KEGG   ORTHOLOGY: K12673
Entry
K12673                      KO                                     
Symbol
ceaS
Name
N2-(2-carboxyethyl)arginine synthase [EC:2.5.1.66]
Pathway
map00331  Clavulanic acid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00674  Clavaminate biosynthesis, arginine + glyceraldehyde-3P => clavaminate
Reaction
R05465  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00331 Clavulanic acid biosynthesis
    K12673  ceaS; N2-(2-carboxyethyl)arginine synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.66  N2-(2-carboxyethyl)arginine synthase
     K12673  ceaS; N2-(2-carboxyethyl)arginine synthase
Other DBs
GO: 0033848
Genes
SYM: K6K13_21960
SFA: Sfla_0555
STRP: F750_6324
SCLF: BB341_07805 BB341_29465
SGM: GCM10017557_20580
SFK: KY5_8018c
SKA: CP970_43095
SVR: CP971_33685
SSPB: CP982_00540
SOV: QZH56_31615
SFIY: F0344_21150
KAB: B7C62_18880
KAU: B6264_26755
SVI: Svir_33370
 » show all
Reference
PMID:14623876
  Authors
Caines ME, Elkins JM, Hewitson KS, Schofield CJ.
  Title
Crystal structure and mechanistic implications of N2-(2-carboxyethyl)arginine synthase, the first enzyme in the clavulanic acid biosynthesis pathway.
  Journal
J Biol Chem 279:5685-92 (2004)
DOI:10.1074/jbc.M310803200
Reference
PMID:14982786
  Authors
Tahlan K, Park HU, Wong A, Beatty PH, Jensen SE
  Title
Two sets of paralogous genes encode the enzymes involved in the early stages of clavulanic acid and clavam metabolite biosynthesis in Streptomyces clavuligerus.
  Journal
Antimicrob Agents Chemother 48:930-9 (2004)
DOI:10.1128/AAC.48.3.930-939.2004
  Sequence
[sclf:BB341_29465]
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