KEGG ORTHOLOGY: K08886

ORTHOLOGY: K08886

Entry

K08886                      KO

Symbol

TNK2, ACK1

Name

activated CDC42 kinase 1 [EC:2.7.10.2 2.7.11.1]

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08886  TNK2, ACK1; activated CDC42 kinase 1
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K08886  TNK2, ACK1; activated CDC42 kinase 1
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K08886  TNK2, ACK1; activated CDC42 kinase 1
Protein kinases [BR:ko01001]
Non-receptor tyrosine kinases
  ACK family
   K08886  TNK2, ACK1; activated CDC42 kinase 1

Other DBs

GO:	0004715 0004712

Genes

HSA:	10188(TNK2)

PTR:	100611576(TNK2)

PPS:	100979625 100985139(TNK2)

GGO:	101148404(TNK2)

PON:	100432977(TNK2)

NLE:	100604750(TNK2) 115837603

MCC:	711655(TNK2)

MCF:	102133737(TNK2)

MTHB:

126946125

MNI:	105470761(TNK2)

CSAB:

103242013(TNK2)

CATY:

105575111(TNK2)

PANU:

100999644(TNK2)

TGE:	112619085(TNK2)

MLEU:

105538793(TNK2)

RRO:	104676389(TNK2)

RBB:	108523308(TNK2)

TFN:	117084468(TNK2)

PTEH:

111544349(TNK2)

CANG:

105525499(TNK2)

CJC:	100409090(TNK2)

SBQ:	101034852(TNK2)

CIMI:

108312844(TNK2)

CSYR:

103253613(TNK2)

MMUR:

105879833(TNK2)

LCAT:

123630444(TNK2)

PCOQ:

105808452(TNK2)

OGA:	100964662(TNK2)

MMU:	51789(Tnk2)

MCAL:

110311392(Tnk2)

MPAH:

110329496(Tnk2)

RNO:	303882(Tnk2)

MCOC:

116085828(Tnk2)

ANU:	117717715(Tnk2)

MUN:	110547666(Tnk2)

CGE:	100754061(Tnk2)

MAUA:

101832890(Tnk2)

PROB:

127227084(Tnk2)

PLEU:

114685389(Tnk2)

MORG:

121461721(Tnk2)

MFOT:

126512202

AAMP:

119825035(Tnk2)

NGI:	103738519(Tnk2)

HGL:	101701156(Tnk2)

CPOC:

100715920(Tnk2)

CCAN:

109694514(Tnk2)

DORD:

105987895(Tnk2)

DSP:	122097445(Tnk2)

PLOP:

125351800(Tnk2)

NCAR:

124992729

MMMA:

107143200(Tnk2)

OCU:

100350340

OPI:	101523332(TNK2)

TUP:	102481186(TNK2)

GVR:	103603663(TNK2)

CFA:	488025(TNK2)

CLUD:

112676699(TNK2)

VVP:	112913524(TNK2)

VLG:	121490428(TNK2)

NPO:	129503667(TNK2)

AML:	100473867(TNK2)

UMR:	103678942(TNK2)

UAH:	113252833(TNK2)

UAR:	123802117(TNK2)

ELK:

111154990

LLV:

125102780

MPUF:

101685054(TNK2)

MNP:	132011889(TNK2)

MLK:	131824663(TNK2)

NVS:	122908844(TNK2)

ORO:	101371325(TNK2)

EJU:	114206996(TNK2)

ZCA:	113917042(TNK2)

MLX:	118006988(TNK2)

NSU:	110582698(TNK2)

LWW:

102742652

FCA:	101098817(TNK2)

PYU:	121036376(TNK2)

PCOO:

112850122(TNK2)

PBG:	122491554(TNK2)

PVIV:

125175006(TNK2)

LRUF:

124526018

PTG:	102961037(TNK2)

PPAD:

109266534(TNK2)

PUC:

125921800

AJU:

106987457

HHV:	120244377(TNK2)

BTA:	280710(TNK2)

BOM:	102264583(TNK2)

