KEGG   ORTHOLOGY: K09047
Entry
K09047                      KO                                     
Symbol
CREB5, CREBPA
Name
cyclic AMP-responsive element-binding protein 5
Pathway
map04022  cGMP-PKG signaling pathway
map04024  cAMP signaling pathway
map04151  PI3K-Akt signaling pathway
map04152  AMPK signaling pathway
map04211  Longevity regulating pathway
map04261  Adrenergic signaling in cardiomyocytes
map04668  TNF signaling pathway
map04714  Thermogenesis
map04725  Cholinergic synapse
map04728  Dopaminergic synapse
map04911  Insulin secretion
map04915  Estrogen signaling pathway
map04918  Thyroid hormone synthesis
map04922  Glucagon signaling pathway
map04925  Aldosterone synthesis and secretion
map04926  Relaxin signaling pathway
map04927  Cortisol synthesis and secretion
map04928  Parathyroid hormone synthesis, secretion and action
map04931  Insulin resistance
map04934  Cushing syndrome
map04935  Growth hormone synthesis, secretion and action
map04962  Vasopressin-regulated water reabsorption
map05016  Huntington disease
map05020  Prion disease
map05030  Cocaine addiction
map05031  Amphetamine addiction
map05034  Alcoholism
map05161  Hepatitis B
map05163  Human cytomegalovirus infection
map05165  Human papillomavirus infection
map05166  Human T-cell leukemia virus 1 infection
map05203  Viral carcinogenesis
map05207  Chemical carcinogenesis - receptor activation
map05215  Prostate cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04024 cAMP signaling pathway
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04022 cGMP-PKG signaling pathway
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04151 PI3K-Akt signaling pathway
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04152 AMPK signaling pathway
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04922 Glucagon signaling pathway
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04915 Estrogen signaling pathway
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04926 Relaxin signaling pathway
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04935 Growth hormone synthesis, secretion and action
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04918 Thyroid hormone synthesis
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04928 Parathyroid hormone synthesis, secretion and action
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04925 Aldosterone synthesis and secretion
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04927 Cortisol synthesis and secretion
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
  09156 Nervous system
   04725 Cholinergic synapse
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04728 Dopaminergic synapse
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
  09149 Aging
   04211 Longevity regulating pathway
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
  09159 Environmental adaptation
   04714 Thermogenesis
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   05203 Viral carcinogenesis
