KEGG ORTHOLOGY: K08731

ORTHOLOGY: K08731

Entry

K08731                      KO

Symbol

BIRC5

Name

baculoviral IAP repeat-containing protein 5

Pathway

map01524

Platinum drug resistance

map04210

Apoptosis

map04215

Apoptosis - multiple species

map04390

Hippo signaling pathway

map05161

Hepatitis B

map05200

Pathways in cancer

map05207

Chemical carcinogenesis - receptor activation

map05210

Colorectal cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04390 Hippo signaling pathway
    K08731  BIRC5; baculoviral IAP repeat-containing protein 5
09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K08731  BIRC5; baculoviral IAP repeat-containing protein 5
   04215 Apoptosis - multiple species
    K08731  BIRC5; baculoviral IAP repeat-containing protein 5
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08731  BIRC5; baculoviral IAP repeat-containing protein 5
   05207 Chemical carcinogenesis - receptor activation
    K08731  BIRC5; baculoviral IAP repeat-containing protein 5
  09162 Cancer: specific types
   05210 Colorectal cancer
    K08731  BIRC5; baculoviral IAP repeat-containing protein 5
  09172 Infectious disease: viral
   05161 Hepatitis B
    K08731  BIRC5; baculoviral IAP repeat-containing protein 5
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K08731  BIRC5; baculoviral IAP repeat-containing protein 5
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K08731  BIRC5; baculoviral IAP repeat-containing protein 5
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K08731  BIRC5; baculoviral IAP repeat-containing protein 5
Peptidases and inhibitors [BR:ko01002]
Peptidase inhibitors
  Family I32: IAP family
   K08731  BIRC5; baculoviral IAP repeat-containing protein 5
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Centromeric chromatin formation proteins
   Kinetochore proteins
    CPC (chromosomal passenger complex)
     K08731  BIRC5; baculoviral IAP repeat-containing protein 5

Other DBs

GO:

0043027

Genes

HSA:	332(BIRC5)

PTR:	455276(BIRC5)

PPS:	100980532(BIRC5)

GGO:	101152864(BIRC5)

PON:	100172652(BIRC5)

NLE:	100598415(BIRC5)

HMH:	116483979(BIRC5)

MCC:	709565(BIRC5)

MCF:	102120307(BIRC5) 102133017

MTHB:

126939275 126963345

MNI:	105469239(BIRC5)

CSAB:

103243654(BIRC5)

CATY:

105577651(BIRC5)

PANU:

101006161(BIRC5)

TGE:	112610215(BIRC5) 112631442

MLEU:

105537660 105545796(BIRC5)

RRO:	104659300(BIRC5)

RBB:	108534183(BIRC5)

TFN:	117066766(BIRC5)

PTEH:

111542352(BIRC5)

CANG:

105521103(BIRC5)

CJC:	100398121(BIRC5)

SBQ:	101046847(BIRC5)

CIMI:

108281839 108301749(BIRC5)

CSYR:

103262808(BIRC5)

MMUR:

105866736(BIRC5)

LCAT:

123650645(BIRC5)

PCOQ:

105824013(BIRC5)

OGA:	100961291(BIRC5)

MMU:	11799(Birc5)

MCAL:

110305684(Birc5)

MPAH:

110332414(Birc5)

RNO:	64041(Birc5)

MCOC:

116078576(Birc5)

ANU:	117711130(Birc5)

MUN:	110550569(Birc5)

CGE:	100769162 118237651(Birc5)

MAUA:

101828099(Birc5)

PROB:

127219827(Birc5)

PLEU:

114708968(Birc5)

MORG:

121436269(Birc5)

MFOT:

126500289

AAMP:

119812960(Birc5)

NGI:	103747285(Birc5)

HGL:	101703201(Birc5)

CPOC:

100527953(Birc5)

CCAN:

109683144(Birc5)

DORD:

106003260(Birc5)

DSP:	122096602(Birc5) 122097907

PLOP:

125365370(Birc5)

NCAR:

124980708

MMMA:

107147207 125610369(Birc5)

OCU:

103346801

OPI:	101522332(BIRC5)

TUP:	102487370(BIRC5)

GVR:	103595967(BIRC5)

CFA:	442936(BIRC5)

VVP:	112920853(BIRC5)

AML:	100475314(BIRC5)

UMR:	103665963(BIRC5)

UAH:	113244569(BIRC5)

UAR:	123803023(BIRC5)

