KEGG ORTHOLOGY: K09188

ORTHOLOGY: K09188

Entry

K09188                      KO

Symbol

MLL3

Name

[histone H3]-lysine4 N-trimethyltransferase MLL3 [EC:2.1.1.354]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

Reaction

R03875

R04866

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

R04867

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Disease

H00907

Kleefstra syndrome

H02434

Diffuse large B-cell lymphoma, not otherwise specified

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K09188  MLL3; [histone H3]-lysine4 N-trimethyltransferase MLL3
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K09188  MLL3; [histone H3]-lysine4 N-trimethyltransferase MLL3
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.354  [histone H3]-lysine4 N-trimethyltransferase
     K09188  MLL3; [histone H3]-lysine4 N-trimethyltransferase MLL3
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K09188  MLL3; [histone H3]-lysine4 N-trimethyltransferase MLL3
   HMT complexes
    MLL3/MLL4 complex
     K09188  MLL3; [histone H3]-lysine4 N-trimethyltransferase MLL3

Other DBs

GO:

0042800

Genes

HSA:	58508(KMT2C)

PTR:	463875(KMT2C)

PPS:	100992231(KMT2C)

GGO:	101134599(KMT2C)

PON:	100450852(KMT2C)

NLE:	100607151(KMT2C)

HMH:	116814558(KMT2C)

MCC:	716753(KMT2C)

MCF:	102128002(KMT2C)

MTHB:

126951568

MNI:	105474928(KMT2C)

CSAB:

103227268(KMT2C)

CATY:

105584763(KMT2C)

PANU:

101009836(KMT2C)

TGE:	112620339(KMT2C)

MLEU:

105542682(KMT2C)

RRO:	104678716(KMT2C)

RBB:	108523124(KMT2C)

TFN:	117072766(KMT2C)

PTEH:

111551529(KMT2C)

CANG:

105511352(KMT2C)

CJC:	100401397(KMT2C)

SBQ:	101043552(KMT2C)

CIMI:

108297195(KMT2C)

CSYR:

103256120(KMT2C)

MMUR:

105883198(KMT2C)

LCAT:

123647436(KMT2C)

PCOQ:

105824618(KMT2C)

OGA:	100940723(KMT2C)

MMU:	231051(Kmt2c)

MCAL:

110295273(Kmt2c)

MPAH:

110316198(Kmt2c)

RNO:	502710(Kmt2c)

MCOC:

116097574(Kmt2c)

ANU:	117720401(Kmt2c)

MUN:	110564205(Kmt2c)

CGE:	100767367(Kmt2c)

MAUA:

101836405(Kmt2c)

PROB:

127235790(Kmt2c)

PLEU:

114700061(Kmt2c)

MORG:

121439912(Kmt2c)

MFOT:

126489435

AAMP:

119808500(Kmt2c)

NGI:	103745326(Kmt2c)

HGL:	101698170(Kmt2c)

CPOC:

100715884(Kmt2c)

CCAN:

109685268(Kmt2c)

DORD:

105993844(Kmt2c)

DSP:	122105863(Kmt2c)

PLOP:

125347338(Kmt2c)

NCAR:

124990225

MMMA:

107148917(Kmt2c)

OCU:

100353688

OPI:	101518895(KMT2C)

TUP:	102479012(KMT2C)

GVR:	103599133(KMT2C)

CFA:	611094(KMT2C)

CLUD:

112663328(KMT2C)

VVP:	112916198(KMT2C)

VLG:	121489565(KMT2C)

NPO:	129515919(KMT2C)

AML:	100465228(KMT2C)

UMR:	103660985(KMT2C)

UAH:	113241427(KMT2C)

UAR:	123788754(KMT2C)

ELK:

111154508

LLV:

125081365

MPUF:

101678014(KMT2C)

MNP:	132015545(KMT2C)

MLK:	131829967(KMT2C)

NVS:	122905221(KMT2C)

ORO:	101365628(KMT2C)

EJU:	114197990(KMT2C)

ZCA:	113911401(KMT2C)

MLX:	118026826(KMT2C)

NSU:	110582776(KMT2C)

LWW:	102733195(KMT2C)

FCA:	101084095(KMT2C)

PYU:	121022936(KMT2C)

PCOO:

112866516(KMT2C)