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
  09162 Cancer: specific types
   05215 Prostate cancer
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   05161 Hepatitis B
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   05163 Human cytomegalovirus infection
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   05165 Human papillomavirus infection
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
  09164 Neurodegenerative disease
   05016 Huntington disease
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   05020 Prion disease
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
  09165 Substance dependence
   05030 Cocaine addiction
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   05031 Amphetamine addiction
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   05034 Alcoholism
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04934 Cushing syndrome
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
Transcription factors [BR:ko03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   AP-1(-like) components, CRE-BP/ATF
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
Other DBs
GO: 0035497
Genes
HSA: 9586(CREB5)
PTR: 463318(CREB5)
PPS: 100973232(CREB5)
GGO: 101153965
PON: 100439720(CREB5)
NLE: 100600059(CREB5)
HMH: 116812715(CREB5)
MCC: 697718(CREB5)
MCF: 102123367(CREB5)
MTHB: 126950050
MNI: 105475779(CREB5)
CSAB: 103226299(CREB5)
CATY: 105595971(CREB5)
PANU: 101007514(CREB5)
TGE: 112621312(CREB5)
MLEU: 105533710(CREB5)
RRO: 104681895(CREB5)
RBB: 108535460(CREB5)
TFN: 117072944(CREB5)
PTEH: 111551841(CREB5)
CANG: 105509398(CREB5)
CJC: 100392579(CREB5)
SBQ: 101054090(CREB5)
CIMI: 108303281(CREB5)
CSYR: 103273492(CREB5)
MMUR: 105855129
LCAT: 123647634
PCOQ: 105807372
OGA: 100952718(CREB5)
MMU: 231991(Creb5)
MCAL: 110296203(Creb5)
MPAH: 110315994(Creb5)
RNO: 500131(Creb5)
MCOC: 116098936(Creb5)
ANU: 117720600(Creb5)
MUN: 110554970(Creb5)
CGE: 100764159(Creb5)
MAUA: 101844837(Creb5)
PROB: 127235522(Creb5)
PLEU: 114689726(Creb5)
MORG: 121439698(Creb5)
MFOT: 126509567
AAMP: 119807891(Creb5)
NGI: 103740829(Creb5)
HGL: 101703315(Creb5)
CPOC: 100719318(Creb5)
CCAN: 109676751
DORD: 105991729(Creb5)
DSP: 122112193(Creb5)
PLOP: 125346776(Creb5)
NCAR: 124991182
MMMA: 107146134(Creb5)
OCU: 100357483
OPI: 101534608(CREB5)
TUP: 102487006(CREB5)
GVR: 103595172(CREB5)
CFA: 475266(CREB5)
CLUD: 112670641(CREB5)
VVP: 112915694
VLG: 121474745(CREB5)
NPO: 129502771(CREB5)
AML: 100474261(CREB5)
UMR: 103658932
UAH: 113262153(CREB5)
UAR: 123789128(CREB5)
ELK: 111147321
LLV: 125080867
MPUF: 101677234(CREB5)
MNP: 132015844(CREB5)
MLK: 131829554(CREB5)
NVS: 122904940(CREB5)
ORO: 101384862(CREB5)
EJU: 114221152(CREB5)
ZCA: 113911563(CREB5)
MLX: 118021299(CREB5)
NSU: 110580150(CREB5)
FCA: 101084784(CREB5)
PYU: 121028557(CREB5)
PCOO: 112866756(CREB5)
PBG: 122488047(CREB5)
PVIV: 125161255(CREB5)
LRUF: 124524308
PTG: 102972337(CREB5)
PPAD: 109263891(CREB5)
