KEGG   ORTHOLOGY: K13384
Entry
K13384                      KO                                     
Symbol
CNMT
Name
(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase [EC:2.1.1.115 2.1.1.140]
Pathway
map00950  Isoquinoline alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00943  Reticuline biosynthesis, dopamine + 4HPAA => (S)-reticuline
Reaction
R04692  S-adenosyl-L-methionine:(S)-coclaurine-N-methyltransferase
R05211  S-adenosyl-L-methionine:(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinolie N- methyltransferase
R05216  S-adenosyl-L-methionine:(R)-norreticuline N- methyltransferase
R08794  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00950 Isoquinoline alkaloid biosynthesis
    K13384  CNMT; (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.115  (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase
     K13384  CNMT; (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase
    2.1.1.140  (S)-coclaurine-N-methyltransferase
     K13384  CNMT; (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase
Other DBs
GO: 0030776 0030794
Genes
PSOM: 113294670 113318496
MSIN: 131232654 131232758 131233314 131233577 131239546
AG: AAU20766 BAB71802(CNMT)
Reference
PMID:11682473
  Authors
Choi KB, Morishige T, Shitan N, Yazaki K, Sato F
  Title
Molecular cloning and characterization of coclaurine N-methyltransferase from cultured cells of Coptis japonica.
  Journal
J Biol Chem 277:830-5 (2002)
DOI:10.1074/jbc.M106405200
  Sequence
[ag:BAB71802]
Reference
PMID:19624470
  Authors
Liscombe DK, Ziegler J, Schmidt J, Ammer C, Facchini PJ
  Title
Targeted metabolite and transcript profiling for elucidating enzyme function: isolation of novel N-methyltransferases from three benzylisoquinoline alkaloid-producing species.
  Journal
Plant J 60:729-43 (2009)
DOI:10.1111/j.1365-313X.2009.03980.x
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