PBG:	122488553(KMT2C)

PVIV:

125160093(KMT2C)

LRUF:

124524239

PTG:	102964154(KMT2C)

PPAD:

109252401(KMT2C)

PUC:

125930941

AJU:

106984461

HHV:	120230926(KMT2C)

BTA:	789336(KMT2C)

BOM:	102267186(KMT2C)

BIU:	109558041(KMT2C)

BBUB:

102396938(KMT2C)

BBIS:

105001180(KMT2C)

CHX:	102181925(KMT2C)

OAS:	101115617(KMT2C)

BTAX:

128046722(KMT2C)

ODA:	120877744(KMT2C)

CCAD:

122438891(KMT2C)

MBEZ:

129552800(KMT2C)

SSC:	100514805(KMT2C)

CFR:	102507730(KMT2C)

CBAI:

105067032(KMT2C)

CDK:	105098689(KMT2C)

VPC:	102534434(KMT2C)

BACU:

103004433(KMT2C)

BMUS:

118900623(KMT2C)

LVE:	103078348(KMT2C)

OOR:	101288516(KMT2C)

DLE:	111176572(KMT2C)

PCAD:

102988929(KMT2C)

PSIU:

116759441(KMT2C)

NASI:

112395773(KMT2C)

ECB:	100064812(KMT2C)

EPZ:	103553137(KMT2C)

EAI:	106823334(KMT2C)

MYB:	102246704(KMT2C)

MYD:	102759674(KMT2C)

MMYO:

118679443(KMT2C)

MLF:	102425917(KMT2C)

PKL:	118704757(KMT2C)

EFUS:

103301773(KMT2C)

MNA:	107524895(KMT2C)

DRO:	112308262(KMT2C)

SHON:

118975535(KMT2C)

AJM:	119039227(KMT2C)

PDIC:

114507487(KMT2C)

PHAS:

123817942(KMT2C)

MMF:	118619604(KMT2C)

PPAM:

129086736(KMT2C)

HAI:	109389650(KMT2C)

RFQ:	117018143(KMT2C)

PALE:

102897550(KMT2C)

PGIG:

120601517(KMT2C)

PVP:	105303780(KMT2C)

RAY:	107520298(KMT2C)

MJV:	108397889(KMT2C)

TOD:	119249083(KMT2C)

SARA:

101549683(KMT2C)

SETR:

126026291(KMT2C)

LAV:	100673765(KMT2C)

TMU:

101349940

ETF:	101664543(KMT2C)

DNM:	101426108(KMT2C)

MDO:	100019161(KMT2C)

GAS:	123249858(KMT2C)

SHR:	100920575(KMT2C)

AFZ:

127564250

PCW:	110223876(KMT2C)

OAA:	100074286(KMT2C)

GGA:	420437(KMT2C)

PCOC:

116238267(KMT2C)

MGP:	100545169(KMT2C)

CJO:	107308762(KMT2C)

TPAI:

128085371(KMT2C)

LMUT:

125696177(KMT2C)

NMEL:

110393789(KMT2C)

APLA:

101796266(KMT2C)

ACYG:

106046952(KMT2C)

CATA:

118251781(KMT2C)

AFUL:

116485841(KMT2C)

TGU:	100227193(KMT2C)

LSR:	110484559(KMT2C)

SCAN:

103813061(KMT2C)

PMOA:

120499797(KMT2C)

OTC:	121337901(KMT2C)

PRUF:

121363768(KMT2C)

GFR:	102031396(KMT2C)

FAB:	101806346(KMT2C)

OMA:	130250007(KMT2C)

PHI:	102099277(KMT2C)

PMAJ:

107216349(KMT2C)

CCAE:

111925501(KMT2C)

CCW:	104686428(KMT2C)

CBRC:

103623953(KMT2C)

ETL:	114062389(KMT2C)

ZAB:	102063460(KMT2C)

ZLE:	135443569(KMT2C)

ACHL:

103801933(KMT2C)

SVG:	106851591(KMT2C)

MMEA:

130573147(KMT2C)

HRT:	120762620(KMT2C)

FPG:	101917176(KMT2C)

FCH:	102047191(KMT2C)

CLV:	102097963(KMT2C)

EGZ:	104130998(KMT2C)

NNI:	104014894(KMT2C)

PCRI:

104027327(KMT2C)

PLET:

104618442(KMT2C)

EHS:	104516448(KMT2C)

PCAO:

104052968

ACUN:

113477175(KMT2C)

TALA:

104366519(KMT2C)

PADL:

103915639(KMT2C)

AFOR:

103905987(KMT2C)

ACHC:

115338945(KMT2C)

HALD:

104310581(KMT2C)

HLE:	104843220(KMT2C)

AGEN:

126038035

GCL:

127012902

CCRI:

104166867

CSTI:

104559749(KMT2C)

CMAC:

104483667

MUI:

104543461

BREG:

104636206(KMT2C)

FGA:

104084400

GSTE:

104263057(KMT2C)

LDI:	104347215(KMT2C)

MNB:	103777989(KMT2C)

OHA:	104337194(KMT2C)

NNT:

104412482

SHAB:

115604961(KMT2C)

DPUB:

104297846(KMT2C)

PGUU:

104461173(KMT2C)

ACAR:

104524952

CPEA:

104396186(KMT2C)

AVIT:

104281017

CVF:	104288042(KMT2C)

RTD:	128906189(KMT2C)

CUCA:

104057025(KMT2C)

TEO:	104383327(KMT2C)

BRHI:

104489768(KMT2C)

AAM:	106485306(KMT2C)

AROW:

112978282(KMT2C)

NPD:	112958121(KMT2C)

TGT:

104569024

DNE:	112981377(KMT2C)

SCAM:

104148877(KMT2C)

ASN:	102379342(KMT2C)

AMJ:	102567474(KMT2C)

CPOO:

109306813(KMT2C)

GGN:	109291225(KMT2C)

PSS:	102459016(KMT2C)

CMY:	102948345(KMT2C)

CCAY:

125631222(KMT2C)

DCC:	119850915(KMT2C)

CPIC:

101953918(KMT2C)

TST:	117872024(KMT2C)

CABI:

116817570(KMT2C)

MRV:	120399324(KMT2C)

ACS:	100556055(kmt2c)

ASAO:

132778987(KMT2C)

PVT:	110071916(KMT2C)

SUND:

121934860(KMT2C)

PBI:

103049419

PMUR:

107303312(KMT2C)

CTIG:

120310214(KMT2C)

TSR:	106556966(KMT2C)

PGUT:

117654789(KMT2C)

APRI:

131198738(KMT2C)

PTEX:

113448992(KMT2C)

NSS:	113419523(KMT2C)

VKO:	123020648(KMT2C)

PMUA:

114607001(KMT2C)

PRAF:

128424424(KMT2C)

ZVI:	118091856(KMT2C)

HCG:	128329288(KMT2C)

GJA:	107123162(KMT2C)

STOW:

125440642(KMT2C)

EMC:	129337741(KMT2C)

XLA:	108718730(kmt2c.L) 108719820(kmt2c.S)

XTR:	100486829(kmt2c)

NPR:	108784343(KMT2C)

RTEM:

120940104(KMT2C)

BBUF:

121002685(KMT2C)

BGAR:

122937808(KMT2C)

MUO:	115466811(KMT2C)

GSH:	117354332(KMT2C)

DRE:	560793(kmt2ca) 568162(kmt2cb)

SRX:	107709778 107711680 107727489 107755698

SANH:

107655805 107664649 107671648 107693534

SGH:	107550009 107557235 107559353 107593836

CCAR:

109050388 109050390 109110986

CAUA:

113038829 113042173(kmt2c) 113046088 113066129

CGIB:

127946125 127950906 128013513 128025086

PTET:

122326787(kmt2cb) 122329988(kmt2ca)

LROH:

127155696(kmt2ca) 127182659(kmt2cb)

OMC:	131530621(kmt2cb) 131533335(kmt2ca)

PPRM:

120475849(kmt2ca) 120482955(kmt2cb)

RKG:	130084410(kmt2ca) 130096489(kmt2cb)

MAMB:

125252002(kmt2cb) 125257560(kmt2ca)

CIDE:

127505482 127506478

MASI:

127431841 127434229 127441623 127442645

TROS:

130551101(kmt2ca) 130553892(kmt2cb)

TDW:	130413552(kmt2ca) 130418290(kmt2cb)

MANU:

129425713(kmt2ca) 129442742(kmt2cb)

