KEGG ORTHOLOGY: K13402

ORTHOLOGY: K13402

Entry

K13402                      KO

Symbol

MTHFD1L

Name

monofunctional C1-tetrahydrofolate synthase, mitochondrial [EC:6.3.4.3]

Pathway

map00670

One carbon pool by folate

map01100

Metabolic pathways

map01240

Biosynthesis of cofactors

Module

M00141

C1-unit interconversion, eukaryotes

Reaction

R00943

formate:tetrahydrofolate ligase (ADP-forming)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    K13402  MTHFD1L; monofunctional C1-tetrahydrofolate synthase, mitochondrial
Enzymes [BR:ko01000]
6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.3  formate---tetrahydrofolate ligase
     K13402  MTHFD1L; monofunctional C1-tetrahydrofolate synthase, mitochondrial

Other DBs

GO:

0004329

Genes

HSA:	25902(MTHFD1L)

PTR:	463073(MTHFD1L)

PPS:	100983723(MTHFD1L)

PON:	100437887(MTHFD1L)

NLE:	100597135(MTHFD1L)

HMH:	116463188 116463240

MCC:	705222(MTHFD1L)

MCF:	101925793(MTHFD1L)

MTHB:

126951996

MNI:

105489167

CSAB:

103241030(MTHFD1L)

CATY:

105589024(MTHFD1L)

PANU:

101014511(MTHFD1L)

TGE:	112622729(MTHFD1L)

MLEU:

105545723(MTHFD1L)

RRO:	104678347(MTHFD1L)

RBB:	108539138(MTHFD1L)

TFN:	117097272(MTHFD1L)

PTEH:

111538624(MTHFD1L)

CANG:

105513029(MTHFD1L)

CJC:	100395925(MTHFD1L)

SBQ:	101041831(MTHFD1L)

CIMI:

108311655(MTHFD1L)

CSYR:

103275880(MTHFD1L)

MMUR:

105858056(MTHFD1L)

LCAT:

123633371(MTHFD1L)

PCOQ:

105819345(MTHFD1L)

OGA:	100957047(MTHFD1L)

MMU:	270685(Mthfd1l)

MCAL:

110302870(Mthfd1l)

MPAH:

110337874(Mthfd1l)

RNO:	361472(Mthfd1l)

MCOC:

116076955(Mthfd1l)

ANU:	117700238(Mthfd1l)

MUN:	110552873(Mthfd1l)

CGE:	100767336(Mthfd1l)

MAUA:

101834424(Mthfd1l)

PROB:

127237645(Mthfd1l)

PLEU:

114683851(Mthfd1l)

MORG:

121466552(Mthfd1l)

MFOT:

126497628

AAMP:

119821424(Mthfd1l)

NGI:	103745750(Mthfd1l)

HGL:	101720005(Mthfd1l)

CPOC:

100733031(Mthfd1l)

CCAN:

109694193(Mthfd1l)

DORD:

105993618(Mthfd1l)

DSP:	122101509(Mthfd1l)

PLOP:

125357407(Mthfd1l)

NCAR:

124989689

MMMA:

107152463(Mthfd1l)

OCU:

100343064

OPI:	101523974(MTHFD1L)

TUP:	102484216(MTHFD1L)

GVR:	103585504(MTHFD1L)

CFA:	476245(MTHFD1L)

CLUD:

112644303(MTHFD1L)

VVP:	112919521(MTHFD1L)

VLG:	121484852(MTHFD1L)

NPO:	129500790(MTHFD1L)

AML:	100477350(MTHFD1L)

UMR:	103666965(MTHFD1L)

UAH:	113259560(MTHFD1L)

UAR:	123797451(MTHFD1L)

ELK:

111158692

LLV:

125102359

MPUF:

101678361(MTHFD1L)

MNP:	132018393(MTHFD1L)

MLK:	131833460(MTHFD1L)

NVS:	122903311(MTHFD1L)

ORO:	101377610(MTHFD1L)

EJU:	114209314(MTHFD1L)

ZCA:	113927029(MTHFD1L) 113935598

MLX:	118001069(MTHFD1L)

NSU:	110583063(MTHFD1L)

LWW:	102735769(MTHFD1L)

FCA:	101082751(MTHFD1L)

PYU:	121013315(MTHFD1L)

PCOO:

112861995(MTHFD1L)

PBG:	122490097(MTHFD1L)

PVIV:

125165391(MTHFD1L)

LRUF:

124528810

PTG:	102969144(MTHFD1L)

PPAD:

109256410(MTHFD1L)

PUC:

125938027

AJU:

106976246

HHV:	120237575(MTHFD1L)

BTA:	534296(MTHFD1L)

BOM:	102266073(MTHFD1L)

BIU:	109563582(MTHFD1L)

BBUB:

102410735(MTHFD1L)

BBIS:

104989210(MTHFD1L)

CHX:	102188948(MTHFD1L)

OAS:	101102245(MTHFD1L)

BTAX:

128053076(MTHFD1L)

ODA:	120862615(MTHFD1L)

CCAD:

122433889(MTHFD1L)

MBEZ:

129560871(MTHFD1L)

SSC:	100154722(MTHFD1L)

CFR:	102504672(MTHFD1L)

CBAI:

105077324(MTHFD1L)

CDK:	105100923(MTHFD1L)

VPC:	102529887(MTHFD1L)

BACU:

103016509

BMUS:

118904916(MTHFD1L)

LVE:

103076725

OOR:	101280612(MTHFD1L)

DLE:	111166931(MTHFD1L)

PCAD:

102983699(MTHFD1L)

PSIU:

116763633(MTHFD1L)

NASI:

112401650(MTHFD1L)

ECB:	100063441(MTHFD1L)

EPZ:	103548986(MTHFD1L)

EAI:	106837310(MTHFD1L)

MYB:	102260498(MTHFD1L)

MYD:	102765614(MTHFD1L)

MMYO:

118659910(MTHFD1L)

MLF:

102429354

PKL:	118705373(MTHFD1L)

EFUS:

103301595(MTHFD1L)

MNA:	107535962(MTHFD1L)

DRO:	112297123(MTHFD1L)

SHON:

118989429(MTHFD1L)

AJM:	119057903(MTHFD1L)

PDIC:

114495349(MTHFD1L)

PHAS:

123822141(MTHFD1L)

MMF:	118621011(MTHFD1L)

PPAM:

129067849(MTHFD1L)

HAI:	109380892(MTHFD1L)

RFQ:	117020545(MTHFD1L)

PALE:

102880268(MTHFD1L)

PGIG:

120593485(MTHFD1L)

PVP:	105293847(MTHFD1L)

RAY:	107513022(MTHFD1L)

MJV:	108405588(MTHFD1L)

TOD:	119253022(MTHFD1L)

SARA:

101550125(MTHFD1L)

SETR:

125996421(MTHFD1L)

LAV:	100672390(MTHFD1L)

TMU:

101346017

ETF:	101653449(MTHFD1L)

DNM:	101419640(MTHFD1L)

MDO:	100032106(MTHFD1L)

GAS:	123243655(MTHFD1L)

SHR:	100913689(MTHFD1L)

AFZ:

127562325

PCW:	110208546(MTHFD1L)

OAA:	100074148(MTHFD1L)

GGA:	421633(MTHFD1L)

PCOC:

116241409(MTHFD1L)

MGP:	100542162(MTHFD1L)

CJO:	107311546(MTHFD1L)

TPAI:

128082898(MTHFD1L)

LMUT:

125689223(MTHFD1L)

NMEL:

110395592(MTHFD1L)

APLA:

101793128(MTHFD1L)

ACYG:

106034225(MTHFD1L)

CATA:

118244152(MTHFD1L)

AFUL:

116487333(MTHFD1L)

TGU:	100224764(MTHFD1L)

LSR:	110476032(MTHFD1L)

SCAN:

103820617(MTHFD1L)

PMOA:

120501351(MTHFD1L)

OTC:	121346245(MTHFD1L)

PRUF:

121354963(MTHFD1L)

GFR:	102039432(MTHFD1L)

FAB:	101810287(MTHFD1L)

OMA:	130250510(MTHFD1L)

PHI:	102103116(MTHFD1L)

PMAJ:

107202026(MTHFD1L)

CCAE:

111926699(MTHFD1L)

CCW:	104693880(MTHFD1L)

CBRC:

103619446(MTHFD1L)

ETL:	114061116(MTHFD1L)

ZAB:	102070243(MTHFD1L)

ACHL:

103799113

SVG:	106851872(MTHFD1L)

MMEA:

130579265(MTHFD1L)

HRT:	120750744(MTHFD1L)

FPG:	101914730(MTHFD1L)

FCH:	102049730(MTHFD1L)

CLV:	102090180(MTHFD1L)

EGZ:	104133557(MTHFD1L)

