KEGG ORTHOLOGY: K10586

ORTHOLOGY: K10586

Entry

K10586                      KO

Symbol

BIRC6, BRUCE

Name

baculoviral IAP repeat-containing protein 6 (apollon) [EC:2.3.2.23]

Pathway

map04120

Ubiquitin mediated proteolysis

map04140

Autophagy - animal

map04214

Apoptosis - fly

map04215

Apoptosis - multiple species

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K10586  BIRC6, BRUCE; baculoviral IAP repeat-containing protein 6 (apollon)
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K10586  BIRC6, BRUCE; baculoviral IAP repeat-containing protein 6 (apollon)
  09143 Cell growth and death
   04214 Apoptosis - fly
    K10586  BIRC6, BRUCE; baculoviral IAP repeat-containing protein 6 (apollon)
   04215 Apoptosis - multiple species
    K10586  BIRC6, BRUCE; baculoviral IAP repeat-containing protein 6 (apollon)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K10586  BIRC6, BRUCE; baculoviral IAP repeat-containing protein 6 (apollon)
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K10586  BIRC6, BRUCE; baculoviral IAP repeat-containing protein 6 (apollon)
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.23  E2 ubiquitin-conjugating enzyme
     K10586  BIRC6, BRUCE; baculoviral IAP repeat-containing protein 6 (apollon)
Peptidases and inhibitors [BR:ko01002]
Peptidase inhibitors
  Family I32: IAP family
   K10586  BIRC6, BRUCE; baculoviral IAP repeat-containing protein 6 (apollon)
Ubiquitin system [BR:ko04121]
Ubiquitin-conjugating enzymes (E2)
  Ubiquitin-conjugating enzymes
   K10586  BIRC6, BRUCE; baculoviral IAP repeat-containing protein 6 (apollon)

Other DBs

GO:	0043027 0061631

Genes

HSA:	57448(BIRC6)

PTR:	459138(BIRC6)

PPS:	100975802(BIRC6)

GGO:	101147286(BIRC6)

PON:	100448259(BIRC6)

NLE:	100601939(BIRC6)

HMH:	116480549(BIRC6)

MCC:	709443(BIRC6)

MCF:	102140795(BIRC6)

MTHB:

126933887

MNI:

105464812

CSAB:

103220526(BIRC6)

CATY:

105578397(BIRC6)

PANU:

100999515(BIRC6)

TGE:	112604521(BIRC6)

MLEU:

105542630(BIRC6)

RRO:	104669445(BIRC6)

RBB:	108528684(BIRC6)

TFN:	117062495(BIRC6)

PTEH:

111545411(BIRC6)

CANG:

105507543(BIRC6)

CJC:	100406149(BIRC6)

SBQ:	101044261(BIRC6)

CIMI:

108308820(BIRC6)

CSYR:

103264237(BIRC6)

MMUR:

105884475(BIRC6)

LCAT:

123636779(BIRC6)

PCOQ:

105816882(BIRC6)

OGA:	100966561(BIRC6)

MMU:	12211(Birc6)

MCAL:

110312483(Birc6)

MPAH:

110335497(Birc6)

RNO:	313876(Birc6)

MCOC:

116079818(Birc6)

ANU:	117716825(Birc6)

MUN:	110557936(Birc6)

CGE:	100689237(Birc6)

MAUA:

101827413(Birc6)

PROB:

127220133(Birc6)

PLEU:

114695967(Birc6)

MORG:

121432966(Birc6)

MFOT:

126514220

AAMP:

119808336(Birc6)

NGI:	103746755(Birc6)

HGL:	101704045(Birc6)

CPOC:

100735665(Birc6)

CCAN:

109697198(Birc6)

DORD:

105983575(Birc6)

DSP:	122122467(Birc6)

PLOP:

125356577(Birc6)

NCAR:

124962731

MMMA:

107137369(Birc6)

OCU:

100342432

OPI:	101526959(BIRC6)

TUP:	102473705(BIRC6)

GVR:	103587630(BIRC6)

CFA:	475718(BIRC6)

CLUD:

112664554(BIRC6)

VVP:	112933011(BIRC6)

VLG:	121490419(BIRC6)

NPO:	129510798(BIRC6)

AML:	100484115(BIRC6)

UMR:	103671900(BIRC6)

UAH:	113241023(BIRC6)

UAR:	123799852(BIRC6)

ELK:

111154155

LLV:

125109560

MPUF:

101685695(BIRC6)

