KEGG ORTHOLOGY: K13515

ORTHOLOGY: K13515

Entry

K13515                      KO

Symbol

LPCAT3, MBOAT5

Name

lysophospholipid acyltransferase 5 [EC:2.3.1.23 2.3.1.-]

Pathway

map00564

Glycerophospholipid metabolism

map04216

Ferroptosis

Reaction

R01318

acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase

R04480

acyl-CoA:1-acyl-sn-glycero-3-phosphoethanolamine O-acyltransferase

R09035

acyl-CoA:1-acyl-sn-glycero-3-phosphoserine O-acyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00564 Glycerophospholipid metabolism
    K13515  LPCAT3, MBOAT5; lysophospholipid acyltransferase 5
09140 Cellular Processes
  09143 Cell growth and death
   04216 Ferroptosis
    K13515  LPCAT3, MBOAT5; lysophospholipid acyltransferase 5
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K13515  LPCAT3, MBOAT5; lysophospholipid acyltransferase 5
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.23  1-acylglycerophosphocholine O-acyltransferase
     K13515  LPCAT3, MBOAT5; lysophospholipid acyltransferase 5
Lipid biosynthesis proteins [BR:ko01004]
Phospholipid acyltransferase
  LPAAT/LPLAT
   K13515  LPCAT3, MBOAT5; lysophospholipid acyltransferase 5

Other DBs

GO:

0047184

Genes

HSA:	10162(LPCAT3)

PTR:	451807(LPCAT3)

PPS:	100991640(LPCAT3)

GGO:	101138654(LPCAT3)

PON:	100449193(LPCAT3)

NLE:	100598156(LPCAT3)

HMH:	116472615(LPCAT3)

MCC:	714639(LPCAT3)

MCF:	102135286(LPCAT3)

MTHB:

126930470

MNI:	105484219(LPCAT3)

CSAB:

103218496(LPCAT3)

CATY:

105583048(LPCAT3)

PANU:

101001677(LPCAT3)

TGE:	112635582(LPCAT3)

MLEU:

105541813(LPCAT3)

RRO:	104680083(LPCAT3)

RBB:	108542026(LPCAT3)

TFN:	117090596(LPCAT3)

PTEH:

111555960(LPCAT3)

CANG:

105519121(LPCAT3)

CJC:	100411203(LPCAT3)

SBQ:	101034415(LPCAT3)

CIMI:

108294989(LPCAT3)

CSYR:

103252209(LPCAT3) 103270796

MMUR:

105868986(LPCAT3)

LCAT:

123640086(LPCAT3)

PCOQ:

105805033(LPCAT3)

OGA:	100946424(LPCAT3)

MMU:	14792(Lpcat3)

MCAL:

110296068(Lpcat3)

MPAH:

110315974(Lpcat3)

RNO:	362434(Lpcat3)

MCOC:

116099567(Lpcat3)

ANU:	117715134(Lpcat3)

MUN:	110548605(Lpcat3)

CGE:	100768200(Lpcat3)

MAUA:

101822631(Lpcat3)

PROB:

127213040(Lpcat3)

PLEU:

114708771(Lpcat3)

MORG:

121435332(Lpcat3)

MFOT:

126514924

AAMP:

119806856(Lpcat3)

NGI:	103727490(Lpcat3)

HGL:	101696621(Lpcat3)

CPOC:

100722595(Lpcat3)

CCAN:

109682815(Lpcat3)

DORD:

105991023(Lpcat3)

DSP:	122101961(Lpcat3)

NCAR:

124981991

MMMA:

107154927(Lpcat3)

OCU:

100342288

OPI:	101519079(LPCAT3)

TUP:	102497710(LPCAT3)

GVR:	103586394(LPCAT3)

CFA:	486715(LPCAT3)

CLUD:

112675372(LPCAT3)

VVP:	112917319(LPCAT3)

VLG:	121479931(LPCAT3)

NPO:	129503353(LPCAT3)

AML:	100472770(LPCAT3)

UMR:	103656177(LPCAT3)

UAH:	113257946(LPCAT3)

UAR:	123781536(LPCAT3)

ELK:

111159817

LLV:

125106462

MPUF:

101677439(LPCAT3)

MNP:	132019899(LPCAT3)

MLK:	131838477(LPCAT3)

NVS:	122892239(LPCAT3)

ORO:	101375900(LPCAT3)

EJU:	114222493(LPCAT3)

ZCA:	113922155(LPCAT3)

MLX:	118025714(LPCAT3)

NSU:	110580863(LPCAT3)

LWW:	102736683(LPCAT3)