BIU:	109556096(TNK2)

BBUB:

102414560(TNK2)

BBIS:

104984538(TNK2)

CHX:	102175249(TNK2)

OAS:	101122917(TNK2)

BTAX:

128043552(TNK2)

ODA:	120869928(TNK2)

CCAD:

122444667(TNK2)

MBEZ:

129539611(TNK2)

SSC:	100513310(TNK2)

CFR:	102507079(TNK2)

CBAI:

105072398(TNK2)

CDK:	105101297(TNK2)

VPC:	102533066(TNK2)

BACU:

103012844(TNK2)

BMUS:

118894271(TNK2)

LVE:	103086492(TNK2)

OOR:	101276197(TNK2)

DLE:	111172004(TNK2)

PCAD:

102982969

PSIU:

116752828(TNK2)

NASI:

112406072(TNK2)

ECB:	100070001(TNK2)

EPZ:	103541091(TNK2)

EAI:	106824419(TNK2)

MYB:	102245333(TNK2)

MYD:	102755693(TNK2)

MMYO:

118675417(TNK2)

MLF:	102423097(TNK2)

PKL:	118722898(TNK2)

EFUS:

103298749(TNK2)

MNA:	107527262(TNK2)

DRO:	112320535(TNK2)

SHON:

118978315(TNK2)

AJM:	119050873(TNK2)

PDIC:

114489618(TNK2)

PHAS:

123826844(TNK2)

MMF:	118617057(TNK2)

PPAM:

129071806(TNK2)

HAI:	109387810(TNK2)

RFQ:	117035443(TNK2)

PALE:

102883444(TNK2)

PGIG:

120593010(TNK2)

PVP:	105309171(TNK2)

RAY:	107505259(TNK2)

MJV:	108397522(TNK2)

TOD:	119257433(TNK2)

SARA:

101556747(TNK2)

SETR:

126010833(TNK2)

LAV:	100667509(TNK2)

TMU:

101357955

ETF:	101652324(TNK2)

DNM:	101425870(TNK2)

MDO:	100021602(TNK2)

GAS:	123242339(TNK2)

AFZ:

127554184

PCW:	110208162(TNK2)

OAA:	100087433(TNK2)

GGA:	431014(TNK2)

PCOC:

116235356(TNK2)

MGP:	100550293(TNK2)

CJO:	107318212(TNK2)

TPAI:

128082599(TNK2)

LMUT:

125697406(TNK2)

NMEL:

110397856(TNK2)

APLA:

101803856(TNK2)

ACYG:

106044789(TNK2)

CATA:

118247094(TNK2)

AFUL:

116492597(TNK2)

TGU:	100228859(TNK2)

LSR:	110473892(TNK2)

SCAN:

103815372(TNK2)

PMOA:

120504398(TNK2)

OTC:	121336522(TNK2)

PRUF:

121353657(TNK2)

GFR:	102041896(TNK2)

FAB:	101808274(TNK2)

OMA:	130256551(TNK2)

PHI:	102100858(TNK2)

PMAJ:

107208652(TNK2)

CCAE:

111933439(TNK2)

CCW:	104687937(TNK2)

CBRC:

103625150(TNK2)

ETL:	114057582(TNK2)

ZAB:	102072061(TNK2)

ZLE:	135451944(TNK2)

SVG:	106850385(TNK2)

MMEA:

130574162(TNK2)

HRT:	120757148(TNK2)

FPG:	101919032(TNK2)

FCH:	102048850(TNK2)

CLV:	102084125(TNK2)

EGZ:	104123395(TNK2)

NNI:	104015659(TNK2)

ACUN:

113483442(TNK2)

TALA:

104365185(TNK2)

PADL:

103916592(TNK2)

AFOR:

103901469

ACHC:

115347273(TNK2)

HLE:	104835176(TNK2)

AGEN:

GCL:

LDI:

OHA:

SHAB:

115612328(TNK2)

DPUB:

104302944(TNK2)

CPEA:

104390607(TNK2)

CVF:	104285020(TNK2)