ELK:

111160341

LLV:

125086892

MPUF:

101676477(BIRC5)

MNP:	132003502(BIRC5)

MLK:	131816466(BIRC5)

NVS:	122905937(BIRC5)

ORO:	101363894(BIRC5)

EJU:	114216173(BIRC5)

ZCA:	113908303(BIRC5)

MLX:	118024214(BIRC5)

NSU:	110572500(BIRC5)

LWW:	102731151(BIRC5)

FCA:	493835(BIRC5)

PYU:	121017987(BIRC5)

PCOO:

112864535(BIRC5)

PBG:	122486155(BIRC5)

PVIV:

125152027(BIRC5)

LRUF:

124513356

PTG:	102950505(BIRC5)

PPAD:

109276862(BIRC5)

PUC:

125926304

AJU:

106981916

HHV:	120228299(BIRC5)

BTA:	414925(BIRC5)

BOM:	102275014(BIRC5)

BIU:	109574440(BIRC5)

BBUB:

102396201(BIRC5) 123334696

BBIS:

105000397(BIRC5)

CHX:	102180077(BIRC5)

OAS:	101123390(BIRC5)

BTAX:

128065504(BIRC5)

ODA:	120866827(BIRC5)

CCAD:

122437556(BIRC5)

MBEZ:

129544663(BIRC5)

SSC:	397266(BIRC5)

CFR:	102511273(BIRC5)

CBAI:

105065598(BIRC5)

CDK:	105092156(BIRC5)

VPC:	102543682(BIRC5)

BACU:

103012250(BIRC5)

BMUS:

118886123(BIRC5)

LVE:	103072055(BIRC5)

OOR:	101284595(BIRC5)

DLE:	111182765(BIRC5)

PCAD:

102977574(BIRC5)

PSIU:

116745382(BIRC5) 116747138

NASI:

112404902 112410443(BIRC5)

ECB:	100050808(BIRC5)

EPZ:	103554048(BIRC5)

EAI:	106845247(BIRC5)

MYB:	102241862 102247286

MYD:	102765549 102766681(BIRC5)

MMYO:

118664013 118671120(BIRC5)

MLF:	102427260 102439527(BIRC5)

PKL:	118704572(BIRC5) 118713057

EFUS:

103291033 103298251(BIRC5)

MNA:	107532046(BIRC5)

DRO:	112298801(BIRC5) 112302993

SHON:

118999731(BIRC5)

AJM:	119058668(BIRC5)

PDIC:

114490782 114503458(BIRC5)

PHAS:

123816756(BIRC5) 123826954

MMF:	118634154(BIRC5)

PPAM:

129086565(BIRC5)

HAI:	109383622(BIRC5)

RFQ:	117014004(BIRC5)

PALE:

102888083(BIRC5)

PGIG:

120600298(BIRC5)

PVP:	105293400(BIRC5)

RAY:	107510062(BIRC5)

MJV:	108407801(BIRC5)

TOD:	119232055(BIRC5)

SARA:

101543114(BIRC5)

SETR:

126013791(BIRC5)

LAV:	100671026(BIRC5)

TMU:

101348672

ETF:	115872347(BIRC5)

DNM:

101420644

MDO:	100031079(BIRC5)

GAS:	123231659 123245520(BIRC5)

SHR:	100934619(BIRC5)

AFZ:

127560698

PCW:	110193934(BIRC5)

OAA:	100087013(BIRC5)

GGA:	374078(BIRC5) 768589

PCOC:

116231736 116233942

MGP:	104911642(BIRC5)

CJO:	107310923(BIRC5) 107316337

TPAI:

128075530(BIRC5) 128077107

LMUT:

125689724(BIRC5) 125696997

NMEL:

110395353(BIRC5) 110400323

APLA:

106017805 113843115(BIRC5)

ACYG:

106039984 106044728(BIRC5)

CATA:

118254691(BIRC5)

AFUL:

116488102(BIRC5)

TGU:	100229685 100232531(BIRC5)

LSR:	110475823 110484624

SCAN:

103814531 103819217

PMOA:

120506157(BIRC5) 120511613

OTC:	121335493 121346373(BIRC5)

PRUF:

121356434 121365308

GFR:	102034875(BIRC5)

FAB:	101808801 101810543(BIRC5)

OMA:	130250754(BIRC5) 130255644

PHI:	102101400 102111696

PMAJ:

107202602 107207386

CCAE:

111921972 111931948

CCW:	104693747 120411781

CBRC:

103612385(BIRC5)

ETL:	114066244 114069101

ZAB:	102070072 106629467

ZLE:	135446031(BIRC5) 135450255

ACHL:

103801622 103808632

SVG:	106855089 106857292

MMEA:

130580484 130581310

HRT:	120750759(BIRC5) 120755093

FPG:	101915727(BIRC5)

FCH:	102049312(BIRC5) 114016184

CLV:	102092273 102095218(BIRC5)

EHS:

104505795

TALA:

104362357(BIRC5) 116965818

ACHC:

115342697 115350343(BIRC5)

HLE:	104838180(BIRC5)

AGEN:

126038379 126052763

GCL:	127014262 127018727

CCRI:

104160455(BIRC5)

CSTI:

104562851(BIRC5)

CMAC:

104482202(BIRC5)

MUI:	104535197(BIRC5)

BREG:

104633063(BIRC5)

FGA:	104071044(BIRC5)

GSTE:

104252066(BIRC5)

LDI:	104350775 104352846(BIRC5)

MNB:	103777974(BIRC5)

SHAB:

115608111 115613995

DPUB:

104305315(BIRC5)

CPEA:

104397439(BIRC5)

AVIT:

104276125(BIRC5)

RTD:	128907766(BIRC5) 128912697

CUCA:

104060753(BIRC5)

TEO:	104382815(BIRC5)

AAM:	106492420 106494127(BIRC5)

AROW:

112977479(BIRC5)

NPD:	112949336(BIRC5) 112954743

TGT:

104579984

DNE:	112983647 112985534(BIRC5)

ASN:	102380435(BIRC5) 106722454

AMJ:	102573002(BIRC5) 106737667(BIRC5B)

CPOO:

109316178(BIRC5) 109322733

GGN:	109296656(BIRC5) 109301862

CMY:	102938634 119567431

CCAY:

125633344(BIRC5) 125644483

DCC:	119853650(BIRC5) 119863151

CPIC:

101941733(BIRC5) 101942470

TST:	117874187(BIRC5)

CABI:

116834050(BIRC5)

MRV:	120374360 120400223(BIRC5)

ACS:	100561388 100566215(birc5)

ASAO:

132768463(BIRC5) 132778124

PVT:	110087327 110090465(BIRC5)

SUND:

121919573 121922797(BIRC5)

PBI:	103064357(BIRC5)

PMUR:

107290052(BIRC5) 107291928

CTIG:

120308685(BIRC5) 120313094

TSR:	106547391(BIRC5)

PGUT:

117663025 117672809

APRI:

131189926 131189927 131190548 131200937

PTEX:

113433987 113436961(BIRC5)

NSS:	113411905(BIRC5) 113412395

VKO:	123018177(BIRC5) 123024299

PMUA:

114585314 114589289(BIRC5)

PRAF:

128399356 128407357(BIRC5)

ZVI:	118079728(BIRC5) 118084290

HCG:	128346907(BIRC5)

GJA:	107115319(BIRC5) 107117947

STOW:

125426211 125427673(BIRC5)

EMC:	129323596 129328660(BIRC5)

XLA:	394382(birc5.S) 398418(birc5.L) 398454(birc5l.L) 735055(birc5l.S)

XTR:	733532(birc5) 733575(birc5l)

NPR:	108800977 108801438

RTEM:

120919626(BIRC5) 120929382

BBUF:

120993933 121004207(BIRC5)

BGAR:

122933331(BIRC5)

MUO:	115465068 115472381 115473575

GSH:	117356405 117367596(BIRC5)

DRE:	246726(birc5b) 373110(birc5a)

SRX:	107708796 107716091 107722191 107755428

SANH:

107681933 107684154 107690959 107695794

SGH:	107571769 107581679 107586566

CCAR:

109046380 109048546 109064084 109066312

CAUA:

113041763 113055953 113099920 113111694

CGIB:

128011948 128025426

PTET:

122329060(birc5b) 122355665(birc5a)

LROH:

127154962(birc5b) 127174287(birc5a)

OMC:	131532327(birc5b) 131551238(birc5a)

PPRM:

120463253(birc5b) 120474830(birc5a)

RKG:	130073659(birc5b) 130105415(birc5a)

MAMB:

125255063(birc5a) 125260700(birc5b)

CIDE:

127523877

MASI:

127420145 127423063 127427456

TROS:

130545189(birc5b) 130569065(birc5a)

TDW:	130409455(birc5b) 130439259(birc5a)

MANU:

129421567(birc5a) 129430623(birc5b)

IPU:	108273465(birc5a) 108274059 108275580(birc5b)

IFU:	128617388(birc5a) 128619822(birc5b) 128625553

PHYP:

113527276 113528386(birc5) 113530836

SMEO:

124388671(birc5a) 124397005

TFD:	113638908(birc5a) 113639462 113658080(birc5b)

TVC:	132859449(birc5a) 132861069 132862337(birc5b)

TRN:	134300044 134321878(birc5a) 134333821(birc5b)

AMEX:

103025428(birc5) 111192978 111194016

CMAO:

118809371(birc5a) 118821318 118822764(birc5b)

EEE:	113571426 113577672 113590300

CHAR:

105897314(birc5b) 105908581(birc5a) 105908958

TRU:	101062741 101064682

TFS:	130527993(birc5a) 130529998(birc5b)

TNG:	GSTEN00024148G001 GSTEN00028102G001

LCO:	104918068 104932614

NCC:	104954876 104956851

TBEN:

117473826(birc5a) 117494429(birc5b)

CGOB:

115010664 115024964

PGEO:

117449321(birc5b) 117464985 117465002

GACU:

117542074(birc5b) 117544966(birc5a)

EMAC:

134870738(birc5b) 134870753(birc5a)

ELY:	117247561(birc5a) 117258637(birc5b)

EFO:	125880727(birc5a) 125891615(birc5b)

PLEP:

121947308(birc5b) 121958815(birc5a)

SLUC:

116038379(birc5b) 116044330(birc5a)

ECRA:

117937202(birc5a) 117947803(birc5b)

ESP:	116670939 116692326

PFLV:

114548056 114559116

GAT:	120818922(birc5a) 120829133(birc5b)

PPUG:

119213327(birc5a) 119222677(birc5b)

AFB:	129091600(birc5a) 129100316(birc5b)

CLUM:

117733821(birc5b) 117748663(birc5a)

PSWI:

130199681(birc5b) 130203759(birc5a)

MSAM:

119887883 119906056(birc5b) 119916083(birc5a)

SCHU:

122867699(birc5a) 122883037(birc5b)

CUD:	121517049(birc5b) 121527871(birc5a)

ALAT:

119010198(birc5a) 119023040(birc5b)

MZE:	101481959 101485763

ONL:	100709346 100709661

OAU:	116320167(birc5a) 116325877(birc5b)

OLA:	101155061 101168459

OML:	112154285(birc5a) 112158719(birc5b)

CSAI:

133419511(birc5a) 133456376(birc5b)

XMA:	102218059 102224158

XCO:	114151496 114158857

XHE:	116711217 116726670

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122823709(birc5a) 122827657 122833711 122833717 122833745

PPRL:

129352302(birc5a) 129372499(birc5b)

CVG:	107086758 107099875

CTUL:

119782245(birc5b) 119793258(birc5a)

GMU:	124872919(birc5b) 124875496(birc5a)

NFU:	107388179 107390640

KMR:	108237147(birc5a) 108244583(birc5b)

ALIM:

106522649 106528792

NWH:	119416924(birc5b) 119423391(birc5a)

AOCE:

111585891 111587248

MCEP:

125022987(birc5a)

CSEM:

103382361 103385084(survivin)

POV:	109627178 109630673

SSEN:

122759397(birc5a) 122777130(birc5b)

HHIP:

117752713(birc5a) 117765022(birc5b)

HSP:	118101071(birc5a) 118111255(birc5b)

PPLT:

128426727(birc5a) 128442002(birc5b)

SMAU:

118288142(birc5a) 118316906(birc5b)

LCF:	108876532(birc5b) 108880779(birc5a)

SDU:	111219265 111220232

SLAL:

111668900 111672046

XGL:	120794443(birc5a) 120804111(birc5b)

HCQ:	109516568 109531332

SSCV:

125989062 125991153

SBIA:

133495868(birc5a) 133505611(birc5b)

PEE:	133402834(birc5b) 133418027(birc5a)

PTAO:

133469370(birc5a) 133484454(birc5b)

BPEC:

110159670 110164468

MALB:

109969183 109971546

BSPL:

114846480(birc5a) 114859194(birc5b)

SJO:	128357459(birc5b) 128381255(birc5a)