FCA:	101088419(LPCAT3)

PYU:	121021914(LPCAT3)

PCOO:

112867600(LPCAT3)

PBG:	122472393(LPCAT3)

PVIV:

125170246(LPCAT3)

LRUF:

124501754

PTG:	102949335(LPCAT3)

PPAD:

109276090(LPCAT3)

PUC:

125918795

AJU:

106965339

HHV:	120220455(LPCAT3)

BTA:	515361(LPCAT3)

BOM:	102284746(LPCAT3)

BIU:	109558904(LPCAT3)

BBUB:

102392030(LPCAT3)

BBIS:

104992166(LPCAT3)

CHX:	102190030(LPCAT3)

OAS:	101108119(LPCAT3)

BTAX:

128047682(LPCAT3)

ODA:	120858749(LPCAT3)

CCAD:

122423317(LPCAT3)

MBEZ:

129535794(LPCAT3)

SSC:	100627653(LPCAT3)

CFR:	102516118(LPCAT3)

CBAI:

105075356(LPCAT3)

CDK:	105098189(LPCAT3)

VPC:	102534025(LPCAT3)

BACU:

103004749(LPCAT3)

BMUS:

118901656(LPCAT3)

LVE:	103085861(LPCAT3)

OOR:	101290229(LPCAT3)

DLE:	111176704(LPCAT3)

PCAD:

102986639(LPCAT3)

PSIU:

116760133(LPCAT3)

NASI:

112391725(LPCAT3)

ECB:	100053035(LPCAT3)

EPZ:	103547035(LPCAT3)

EAI:	106847310(LPCAT3)

MYB:	102256221(LPCAT3)

MYD:	102755432(LPCAT3)

MMYO:

118652147(LPCAT3)

MLF:	102432591(LPCAT3)

PKL:	118730586(LPCAT3)

EFUS:

103289039(LPCAT3)

MNA:	107544065(LPCAT3)

DRO:	112321652(LPCAT3)

SHON:

119002525(LPCAT3)

AJM:	119065666(LPCAT3)

PDIC:

114513020(LPCAT3)

PHAS:

123810597(LPCAT3)

MMF:	118623867(LPCAT3)

PPAM:

129085047(LPCAT3)

HAI:	109373659(LPCAT3)

RFQ:	117028518(LPCAT3)

PALE:

102896872(LPCAT3)

PGIG:

120611675(LPCAT3)

PVP:	105295938(LPCAT3)

RAY:	107519812(LPCAT3)

MJV:	108384827(LPCAT3)

TOD:	119247762(LPCAT3)

SARA:

101546809(LPCAT3)

SETR:

126006670(LPCAT3)

LAV:	100653557(LPCAT3)

TMU:

101358882

ETF:	101641317(LPCAT3)

DNM:	101438754(LPCAT3)

MDO:	100016730(LPCAT3)

GAS:	123250432(LPCAT3)

SHR:	100924769(LPCAT3)

AFZ:

127538872

PCW:	110213735(LPCAT3)

OAA:	100084970(LPCAT3)

GGA:	418293(LPCAT3)

PCOC:

116240007(LPCAT3)

MGP:	100541281(LPCAT3)

CJO:	107318603(LPCAT3)

TPAI:

128089884(LPCAT3)

LMUT:

125685270(LPCAT3)

NMEL:

110398277(LPCAT3)

APLA:

101791589(LPCAT3)

ACYG:

106047840(LPCAT3)

CATA:

118247560(LPCAT3)

AFUL:

116501519(LPCAT3)

TGU:	100225934(LPCAT3)

LSR:	110480844(LPCAT3)

SCAN:

103812467(LPCAT3)

PMOA:

120506356(LPCAT3)

OTC:	121339189(LPCAT3)

PRUF:

121351520(LPCAT3)

GFR:	102041216(LPCAT3)

FAB:	101812408(LPCAT3)

OMA:	130250669(LPCAT3)

PHI:	102112295(LPCAT3)

PMAJ:

107207104(LPCAT3)

CCAE:

111938172(LPCAT3)

CCW:	104687134(LPCAT3)

CBRC:

103613959(LPCAT3)

ETL:	114058147(LPCAT3)

ZAB:	102071586(LPCAT3)

ZLE:	135453089(LPCAT3)

ACHL:

103804628(LPCAT3)

SVG:	106857863(LPCAT3)

MMEA:

130574788(LPCAT3)

HRT:	120748715(LPCAT3)

FPG:	101919880(LPCAT3)

FCH:	102054777(LPCAT3)

CLV:	102085502(LPCAT3)

EGZ:	104126543(LPCAT3)