RTD:	128910997(TNK2)

CUCA:

104063179(TNK2)

AAM:	106498025(TNK2)

AROW:

112968530(TNK2)

NPD:	112952505(TNK2)

TGT:

104575056

DNE:	112979392(TNK2)

SCAM:

104148809(TNK2)

ASN:	102380247(TNK2)

AMJ:	102560234(TNK2)

CPOO:

109308536(TNK2)

GGN:	109288088(TNK2)

CMY:	102938461(TNK2)

CCAY:

125642816(TNK2)

DCC:	119861784(TNK2)

CPIC:

101935908(TNK2)

TST:	117882711(TNK2)

CABI:

116823009(TNK2)

MRV:	120371839(TNK2)

ACS:

107982273

ASAO:

132770379(TNK2)

PVT:	110091397(TNK2)

SUND:

121925342(TNK2)

PBI:	103055077(TNK2)

PMUR:

107299307

CTIG:

120317301(TNK2)

TSR:	106549017(TNK2)

PGUT:

117660025(TNK2)

APRI:

131200674(TNK2)

PTEX:

113450485

NSS:	113427489(TNK2)

VKO:	123036795(TNK2)

PMUA:

114598185(TNK2)

PRAF:

128413325(TNK2)

ZVI:	118093964(TNK2)

HCG:	128350084(TNK2)

GJA:	107120847(TNK2)

STOW:

125434565(TNK2)

EMC:	129332849(TNK2)

XLA:	108716957(tnk2.L) 108718062(tnk2.S)

XTR:	100124754(tnk2)

NPR:	108791179(TNK2) 108803092 108803558

RTEM:

120936880(TNK2)

BBUF:

120998000(TNK2)

BGAR:

122934495(TNK2)

MUO:

115478595

GSH:	117366672(TNK2)

DRE:	100148041 559119(tnk2b)

SRX:	107705304 107721909 107725874 107728404

SANH:

107653507 107660324 107663695 107685449

SGH:	107550440 107571661 107586742 107590233

CCAR:

109061807 109066646 109103277

CAUA:

113045742 113066174 113100917 113115169

CGIB:

127946159 127950875 128012883 128022457

PTET:

122325487(tnk2b) 122330152(tnk2a)

LROH:

127155974(tnk2a) 127174606(tnk2b)

OMC:	131531183(tnk2b) 131533639(tnk2a)

PPRM:

120479492(tnk2b) 120488439(tnk2a)

RKG:	130083985(tnk2a) 130097841(tnk2b)

MAMB:

125251526(tnk2b) 125258125(tnk2a)

CIDE:

127496015 127505845

MASI:

127431608 127434486 127441474 127442005

TROS:

130547258(tnk2a) 130554425(tnk2b)

TDW:	130413515(tnk2a) 130417963(tnk2b)

MANU:

129425532(tnk2a) 129442562(tnk2b)

IPU:	108256568(tnk2a) 108280487(tnk2b)

IFU:	128600029(tnk2a) 128624294(tnk2b)

PHYP:

113541165 113546393(tnk2)

SMEO:

124375616(tnk2a) 124403180(tnk2b)

TFD:	113650135(tnk2b) 113660335(tnk2a)

TVC:	132840460(tnk2a) 132844484(tnk2b)

TRN:	134300906(tnk2a) 134302847(tnk2b)

AMEX:

103029100 103035769(tnk2)

CMAO:

118797003(tnk2b) 118798723(tnk2a)

EEE:	113576164 113590365

CHAR:

105894719(tnk2a) 105899224(tnk2b)

TRU:	101071846(tnk2) 101077037

TFS:	130513824(tnk2a) 130538891(tnk2b)

TNG:	GSTEN00015047G001 GSTEN00025483G001

LCO:	104932774(tnk2) 104937021

NCC:	104945570 104950900

TBEN:

117488820(tnk2b) 117498509(tnk2a)

CGOB:

115022518(tnk2) 115025737

PGEO:

117462119 117466071(tnk2a)

GACU:

117544766(tnk2a) 117545609(tnk2b)

