Entry
Symbol
trpCF
Name
indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase [EC:
4.1.1.48 5.3.1.24 ]
Pathway
map00400 Phenylalanine, tyrosine and tryptophan biosynthesis
map01110 Biosynthesis of secondary metabolites
Module
M00023 Tryptophan biosynthesis, chorismate => tryptophan
Reaction
R03508 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase(cyclizing)
R03509 N-(5-phospho-beta-D-ribosyl)anthranilate ketol-isomerase
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09100 Metabolism
09105 Amino acid metabolism
00400 Phenylalanine, tyrosine and tryptophan biosynthesis
K13498 trpCF; indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase
Enzymes [BR:ko01000 ]
4. Lyases
4.1 Carbon-carbon lyases
4.1.1 Carboxy-lyases
4.1.1.48 indole-3-glycerol-phosphate synthase
K13498 trpCF; indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase
5. Isomerases
5.3 Intramolecular oxidoreductases
5.3.1 Interconverting aldoses and ketoses, and related compounds
5.3.1.24 phosphoribosylanthranilate isomerase
K13498 trpCF; indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase
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Reference
Authors
Kirschner K, Szadkowski H, Henschen A, Lottspeich F
Title
Limited proteolysis of N-(5'-phosphoribosyl)anthranilate isomerase: indoleglycerol phosphate synthase from Escherichia coli yields two different enzymically active, functional domains.
Journal
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