KEGG ORTHOLOGY: K13376

ORTHOLOGY: K13376

Entry

K13376                      KO

Symbol

TGFB2

Name

transforming growth factor beta-2

Pathway

map04010

MAPK signaling pathway

map04060

Cytokine-cytokine receptor interaction

map04068

FoxO signaling pathway

map04110

Cell cycle

map04218

Cellular senescence

map04350

TGF-beta signaling pathway

map04380

Osteoclast differentiation

map04390

Hippo signaling pathway

map04933

AGE-RAGE signaling pathway in diabetic complications

map05140

Leishmaniasis

map05142

Chagas disease

map05144

Malaria

map05145

Toxoplasmosis

map05146

Amoebiasis

map05152

Tuberculosis

map05161

Hepatitis B

map05166

Human T-cell leukemia virus 1 infection

map05200

Pathways in cancer

map05205

Proteoglycans in cancer

map05206

MicroRNAs in cancer

map05210

Colorectal cancer

map05211

Renal cell carcinoma

map05212

Pancreatic cancer

map05220

Chronic myeloid leukemia

map05225

Hepatocellular carcinoma

map05226

Gastric cancer

map05321

Inflammatory bowel disease

map05323

Rheumatoid arthritis

map05410

Hypertrophic cardiomyopathy

map05414

Dilated cardiomyopathy

map05415

Diabetic cardiomyopathy

Disease

H00083

Allograft rejection

H00084

Graft-versus-host disease

H00800

Loeys-Dietz syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K13376  TGFB2; transforming growth factor beta-2
   04350 TGF-beta signaling pathway
    K13376  TGFB2; transforming growth factor beta-2
   04390 Hippo signaling pathway
    K13376  TGFB2; transforming growth factor beta-2
   04068 FoxO signaling pathway
    K13376  TGFB2; transforming growth factor beta-2
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K13376  TGFB2; transforming growth factor beta-2
09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K13376  TGFB2; transforming growth factor beta-2
   04218 Cellular senescence
    K13376  TGFB2; transforming growth factor beta-2
09150 Organismal Systems
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K13376  TGFB2; transforming growth factor beta-2
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K13376  TGFB2; transforming growth factor beta-2
   05206 MicroRNAs in cancer
    K13376  TGFB2; transforming growth factor beta-2
   05205 Proteoglycans in cancer
    K13376  TGFB2; transforming growth factor beta-2
  09162 Cancer: specific types
   05210 Colorectal cancer
    K13376  TGFB2; transforming growth factor beta-2
   05212 Pancreatic cancer
    K13376  TGFB2; transforming growth factor beta-2
   05225 Hepatocellular carcinoma
    K13376  TGFB2; transforming growth factor beta-2
   05226 Gastric cancer
    K13376  TGFB2; transforming growth factor beta-2
   05220 Chronic myeloid leukemia
    K13376  TGFB2; transforming growth factor beta-2
   05211 Renal cell carcinoma
    K13376  TGFB2; transforming growth factor beta-2
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K13376  TGFB2; transforming growth factor beta-2
   05161 Hepatitis B
    K13376  TGFB2; transforming growth factor beta-2
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    K13376  TGFB2; transforming growth factor beta-2
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K13376  TGFB2; transforming growth factor beta-2
   05144 Malaria
    K13376  TGFB2; transforming growth factor beta-2
   05145 Toxoplasmosis
    K13376  TGFB2; transforming growth factor beta-2
   05140 Leishmaniasis
    K13376  TGFB2; transforming growth factor beta-2
   05142 Chagas disease
    K13376  TGFB2; transforming growth factor beta-2
  09163 Immune disease
   05323 Rheumatoid arthritis
    K13376  TGFB2; transforming growth factor beta-2
   05321 Inflammatory bowel disease
    K13376  TGFB2; transforming growth factor beta-2
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K13376  TGFB2; transforming growth factor beta-2
   05414 Dilated cardiomyopathy
    K13376  TGFB2; transforming growth factor beta-2
   05415 Diabetic cardiomyopathy
    K13376  TGFB2; transforming growth factor beta-2
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K13376  TGFB2; transforming growth factor beta-2
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K13376  TGFB2; transforming growth factor beta-2
   00536 Glycosaminoglycan binding proteins
    K13376  TGFB2; transforming growth factor beta-2
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Transforming growth factors (RSTK binding)
   K13376  TGFB2; transforming growth factor beta-2
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Growth factors/receptors
   K13376  TGFB2; transforming growth factor beta-2