EMAC:

134858139(tnk2a) 134866213(tnk2b)

ELY:	117264929(tnk2a) 117272132

EFO:	125881811(tnk2a) 125901565(tnk2b)

PLEP:

121951221 121960594(tnk2a)

SLUC:

116045459(tnk2b) 116048549(tnk2a)

ECRA:

117937565(tnk2a) 117954277(tnk2b)

ESP:	116671937 116699218

PFLV:

114549560 114565828(tnk2)

GAT:	120811529(tnk2a) 120816163(tnk2b)

PPUG:

119198983(tnk2a) 119209137(tnk2b)

AFB:	129089050(tnk2b) 129110744(tnk2a)

CLUM:

117745920(tnk2b) 117749427(tnk2a)

PSWI:

130197541(tnk2b) 130206562(tnk2a)

MSAM:

119893390 119902414(tnk2b) 119912467(tnk2a)

SCHU:

122866939(tnk2a) 122887579(tnk2b)

CUD:	121519595(tnk2b) 121527581(tnk2a)

ALAT:

119008466(tnk2a) 119010782(tnk2b)

MZE:	101467047(tnk2) 101486880

ONL:	100691969 100695859(tnk2)

OAU:	116314673(tnk2b) 116324449(tnk2a)

OLA:	101170708 101171868

OML:	112147140 112151609(tnk2a)

CSAI:

133423504(tnk2a) 133453098(tnk2b)

XMA:	102225582 102230989(tnk2)

XCO:	114137085 114147190

XHE:	116712034 116721561(tnk2)

PRET:

103456754 103478968(tnk2)

PFOR:

103140051 103140539

PLAI:

106935764 106958039(tnk2)

PMEI:

106903607(tnk2) 106914952

GAF:	122823942(tnk2a) 122841301(tnk2b)

PPRL:

129361683(tnk2b) 129378923(tnk2a)

CVG:	107083647(tnk2) 107094814

CTUL:

119771465(tnk2a) 119779295(tnk2b)

GMU:	124858024(tnk2a) 124869694(tnk2b)

NFU:	107383061 107384322(tnk2)

KMR:	108234735(tnk2a) 108238299(tnk2b)

ALIM:

106515535 106521505(tnk2)

NWH:	119414909 119426856(tnk2a)

AOCE:

111570220 111588092(tnk2)

MCEP:

124995844(tnk2a) 125010804(tnk2b)

CSEM:

103377316 103396201

POV:	109641301(tnk2) 109645895

SSEN:

122767732 122779908(tnk2a)

HHIP:

117754174(tnk2a) 117778198(tnk2b)

HSP:	118098677(tnk2a) 118117663(tnk2b)

PPLT:

128425799(tnk2a) 128454119

SMAU:

118291362(tnk2a) 118310980

LCF:	108883852(tnk2b) 108885110(tnk2a)

SDU:	111224320 111228845

SLAL:

111645756 111666504(tnk2)

XGL:	120789560(tnk2a) 120798686(tnk2b)

HCQ:	109520567 109524700

SSCV:

125984585 125986162

SBIA:

133492595(tnk2a) 133511366

PEE:	133396718(tnk2a) 133411941

PTAO:

133470113(tnk2a) 133488599(tnk2b)

BPEC:

110161279 110173462(tnk2)

MALB:

109962201 109974044

BSPL:

114844305(tnk2b) 114853572(tnk2a)

SJO:	128368599(tnk2b) 128382311(tnk2a)

SASA:

106568689(tnk2) 106579455 106590482 106596996

STRU:

115151531 115156591 115170146

OTW:	112216492(tnk2a) 112240862 112260257(tnk2b)

OMY:	110489646 110508241 110529993(tnk2b) 110535368(tnk2a)

OGO:	123991294(tnk2a) 124009211 124042144

ONE:	115101603 115104500 115114092(tnk2) 115131024

OKI:	109871850 109875210 109900138 109909658

OKE:	118371248(tnk2a) 118395167 118402293 127906054

SALP:

111956580(tnk2)

