KEGG   ORTHOLOGY: K12250
Entry
K12250                      KO                                     
Symbol
ptlA
Name
pentalenene synthase [EC:4.2.3.7]
Pathway
map00909  Sesquiterpenoid and triterpenoid biosynthesis
map00998  Biosynthesis of various antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00819  Pentalenolactone biosynthesis, farnesyl-PP => pentalenolactone
Reaction
R02305  2-trans,6-trans-farnesyldiphosphate diphosphate-lyase (cyclizing, pentalenene-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00909 Sesquiterpenoid and triterpenoid biosynthesis
    K12250  ptlA; pentalenene synthase
  09110 Biosynthesis of other secondary metabolites
   00998 Biosynthesis of various antibiotics
    K12250  ptlA; pentalenene synthase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.3  Acting on phosphates
    4.2.3.7  pentalenene synthase
     K12250  ptlA; pentalenene synthase
Other DBs
GO: 0050467
Genes
MFB: MFUL124B02_01475 MFUL124B02_01480
PTRI: KDC22_17270
NYU: D7D52_27555
SMA: SAVERM_2998(ptlA)
SBH: SBI_09679
SCI: B446_29695
SCW: TU94_27405
SLE: sle_13160(sle_13160)
SSIA: A7J05_09240
SRK: FGW37_27330
SVR: CP971_04990
SCIN: CP977_32300
SPLA: CP981_00105
SHUN: DWB77_06666(ptlA)
SHAR: HUT13_06550
SPEU: CGZ69_00970
SGJ: IAG43_11500 IAG43_27155
SHK: J2N69_35805
SMAO: CAG99_22035
SCAE: IHE65_36335
SYUN: MOV08_02850 MOV08_41460
SOV: QZH56_04205
KBU: Q4V64_00250
 » show all
Reference
PMID:8180213
  Authors
Cane DE, Sohng JK, Lamberson CR, Rudnicki SM, Wu Z, Lloyd MD, Oliver JS, Hubbard BR
  Title
Pentalenene synthase. Purification, molecular cloning, sequencing, and high-level expression in Escherichia coli of a terpenoid cyclase from Streptomyces UC5319.
  Journal
Biochemistry 33:5846-57 (1994)
DOI:10.1021/bi00185a024
  Sequence
[sbh:SBI_09679]
Reference
PMID:16681390
  Authors
Tetzlaff CN, You Z, Cane DE, Takamatsu S, Omura S, Ikeda H
  Title
A gene cluster for biosynthesis of the sesquiterpenoid antibiotic pentalenolactone in Streptomyces avermitilis.
  Journal
Biochemistry 45:6179-86 (2006)
DOI:10.1021/bi060419n
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