SASA:

106572692 106610005(birc5)

STRU:

115152911(birc5) 115165488

OTW:	112216626(birc5b) 112259586(birc5a)

OMY:	110502934(birc5a) 110532707(birc5b) 118939474

OGO:	124023136(birc5b) 124038582(birc5a)

ONE:	115112869(birc5) 115124792

OKI:	109900053(birc5) 109908605

OKE:	118377015(birc5b) 118377721(birc5a)

SALP:

111966102 111978782(birc5)

SNH:	120045725(birc5a) 120059587(birc5b)

CCLU:

121537396(birc5b) 121577642(birc5a)

ELS:	105013536 105031550

SFM:	108924792(birc5) 108939213

PKI:	111848326(birc5) 111853929

AANG:

118207533(birc5b) 118216302 118218170

LOC:	102690217(birc5) 102696960

PSPA:

121295344(birc5a) 121308868(birc5b)

ARUT:

117400943(birc5b) 117424092(birc5a)

PSEX:

120517963(birc5a) 120526745(birc5b)

LCM:	102346472 102348297(BIRC5)

CMK:	103175557(birc5a)

RTP:	109938723(birc5a)

CPLA:

122540557 122562224(birc5a)

HOC:	132827773(birc5a)

LERI:

129708229(birc5a) 129709585 129712476

PMRN:

116949676 116951539

LRJ:	133340673 133347836

BFO:

BBEL:

CIN:

SCLV:

SPU:

APLC:

AJC:

SKO:

DME:	Dmel_CG12265(Det)

DER:

6552326

DSE:

6616779

DSI:	Dsimw501_GD19147(Dsim_GD19147)

DYA:	Dyak_GE10116

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI24770

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:	119677668 119684329

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

134202467 134203739 134212333

CQU:	CpipJ_CPIJ006694

CPII:

CNS:

BCOO:

AME:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

BMOR:

100302609(Iap2)

BMAN:

114248076

MSEX:

115449461

DPL:	KGM_201142

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

AAGE:

HAW:	110378778(det)

HZE:

TNL:

SLIU:

OFU:

ATRA:

PXY:

PGW:

LGLY:

CCRN:

API:	100159292(Det) 100569400

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:	103508457 103516527 103522644 103523747

CLEC:

106664242

HHAL:

106689514

NLU:	111052464 120350633 120352145

HVI:

MQU:

FOC:

TPAL:

ZNE:

CSEC:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_307098

DMK:

DPZ:

PVM:

PJA:

PCHN:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

119113400 119113401 119114302

DSV:	119431547 119437413 119440115 119440135 119441998

RSAN:

119387565

RMP:	119159703 119159704 119162094

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:	129216989 129233718

SDM:

118192059

LPOL:

111083946

CEL:	CELE_C50B8.2(bir-2) CELE_T27F2.3(bir-1)

CBR:	CBG_11537(Cbr-bir-2) CBG_23296(Cbr-bir-1)

CRQ:	GCK72_018078 GCK72_018601 GCK72_019406 GCK72_019455

BMY:	BM_BM8420(Bm8420)

LOA:	LOAG_04028

TSP:

Tsp_10804

LGI:	LOTGIDRAFT_125617 LOTGIDRAFT_229109

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

RPHI:

DPOL:

OBI:

LJP:

LAK:

EGL:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

TAD:	TRIADDRAFT_56224

AQU:	100634627 100635173

TDC:

119359119

PCHM:

VFPPC_17662

SHS:	STEHIDRAFT_65375

GTR:	GLOTRDRAFT_63085

CPUT:

CONPUDRAFT_54433

EIN:	Eint_050680

EHE:	EHEL_050740

ERO:	EROM_050670

NCE:	NCER_100918

GTT:	GUITHDRAFT_107595

NGR:	NAEGRDRAFT_61105

» show all

Reference

PMID:16534789

Authors

Fangusaro JR, Caldas H, Jiang Y, Altura RA

Title

Survivin: an inhibitor of apoptosis in pediatric cancer.

Journal

Pediatr Blood Cancer 47:4-13 (2006)
DOI:10.1002/pbc.20805

Reference

PMID:9256286

Authors

Ambrosini G, Adida C, Altieri DC

Title

A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma.

Journal

Nat Med 3:917-21 (1997)
DOI:10.1038/nm0897-917

Sequence

[hsa:332]

LinkDB

DBGET integrated database retrieval system