KEGG ORTHOLOGY: K11974

ORTHOLOGY: K11974

Entry

K11974                      KO

Symbol

RNF31, HOIP

Name

E3 ubiquitin-protein ligase RNF31 [EC:2.3.2.31]

Pathway

map04217

Necroptosis

map04621

NOD-like receptor signaling pathway

map05131

Shigellosis

Disease

H02525

Disorders of innate immunity

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K11974  RNF31, HOIP; E3 ubiquitin-protein ligase RNF31
09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K11974  RNF31, HOIP; E3 ubiquitin-protein ligase RNF31
09160 Human Diseases
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K11974  RNF31, HOIP; E3 ubiquitin-protein ligase RNF31
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K11974  RNF31, HOIP; E3 ubiquitin-protein ligase RNF31
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.31  RBR-type E3 ubiquitin transferase
     K11974  RNF31, HOIP; E3 ubiquitin-protein ligase RNF31
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  Single Ring-finger type E3
   RBR proteins
    K11974  RNF31, HOIP; E3 ubiquitin-protein ligase RNF31
  Multi subunit Ring-finger type E3
   LUBAC complex
    K11974  RNF31, HOIP; E3 ubiquitin-protein ligase RNF31

Genes

HSA:	55072(RNF31)

PTR:	452810(RNF31)

PPS:	100971526(RNF31)

GGO:	101146596(RNF31)

PON:	100433825(RNF31)

NLE:	100606080(RNF31)

HMH:	116484958(RNF31)

MCC:	715239(RNF31)

MCF:	101925453(RNF31)

MTHB:

126958799

MNI:	105477855(RNF31)

CSAB:

103228711(RNF31)

CATY:

105600245(RNF31)

PANU:

101015955(RNF31)

TGE:	112628625(RNF31)

MLEU:

105532715(RNF31)

RRO:	104662695(RNF31)

RBB:	108540921(RNF31)

TFN:	117069911(RNF31)

PTEH:

111552933(RNF31)

CANG:

105503732(RNF31)

CJC:

100407708

SBQ:	101048716(RNF31)

CIMI:

108315371(RNF31)

CSYR:

103272249(RNF31)

MMUR:

105866585(RNF31)

LCAT:

123650767(RNF31)

PCOQ:

105812738(RNF31)

OGA:	100943199(RNF31)

MMU:	268749(Rnf31)

MCAL:

110309048(Rnf31)

MPAH:

110325297(Rnf31)

RNO:	364386(Rnf31)

MCOC:

116084366(Rnf31)

ANU:	117705286(Rnf31)

MUN:	110556518(Rnf31)

CGE:	100760689(Rnf31)

MAUA:

101836495(Rnf31)

PROB:

127230362(Rnf31)

PLEU:

114708667(Rnf31)

MORG:

121434949(Rnf31)

MFOT:

126490903

AAMP:

119799967(Rnf31)

NGI:	103739429(Rnf31)

HGL:	101702384(Rnf31)

CPOC:

100733433(Rnf31)

CCAN:

109685866(Rnf31)

DORD:

105992527(Rnf31)

DSP:	122113390(Rnf31)

PLOP:

125363470(Rnf31)

NCAR:

124976668

MMMA:

107147714(Rnf31)

OCU:

100348420

OPI:	101525507(RNF31)

TUP:	102496915(RNF31)

GVR:	103590164(RNF31)

CFA:	480259(RNF31)

CLUD:

112657145(RNF31)

VVP:	112926536(RNF31)

VLG:	121493249(RNF31)

NPO:	129499450(RNF31)

AML:	100475726(RNF31)

UMR:	103679278(RNF31)

UAH:	113245982(RNF31)

UAR:	123795751(RNF31)

ELK:

111140716

LLV:

125104308

MPUF:

101688660(RNF31)

MNP:	131999832(RNF31)

MLK:	131836381(RNF31)

NVS:	122894436(RNF31)

ORO:	101380103(RNF31)

EJU:	114217960(RNF31)

ZCA:	113910419(RNF31)

MLX:	118003728(RNF31)

NSU:	110585592(RNF31)

LWW:	102750061(RNF31)

FCA:	101100727(RNF31)

PYU:	121031551(RNF31)

PCOO:

112856032(RNF31)

PBG:	122468926(RNF31)

PVIV:

125167366(RNF31)

LRUF:

124508843

PTG:	102956362(RNF31)

PPAD:

109254989(RNF31)

PUC:

125909646

AJU:

106987844

HHV:	120247002(RNF31)

BTA:	509856(RNF31)

BOM:	102268917(RNF31)

BIU:	109564780(RNF31)

BBUB:

102394663(RNF31)

BBIS:

104982029(RNF31)

CHX:	102191244(RNF31)

OAS:	101116911(RNF31)

BTAX:

128053829(RNF31)

ODA:	120853459(RNF31)

CCAD:

122443168(RNF31)

MBEZ:

129562922(RNF31)

CFR:	102519901(RNF31)

CBAI:

105068802(RNF31)

CDK:	105102415(RNF31)

VPC:	102539877(RNF31)

BACU:

102998158(RNF31)

BMUS:

118889717(RNF31)

LVE:	103069602(RNF31)

OOR:	101273068(RNF31)

DLE:	111164115(RNF31)

PCAD:

102993320(RNF31)

PSIU:

116748511(RNF31)

NASI:

112404986(RNF31)

EPZ:	103564024(RNF31)

EAI:	106848580(RNF31)

MYB:	102253242(RNF31)

MYD:	102767669(RNF31)

MMYO:

118678817(RNF31)

MLF:	102425491(RNF31)

PKL:	118725800(RNF31)

EFUS:

103301488(RNF31)

MNA:	107531721(RNF31)

DRO:	112301153(RNF31)

SHON:

118980886(RNF31)

AJM:	119037290(RNF31)

PDIC:

114492282(RNF31)

PHAS:

123820405(RNF31)

MMF:	118631113(RNF31)

PPAM:

129074155(RNF31)

HAI:	109393686(RNF31)

RFQ:	117022770(RNF31)

PALE:

102895242(RNF31)

PGIG:

120608506(RNF31)

PVP:	105309386(RNF31)

RAY:	107498005(RNF31)

MJV:	108391108(RNF31)

TOD:	119238945(RNF31)

SARA:

101542500(RNF31)

SETR:

126001179(RNF31)

LAV:	100653883(RNF31)

TMU:

101345431

ETF:	101641682(RNF31)

DNM:	101436592(RNF31)

MDO:	100030741(RNF31)

GAS:	123237972(RNF31)

SHR:	100915026(RNF31)

AFZ:

127551081

PCW:	110195063(RNF31)

OAA:	100089859(RNF31)

GGA:

107051192

PCOC:

116239783

LMUT:

125687523(RNF31)

LSR:	110481021(RNF31)

FAB:	101821219(RNF31)

OMA:	130264473(RNF31)

PHI:	106628974(RNF31)

ACHL:

103806025(RNF31)

AGEN:

126037348

ASN:	102385975(RNF31)

AMJ:	102561826(RNF31)

CMY:	119567958(RNF31)

CCAY:

125622245(RNF31)

DCC:	119841586(RNF31)

CPIC:

101951677(RNF31)

MRV:	120380881(RNF31)

ACS:	100556556(rnf31)

ASAO:

132777608(RNF31)

PVT:

110087544

SUND:

121932883(RNF31)

PBI:	103053864(RNF31)

PMUR:

107293085(RNF31)

CTIG:

120305772(RNF31)

PGUT:

117657286(RNF31)

APRI:

131196880(RNF31)

PTEX:

113448777(RNF31)

NSS:

113429378

VKO:	123018658(RNF31)

PMUA:

114581718(RNF31)

PRAF:

128400581(RNF31)

ZVI:

118095161

HCG:	128328780(RNF31)

GJA:	107115105(RNF31)

STOW:

125444422(RNF31)

EMC:	129338345(RNF31)

XLA:	108719312 779341(rnf31.S)

XTR:	100036616(rnf31)

NPR:	108797950(RNF31)

RTEM:

120941203 120941306(RNF31)

BBUF:

120989058(RNF31)

BGAR:

122922472(RNF31)

MUO:	115457740(RNF31)

GSH:	117350175(RNF31)

DRE:	100334178 567642(si:dkey-181m9.8)

SRX:	107714829 107714842 107728933 107729152

SANH:

107674166 107674392 107679331(rnf31)

SGH:	107584546(rnf31) 107584711 107602534

CCAR:

109052467 109095459 109106128

CAUA:

113045555 113045951 113069727 113117256 113117475 113117593

CGIB:

127951330 127951346(si:dkey-181m9.8) 128029219 128029319

PTET:

122323835(si:dkey-181m9.8) 122360584

LROH:

127154085(si:dkey-181m9.8) 127180205

OMC:	131526122 131527744(si:dkey-181m9.8)

PPRM:

120482550 120482858(si:dkey-181m9.8)

RKG:	130076052(si:dkey-181m9.8) 130089381

MAMB:

125251285(si:dkey-181m9.8) 125251677

CIDE:

127498416 127499732(si:dkey-181m9.8)

MASI:

127440448 127440452(si:dkey-181m9.8) 127442352

TROS:

130554094(si:dkey-181m9.8) 130554885

TDW:	130417398 130417763(si:dkey-181m9.8)

MANU:

129442180 129442204(si:dkey-181m9.8)

IPU:	108280439 108280771(si:dkey-181m9.8)

IFU:	128623928(si:dkey-181m9.8) 128624183

PHYP:

113543141 113543213(rnf31)

SMEO:

124402863(si:dkey-181m9.8) 124403334

TFD:	113640272(si:dkey-181m9.8) 113640333

TVC:	132848084 132848229(si:dkey-181m9.8)

TRN:	134302628(si:dkey-181m9.8) 134302737(rnf31)

AMEX:

103030581(rnf31) 103040600

CMAO:

118796819(si:dkey-181m9.8) 118797116

EEE:	113571988 113572004

CHAR:

105900621(si:dkey-181m9.8) 105900647 105905240

TRU:	101064102(rnf31) 101065618 101068646 115247907

TFS:	130514024 130539128(si:dkey-181m9.8) 130539291

TNG:	GSTEN00016545G001

LCO:	104932664 104939164(rnf31) 104939449

TBEN:

117473196 117495465

CGOB:

115022248 115025344(rnf31)

PGEO:

117444189 117462841 117466075

GACU:

117537740 117561326

EMAC:

134858125 134866247(rnf31)

ELY:	117264766 117272539

EFO:	125881935 125902725(si:dkey-181m9.8) 125902783

PLEP:

121951786 121960963

SLUC:

116040012 116043921 116064112(si:dkey-181m9.8)

ECRA:

117938319 117954589

ESP:	116672603 116678163 116699627

PFLV:

114549446 114565356 114566071

GAT:	120815969(si:dkey-181m9.8) 120816131

PPUG:

119198578 119209264 119209422

AFB:	129089244(si:dkey-181m9.8) 129094943 129110431

CLUM:

117746143(si:dkey-181m9.8) 117746773 117749502

PSWI:

130197694 130205898

MSAM:

119902552 119902755(si:dkey-181m9.8) 119917796

SCHU:

122866321 122886338 122887077

CUD:	121520475 121527237

ALAT:

119008313 119011622(si:dkey-181m9.8) 119011826

MZE:	101471460 101472240(rnf31) 101483179

ONL:	100707250 100711514 100712157

OAU:	116322153 116324139(si:dkey-181m9.8) 116326318

OLA:	101155382 101162956 101174057

OML:	112144261 112151240 112151771

XMA:	102231972(rnf31) 111608983

XCO:	114136627(rnf31) 114146846

XHE:	116711449(rnf31) 116721955

PRET:

103456714(rnf31) 103460775

PFOR:

103131109 103146938(rnf31)

PLAI:

106937080 106965297(rnf31)

PMEI:

106933355 106933877(rnf31)

GAF:	122824381 122841840(si:dkey-181m9.8)

PPRL:

129378969

CVG:	107089416(rnf31)

CTUL:

119778724 119796388

GMU:	124857801 124870018(si:dkey-181m9.8)

NFU:	107383099(rnf31) 107384344

KMR:	108234713 108250420 108250625(si:dkey-181m9.8)

ALIM:

106511035 106522307(rnf31) 106525968

NWH:

119426227

AOCE:

111562492 111568988 111570370

MCEP:

124995937 125010773 125010907(si:dkey-181m9.8)

CSEM:

103377157(rnf31) 103396613 103398744

POV:	109644108 109644332 109647098(rnf31)

SSEN:

122760025(si:dkey-181m9.8) 122764163 122771057

HHIP:

117753669 117777756 117777833(si:dkey-181m9.8)

HSP:	118098446 118117452(si:dkey-181m9.8) 118117722

PPLT:

128425448 128455044 128455061(si:dkey-181m9.8)

SMAU:

118291520 118311474

LCF:	108884948(si:dkey-181m9.8) 108885061 108891897 108896760

SDU:	111233929 111237348 111238327(rnf31)

SLAL:

111647268 111648339 111657059

XGL:	120789832 120799354 120799678

HCQ:

109524061

SSCV:

125985510 125986342

SBIA:

133511346(rnf31)

PEE:	133396810 133412034(rnf31)

PTAO:

133470551 133488575(rnf31)

BPEC:

110162704 110174110 110175048

MALB:

109951163 109959941(rnf31) 109965882

BSPL:

114844318(si:dkey-181m9.8) 114844705 114853294

SJO:	128369243 128369848 128382269

SASA:

106568680 106569248 106579548 106590402 106599357

STRU:

115150784 115156584 115157031 115169744 115195517

OTW:	112226925 112233601 112234068 112260171(si:dkey-181m9.8) 112260489

OMY:	110489697 110508709 110529988(si:dkey-181m9.8) 110530336 110536554

OGO:	123991334 124009506 124009669(si:dkey-181m9.8) 124039576 124041843

ONE:	115103070 115104920 115114258 115114438 115131028

OKI:	109872240 109874849 109875181 109899278 109909839

OKE:	118370239 118373172 118394673 118402089 118402462(si:dkey-181m9.8)

SALP:

111957222 111957287 111972806 111979420

SNH:	120019841 120027837 120050990 120055254 120055697(si:dkey-181m9.8)

CCLU:

121534552(si:dkey-181m9.8) 121535239 121549863 121569228 121580938

ELS:	105019579 105022719 105025097

SFM:	108923311 108927796 108937533

PKI:	111846210 111850879 111859543

AANG:

118224942 118232756(si:dkey-181m9.8) 118234561

LOC:

107078305

PSPA:

121305245

PSEX:

120525397 120530138

LCM:	102358723(RNF31)

CMK:	103180748(si:dkey-181m9.8)

RTP:	109920465(si:dkey-181m9.8)

CPLA:

122549033(si:dkey-181m9.8)

HOC:	132807016 132815444(si:dkey-181m9.8)

PMRN:

116944277(RNF31)

LRJ:

133350974

BFO:

118418100

BBEL:

109472050 109473752

CIN:	100170050(zf(ring/c6hc)-6)

SCLV:

120337678

SPU:	100889576 100892326

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG11321(LUBEL)

DER:

6541984

DSE:

6611441

DSI:	Dsimw501_GD22542(Dsim_GD22542)

DYA:	Dyak_GE18404

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DMO:	Dmoj_GI17301

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

HIS:

AGA:

ACOZ:

AARA:

AMER:

AFUN:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ007110

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_211126

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CFEL:

CCRN:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM464880

FOC:

ZNE:

CSEC:

SGRE:

IEL:

FCD:

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

HAZT:

EAF:

LSM:

TCF:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

UDV:

SDM:

LPOL:

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:	111135548 111135635

CANU:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HSY:

AQU:

Reference

PMID:19237537

Authors

Ehrlund A, Anthonisen EH, Gustafsson N, Venteclef N, Robertson Remen K, Damdimopoulos AE, Galeeva A, Pelto-Huikko M, Lalli E, Steffensen KR, Gustafsson JA, Treuter E

Title

E3 ubiquitin ligase RNF31 cooperates with DAX-1 in transcriptional repression of steroidogenesis.

Journal

Mol Cell Biol 29:2230-42 (2009)
DOI:10.1128/MCB.00743-08

Reference

PMID:22863777

Authors

Smit JJ, Monteferrario D, Noordermeer SM, van Dijk WJ, van der Reijden BA, Sixma TK

Title

The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension.

Journal

EMBO J 31:3833-44 (2012)
DOI:10.1038/emboj.2012.217

Reference

PMID:17006537

Authors

Kirisako T, Kamei K, Murata S, Kato M, Fukumoto H, Kanie M, Sano S, Tokunaga F, Tanaka K, Iwai K

Title

A ubiquitin ligase complex assembles linear polyubiquitin chains.

Journal

EMBO J 25:4877-87 (2006)
DOI:10.1038/sj.emboj.7601360

Sequence

[hsa:55072]

LinkDB

DBGET integrated database retrieval system