KEGG   ORTHOLOGY: K10187
Entry
K10187                      KO                                     
Symbol
cyc2
Name
germacradienol/geosmin synthase [EC:4.2.3.22 4.2.3.75 4.1.99.16]
Pathway
map00909  Sesquiterpenoid and triterpenoid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R07647  2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol-forming]
R07648  2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(-)-germacrene D-forming]
R08543  (2E,6E)-farnesyl-diphosphate diphosphate-lyase (adding water;acetone-geosmin-forming)
R09487  germacradienol geosmin-lyase (acetone forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00909 Sesquiterpenoid and triterpenoid biosynthesis
    K10187  cyc2; germacradienol/geosmin synthase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.99  Other carbon-carbon lyases
    4.1.99.16  geosmin synthase
     K10187  cyc2; germacradienol/geosmin synthase
  4.2  Carbon-oxygen lyases
   4.2.3  Acting on phosphates
    4.2.3.22  germacradienol synthase
     K10187  cyc2; germacradienol/geosmin synthase
    4.2.3.75  (-)-germacrene D synthase
     K10187  cyc2; germacradienol/geosmin synthase
Other DBs
GO: 0034004 0052577
Genes
MXA: MXAN_6247
MSD: MYSTI_06763
MYM: A176_000650
MYX: QEG98_34370
CCX: COCOR_07379(cyc2)
MFU: LILAB_15255
MMAS: MYMAC_005982
SUR: STAUR_1114(geoA2)
AGE: AA314_02305 AA314_08732
AVM: JQX13_43635
MBD: MEBOL_001975
CFUS: CYFUS_002616
SCL: sce1440
SCU: SCE1572_16350
CCRO: CMC5_068260
MRM: A7982_08001
HOH: Hoch_1257
NANN: O0S08_24410 O0S08_35550
NBR: O3I_014240
NOZ: DMB37_34650
NAH: F5544_16725
NTC: KHQ06_14685
NHU: H0264_13605
NYA: LTV02_19175
SPIN: KV203_07525
SCO: SCO6073(SC9B1.20)
SALB: XNR_1297
SMA: SAVERM_2163(geoA)
SGR: SGR_6839(geoA)
SGB: WQO_01005
SFI: SFUL_319
SANL: KZO11_00565
SGRF: SGFS_033720
SCYE: R2B67_35190
SCB: SCAB_20121(geoA)
SSX: SACTE_0245
SVL: Strvi_9069
SHY: SHJG_7148
SHO: SHJGH_6908
SRC: M271_26075
SMAL: SMALA_3748
SSOI: I1A49_22455
SFA: Sfla_6028
SBH: SBI_02068
SVE: SVEN_0269 SVEN_0552
SDV: BN159_2274(cyc2)
SALS: SLNWT_0774
STRP: F750_0540
SCI: B446_28510
SLV: SLIV_07775(cyc2)
SGU: SGLAU_26100
SVT: SVTN_02895
STRE: GZL_04447
SCW: TU94_25990
SLD: T261_3872
SLC: SL103_34365
SXI: SXIM_51240
STRM: M444_26920
STRC: AA958_01915
SAMB: SAM23877_5788(cyc)
SPRI: SPRI_6965
SCZ: ABE83_34050
SCX: AS200_11935
SRW: TUE45_06695(cyc2)
STRF: ASR50_27725
SLE: sle_16070(sle_16070)
SRN: A4G23_00120(cyc2)
SPAV: Spa2297_25605
STRT: A8713_25265
SCLF: BB341_26965
SGS: AVL59_11955
STSI: A4E84_31220
SKY: D0C37_08035
SALW: CP975_28380 CP975_33095
SGM: GCM10017557_17550(cyc2)
SCAD: DN051_10555
SPHW: NFX46_09915
SLS: SLINC_6548
SNR: SNOUR_19870
SALU: DC74_4443
SALL: SAZ_23610
SPLU: LK06_026700
STRD: NI25_09000
SNW: BBN63_17575
SAUO: BV401_22145
SSIA: A7J05_08620
SVU: B1H20_00605
SPUN: BFF78_10710
SGV: B1H19_22450
SLAU: SLA_0172
SALF: SMD44_07198(cyc2)
SALJ: SMD11_6421(cyc2)
SLX: SLAV_09415(cyc1)
STRO: STRMOE7_21145
SFK: KY5_6300
SNZ: DC008_27320
SGE: DWG14_02009(cyc2)
SRJ: SRO_1735
SLK: SLUN_03000
SDX: C4B68_09160
SGD: ELQ87_08740
SQZ: FQU76_00840
SCYA: EJ357_36215
SAST: CD934_06110
SNQ: CP978_26325
STIR: DDW44_29705
SKA: CP970_09515
SGZ: C0216_09490
SVN: CP980_07125
SNK: CP967_32685
SHAW: CEB94_31845
SRK: FGW37_30680
SFIC: EIZ62_31190
SGAL: CP966_28425
SSPO: DDQ41_30295
SVR: CP971_17330
SPAD: DVK44_16910