Genes

HSA:	7042(TGFB2)

PTR:	457742(TGFB2)

PPS:	100985755(TGFB2)

GGO:	101125504(TGFB2)

PON:	100461291(TGFB2)

NLE:	100596183(TGFB2)

HMH:	116457529(TGFB2)

MCC:	707540(TGFB2)

MCF:	101925182(TGFB2)

MTHB:

126948495

MNI:	105493507(TGFB2)

CSAB:

103230082(TGFB2)

CATY:

105577004(TGFB2)

PANU:

101009253(TGFB2)

TGE:	112636300(TGFB2)

MLEU:

105544786(TGFB2)

RRO:	104662252(TGFB2)

RBB:	108528282(TGFB2)

TFN:	117074794(TGFB2)

PTEH:

111537117(TGFB2)

CANG:

105502787(TGFB2)

CJC:	100390586(TGFB2)

SBQ:	101044624(TGFB2)

CIMI:

108302657(TGFB2)

CSYR:

103254860(TGFB2)

MMUR:

105868760(TGFB2)

LCAT:

123626839(TGFB2)

PCOQ:

105826908(TGFB2)

OGA:	100956747(TGFB2)

MMU:	21808(Tgfb2)

MCAL:

110292955(Tgfb2)

MPAH:

110321649(Tgfb2)

RNO:	81809(Tgfb2)

MCOC:

116068447(Tgfb2)

ANU:	117716112(Tgfb2)

MUN:	110549244(Tgfb2)

CGE:	100774918(Tgfb2)

MAUA:

101832748(Tgfb2)

PROB:

127223750(Tgfb2)

PLEU:

114698210(Tgfb2)

MORG:

121435842(Tgfb2)

MFOT:

126505361

AAMP:

119827432(Tgfb2)

NGI:	103728817(Tgfb2)

HGL:	101707457(Tgfb2)

CPOC:

100720726(Tgfb2)

CCAN:

109698650(Tgfb2)

DORD:

105984796(Tgfb2)

DSP:	122109464(Tgfb2)

PLOP:

125359114(Tgfb2)

NCAR:

124962328

MMMA:

107140543(Tgfb2)

OCU:	100009371(TGFB2)

OPI:	101516556(TGFB2)

TUP:	102500482(TGFB2)

GVR:	103604625(TGFB2)

CFA:	488596(TGFB2)

CLUD:

112643136(TGFB2)

VVP:	112914338(TGFB2)

VLG:	121471376(TGFB2)

NPO:	129515208(TGFB2)

AML:	100463584(TGFB2)

UMR:	103658194(TGFB2)

UAH:	113268733(TGFB2)

UAR:	123800112(TGFB2)

ELK:

111151068

LLV:

125085760

MPUF:

101677182(TGFB2)

MNP:	132025704(TGFB2)

MLK:	131815106(TGFB2)

NVS:	122918428(TGFB2)

ORO:	101380860(TGFB2)

EJU:	114210508(TGFB2)

ZCA:	113932123(TGFB2)

MLX:	118014087(TGFB2)

NSU:	110588122(TGFB2)

LWW:	102727105(TGFB2)

FCA:	101093414(TGFB2)

PYU:	121020862(TGFB2)

PCOO:

112864785(TGFB2)

PBG:	122476025(TGFB2)

PVIV:

125155525(TGFB2)

LRUF:

124510378

PTG:	102951894(TGFB2)

PPAD:

109276581(TGFB2)

PUC:

125925521

AJU:

106979500

HHV:	120221741(TGFB2)

BTA:	534069(TGFB2)