IPU:	108267465(kmt2cb) 108272993(kmt2ca)

IFU:	128607693(kmt2ca) 128609781(kmt2cb)

PHYP:

113540030 113545405(kmt2c)

SMEO:

124383970(kmt2ca) 124387745(kmt2cb)

TFD:	113640089(kmt2cb) 113656630(kmt2ca)

TVC:	132845514(kmt2ca) 132848202(kmt2cb)

TRN:	134309797(kmt2ca) 134312085(kmt2cb)

AMEX:

103033881 103041268

CMAO:

118815568(kmt2ca) 118826193(kmt2cb)

EEE:	113570107 113589795

CHAR:

105889223(kmt2ca) 105891315(kmt2cb)

TRU:	101071853 101075083 105419488

TFS:	130513811 130539415(kmt2cb)

TNG:	GSTEN00025312G001 GSTEN00028349G001

LCO:	104918307 104938105

NCC:	104957667(kmt2c)

TBEN:

117488269(kmt2cb)

CGOB:

115021962(kmt2c)

PGEO:

117462421(kmt2cb)

GACU:

117558315(kmt2cb)

EMAC:

134865840(kmt2cb) 134883941

ELY:	117263913(kmt2cb) 117264300

EFO:	125881947 125901664(kmt2cb)

PLEP:

121951133(kmt2cb)

SLUC:

116046070(kmt2cb) 116057843(kmt2ca) 118494350

ECRA:

117954862(kmt2cb)

ESP:	116699448(kmt2c)

PFLV:

114548971 114565863

GAT:	120812052 120815682(kmt2cb)

PPUG:

119198388 119209337(kmt2cb)

AFB:	129089370(kmt2cb) 129111059

CLUM:

117746087(kmt2cb) 117749363

PSWI:

130197523(kmt2cb)

MSAM:

119897280 119902079(kmt2cb)

SCHU:

122866515(kmt2ca) 122887055(kmt2cb)

CUD:	121520025(kmt2cb) 121527127

ALAT:

119008407(kmt2ca) 119011051(kmt2cb)

MZE:	101465418 101481911

ONL:	100692488 100710717

OAU:	116316974 116336523(kmt2ca)

OLA:	101162786 101171448

OML:	112147812(kmt2cb) 112151375

CSAI:

133423495 133452734(kmt2cb)

XMA:	102216709 102222583(kmt2c)

XCO:	114136765 114145996(kmt2c)

XHE:	116711590 116721167

PRET:

103460165(kmt2c) 103479582

PFOR:

103143029 103156870(kmt2c)

PLAI:

106937609(kmt2c) 106949143

PMEI:

106919800(kmt2c) 106934157

GAF:	122823930(kmt2ca) 122841199(kmt2cb)

PPRL:

129356909 129361937(kmt2cb)

CVG:	107083362(kmt2c) 107101949

CTUL:

119782752 119795676(kmt2cb)

GMU:	124858406(kmt2ca) 124869701(kmt2cb)

NFU:	107374212 107383945(kmt2c)

KMR:	108239632(kmt2cb) 108251294

ALIM:

106534057(kmt2c) 106534301 106535402

NWH:	119415074(kmt2cb) 119426464

AOCE:

111563576 111570146(kmt2c)

MCEP:

124995447 125010715(kmt2cb)

CSEM:

103377343(kmt2c) 103396169

POV:	109639815(kmt2c) 109644301

SSEN:

122758698 122778117

HHIP:

117753901 117777677(kmt2cb)

HSP:	118098932 118118312(kmt2cb)

PPLT:

128425543 128454886(kmt2cb)

SMAU:

118291461 118310357(kmt2cb)

LCF:	108883444(kmt2cb) 108890120

SDU:	111236883 111238975

SLAL:

111651182 111670500(kmt2c)

XGL:	120789866 120799116(kmt2cb)

HCQ:	109521240 109526300

SSCV:

125984481 125985779

SBIA:

133492394 133510581(kmt2cb)

PEE:	133396356 133412044(kmt2cb)

PTAO:

133470583 133488838(kmt2cb)

BPEC:

110159445 110166930

MALB:

109957735 109974986(kmt2c)

BSPL:

114844982(kmt2cb) 114853983

SJO:	128369146(kmt2cb)

SASA:

106569192 106579599 106590429 106599252

STRU:

115150500 115157103 115169671 115195273

OTW:	112226861 112232703 112233554 112260547

OMY:	110490933 110508653 110530401 110535292

OGO:	123990418(kmt2ca) 124010018 124040486 124041794

ONE:	115103015 115104488 115114491 115130171

OKI:	109871531 109875158 109899297 109909640

OKE:	118361750(kmt2ca) 118370518 118395216 118402033

SALP:

111953862 111956861 111957019 111973505 111979462

SNH:	120019822 120027884(kmt2ca) 120050620 120055304

CCLU:

121535290 121549477 121568683 121581316

ELS:	105019052 105019546

SFM:	108931734(kmt2c) 108937588

PKI:	111845839 111851671(kmt2c)

AANG:

118226485(kmt2ca) 118234703

LOC:	102682648(kmt2c)

PSPA:

121310091 121314053

ARUT:

117394699 117400327 117966669

PSEX:

120529948(kmt2ca)

LCM:	102347272(KMT2C)

CMK:

103189435

CPLA:

122550327(kmt2ca)

HOC:	132815844(kmt2ca)

LERI:

129714455(kmt2ca)

BFO:	118403620 118403621

BBEL:

CIN:

SCLV:

SPU:

APLC:

SKO:

DME:	Dmel_CG3848(trr)

DER:

6555719

DSE:

6616046

DSI:	Dsimw501_GD16408(Dsim_GD16408)

DYA:	Dyak_GE16999

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI21761

DAZ:

DNV:

DHE:

BDR:

AOQ:

TDA:	119678846 119679409

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ACOZ:

AARA:

AMER:

ASTE:

AAG:

AALB:

CQU:	CpipJ_CPIJ011192 CpipJ_CPIJ011193

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:	105148205 105148261

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CCIN:

TCA:

DPA:

SOY:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_208927

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

PXY:

LGLY:

API:	100159693 100571907

DNX:	107162062 107162063

AGS:

RMD:

BTAB:

CLEC:

HHAL:

PHU:	Phum_PHUM411800

FOC:

113206615

TPAL:

117649666

ZNE:	110838850 110838870

CSEC:

111873928

FCD:

110850681

DPX:	DAPPUDRAFT_51465

DMK:

PVM:

PJA:

PCHN:

HAME:

PCLA:

PTRU:

LSM:

PPOI:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

PTEP:

CEL:	CELE_T12D8.1(set-16)

CBR:	CBG_18244(Cbr-set-16)

CRQ:	GCK72_010339

NAI:	NECAME_02467

LOA:	LOAG_17819

LGI:	LOTGIDRAFT_215812

PCAN:

112558293 112558303

BGT:	106050290 106050292

GAE:

HRF:

HRJ:

MYI:

PMAX:

OBI:

OSN:

LAK:	106170103 106176161

SMM:	Smp_070170 Smp_138030

SHX:	MS3_00007489(KMT2D)

OVI:	T265_12021 T265_12618 T265_13605

EGL:	EGR_00975 EGR_08154

NVE:

EPA:

ATEN:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

CME:	CYME_CMD005C

GSL:	Gasu_28030

CCP:	CHC_T00005548001

SRE:	PTSG_07559

DFA:

DFA_05766

» show all

Reference

PMID:11891048

Authors

Ruault M, Brun ME, Ventura M, Roizes G, De Sario A

Title

MLL3, a new human member of the TRX/MLL gene family, maps to 7q36, a chromosome region frequently deleted in myeloid leukaemia.

Journal

Gene 284:73-81 (2002)
DOI:10.1016/S0378-1119(02)00392-X

Sequence

[hsa:58508]

Reference

PMID:20236313

Authors

Ansari KI, Mandal SS

Title

Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing.

Journal

FEBS J 277:1790-804 (2010)
DOI:10.1111/j.1742-4658.2010.07606.x

Reference

PMID:17500065

Authors

Cho YW, Hong T, Hong S, Guo H, Yu H, Kim D, Guszczynski T, Dressler GR, Copeland TD, Kalkum M, Ge K

Title

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.

Journal

J Biol Chem 282:20395-406 (2007)
DOI:10.1074/jbc.M701574200

Sequence

[hsa:58508]

LinkDB

DBGET integrated database retrieval system