SAQU: EJC51_36445
SGF: HEP81_01918
SCAV: CVT27_00465
SSEO: D0Z67_23170
SBY: H7H31_13965
SRIM: CP984_29865
SSUB: CP968_07850
SPHV: F9278_38075
SCIN: CP977_03065
SFUG: CNQ36_25980
SPAC: B1H29_08340
STSU: B7R87_32680
SCHA: CP983_09805
SGX: H4W23_03680
SCOE: CP976_33675
SBAT: G4Z16_14665
SSPB: CP982_33700
SNF: JYK04_06546(cyc2)
SPLA: CP981_20875
SBRO: GQF42_32880
STUI: GCM10017668_55740(cyc2)
SATA: C5746_02905
SCHF: IPT68_28555
SHUN: DWB77_03759(cyc2)
SHAR: HUT13_25895
SCYG: S1361_30400(cyc2)
SFEU: IM697_32630
SLIA: HA039_17755
SDW: K7C20_20210
SVD: CP969_29395
SCAL: I6J39_00730
SAUH: SU9_018255
SFB: CP974_00685
SPRA: CP972_28320
SPEU: CGZ69_02405
SROI: IAG44_08725
SGJ: IAG43_02220
SHK: J2N69_29585
SANU: K7396_16690
STRY: EQG64_00720
SDD: D9753_07640
SACT: DMT42_29860
SMAO: CAG99_12820
SGOB: test1122_08905 test1122_25330
SINE: KI385_24560
SLF: JEQ17_12070
SDEC: L3078_35570
SAOV: G3H79_05130
SDUR: M4V62_08365
SYAN: NRK68_27210
SRUG: F0345_21565
SAKB: K1J60_10395
STAA: LDH80_05320
SNIG: HEK616_67550(cyc2)
SVIO: HWN34_07160
SCAE: IHE65_09900
STUB: MMF93_09085
SSPN: LXH13_30640
SCIR: STRCI_006311
SXT: KPP03845_105794(cyc2_1)
SLON: LGI35_33135
SDRZ: NEH16_29520
STUD: STRTU_003254
STEE: F3L20_12610
SGK: PET44_25485
SANT: QR300_22810
SYUN: MOV08_19910
SARG: HKX69_07350
SJN: RI060_08975
SCYN: N8I84_30570
SOV: QZH56_33735
SFIY: F0344_33695
SHAU: K9S39_12905
SKG: KJK29_07040
SCOA: QU709_08660
SLAI: P8A22_36895
SFP: QUY26_06250
SCHG: NRO40_01380
STTN: BSL84_26640
SINN: ABB07_08020
STRZ: OYE22_13780
SCAY: PYS65_07625
SCT: SCAT_2953(cyc)
SCY: SCATT_29440
KSK: KSE_46080(geoA)
KAB: B7C62_00490
KAU: B6264_12330
KIT: CFP65_0675 CFP65_6829
KIS: HUT16_21240
STRI: C7M71_007765
YIA: LO772_26615
STRH: GXP74_15410
AGLA: OIE69_19960
KFL: Kfla_4247
NGV: CDO52_17055
STRR: EKD16_02015(cyc2)
ACTW: F7P10_28090
AGRA: AGRA3207_002480
AMAZ: LUW76_35960
ACIR: OG979_26335
SPIQ: OHA34_15550 OHA34_15730
ACTQ: OG417_01085
SRO: Sros_0075
NOA: BKM31_47430
NOW: GBF35_49900
NCX: Nocox_40695(cyc2)
NGN: LCN96_09125 LCN96_54695
NFS: OIE67_45720
MHAI: OHB01_00735
FRA: Francci3_4231
FAL: FRAAL6507
FRE: Franean1_5559
FRI: FraEuI1c_3502
SEN: SACE_3187 SACE_3977 SACE_4907
SACG: FDZ84_36100
AMD: AMED_1325
AMN: RAM_06720
AMM: AMES_1317
AMZ: B737_1318
AOI: AORI_7417
AJA: AJAP_38785
AMYC: CU254_05185
AMYB: BKN51_30485
AAB: A4R43_38405
AMYY: YIM_39645(cyc2)
AORI: SD37_03385
AACD: LWP59_11790
APRT: MUY14_30005
AROO: NQK81_28485
ATHM: L1857_15985
ARHD: VSH64_44360
AMOG: QRX60_04510
APRE: CNX65_04920
AMI: Amir_0977
SESP: BN6_11180(geoA)
SSYI: EKG83_05700
KAL: KALB_676 KALB_677
KUT: JJ691_71460
KBU: Q4V64_40395
KPHY: AOZ06_40930
LED: BBK82_06540
ALO: CRK56063
PMAD: BAY61_21455
ACTU: Actkin_00570(cyc2)
CROS: N8J89_23320
PSUU: Psuf_085020(cyc2)
CATI: CS0771_03970(cyc2)
DVC: Dvina_35855
DMAT: Dmats_30680
CAI: Caci_6200
SNA: Snas_1127
GLY: K3N28_04695
AEY: CDG81_12895
NPU: Npun_R2756
NED: HUN01_24355
CSG: Cylst_4391
CALO: Cal7507_2995
DHT: NG743_19380
ALAX: NIES50_53430
SCYT: SAMD_63780
KBS: EPA93_38090
 » show all
Reference
PMID:12563033
  Authors
Gust B, Challis GL, Fowler K, Kieser T, Chater KF
  Title
PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin.
  Journal
Proc Natl Acad Sci U S A 100:1541-6 (2003)
DOI:10.1073/pnas.0337542100
  Sequence
[sco:SCO6073]
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