KEGG   ORTHOLOGY: K10214
Entry
K10214                      KO                                     
Symbol
ACOX2
Name
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase [EC:1.17.99.3]
Pathway
map00120  Primary bile acid biosynthesis
map01100  Metabolic pathways
map03320  PPAR signaling pathway
map04146  Peroxisome
Module
M00104  Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate
M00862  beta-Oxidation, peroxisome, tri/dihydroxycholestanoyl-CoA => choloyl/chenodeoxycholoyl-CoA
Reaction
R08735  (25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA:acceptor 24,25-oxidoreductase
R08740  (25S)-3alpha,7alpha-dihydroxy-5beta-cholestanoyl-CoA:acceptor 24,25-oxidoreductase
Disease
H00628  Congenital bile acid synthesis defect
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00120 Primary bile acid biosynthesis
    K10214  ACOX2; 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase
 09140 Cellular Processes
  09141 Transport and catabolism
   04146 Peroxisome
    K10214  ACOX2; 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase
 09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    K10214  ACOX2; 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.17  Acting on CH or CH2 groups
   1.17.99  With unknown physiological acceptors
    1.17.99.3  3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase
     K10214  ACOX2; 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase
Other DBs
GO: 0033791
Genes
HSA: 8309(ACOX2)
PTR: 460479(ACOX2)
PPS: 100987633(ACOX2)
GGO: 101135855(ACOX2)
PON: 100173031(ACOX2)
NLE: 100579193(ACOX2)
HMH: 116469171(ACOX2)
MCC: 701565(ACOX2)
MCF: 102142571(ACOX2)
MTHB: 126948824
MNI: 105482947(ACOX2)
CSAB: 103227815(ACOX2)
CATY: 105585630(ACOX2)
PANU: 101010658(ACOX2)
TGE: 112618624(ACOX2)
MLEU: 105552659(ACOX2)
RRO: 104660198(ACOX2)
RBB: 108543617(ACOX2)
TFN: 117083061(ACOX2)
PTEH: 111532709(ACOX2)
CANG: 105515406(ACOX2)
CJC: 100404475(ACOX2)
SBQ: 101051802(ACOX2)
CIMI: 108303497(ACOX2)
CSYR: 103260875(ACOX2)
MMUR: 105884922(ACOX2)
LCAT: 123623526(ACOX2)
PCOQ: 105805735(ACOX2)
OGA: 100958565(ACOX2)
MMU: 93732(Acox2)
MCAL: 110309300(Acox2)
MPAH: 110325739(Acox2)
RNO: 252898(Acox2)
MCOC: 116073384(Acox2)
ANU: 117706119(Acox2)
MUN: 110554615(Acox2)
CGE: 100766043(Acox2)
MAUA: 101831411(Acox2)
PROB: 127238208(Acox2)
PLEU: 114680724(Acox2)
MORG: 121455134(Acox2)
MFOT: 126513015
AAMP: 119827884(Acox2)
NGI: 103740540(Acox2)
HGL: 101716015(Acox2)
CPOC: 100730978(Acox2)
CCAN: 109697261(Acox2)
DORD: 105981391(Acox2)
DSP: 122107967(Acox2)
PLOP: 125358690(Acox2)
NCAR: 124969525
MMMA: 107149659(Acox2)
OCU: 100009549(ACOX2)
OPI: 101527454(ACOX2)
TUP: 102491187(ACOX2)
GVR: 103593550(ACOX2)
CFA: 100855488(ACOX2)