BOM:	102283491(TGFB2)

BIU:	109570509(TGFB2)

BBUB:

102390629(TGFB2)

BBIS:

104998204(TGFB2)

CHX:	100861228(TGFB2)

OAS:	554322(TGFB2)

BTAX:

128061503(TGFB2)

ODA:	120880130(TGFB2)

CCAD:

122452400(TGFB2)

MBEZ:

129551685(TGFB2)

SSC:	397084(TGFB2)

CFR:	102505811(TGFB2)

CBAI:

105083972(TGFB2)

CDK:	105100091(TGFB2)

VPC:	102543548(TGFB2)

BACU:

103001453(TGFB2)

BMUS:

118906756(TGFB2)

LVE:	103070826(TGFB2)

OOR:	101276254(TGFB2)

DLE:	111177477(TGFB2)

PCAD:

102993033(TGFB2)

PSIU:

116747679(TGFB2)

NASI:

112395811(TGFB2)

ECB:	100050377(TGFB2) 111771316

EPZ:	103543045(TGFB2)

EAI:	106836714(TGFB2)

MYB:	102250887(TGFB2)

MYD:	102755920(TGFB2)

MMYO:

118678846(TGFB2)

MLF:	102431488(TGFB2)

PKL:	118727653(TGFB2)

EFUS:

103293466(TGFB2)

MNA:	107543622(TGFB2)

DRO:	112318906(TGFB2)

SHON:

119003169(TGFB2)

AJM:	119045813(TGFB2)

PDIC:

114512425(TGFB2)

PHAS:

123804941(TGFB2)

MMF:	118640680(TGFB2)

PPAM:

129072973(TGFB2)

HAI:	109381205(TGFB2)

RFQ:	117018527(TGFB2)

PALE:

102881295(TGFB2)

PGIG:

120619172(TGFB2)

PVP:	105296163(TGFB2)

RAY:	107520844(TGFB2)

MJV:	108403151(TGFB2)

TOD:	119234883(TGFB2)

SARA:

101549205(TGFB2)

SETR:

126003348(TGFB2)

LAV:	100656534(TGFB2)

TMU:

101347669

ETF:	101639819(TGFB2)

DNM:	101444912(TGFB2)

MDO:	100017548(TGFB2)

GAS:	123247856(TGFB2)

SHR:	100914910(TGFB2)

AFZ:

127562518

PCW:	110205565(TGFB2)

OAA:	100080176(TGFB2)

GGA:	421352(TGFB2)

PCOC:

116230622(TGFB2)

MGP:	100549559(TGFB2)

CJO:	107311051(TGFB2)

TPAI:

128081780(TGFB2)

LMUT:

125689607(TGFB2)

NMEL:

110395798(TGFB2)

APLA:

101794148(TGFB2)

ACYG:

106031565(TGFB2)

CATA:

118253345(TGFB2)

AFUL:

116488326(TGFB2)

TGU:	100231617(TGFB2)

LSR:	110479104(TGFB2)

SCAN:

103821503(TGFB2)

PMOA:

120496994(TGFB2)

OTC:	121347800(TGFB2)

PRUF:

121358714(TGFB2)

GFR:	102037698(TGFB2)

FAB:	101814341(TGFB2)

OMA:	130251422(TGFB2)

PHI:	102114598(TGFB2)

PMAJ:

107202393(TGFB2)

CCAE:

111926211(TGFB2)

CCW:	104685626(TGFB2)

CBRC:

103612645(TGFB2)

ETL:	114064354(TGFB2)

ZAB:	102066530(TGFB2)

ZLE:	135445923(TGFB2)

ACHL:

103811139(TGFB2)

SVG:	106853582(TGFB2)

MMEA:

130585664(TGFB2)

HRT:	120750747(TGFB2)

FPG:	101917357(TGFB2)

FCH:	102047778(TGFB2)

CLV:	102085196(TGFB2)

EGZ:	104133428(TGFB2)

NNI:	104019653(TGFB2)

PCRI:

104027607(TGFB2)

PLET:

104619128(TGFB2)

EHS:	104513881(TGFB2)

PCAO:

104051839(TGFB2)

ACUN:

113478516(TGFB2)

TALA:

104357470(TGFB2)

PADL:

103916133(TGFB2)

AFOR:

103896919(TGFB2)

ACHC:

115350306(TGFB2)

HALD:

104319252(TGFB2)

HLE:	104828464(TGFB2)

AGEN:

126052724

GCL:

127014818

CCRI:

104167513

CSTI:

104560095(TGFB2)

CMAC:

104483848(TGFB2)

MUI:	104537821(TGFB2)

BREG:

104643500(TGFB2)

FGA:	104077136(TGFB2)

GSTE:

104262628(TGFB2)

LDI:	104349792(TGFB2)

MNB:	103769876(TGFB2)

OHA:	104327864(TGFB2)

NNT:	104408091(TGFB2)

SHAB:

115613819(TGFB2)

DPUB:

104299873(TGFB2)

PGUU:

104470023(TGFB2)

ACAR:

104529703(TGFB2)

CPEA:

104386187(TGFB2)

AVIT:

104275881(TGFB2)

CVF:	104294674(TGFB2)

RTD:	128907397(TGFB2)

CUCA:

104064807(TGFB2)

TEO:	104383292(TGFB2)

BRHI:

104499334(TGFB2)

AAM:	106490440(TGFB2)

AROW:

112977002(TGFB2)

NPD:	112955150(TGFB2)

TGT:	104569570(TGFB2)

DNE:	112988119(TGFB2)

SCAM:

104140308(TGFB2)

ASN:	102382227(TGFB2)

AMJ:	102562163(TGFB2)

CPOO:

109319735(TGFB2)

GGN:	109296861(TGFB2)

PSS:	102452874(TGFB2)

CMY:	102946116(TGFB2)

CCAY:

125633641(TGFB2)

DCC:	119854030(TGFB2)

CPIC:

101945771(TGFB2)

TST:	117874463(TGFB2)

CABI:

116828212(TGFB2)

MRV:	120402154(TGFB2)

ACS:	100568228(tgfb2)

ASAO:

132761412(TGFB2) 132764403

PVT:	110083352 110087066(TGFB2)

SUND:

121915414 121916287(TGFB2)

PBI:	103063485(TGFB2) 103067099

PMUR:

107293669(TGFB2) 107299193

CTIG:

120297457 120306706(TGFB2) 120317025

TSR:	106538869(TGFB2) 106539344

PGUT:

117671719(TGFB2)

APRI:

131186500 131189310(TGFB2)

PTEX:

113433267(TGFB2)

NSS:	113421978(TGFB2)

VKO:	123021868(TGFB2) 123032486

PMUA:

114586591 114594660(TGFB2)

PRAF:

128403307 128411119(TGFB2)

ZVI:	118076237 118083182(TGFB2)

HCG:	128336909 128350566(TGFB2)

GJA:	107110247(TGFB2) 107115203

STOW:

125432433(TGFB2) 125436846

EMC:	129325429 129343345(TGFB2)

XLA:	108717706(tgfb2.S) 373801(tgfb2.L)

XTR:	100489680(tgfb2)

NPR:	108795797(TGFB2)

RTEM:

120937894(TGFB2)

BBUF:

120999513(TGFB2)

BGAR:

122934301(TGFB2)

MUO:	115465504(TGFB2) 115480969

GSH:	117357506(TGFB2) 117365102

DRE:	369194(tgfb2) 559723(tgfb2l)

SRX:	107718496 107725266 107737029(tgfb2) 107758502

SANH:

107660799 107689010 107698022 107703928(tgfb2)

SGH:	107559262 107562423(tgfb2) 107589143 107598937

CCAR:

109081563(tgfb2) 109101640 109105720

CAUA:

113045114 113059794(tgfb2) 113113758 113116533

CGIB:

127970925 127974945 128026998 128030893

PTET:

122357923(tgfb5) 122360659(tgfb2)

LROH:

127176018(tgfb5) 127178652(tgfb2)

OMC:	131522136(tgfb2) 131553788(tgfb5)

PPRM:

120460645(tgfb5) 120462707(tgfb2)

RKG:	130084737(tgfb5) 130096578(tgfb2)

MAMB:

125242838(tgfb2) 125275660(tgfb5)

CIDE:

127494595 127496922

MASI:

127412895 127418235 127452537 127453885

TROS:

130549987(tgfb2) 130563435(tgfb5)

TDW:	130433538(tgfb2) 130437978(tgfb5)

MANU:

129422680(tgfb5) 129447838(tgfb2)

IPU:	108268908(tgfb5) 108269996

IFU:	128611433(tgfb5) 128612704(tgfb2)

PHYP:

113526787(tgfb2) 113528823

SMEO:

124385029(tgfb2) 124385821(tgfb5)

TFD:	113636131(tgfb5) 113644518(tgfb2)

TVC:	132845709(tgfb2) 132855840(tgfb5)

TRN:	134310529(tgfb2) 134319310(tgfb5)

AMEX:

103026112(tgfb2) 103042476

CMAO:

118806906(tgfb5) 118819641(tgfb2)

EEE:	113572191(tgfb2) 113581676

CHAR:

105905499(tgfb2) 105911025(tgfb5)

TRU:	101066787 101074584 115250449

TFS:	130531660(tgfb5) 130532398(tgfb2)

TNG:	GSTEN00011872G001 GSTEN00031190G001

LCO:	104925539 104936633(tgfb2)

NCC:

104945388

TBEN:

117470704(tgfb2) 117488821(tgfb5)

CGOB:

115014648 115021567(tgfb2)

PGEO:

117454118(tgfb5) 117460968(tgfb2)

GACU:

117543536(tgfb5) 117555508(tgfb2)

EMAC:

134859818(tgfb5) 134862041(tgfb2)

ELY:	117251444(tgfb5) 117264719(tgfb2)

EFO:	125892868(tgfb2) 125894017(tgfb5)

PLEP:

121946355(tgfb2) 121947966(tgfb5)

SLUC:

116052623(tgfb5) 116064582(tgfb2)

ECRA:

117946043(tgfb2) 117951661(tgfb5)

ESP:	116697037 116699436(tgfb2)

PFLV:

114557393(tgfb2) 114562717

GAT:	120810593(tgfb2) 120817123(tgfb5)

PPUG:

119197865(tgfb2) 119210068(tgfb5)

AFB:	129090050(tgfb5) 129110263(tgfb2)

CLUM:

117728311(tgfb2) 117737528(tgfb5)

PSWI:

130206475(tgfb2) 130209644(tgfb5)

MSAM:

119889077(tgfb5) 119896887(tgfb2)

SCHU:

122880230(tgfb5) 122880976(tgfb2)

CUD:	121515929(tgfb5)

ALAT:

119006720(tgfb2) 119008099(tgfb5)

MZE:	101466107 101469764(tgfb2)

ONL:	100690458 100707856(tgfb2)

OAU:	116317211(tgfb5) 116327679(tgfb2)

OLA:

101155037

OML:	112152993(tgfb5)

CSAI:

133447112(tgfb5)

XMA:

102223216

XCO:

114139436

XHE:

116714966

PRET:

103471446(tgfb2)

PFOR:

103136874 103136935

PLAI:

106936703 106950532(tgfb2)

PMEI:

106915805 106915806

GAF:	122836982(tgfb5)

PPRL:

129362734(tgfb5)

CVG:	107087932(tgfb2)

CTUL:

119784511(tgfb5)

GMU:	124860909(tgfb5)

NFU:

107377547

KMR:	108231423(tgfb5)

ALIM:

106515824

NWH:	119408933(tgfb5)

AOCE:

111569136(tgfb2) 111576372

MCEP:

125008120(tgfb5) 125016524(tgfb2)

CSEM:

103388748(tgfb2) 103390834

POV:	109631969(tgfb2) 109642431

SSEN:

122774279(tgfb2) 122778128(tgfb5)

HHIP:

117769623(tgfb5) 117777108(tgfb2)

HSP:	118112176(tgfb5) 118113442(tgfb2)

PPLT:

128445990(tgfb5) 128449959(tgfb2)

SMAU:

118285006(tgfb2) 118318986(tgfb5)

LCF:	108872574(tgfb5) 108886089

SDU:	111227872(tgfb2) 111232504

SLAL:

111655785 111664155(tgfb2)

XGL:	120784280(tgfb2) 120784927(tgfb5)

HCQ:	109511954 109521921(tgfb2)

SSCV:

125974957 125980128

SBIA:

133500636(tgfb2) 133509095(tgfb5)

PEE:	133401102(tgfb2) 133407580(tgfb5)

PTAO:

133479548(tgfb2) 133484883(tgfb5)

BPEC:

110158948 110159085(tgfb2)

MALB:

109956839 109973033(tgfb2)

BSPL:

114842806(tgfb2) 114864697(tgfb5)

SJO:	128362495(tgfb5) 128365749(tgfb2)

SASA:

106584161 106604392 106605021 106612106

STRU:

115168917 115175550 115177416 115205573

OTW:	112221169(tgfb5) 112223175 112234066(tgfb2) 112255920

OMY:	110489077(tgfb5) 110490140 110519367(tgfb2)

OGO:	123993600(tgfb5) 123998211 124006045(tgfb2)

ONE:	115106696 115130946 115141421

OKI:	109864860 109902227 109910338

OKE:	118364018 118367254 118381108(tgfb5)

SALP:

111965309(tgfb2) 111965954 111967092 112081109

SNH:	120031484 120047387(tgfb5) 120047527 120062054

CCLU:

121536830 121543497 121545895(tgfb5) 121585906

ELS:	105007294(tgfb2) 105026733

SFM:	108925415 108929121(tgfb2)

PKI:	111835201 111851556(tgfb2)

AANG:

118210344(tgfb2) 118222676(tgfb5) 118229069

LOC:	102682814 102683493(tgfb2)

PSPA:

121306334(tgfb5) 121315977 121317109

ARUT:

117398621 117402519 117410435 117962646

PSEX:

120539363(tgfb5)

LCM:	102352268 102358422(TGFB2)

CMK:	103185816(tgfb2)

RTP:	109911779(tgfb2) 109926035(tgfb5)

CPLA:

122552812(tgfb2)

HOC:	132814768 132819744(tgfb2)

LERI:

129699713(tgfb2)

PMRN:

116939388 116947177 116953922

LRJ:	133347010 133356237 133360030

BBEL:

109472278

CIN:	778780(tgfbeta2)

SCLV:

120336447 120336554

SPU:	115929733 588471

LPIC:

129264215

SKO:	100329003(TGFbeta2)

VDE:

111249885

VJA:

111273048

EPA:	110252767 110252794

PDAM:

113671019

AQU:

105312053

» show all

Reference

PMID:19050695

Authors

Chen YG

Title

Endocytic regulation of TGF-beta signaling.

Journal

Cell Res 19:58-70 (2009)
DOI:10.1038/cr.2008.315

Reference

PMID:15896309

Authors

Singla DK, Sun B

Title

Transforming growth factor-beta2 enhances differentiation of cardiac myocytes from embryonic stem cells.

Journal

Biochem Biophys Res Commun 332:135-41 (2005)
DOI:10.1016/j.bbrc.2005.04.098

Sequence

[hsa:7042]

Reference

PMID:3322813

Authors

de Martin R, Haendler B, Hofer-Warbinek R, Gaugitsch H, Wrann M, Schlusener H, Seifert JM, Bodmer S, Fontana A, Hofer E

Title

Complementary DNA for human glioblastoma-derived T cell suppressor factor, a novel member of the transforming growth factor-beta gene family.

Journal

EMBO J 6:3673-7 (1987)
DOI:10.1002/j.1460-2075.1987.tb02700.x

Sequence

[hsa:7042]

LinkDB

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