Entry |
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Symbol |
HSD3B7
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Name |
cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase [EC: 1.1.1.181]
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Pathway |
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Module |
M00104 | Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate |
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Reaction |
R04263 | 7alpha-hydroxycholesterol:NAD+ 3-oxidoreductase |
R08721 | (24S)-cholest-5-ene-3beta,7alpha,24-triol:NAD+ 3-oxidoreductase |
R08723 | cholest-5-ene-3beta,7alpha,25-triol:NAD+ 3-oxidoreductase |
R08724 | 7alpha,27-dihydroxycholesterol:NAD+ 3-oxidoreductase |
R08728 | 3beta,7alpha-dihydroxy-5-cholestenoate:NAD+ 3-oxidoreductase |
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Disease |
H00628 | Congenital bile acid synthesis defect |
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Brite |
KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09103 Lipid metabolism
00120 Primary bile acid biosynthesis
K12408 HSD3B7; cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase
Enzymes [BR:ko01000]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.181 cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase
K12408 HSD3B7; cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase
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Other DBs |
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Genes |
» show all
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Reference |
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Authors |
Schwarz M, Wright AC, Davis DL, Nazer H, Bjorkhem I, Russell DW |
Title |
The bile acid synthetic gene 3beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis. |
Journal |
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Sequence |
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LinkDB |
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