CLUD: 112665973(ACOX2)
VVP: 112909557(ACOX2)
VLG: 121495008(ACOX2)
NPO: 129521839(ACOX2)
AML: 100483316(ACOX2)
UMR: 103674276(ACOX2)
UAH: 113257024(ACOX2)
UAR: 123798800(ACOX2)
ELK: 111144181
LLV: 125078328
MPUF: 101687162(ACOX2)
MNP: 132011451(ACOX2)
MLK: 131824071(ACOX2)
NVS: 122909308(ACOX2)
ORO: 101386426(ACOX2)
EJU: 114214660(ACOX2)
ZCA: 113916645(ACOX2)
MLX: 118005730(ACOX2)
NSU: 110584818(ACOX2)
LWW: 102749711(ACOX2)
FCA: 101101039(ACOX2)
PYU: 121016789(ACOX2)
PCOO: 112852623(ACOX2)
PBG: 122487375(ACOX2)
PVIV: 125158271(ACOX2)
LRUF: 124524999
PTG: 102972085(ACOX2)
PPAD: 109279078(ACOX2)
PUC: 125929528
AJU: 106968832
HHV: 120238645(ACOX2)
BTA: 514969(ACOX2)
BOM: 102287053(ACOX2)
BIU: 109576197(ACOX2)
BBUB: 102404658(ACOX2)
BBIS: 104997077(ACOX2)
CHX: 102184385(ACOX2)
OAS: 101121460(ACOX2)
BTAX: 128044329(ACOX2)
ODA: 120867983(ACOX2)
CCAD: 122424314(ACOX2)
MBEZ: 129547971(ACOX2)
SSC: 100516877(ACOX2)
CFR: 102512694(ACOX2)
CBAI: 105079554(ACOX2)
CDK: 105089810(ACOX2)
VPC: 102527334(ACOX2)
BACU: 102999785(ACOX2)
BMUS: 118903835(ACOX2)
LVE: 103086040(ACOX2)
OOR: 101288466(ACOX2)
DLE: 111174239(ACOX2)
PCAD: 102973306(ACOX2)
PSIU: 116762734(ACOX2)
NASI: 112400617(ACOX2)
ECB: 100050425(ACOX2)
EPZ: 103550743(ACOX2)
EAI: 106848667(ACOX2)
MYB: 102260512(ACOX2)
MYD: 102766328(ACOX2)
MMYO: 118667935(ACOX2)
MLF: 102428739(ACOX2)
PKL: 118715071(ACOX2)
EFUS: 103290449(ACOX2)
MNA: 107531454(ACOX2)
DRO: 112301264(ACOX2)
SHON: 118983389(ACOX2)
AJM: 119043406(ACOX2)
PDIC: 114501728(ACOX2)
PHAS: 123814456(ACOX2)
MMF: 118633599(ACOX2)
PPAM: 129088225(ACOX2)
HAI: 109388232(ACOX2)
RFQ: 117036966(ACOX2)
PALE: 102884254(ACOX2)
PGIG: 120599535(ACOX2)
PVP: 105299837(ACOX2)
RAY: 107503398(ACOX2)
MJV: 108394908(ACOX2)
TOD: 119230556(ACOX2)
SARA: 101557002(ACOX2)
SETR: 126013205(ACOX2)
LAV: 100655728(ACOX2)
TMU: 101353097
ETF: 101638572(ACOX2)
DNM: 101442926(ACOX2)
MDO: 100028782(ACOX2)
GAS: 123246882(ACOX2)
SHR: 100924634(ACOX2)
AFZ: 127550706
PCW: 110195963(ACOX2)
OAA: 100074731(ACOX2)
GGA: 416068(ACOX2)
PCOC: 116237336(ACOX2)
MGP: 100545690(ACOX2)
CJO: 107319785(ACOX2)
TPAI: 128078692(ACOX2)
LMUT: 125698947(ACOX2)
NMEL: 110404665(ACOX2)
APLA: 101804343(ACOX2)
ACYG: 106035476(ACOX2)
CATA: 118248178(ACOX2)
AFUL: 116493226(ACOX2)
TGU: 100228411(ACOX2)
LSR: 110470870(ACOX2)
SCAN: 103817065(ACOX2)
PMOA: 120514182(ACOX2)
OTC: 121347290(ACOX2)
PRUF: 121350699(ACOX2)
GFR: 102044390(ACOX2)
FAB: 101820029(ACOX2)
OMA: 130258427(ACOX2)
PHI: 102102070(ACOX2)
PMAJ: 107210348(ACOX2)
CCAE: 111935016(ACOX2)
CCW: 104683332(ACOX2)
CBRC: 103614344(ACOX2)
ETL: 114056799(ACOX2)
ZAB: 102066854(ACOX2)
ACHL: 103802722(ACOX2)
SVG: 106851091(ACOX2)
MMEA: 130589161(ACOX2)
HRT: 120758395(ACOX2)
