KEGG   ORTHOLOGY: K13395
Entry
K13395                      KO                                     
Symbol
CYP719A1_2_3_13
Name
(S)-stylopine/(S)-canadine/(S)-nandinine synthase [EC:1.14.19.64 1.14.19.68 1.14.19.73]
Pathway
map00950  Isoquinoline alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00945  Sanguinarine biosynthesis, (S)-reticuline => sanguinarine
M00946  Noscapine biosynthesis, (S)-reticuline => noscapine
Reaction
R04400  (S)-tetrahydrocolumbamine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (methylenedioxy-bridge-forming)
R04690  (S)-cheilanthifoline,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (methylenedioxy-bridge-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00950 Isoquinoline alkaloid biosynthesis
    K13395  CYP719A1_2_3_13; (S)-stylopine/(S)-canadine/(S)-nandinine synthase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K13395  CYP719A1_2_3_13; (S)-stylopine/(S)-canadine/(S)-nandinine synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.19  With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
    1.14.19.64  (S)-stylopine synthase
     K13395  CYP719A1_2_3_13; (S)-stylopine/(S)-canadine/(S)-nandinine synthase
    1.14.19.68  (S)-canadine synthase
     K13395  CYP719A1_2_3_13; (S)-stylopine/(S)-canadine/(S)-nandinine synthase
    1.14.19.73  (S)-nandinine synthase
     K13395  CYP719A1_2_3_13; (S)-stylopine/(S)-canadine/(S)-nandinine synthase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, plant type
  CYP719 family
   K13395  CYP719A1_2_3_13; (S)-stylopine/(S)-canadine/(S)-nandinine synthase
Other DBs
GO: 0047052 0047056 0102632
Genes
NNU: 104604446
PSOM: 113322097 113347890
MSIN: 131224026 131255012 131255027 131255031 131255053 131255539 131258159 131258160 131258162 131258168 131258169 131258172 131258174
AG: AAU20771 ABR14721(CYP719A13) BAB68769(CYP719A1) BAD98249(CYP719A3) BAD98250(CYP719A2)
Reference
PMID:15722473 (CYP719A)
  Authors
Samanani N, Park SU, Facchini PJ
  Title
Cell type-specific localization of transcripts encoding nine consecutive enzymes involved in protoberberine alkaloid biosynthesis.
  Journal
Plant Cell 17:915-26 (2005)
DOI:10.1105/tpc.104.028654
  Sequence
[ag:AAU20771]
Reference
PMID:12732624 (CYP719A1)
  Authors
Ikezawa N, Tanaka M, Nagayoshi M, Shinkyo R, Sakaki T, Inouye K, Sato F
  Title
Molecular cloning and characterization of CYP719, a methylenedioxy bridge-forming enzyme that belongs to a novel P450 family, from cultured Coptis japonica cells.
  Journal
J Biol Chem 278:38557-65 (2003)
DOI:10.1074/jbc.M302470200
  Sequence
[ag:BAB68769]
Reference
PMID:17250743 (CYP719A2 CYP719A3)
  Authors
Ikezawa N, Iwasa K, Sato F
  Title
Molecular cloning and characterization of methylenedioxy bridge-forming enzymes involved in stylopine biosynthesis in Eschscholzia californica.
  Journal
FEBS J 274:1019-35 (2007)
DOI:10.1111/j.1742-4658.2007.05652.x
  Sequence
[ag:BAD98250 BAD98249]
Reference
PMID:21094631 (CYP719A13)
  Authors
Diaz Chavez ML, Rolf M, Gesell A, Kutchan TM
  Title
Characterization of two methylenedioxy bridge-forming cytochrome P450-dependent enzymes of alkaloid formation in the Mexican prickly poppy Argemone mexicana.
  Journal
Arch Biochem Biophys 507:186-93 (2011)
DOI:10.1016/j.abb.2010.11.016
  Sequence
[ag:ABR14721]
LinkDB

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