PUC: 125930855
AJU: 106987665
HHV: 120230339(CREB5)
BTA: 534129(CREB5)
BOM: 102275204(CREB5)
BIU: 109557489(CREB5)
BBUB: 102400864(CREB5)
BBIS: 104999800(CREB5)
CHX: 102190378(CREB5)
OAS: 101112976(CREB5)
BTAX: 128046584(CREB5)
ODA: 120877414(CREB5)
CCAD: 122438446(CREB5)
MBEZ: 129552502(CREB5)
SSC: 100515635(CREB5)
CFR: 102514154(CREB5)
CBAI: 105082021(CREB5)
CDK: 105095833(CREB5)
VPC: 102540303(CREB5)
BACU: 103009193(CREB5)
BMUS: 118900738(CREB5)
LVE: 103081811(CREB5)
OOR: 101289047(CREB5)
DLE: 111180225(CREB5)
PCAD: 102985635(CREB5)
PSIU: 116759616(CREB5)
NASI: 112406282(CREB5)
ECB: 100054803(CREB5)
EPZ: 103549839(CREB5)
EAI: 106831046(CREB5)
MYB: 102240701(CREB5)
MYD: 102769297(CREB5)
MMYO: 118666077(CREB5)
MLF: 102439961(CREB5)
PKL: 118727782(CREB5)
EFUS: 103291632(CREB5)
MNA: 107544390(CREB5)
DRO: 112306927(CREB5)
SHON: 118983579(CREB5)
AJM: 119035286(CREB5)
PDIC: 114508223(CREB5)
PHAS: 123811809(CREB5)
MMF: 118620061(CREB5)
PPAM: 129063111(CREB5)
HAI: 109381368(CREB5)
RFQ: 117012438(CREB5)
PALE: 102884583(CREB5)
PGIG: 120602391(CREB5)
PVP: 105293217
RAY: 107505683(CREB5)
MJV: 108405132(CREB5)
TOD: 119243789(CREB5)
SARA: 101554016(CREB5)
SETR: 126020515(CREB5)
LAV: 100675079(CREB5)
TMU: 101345798
ETF: 101648034(CREB5)
DNM: 101426399(CREB5)
MDO: 100032634(CREB5)
SHR: 100922067(CREB5)
AFZ: 127539046
PCW: 110213063(CREB5)
OAA: 100080655(CREB5)
GGA: 428435(CREB5)
PCOC: 116227073(CREB5)
MGP: 100541001(CREB5)
CJO: 107309226(CREB5)
TPAI: 128086152(CREB5)
LMUT: 125696233(CREB5)
NMEL: 110394289(CREB5)
APLA: 101797962(CREB5)
ACYG: 106030241(CREB5)
CATA: 118252757(CREB5)
AFUL: 116486836(CREB5)
TGU: 100228299(CREB5)
LSR: 110474631(CREB5)
SCAN: 103812908(CREB5)
PMOA: 120501239(CREB5)
OTC: 121339559(CREB5)
PRUF: 121352894(CREB5)
GFR: 102044631(CREB5)
FAB: 101805839(CREB5)
OMA: 130249816(CREB5)
PHI: 102103048(CREB5)
PMAJ: 107200380(CREB5)
CCAE: 111923428(CREB5)
CCW: 104689082(CREB5)
CBRC: 103614139(CREB5)
ETL: 114055673(CREB5)
ZAB: 102074025(CREB5)
ZLE: 135443835(CREB5)
ACHL: 103799140(CREB5)
SVG: 106864366(CREB5)
MMEA: 130573218(CREB5)
HRT: 120762062(CREB5)
FPG: 101920362(CREB5)
FCH: 102055392(CREB5)
CLV: 102084581(CREB5)
EGZ: 104126134(CREB5)
NNI: 104013914(CREB5)
PCAO: 104052801(CREB5)
ACUN: 113476866(CREB5)
TALA: 104357640(CREB5)
PADL: 103918402(CREB5)
AFOR: 103906673
ACHC: 115339826(CREB5)
HLE: 104838041(CREB5)
AGEN: 126037854
GCL: 127013018
CCRI: 104162270(CREB5)
CSTI: 104554297(CREB5)
CMAC: 104476393(CREB5)
MUI: 104546411
BREG: 104638272(CREB5)
GSTE: 104264566
LDI: 104348309(CREB5)
MNB: 103769411(CREB5)
OHA: 104333341(CREB5)
NNT: 104413376(CREB5)
SHAB: 115616153(CREB5)
DPUB: 104307525(CREB5)
PGUU: 104468972(CREB5)
ACAR: 104532451(CREB5)
CPEA: 104397560(CREB5)
AVIT: 104277597(CREB5)
CVF: 104288387(CREB5)
RTD: 128905676(CREB5)
CUCA: 104059165(CREB5)
TEO: 104372767
BRHI: 104496419(CREB5)
AAM: 106483468(CREB5)
AROW: 112973076(CREB5)
NPD: 112957231(CREB5)
TGT: 104576069(CREB5)
DNE: 112985299(CREB5)