NNI:	104009773(LPCAT3)

PCRI:

104032055(LPCAT3)

PLET:

104614869(LPCAT3)

EHS:	104515161(LPCAT3)

PCAO:

104047336(LPCAT3)

ACUN:

113479859(LPCAT3)

TALA:

104361018(LPCAT3)

PADL:

103920887(LPCAT3)

AFOR:

103905458(LPCAT3)

ACHC:

115343496(LPCAT3)

HALD:

104311505(LPCAT3)

HLE:	104831869(LPCAT3)

AGEN:

126049018

GCL:

127025618

CCRI:

104161371(LPCAT3)

CSTI:

104551092(LPCAT3)

CMAC:

104481544(LPCAT3)

MUI:	104543683(LPCAT3)

BREG:

104643452(LPCAT3)

FGA:	104070714(LPCAT3)

GSTE:

104251732(LPCAT3)

LDI:	104340969(LPCAT3)

MNB:	103781925(LPCAT3)

OHA:	104327131(LPCAT3)

NNT:	104410202(LPCAT3)

SHAB:

115601498(LPCAT3)

DPUB:

104299456(LPCAT3)

PGUU:

104466485(LPCAT3)

ACAR:

104521237(LPCAT3)

CPEA:

104389835(LPCAT3)

AVIT:

104272663(LPCAT3)

CVF:	104293361(LPCAT3)

RTD:	128904226(LPCAT3)

CUCA:

104064393(LPCAT3)

TEO:	104382484(LPCAT3)

BRHI:

104491855(LPCAT3)

AAM:	106497265(LPCAT3)

AROW:

112972990(LPCAT3)

NPD:	112945570(LPCAT3)

TGT:	104565674(LPCAT3)

DNE:	112991067(LPCAT3)

SCAM:

104150755(LPCAT3)

ASN:	102373866(LPCAT3)

AMJ:	102571041(LPCAT3)

CPOO:

109319375(LPCAT3)

GGN:	109304344(LPCAT3)

PSS:	102460515(LPCAT3)

CMY:	102933144(LPCAT3)

CCAY:

125622681(LPCAT3)

DCC:	119850427(LPCAT3)

CPIC:

101944358(LPCAT3)

TST:	117885635(LPCAT3)

CABI:

116821042(LPCAT3)

MRV:	120401912(LPCAT3)

ACS:	100560524(lpcat3)

ASAO:

132767525(LPCAT3)

PVT:	110084653(LPCAT3)

SUND:

121920953(LPCAT3)

PBI:	103065282(LPCAT3)

PMUR:

107285779(LPCAT3)

CTIG:

120306113(LPCAT3)

TSR:	106553376(LPCAT3)

PGUT:

117661829(LPCAT3)

APRI:

131193688(LPCAT3)

PTEX:

113444542(LPCAT3)

NSS:	113424520(LPCAT3)

VKO:	123033178(LPCAT3)

PMUA:

114587355(LPCAT3)

PRAF:

128404594(LPCAT3)

ZVI:	118097600(LPCAT3)

HCG:	128342823(LPCAT3)

GJA:	107116802(LPCAT3)

STOW:

125436264(LPCAT3)

EMC:	129345384(LPCAT3)

XLA:	447297(lpcat3.S) 496208(lpcat3.L)

XTR:	100498491(lpcat3)

NPR:	108784381(LPCAT3)

RTEM:

120922640 120922804

BBUF:

121004774(LPCAT3)

BGAR:

122940703(LPCAT3)

MUO:	115457594(LPCAT3)

GSH:	117350136(LPCAT3)

DRE:	555566(lpcat3)

SRX:	107724688 107744283

SANH:

107672973 107700199

SGH:	107549488 107598391

CCAR:

109048698 109081746 109103987

CAUA:

113059962 113116386

CGIB:

127974887 128031117

PTET:

122360252(lpcat3)

LROH:

127178136(lpcat3)

OMC:	131522385(lpcat3)

PPRM:

120484452(lpcat3)

RKG:	130103633(lpcat3)

MAMB:

125242878(lpcat3)

CIDE:

127496650

MASI:

127452727 127453959

TROS:

130558466(lpcat3)

TDW:	130433491(lpcat3)

MANU:

129447877(lpcat3)

IPU:

108266630

IFU:	128608113(lpcat3)

PHYP:

113542576(lpcat3)

SMEO:

124384673(lpcat3)

TFD:	113643470(lpcat3)

TVC:	132846099(lpcat3)

TRN:	134310941(lpcat3)

AMEX:

103027610(lpcat3)

CMAO:

118824861(lpcat3)