MNP:	132021266(BIRC6)

MLK:	131840550(BIRC6)

NVS:	122915173(BIRC6)

ORO:	101373264(BIRC6)

EJU:	114219707(BIRC6)

ZCA:	113937068(BIRC6)

MLX:	118007752(BIRC6)

NSU:	110587374(BIRC6)

LWW:	102736443(BIRC6)

FCA:	101087396(BIRC6)

PYU:	121044324(BIRC6)

PCOO:

112864117(BIRC6)

PBG:	122466918(BIRC6)

PVIV:

125161701(BIRC6)

LRUF:

124504225

PTG:	102952639(BIRC6)

PPAD:

109266097(BIRC6)

PUC:

125937546

AJU:

106967931

HHV:	120244017(BIRC6)

BTA:	534211(BIRC6)

BOM:	102268689(BIRC6)

BIU:	109565520(BIRC6)

BBUB:

102406486(BIRC6)

BBIS:

104980946(BIRC6)

CHX:	102189592(BIRC6)

OAS:	101103635(BIRC6)

BTAX:

128056703(BIRC6)

ODA:	120851654(BIRC6)

CCAD:

122441545(BIRC6)

MBEZ:

129539673(BIRC6)

SSC:	100049694(BIRC6)

CFR:	102504932(BIRC6)

CBAI:

105079050(BIRC6)

CDK:	105095609(BIRC6)

VPC:	102537850(BIRC6)

BACU:

102999046(BIRC6)

BMUS:

118906413(BIRC6)

LVE:	103072550(BIRC6)

OOR:	101287884(BIRC6)

DLE:	111174900(BIRC6)

PCAD:

102980704(BIRC6)

PSIU:

116763956(BIRC6)

NASI:

112390975(BIRC6)

ECB:	100070568(BIRC6)

EPZ:	103562047(BIRC6)

EAI:	106839892(BIRC6)

MYB:	102240528(BIRC6)

MYD:	102754641(BIRC6)

MMYO:

118669118(BIRC6)

MLF:	102418471(BIRC6)

PKL:	118717126(BIRC6)

EFUS:

103283130(BIRC6)

MNA:	107541792(BIRC6)

DRO:	112297819(BIRC6)

SHON:

119001285(BIRC6)

AJM:	119050340(BIRC6)

PDIC:

114498432(BIRC6)

PHAS:

123811548(BIRC6)

MMF:	118630719(BIRC6)

PPAM:

129066482(BIRC6)

HAI:	109388784(BIRC6)

RFQ:	117033398(BIRC6)

PALE:

102887070(BIRC6)

PGIG:

120621794(BIRC6)

PVP:	105300068(BIRC6)

RAY:	107505747(BIRC6)

MJV:	108395582(BIRC6)

TOD:	119259416(BIRC6)

SARA:

101544987(BIRC6)

SETR:

126024312(BIRC6)

LAV:	100674455(BIRC6)

TMU:

101346617

ETF:	101662909(BIRC6)

DNM:	101445554(BIRC6)

MDO:	100027051(BIRC6)

GAS:	123237055(BIRC6)

SHR:	100915294(BIRC6)

AFZ:

127548640

PCW:	110198157(BIRC6)

OAA:	100079899(BIRC6)

GGA:	421463(BIRC6)

PCOC:

116229096(BIRC6)

MGP:	100542265(BIRC6)

CJO:	107311278(BIRC6)

TPAI:

128081047(BIRC6)

LMUT:

125690062(BIRC6)

NMEL:

110396654(BIRC6)

APLA:

101791861(BIRC6)

ACYG:

106029549(BIRC6)

CATA:

118257218(BIRC6)

AFUL:

116487556(BIRC6)

TGU:	100225419(BIRC6)

LSR:	110480419(BIRC6)

SCAN:

103817527(BIRC6)

PMOA:

120506808(BIRC6)

OTC:	121335729(BIRC6)

PRUF:

121358694(BIRC6)

GFR:	102040419(BIRC6)

FAB:	101809247(BIRC6)

OMA:	130250629(BIRC6)

PHI:	102112753(BIRC6)

PMAJ:

107201726(BIRC6)

CCAE:

111927090(BIRC6)

CCW:	104684369(BIRC6)

CBRC:

103624137(BIRC6)

ETL:	114065177(BIRC6)

ZAB:	102064117(BIRC6)

ZLE:	135445750(BIRC6)

ACHL:

103803737(BIRC6)