SCAM: 104145130(CREB5)
ASN: 102372372
AMJ: 102576266(CREB5)
CPOO: 109310251(CREB5)
GGN: 109291585(CREB5)
PSS: 102453617(CREB5)
CMY: 102933695(CREB5)
CCAY: 125631578(CREB5)
DCC: 119852134(CREB5)
CPIC: 101933432(CREB5)
TST: 117872346(CREB5)
CABI: 116820977(CREB5)
MRV: 120399045(CREB5)
ACS: 100567734(creb5)
ASAO: 132778729(CREB5)
PVT: 110072290(CREB5)
SUND: 121932505(CREB5)
PBI: 103060982(CREB5)
PMUR: 107282774
CTIG: 120307325(CREB5)
TSR: 106541450(CREB5)
PGUT: 117655170(CREB5)
APRI: 131198637(CREB5)
PTEX: 113441289(CREB5)
NSS: 113415968(CREB5)
VKO: 123033824(CREB5)
PMUA: 114607489(CREB5)
PRAF: 128398467(CREB5)
ZVI: 118092189(CREB5)
HCG: 128330219(CREB5)
GJA: 107105766(CREB5)
STOW: 125440961(CREB5)
EMC: 129337694(CREB5)
XLA: 108718906(creb5.L) 108719935(creb5.S)
XTR: 100498464(creb5)
NPR: 108803870(CREB5)
RTEM: 120940218(CREB5)
BBUF: 121002216(CREB5)
BGAR: 122937898(CREB5)
MUO: 115460129(CREB5)
GSH: 117354022(CREB5)
DRE: 101886947(creb5a) 565910(creb5b)
SRX: 107710349 107743158(creb5) 107745374 107748653
SANH: 107654766 107684542 107685539 107688348
SGH: 107550799 107550832 107592000 107596650 107602393
CCAR: 109074141 109106413(creb5) 109111796
CAUA: 113060178 113062268 113116269 113120056
CGIB: 127934923 127974585 127978585 128030994
PTET: 122324210(creb5a) 122360407(creb5b)
LROH: 127179169(creb5b) 127182288(creb5a)
OMC: 131522181(creb5b) 131525218(creb5a)
PPRM: 120483715 120483717 120494964(creb5b)
RKG: 130070126(creb5b)
MAMB: 125243100(creb5b) 125275383(creb5a)
CIDE: 127497547 127501544
MASI: 127421591 127425509 127452982 127454438
TROS: 130557805(creb5b) 130566493(creb5a)
TDW: 130415954(creb5a) 130433219(creb5b)
MANU: 129449023(creb5b) 129454859(creb5a)
IPU: 108257012(creb5a) 108270486(creb5b)
IFU: 128600618(creb5a) 128609298(creb5b)
PHYP: 113536287 113542461(creb5)
SMEO: 124376449(creb5a) 124385038(creb5b)
TFD: 113641601(creb5a) 113644441(creb5b)
TVC: 132837432(creb5a) 132846009(creb5b)
TRN: 134305804(creb5a) 134310140(creb5b)
AMEX: 103036725(creb5a)
CMAO: 118805839(creb5a) 118816546(creb5b)
EEE: 113571214(creb5) 113580399
CHAR: 105891976(creb5b)
TRU: 101061266(creb5) 101065138
TFS: 130517831(creb5a) 130532616(creb5b)
TNG: GSTEN00017470G001 GSTEN00034125G001
LCO: 104927758(creb5) 104940561
NCC: 104941125 104949893(creb5)
TBEN: 117477944 117480699(creb5b)
CGOB: 115015830 115020880(creb5)
PGEO: 117455612 117461238(creb5b)
GACU: 117554058(creb5b) 117562866
EMAC: 134861640(creb5b) 134874532
ELY: 117263157(creb5a) 117265323(creb5b)
EFO: 125893489(creb5b) 125904702(creb5a)
PLEP: 121945545(creb5b) 121957945(creb5a)
SLUC: 116049397(creb5b) 116066858
ECRA: 117946489(creb5b) 117956234(creb5a)
ESP: 116691490(creb5) 116702071
PFLV: 114557902(creb5) 114567851
GAT: 120810763(creb5b) 120826619
PPUG: 119197752(creb5b) 119219312(creb5a)
AFB: 129097363(creb5a) 129109999(creb5b)
CLUM: 117739531 117745026(creb5b)
PSWI: 130193445 130212670(creb5b)
MSAM: 119897742(creb5b) 119907284
SCHU: 122864073 122881377(creb5b)