SNH:	120019938 120027696(tnk2a) 120050329 120055731(tnk2b)

CCLU:

121534923 121549818(tnk2a) 121569277 121580605

ELS:	105021982 105024998(tnk2)

SFM:	108927754 108935258(tnk2)

PKI:	111839916 111847401

AANG:

118226302 118230760

LOC:	102688265(tnk2)

PSPA:

121322920 121326797

ARUT:

117416528 117423530

PSEX:

120536093(tnk2b)

LCM:	102364138(TNK2)

CMK:	103183178(tnk2b)

CPLA:

122556040(tnk2b)

HOC:	132821837(tnk2b)

LERI:

129693627 129703237(tnk2b)

PMRN:

116950409(TNK2)

LRJ:	133352354(TNK2)

BFO:

BBEL:

CIN:

SCLV:

SPU:	587777 594771

LPIC:

APLC:

SKO:

DER:

DSI:	Dsimw501_GD13814(Dsim_GD13814)

DYA:	Dyak_GE21413

DSR:

110183674

DPO:

4812637

DPE:

6601877

DMN:	108151901 117186827

DWI:

6645363

DMO:	Dmoj_GI13196

DAZ:

DNV:

DHE:

MDE:

LCQ:

AGA:

ACOZ:

AARA:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ000816

CPII:

120412716

AME:	413052 552576

ACER:

107996460 108003442

ALAB:

122711519 122717125

ADR:	102676997 102681833

AFLR:

100865498 100866491

BIM:	100747574 100750002

BBIF:

117214290 117214497

BVK:	117242475 117242636

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:	122527153 122537331

CCAL:

108626579 108632803

OBB:	114871501 114877840

OLG:	117606507 117608967

MGEN:

117220969 117224098

NMEA:

116430771 116434967

CGIG:

122402973

SOC:	105199766 105202478

MPHA:

105832564

AEC:	105144038 105148022

ACEP:

105627416

PBAR:

105423546

VEM:	105558442 105569071

HST:	105182451 105183739

DQU:	106749126 106749216

CFO:	105250290 105254223

FEX:	115236616 115242217

LHU:	105675482 105678018

PGC:	109859857 109859859

OBO:	105275516 105280462

PCF:	106784049 106789690

PFUC:

122518990 122519079

VPS:	122630660 122634453

VCRB:

124424451 124430214

VVE:	124950771 124954694

NVI:	100121126 100123948

CSOL:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

TCA:	656701 659416 664095

DPA:	109533569 109539321

ATD:	109597180 109601494

DVV:	126882893 126888763

NVL:	108559841 108566526

BMOR:

101738858

DPL:	KGM_212131

PMAC:

ZCE:

AAGE:

HAW:

TNL:

ATRA:

PXY:

LGLY:

API:	100164910 100168786

DNX:	107163465 107163533

AGS:	114119727 114125168

RMD:	113554960 113560346 113560424

ACOO:

DVT:

BTAB:

CLEC:

NLU:	111063500 111064084

MQU:	129002357 129002471

PHU:	Phum_PHUM257990

ZNE:

SGRE:

BROR:

FCD:

DPX:	DAPPUDRAFT_304375

DMK:

DPZ:

PJA:

PCHN:

HAME:

PCLA:

CQD:

PTRU:

HAZT:

EAF:

LSM:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

CEL:	CELE_B0302.1(sid-3)

CBR:	CBG_15949(Cbr-kin-25)

CRQ:	GCK72_023397

LOA:	LOAG_18027

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MMER:

RPHI:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_164930

SHX:	MS3_00003449(TNK1)

OVI:	T265_14891

LLON:

135496974

NVE:	5513616 5520002

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:	100203145 100208784

HSY:

130641974

» show all

Reference

PMID:8497321

Authors

Manser E, Leung T, Salihuddin H, Tan L, Lim L

Title

A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42.

Journal

Nature 363:364-7 (1993)
DOI:10.1038/363364a0

Sequence

[hsa:10188]

LinkDB

DBGET integrated database retrieval system