NNI:	104013796(MTHFD1L)

EHS:	104513976(MTHFD1L)

PCAO:

104041839(MTHFD1L)

ACUN:

113478659(MTHFD1L)

TALA:

104367930(MTHFD1L)

PADL:

103917054(MTHFD1L)

AFOR:

103900779(MTHFD1L)

ACHC:

115345034(MTHFD1L)

HLE:	104840745(MTHFD1L)

AGEN:

126038875

GCL:

127014556

CSTI:

104550267(MTHFD1L)

BREG:

104641388

GSTE:

104258696

LDI:	104348336(MTHFD1L)

MNB:	103773054(MTHFD1L)

OHA:	104328703(MTHFD1L)

NNT:

104410663

SHAB:

115613849(MTHFD1L)

DPUB:

104297172(MTHFD1L)

PGUU:

104472145(MTHFD1L)

ACAR:

104529901

CPEA:

104390799(MTHFD1L)

AVIT:

104278284

CVF:	104285588(MTHFD1L)

RTD:	128906697(MTHFD1L)

CUCA:

104062276(MTHFD1L)

TEO:	104382087(MTHFD1L)

BRHI:

104498294

AAM:	106496896(MTHFD1L)

AROW:

112974666(MTHFD1L)

NPD:	112951670(MTHFD1L)

TGT:	104577353(MTHFD1L)

DNE:	112996597(MTHFD1L)

SCAM:

104140153(MTHFD1L)

ASN:

102382003

AMJ:	106736958(MTHFD1L)

CPOO:

109320115(MTHFD1L)

GGN:	109304727(MTHFD1L)

PSS:	102448225(MTHFD1L)

CMY:	102934023(MTHFD1L)

CCAY:

125634058(MTHFD1L)

DCC:	119852794(MTHFD1L)

CPIC:

101936119(MTHFD1L)

TST:	117874841(MTHFD1L)

CABI:

116825987(MTHFD1L)

MRV:	120400820(MTHFD1L)

ACS:	100551820(mthfd1l)

ASAO:

132761057(MTHFD1L)

PVT:	110082112(MTHFD1L)

SUND:

121918875(MTHFD1L)

PBI:	103057636(MTHFD1L)

PMUR:

107292712(MTHFD1L)

CTIG:

120309556(MTHFD1L)

TSR:	106552377(MTHFD1L)

PGUT:

117666365(MTHFD1L)

APRI:

131191454(MTHFD1L)

PTEX:

113439686(MTHFD1L)

NSS:	113411275(MTHFD1L)

VKO:	123019737(MTHFD1L)

PMUA:

114594251(MTHFD1L)

PRAF:

128410655(MTHFD1L)

ZVI:	118082011(MTHFD1L)

HCG:	128343373(MTHFD1L)

GJA:	107123003(MTHFD1L)

STOW:

125428547(MTHFD1L)

EMC:	129335537(MTHFD1L)

XLA:	108716671(mthfd1l.L)

XTR:	100145211(mthfd1l)

NPR:	108796152(MTHFD1L)

RTEM:

120937542(MTHFD1L)

BBUF:

120998728(MTHFD1L)

BGAR:

122936228(MTHFD1L)

MUO:	115464748(MTHFD1L)

GSH:	117357673(MTHFD1L)

DRE:	100034522(mthfd1l)

SRX:	107711640 107721348

SANH:

107659212 107665399

SGH:	107555742 107556131

CCAR:

109113007

CAUA:

113063150 113077461

CGIB:

127938841 127983618

PTET:

122325365(mthfd1l)

LROH:

127182782(mthfd1l)

OMC:	131527422(mthfd1l)

PPRM:

120494164(mthfd1l)

RKG:	130091819(mthfd1l)

MAMB:

125277897(mthfd1l)

CIDE:

127502967

MASI:

127410335 127415620

TROS:

130566120(mthfd1l)

TDW:	130434287(mthfd1l)

MANU:

129429518(mthfd1l)

IPU:

108257638

IFU:	128600917(mthfd1l)

PHYP:

113532344(mthfd1l)

SMEO:

124376981(mthfd1l)

TFD:	113653767(mthfd1l)

TVC:	132843052(mthfd1l)

TRN:	134320144(mthfd1l)

AMEX:

103042511(mthfd1l)

CMAO:

118815701(mthfd1l)

EEE:	113570409(mthfd1l)

CHAR:

105909492(mthfd1l)

TRU:	101064259(mthfd1l)

