KEGG   ORTHOLOGY: K12927
Entry
K12927            Tight     KO                                     
Symbol
AG22
Name
abietadiene/neoabietadiene/copalyl diphosphate synthase [EC:4.2.3.18 4.2.3.132 5.5.1.12]
Pathway
map00904  Diterpenoid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R06298  (+)-copalyl-diphosphate lyase (decyclizing)
R06301  (+)-copalyl-diphosphate diphosphate-lyase [cyclizing, abieta-7,13-diene-forming]
R06303  (+)-copaly-diphosphate diphosphate-lyase (cyclizing, neoabietadiene-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00904 Diterpenoid biosynthesis
    K12927  AG22; abietadiene/neoabietadiene/copalyl diphosphate synthase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.3  Acting on phosphates
    4.2.3.18  abieta-7,13-diene synthase
     K12927  AG22; abietadiene/neoabietadiene/copalyl diphosphate synthase
    4.2.3.132  neoabietadiene synthase
     K12927  AG22; abietadiene/neoabietadiene/copalyl diphosphate synthase
 5. Isomerases
  5.5  Intramolecular lyases
   5.5.1  Intramolecular lyases (only sub-subclass identified to date)
    5.5.1.12  copalyl diphosphate synthase
     K12927  AG22; abietadiene/neoabietadiene/copalyl diphosphate synthase
Other DBs
GO: 0050554 0050559
Genes
AG: AAB05407(AG22)
Reference
  Authors
Peters RJ1, Ravn MM, Coates RM, Croteau RB
  Title
Bifunctional abietadiene synthase: free diffusive transfer of the (+)-copalyl diphosphate intermediate between two distinct active sites.
  Journal
J Am Chem Soc 123:8974-8 (2001)
DOI:10.1021/ja010670k
  Sequence
LinkDB

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