CUD: 121513984(creb5b) 121523912
ALAT: 119005491(creb5b) 119015778
MZE: 101464485 101486831(creb5)
ONL: 100690870(creb5) 100707290
OAU: 116325419(creb5b) 120435909
OLA: 101157318(creb5) 101173798
OML: 112143939(creb5b) 112159861(creb5a)
CSAI: 133429815(creb5b) 133461637
XMA: 102224332(creb5) 102237102
XCO: 114141104(creb5) 114155699
XHE: 116717012(creb5) 116730719
PRET: 103472184 103478569(creb5)
PFOR: 103145256 103150383(creb5)
PLAI: 106945357(creb5) 106950183
PMEI: 106915394 106922198(creb5)
GAF: 122831432(creb5b) 122843739
PPRL: 129371374(creb5b) 129378597
CVG: 107082305(creb5) 107084368
CTUL: 119772846(creb5b) 119779523(creb5a)
GMU: 124866297(creb5b) 124879441(creb5a)
NFU: 107383381 107395571(creb5)
KMR: 108238370 108241930(creb5b)
ALIM: 106517749 106519496 106537063
NWH: 119410110(creb5b) 119426107
AOCE: 111570283 111588838(creb5)
MCEP: 125016879(creb5b) 125020079(creb5a)
CSEM: 103388419(creb5) 103394221
POV: 109631674 109633022 109645670 109647248
SSEN: 122774857(creb5b) 122786585
HHIP: 117770680 117776347(creb5b)
HSP: 118114366(creb5b) 118124791
PPLT: 128449346(creb5b) 128462163(creb5a)
SMAU: 118291868(creb5a) 118302629(creb5b)
LCF: 108877062(creb5a) 108891362(creb5b)
SDU: 111223427 111238792(creb5)
SLAL: 111652760(creb5) 111673321
XGL: 120783634(creb5b) 120785962(creb5a)
HCQ: 109512009 109525639(creb5)
SSCV: 125975544 125986734
SBIA: 133497946 133501503(creb5b)
PEE: 133395653 133401690(creb5b)
PTAO: 133471154 133479459(creb5b)
BPEC: 110171756(creb5)
MALB: 109967324(creb5) 109968120
BSPL: 114843559(creb5b) 114865771(creb5a)
SJO: 128366578(creb5b) 128373933
SASA: 106570526 106573409 106588860
STRU: 115173958 115175467 115187728(creb5)
OTW: 112225187(creb5b) 112234312 112264407
OMY: 110487967 110496864 110514129(creb5b)
OGO: 124019491(creb5b) 124042704
ONE: 115125066 115128658(creb5)
OKI: 109876563 109903342 109907255 116359319(creb5)
OKE: 118397944 118398990 127918933
SALP: 111954764 111955868(creb5)
SNH: 120022583 120027424 120038026 120040297(creb5b)
CCLU: 121558335 121572047 121585851 121586690
ELS: 105018814(creb5) 105023646
SFM: 108927363 108933413
PKI: 111839001 111846972
AANG: 118214961(creb5b) 118232775
LOC: 102686564(creb5)
PSPA: 121313641 121315117(creb5b)
ARUT: 117400636 117435811
PSEX: 120515627(creb5b)
LCM: 102347706(CREB5)
CMK: 103183158(creb5b)
CPLA: 122549682(creb5b)
HOC: 132815976(creb5b)
LERI: 129711928(creb5b)
PMRN: 116948658
LRJ: 133349706
SCLV: 120342157
DFR: 124493657
 » show all
Reference
PMID:8440710
  Authors
Nomura N, Zu YL, Maekawa T, Tabata S, Akiyama T, Ishii S
  Title
Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1.
  Journal
J Biol Chem 268:4259-66 (1993)
  Sequence
[hsa:9586]
Reference
PMID:25076032
  Authors
Qi L, Ding Y
  Title
Involvement of the CREB5 regulatory network in colorectal cancer metastasis.
  Journal
Yi Chuan 36:679-84 (2014)
DOI:10.3724/SP.J.1005.2014.0679
  Sequence
[hsa:9586]
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