TFS:	130515796(mthfd1l)

TNG:	GSTEN00023066G001

LCO:	104928886(mthfd1l)

NCC:	104962356(mthfd1l)

TBEN:

117492566(mthfd1l)

PGEO:

117439909(mthfd1l)

GACU:

117537532(mthfd1l)

EMAC:

134877245(mthfd1l)

ELY:	117270383(mthfd1l) 117271150

EFO:	125897258(mthfd1l)

PLEP:

121955373(mthfd1l)

SLUC:

116066211(mthfd1l)

ECRA:

117961440(mthfd1l)

ESP:	116705830(mthfd1l)

PFLV:

114573076(mthfd1l)

GAT:	120808165(mthfd1l)

PPUG:

119195375(mthfd1l)

AFB:	129106870(mthfd1l)

CLUM:

117727042(mthfd1l)

PSWI:

130202894(mthfd1l)

MSAM:

119909050(mthfd1l) 119909357

SCHU:

122863184(mthfd1l)

CUD:	121521863(mthfd1l)

ALAT:

119012889(mthfd1l)

MZE:	101482183(mthfd1l)

ONL:	100699583(mthfd1l)

OAU:	116310749(mthfd1l)

OLA:	101162177(mthfd1l)

OML:	112158276(mthfd1l)

CSAI:

133464902(mthfd1l)

XMA:	102230963(mthfd1l)

XCO:	114158873(mthfd1l)

XHE:	116733893(mthfd1l)

PRET:

103457517(mthfd1l)

PFOR:

103134842(mthfd1l)

PLAI:

106946719(mthfd1l)

PMEI:

106934223

GAF:	122825506(mthfd1l)

PPRL:

129352476(mthfd1l)

CVG:	107101868(mthfd1l)

CTUL:

119781255(mthfd1l)

GMU:	124882338(mthfd1l)

NFU:	107377559(mthfd1l)

KMR:	108240097(mthfd1l)

ALIM:

106519788(mthfd1l)

NWH:	119418227(mthfd1l)

AOCE:

111574965

MCEP:

124999073(mthfd1l)

CSEM:

103381100

POV:	109636111(mthfd1l)

SSEN:

122784486(mthfd1l)

HHIP:

117757953(mthfd1l)

HSP:	118099366(mthfd1l)

PPLT:

128460518(mthfd1l)

SMAU:

118290110(mthfd1l)

LCF:

108880921

SDU:	111238474(mthfd1l)

SLAL:

111655585(mthfd1l)

XGL:	120788805(mthfd1l)

HCQ:

109527607

SSCV:

125989947

SBIA:

133496606(mthfd1l)

PEE:	133416872(mthfd1l)

PTAO:

133467980(mthfd1l)

BPEC:

110153231(mthfd1l)

MALB:

109953407(mthfd1l)

BSPL:

114849645(mthfd1l)

SJO:	128377257(mthfd1l)

SASA:

100306829(mthfd1l)

STRU:

115180582(mthfd1l)

OTW:	112217716(mthfd1l)

OMY:	110522392(mthfd1l)

OGO:	123995235(mthfd1l)

ONE:	115139267(mthfd1l)

OKI:	109866478(mthfd1l)

OKE:	118373790(mthfd1l)

SALP:

111972649(mthfd1l)

SNH:	120019072(mthfd1l)

CCLU:

121548779(mthfd1l)

ELS:	105017489(mthfd1l)

SFM:	108920486(mthfd1l)

PKI:	111856751(mthfd1l)

AANG:

118228770(mthfd1l)

LOC:	102682285(mthfd1l)

PSPA:

121316958(mthfd1l)

ARUT:

117402512 117410603(mthfd1l)

PSEX:

120525476(mthfd1l)

LCM:	102356084(MTHFD1L)

CMK:	103179237(mthfd1l)

CPLA:

122553269(mthfd1l)

HOC:	132819502(mthfd1l)

LERI:

129699344(mthfd1l)

LRJ:	133356275 133356276

ABRU:

129966028

SDM:

118192031

» show all

Reference

PMID:12937168

Authors

Prasannan P, Pike S, Peng K, Shane B, Appling DR

Title

Human mitochondrial C1-tetrahydrofolate synthase: gene structure, tissue distribution of the mRNA, and immunolocalization in Chinese hamster ovary calls.

Journal

J Biol Chem 278:43178-87 (2003)
DOI:10.1074/jbc.M304319200

Sequence

[hsa:25902]

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