KEGG   ORTHOLOGY: K12692
Entry
K12692            Tight     KO                                     
Symbol
H6H
Name
hyoscyamine (6S)-dioxygenase / 6beta-hydroxyhyoscyamine epoxidase [EC:1.14.11.11 1.14.20.13]
Pathway
map00960  Tropane, piperidine and pyridine alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R03737  (6S)-6beta-hydroxyhyoscyamine,2-oxoglutarate:oxygen oxidoreductase (epoxide-forming)
R03812  L-hyoscyamine,2-oxoglytarate:oxygen oxidoreductase ((6S)-hydroxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00960 Tropane, piperidine and pyridine alkaloid biosynthesis
    K12692  H6H; hyoscyamine (6S)-dioxygenase / 6beta-hydroxyhyoscyamine epoxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.11  hyoscyamine (6S)-dioxygenase
     K12692  H6H; hyoscyamine (6S)-dioxygenase / 6beta-hydroxyhyoscyamine epoxidase
   1.14.20  With 2-oxoglutarate as one donor, and the other dehydrogenated
    1.14.20.13  6beta-hydroxyhyoscyamine epoxidase
     K12692  H6H; hyoscyamine (6S)-dioxygenase / 6beta-hydroxyhyoscyamine epoxidase
Other DBs
GO: 0047998 0047594
Genes
AG: BAA05630(H6H) BAA78340(H6H)
Reference
PMID:8066129
  Authors
Kanegae T, Kajiya H, Amano Y, Hashimoto T, Yamada Y
  Title
Species-dependent expression of the hyoscyamine 6 beta-hydroxylase gene in the pericycle.
  Journal
Plant Physiol 105:483-90 (1994)
DOI:10.1104/pp.105.2.483
  Sequence
[ag:BAA05630]
Reference
PMID:8354403
  Authors
Hashimoto T, Matsuda J, Yamada Y
  Title
Two-step epoxidation of hyoscyamine to scopolamine is catalyzed by bifunctional hyoscyamine 6 beta-hydroxylase.
  Journal
FEBS Lett 329:35-9 (1993)
DOI:10.1016/0014-5793(93)80187-y
LinkDB

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