FPG: 101910731(ACOX2)
FCH: 102048175(ACOX2)
CLV: 102092775(ACOX2)
EGZ: 104134791(ACOX2)
NNI: 104016906(ACOX2)
PCRI: 104034223(ACOX2)
PLET: 104628479(ACOX2)
EHS: 104516442(ACOX2)
PCAO: 104041431(ACOX2)
ACUN: 113484962(ACOX2)
TALA: 104357214(ACOX2)
PADL: 103918901(ACOX2)
AFOR: 103903237(ACOX2)
ACHC: 115353747(ACOX2)
HALD: 104323861(ACOX2)
HLE: 104833984(ACOX2)
AGEN: 126049759
GCL: 127021570
CCRI: 104154848(ACOX2)
CSTI: 104549918(ACOX2)
CMAC: 104476997(ACOX2)
MUI: 104533437(ACOX2)
BREG: 104632277(ACOX2)
FGA: 104076315(ACOX2)
GSTE: 104260140(ACOX2)
LDI: 104349688(ACOX2)
MNB: 103769714(ACOX2)
OHA: 104331333(ACOX2)
NNT: 104403304(ACOX2)
SHAB: 115614772(ACOX2)
DPUB: 104305103(ACOX2)
PGUU: 104465920(ACOX2)
ACAR: 104532473(ACOX2)
CPEA: 104388179(ACOX2)
AVIT: 104272361(ACOX2)
CVF: 104293064(ACOX2)
RTD: 128915531(ACOX2)
CUCA: 104064609
TEO: 104378997(ACOX2)
BRHI: 104496268(ACOX2)
AAM: 106489663(ACOX2)
AROW: 112976606(ACOX2)
NPD: 112958598(ACOX2)
TGT: 104580279(ACOX2)
DNE: 112984663(ACOX2)
SCAM: 104144689(ACOX2)
ASN: 102380977(ACOX2)
AMJ: 102563802(ACOX2)
CPOO: 109311219(ACOX2)
GGN: 109289012(ACOX2)
PSS: 102450027(ACOX2)
CMY: 102935400(ACOX2)
CCAY: 125640597(ACOX2)
DCC: 119858606(ACOX2)
CPIC: 101950611(ACOX2)
TST: 117879967(ACOX2)
CABI: 116825650(ACOX2)
MRV: 120368668(ACOX2)
ACS: 100556696(acox2)
ASAO: 132769437(ACOX2)
PVT: 110079915(ACOX2)
SUND: 121920729 121920730 121924949
PBI: 103062545(ACOX2)
PMUR: 107296584(ACOX2)
CTIG: 120300493(ACOX2)
TSR: 106550842(ACOX2)
PGUT: 117660659(ACOX2)
APRI: 131190239(ACOX2)
PTEX: 113450449(ACOX2)
NSS: 113422110(ACOX2)
VKO: 123034601(ACOX2)
PMUA: 114591888(ACOX2)
PRAF: 128408517(ACOX2)
ZVI: 118080857(ACOX2)
HCG: 128344586(ACOX2)
GJA: 107119599(ACOX2)
STOW: 125429067 125429068
EMC: 129326958 129329209
XLA: 414480(acox2.L)
XTR: 548740(acox2)
NPR: 108791853(ACOX2)
RTEM: 120945173(ACOX2)
BBUF: 120979104 120979105 120979106
BGAR: 122943473 122943873
MUO: 115472392(ACOX2)
GSH: 117351297(ACOX2)
LCM: 102363316(ACOX2)
CMK: 103179753
RTP: 109920851
CPLA: 122559256(kctd6a)
HOC: 132822352
LERI: 129704474
CIN: 100186223
SCLV: 120340587
 » show all
Reference
PMID:9218493
  Authors
Pedersen JI, Eggertsen G, Hellman U, Andersson U, Bjorkhem I
  Title
Molecular cloning and expression of cDNA encoding 3alpha,7alpha,12alpha-trihydroxy-5beta-chole stanoyl-CoA oxidase from rabbit liver.
  Journal
J Biol Chem 272:18481-9 (1997)
DOI:10.1074/jbc.272.29.18481
  Sequence
[ocu:100009549]
Reference
PMID:12543708
  Authors
Russell DW
  Title
The enzymes, regulation, and genetics of bile acid synthesis.
  Journal
Annu Rev Biochem 72:137-74 (2003)
DOI:10.1146/annurev.biochem.72.121801.161712
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