SVG:	106853288(BIRC6)

MMEA:

130583958(BIRC6)

HRT:	120750769(BIRC6)

FPG:	101911521(BIRC6)

FCH:	102048946(BIRC6)

CLV:	102090283(BIRC6)

EGZ:	104124129(BIRC6)

NNI:	104018677(BIRC6)

PLET:

104618328(BIRC6)

EHS:	104507488(BIRC6)

PCAO:

104050822(BIRC6)

ACUN:

113477918(BIRC6)

TALA:

104363254(BIRC6)

PADL:

103922846(BIRC6)

AFOR:

103902690(BIRC6)

ACHC:

115350095(BIRC6)

HLE:	104840346(BIRC6)

AGEN:

126051397

GCL:

127014865

CCRI:

104162721(BIRC6)

CSTI:

104549355(BIRC6)

CMAC:

104481212(BIRC6)

MUI:	104548139(BIRC6)

BREG:

104642604

FGA:	104077962(BIRC6)

GSTE:

104259061(BIRC6)

LDI:	104342993(BIRC6)

MNB:	103782068(BIRC6)

OHA:	104329281(BIRC6)

NNT:	104402966(BIRC6)

SHAB:

115613905(BIRC6)

DPUB:

104310304(BIRC6)

PGUU:

104461177(BIRC6)

ACAR:

104530949(BIRC6)

CPEA:

104394917(BIRC6)

AVIT:

104279421(BIRC6)

CVF:	104282312(BIRC6)

RTD:	128907455(BIRC6)

CUCA:

104067939(BIRC6)

TEO:	104379539(BIRC6)

AAM:

106485476

AROW:

112973385(BIRC6)

NPD:	112957542(BIRC6)

TGT:

104566230

DNE:	112997112(BIRC6)

SCAM:

104151735(BIRC6)

ASN:	102380478(BIRC6)

AMJ:	102562434(BIRC6)

CPOO:

109319087(BIRC6)

GGN:	109304229(BIRC6)

PSS:	102458066(BIRC6)

CMY:	102939825(BIRC6)

CCAY:

125633801(BIRC6)

DCC:	119852619(BIRC6)

CPIC:

101943023(BIRC6)

TST:	117874612(BIRC6)

CABI:

116831042(BIRC6)

MRV:	120401698(BIRC6)

ACS:	100555646(birc6)

ASAO:

132761271(BIRC6)

PVT:	110083924(BIRC6)

SUND:

121921427(BIRC6)

PBI:	103057238(BIRC6)

PMUR:

107287473(BIRC6)

CTIG:

120312081(BIRC6)

TSR:	106543083(BIRC6)

PGUT:

117671878(BIRC6)

APRI:

131188732(BIRC6)

PTEX:

113433137(BIRC6)

NSS:	113420011(BIRC6)

VKO:	123034676(BIRC6)

PMUA:

114594498(BIRC6)

PRAF:

128410941(BIRC6)

ZVI:	118081800(BIRC6)

HCG:	128348120(BIRC6)

GJA:	107122648(BIRC6)

STOW:

125426058(BIRC6)

EMC:	129328047(BIRC6)

XLA:	108716679(birc6.L) 108717825(birc6.S)

XTR:	100135722(birc6)

NPR:	108784163(BIRC6)

RTEM:

120935746(BIRC6)

BBUF:

120998747(BIRC6)

BGAR:

122934097(BIRC6)

MUO:	115465785(BIRC6)

GSH:	117356454(BIRC6)

DRE:	796547(birc6)

SRX:	107744716(birc6) 107755968

SANH:

107670830 107689818

SGH:	107553750 107583536

CCAR:

109070478

CAUA:

113113695 113117138

CGIB:

127976740 128031580

PTET:

122361811(birc6)

LROH:

127180251(birc6)

OMC:	131523564(birc6)

PPRM:

120477742(birc6)

RKG:	130070594(birc6)

MAMB:

125268728(birc6)

CIDE:

127498022

MASI:

127411149 127455575

TROS:

130560812(birc6)

TDW:	130437357(birc6)

MANU:

129418073(birc6)

IPU:

108269600

IFU:	128613096(birc6)

SMEO:

124389829(birc6)

TFD:	113662073(birc6)

TVC:	132852651(birc6)

TRN:	134324916(birc6)

AMEX:

103024424(birc6)

CMAO:

118824204

EEE:	113590257(birc6)

CHAR:

105911599(birc6)

TRU:	101070484(birc6)

