE: EK0264_04565
JCY: M6B22_02735
BSOL: FSW04_11520
BALA: DSM104299_01895(mcl)
CWO: Cwoe_4213
PARN: NBH00_07200
SBAE: DSM104329_01824(mcl) DSM104329_03745(mcl1)
PBAJ: LRS13_14185
TALU: JDY09_03170
AYM: YM304_14270
ATQ: GH723_12970
AQZ: KSP35_02830
IAM: HC251_13125
IMA: PO878_12810
DHI: LH044_19160
RRS: RoseRS_4173
RCA: Rcas_0912
CAU: Caur_0174
CHL: Chy400_0187
CAG: Cagg_1328
TRO: trd_0455
STI: Sthe_2064
GGR: HKW67_06650
 » show all
Reference
PMID:6094488
  Authors
Fulton GL, Nunn DN, Lidstrom ME
  Title
Molecular cloning of a malyl coenzyme A lyase gene from Pseudomonas sp. strain AM1, a facultative methylotroph.
  Journal
J Bacteriol 160:718-23 (1984)
DOI:10.1128/JB.160.2.718-723.1984
Reference
PMID:17259315
  Authors
Friedmann S, Alber BE, Fuchs G
  Title
Properties of R-citramalyl-coenzyme A lyase and its role in the autotrophic 3-hydroxypropionate cycle of Chloroflexus aurantiacus.
  Journal
J Bacteriol 189:2906-14 (2007)
DOI:10.1128/JB.01620-06
Reference
PMID:12374834
  Authors
Herter S, Busch A, Fuchs G
  Title
L-Malyl-coenzyme A lyase/beta-methylmalyl-coenzyme A lyase from Chloroflexus aurantiacus, a bifunctional enzyme involved in autotrophic CO(2) fixation.
  Journal
J Bacteriol 184:5999-6006 (2002)
DOI:10.1128/JB.184.21.5999-6006.2002
  Sequence
[cau:Caur_0174]
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