TFS:	130533871(birc6)

TNG:	GSTEN00010001G001

LCO:	104929305(birc6)

TBEN:

117475995(birc6)

CGOB:

115020147(birc6)

PGEO:

117459593(birc6)

GACU:

117545292(birc6)

EMAC:

134858709(birc6)

ELY:	117248613(birc6)

EFO:	125903941(birc6)

PLEP:

121954331(birc6)

SLUC:

116049930(birc6)

ECRA:

117960771(birc6)

ESP:	116705618(birc6)

PFLV:

114572320(birc6)

GAT:	120821068(birc6)

PPUG:

119214370(birc6)

AFB:	129092486(birc6)

CLUM:

117743977(birc6)

PSWI:

130207186(birc6)

MSAM:

119917322(birc6)

SCHU:

122884905(birc6)

CUD:	121511000(birc6)

ALAT:

119033072(birc6)

MZE:	101476137(birc6)

ONL:	100690623(birc6)

OAU:	116312933(birc6)

OLA:	101173043(birc6)

OML:	112161497(birc6)

CSAI:

133463533(birc6)

XMA:	102219089(birc6)

XCO:	114138326(birc6)

XHE:	116713791(birc6)

PRET:

103476564(birc6)

PFOR:

103153116(birc6)

PLAI:

106958545(birc6)

PMEI:

106927841(birc6)

GAF:	122842358(birc6)

PPRL:

129359563(birc6)

CVG:	107102365(birc6)

CTUL:

119796165(birc6)

GMU:	124859542(birc6)

NFU:	107375479(birc6)

KMR:	108244051(birc6)

ALIM:

106535036

NWH:	119413933(birc6)

AOCE:

111586796(birc6)

MCEP:

125019166(birc6)

CSEM:

103387705(birc6)

POV:	109632450(birc6)

SSEN:

122781908(birc6)

HHIP:

117775287(birc6)

HSP:	118119042(birc6)

PPLT:

128453824(birc6)

SMAU:

118284187(birc6)

LCF:

108884801

SDU:	111236425(birc6)

SLAL:

111672964(birc6)

XGL:	120796749(birc6)

HCQ:	109523048(birc6)

SSCV:

125978480

SBIA:

133509865(birc6)

PEE:	133409908(birc6)

PTAO:

133485611(birc6)

BPEC:

110158156(birc6)

MALB:

109960050(birc6)

BSPL:

114842060(birc6)

SJO:	128373336(birc6)

SASA:

106576946 106606575

STRU:

115153168 115193824

OTW:	112252964(birc6) 112254114

OMY:	110502424 110528213(birc6)

OGO:	124038225 124041292

ONE:	115113252 115135156

OKI:	109889902 109899695

OKE:	118361340 118369665(birc6)

SALP:

111951839 111977543

SNH:	120017619(birc6) 120046546

CCLU:

121553180(birc6) 121570187

ELS:	105023260(birc6)

SFM:	108918038(birc6)

PKI:	111839558(birc6)

AANG:

118218320(birc6)

LOC:	102698367(birc6)

PSPA:

121315672 121316749

ARUT:

117402834 117411422

PSEX:

120517004(birc6)

LCM:	102355826(BIRC6)

CMK:	103181770(birc6)

RTP:	109933463(birc6)

CPLA:

122552671(birc6)

HOC:	132819680(birc6)

LERI:

129699814(birc6)

PMRN:

116939418(BIRC6)

LRJ:	133347041(BIRC6)

BFO:

118421179

BBEL:

109472224

SCLV:

120331516 120337856 120341671

SPU:

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG6303(Bruce)

DER:

6552038

DSE:

6621674

DSI:	Dsimw501_GD20723(Dsim_GD20723)

DYA:	Dyak_GE24690

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI24031

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:	119676365 119678027

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

HIS:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ002689

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_214621

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

AAGE:

HAW:	110379539(Bruce)

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CFEL:

BTAB:

NLU:

HVI:

MQU:

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

DPX:	DAPPUDRAFT_317519

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

PPOI:

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:	111129365 111130310

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_159540

LLON:

NVE:

EPA:

ATEN:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

Reference

PMID:14765125

Authors

Qiu XB, Markant SL, Yuan J, Goldberg AL

Title

Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis.

Journal

EMBO J 23:800-10 (2004)
DOI:10.1038/sj.emboj.7600075

Sequence

[hsa:57448]

LinkDB

DBGET integrated database retrieval system