EEE:	113570654(lpcat3)

CHAR:

116222417(lpcat3)

TRU:	101074488 115246527

TFS:	130532971(lpcat3)

TNG:	GSTEN00015319G001

LCO:	104932537(lpcat3)

NCC:	104949837(lpcat3)

TBEN:

117494795(lpcat3)

PGEO:

117461147(lpcat3)

GACU:

117551822(lpcat3)

EMAC:

134861265(lpcat3)

ELY:	117265231(lpcat3)

EFO:	125893134(lpcat3)

PLEP:

121945266(lpcat3)

SLUC:

116049723(lpcat3)

ECRA:

117946238(lpcat3)

ESP:	116691254(lpcat3)

PFLV:

114557494(lpcat3)

GAT:	120810839(lpcat3)

PPUG:

119197244(lpcat3)

AFB:	129109538(lpcat3)

CLUM:

117745463(lpcat3)

PSWI:

130213460(lpcat3)

MSAM:

119897419(lpcat3)

SCHU:

122882047(lpcat3)

CUD:	121513611(lpcat3)

ALAT:

119006347(lpcat3)

MZE:	101482416(lpcat3)

ONL:	100707556(lpcat3)

OAU:	116323778(lpcat3)

OLA:	101154975(lpcat3)

OML:	112143673(lpcat3)

CSAI:

133435081(lpcat3)

XMA:	102235292(lpcat3)

XCO:	114141521(lpcat3)

XHE:	116717590(lpcat3)

PRET:

103477986(lpcat3)

PFOR:

103136761(lpcat3)

PLAI:

106951130(lpcat3)

PMEI:

106927919(lpcat3)

GAF:	122830991(lpcat3)

PPRL:

129371286(lpcat3)

CVG:	107082155(lpcat3)

CTUL:

119783074(lpcat3)

GMU:	124865489(lpcat3)

NFU:	107379474(lpcat3)

KMR:	108235414(lpcat3)

ALIM:

106521062(lpcat3)

NWH:	119409343(lpcat3)

AOCE:

111571075(lpcat3)

MCEP:

125015833(lpcat3)

CSEM:

103387963(lpcat3)

POV:	109633281(lpcat3)

SSEN:

122774911(lpcat3)

HHIP:

117776804(lpcat3)

HSP:	118113202(lpcat3)

PPLT:

128449644(lpcat3)

SMAU:

118315082(lpcat3)

LCF:

108880739

SDU:	111230069(lpcat3)

SLAL:

111669906(lpcat3)

XGL:	120784095(lpcat3)

HCQ:	109515376(lpcat3)

SSCV:

125975726

SBIA:

133500715(lpcat3)

PEE:	133401411(lpcat3)

PTAO:

133479248(lpcat3)

BPEC:

110163017(lpcat3)

MALB:

109966229(lpcat3)

BSPL:

114842935(lpcat3)

SJO:	128365843(lpcat3)

SASA:

106583352 106605098

STRU:

115176530 115177274

OTW:	112223113 112246549

OMY:	110489329 110517876

OGO:	123997564 124006388

ONE:	115105805 115141326

OKI:	109902177 109910315

OKE:	118364249 118367323

SALP:

111959007 111965224

SNH:	120030861 120048308

CCLU:

121562191(lpcat3)

ELS:	105028246(lpcat3)

SFM:	108922088(lpcat3)

PKI:	111835371(lpcat3)

AANG:

118211506(lpcat3)

LOC:	102689232(lpcat3)

PSPA:

121296490 121325743

ARUT:

117425742(lpcat3)

PSEX:

120535734(lpcat3)

LCM:	102355729(LPCAT3)

PMRN:

116958284(LPCAT3)

BFO:	118430670 118430917

BBEL:

109479765 109487511

CIN:

100186495

SCLV:

120328699

SPU:	100892797 115924721 580778 593457

LPIC:

129276376 129276416 129276432

APLC:

110986527 110986541

SKO:

102809751

DME:	Dmel_CG9655(nes)

DER:

6545256

DSE:

6618397

DSI:	Dsimw501_GD12294(Dsim_GD12294)

DYA:	Dyak_GE22515 Dyak_GE22919

DAN:

6493642

DSR:

110190107

DPO:	4811983 6903581

DPE:	6593954 6602379

DMN:	108151961 108164308

DWI:

6643093

DGR:

6557712

DMO:	Dmoj_GI13549

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:	119670443 119672339

MDE:

101889232

SCAC:

106089973

LCQ:

111683816

LSQ:	119612795 119613185

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ005745

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_212571

BANY:

MJU:

NIQ:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

PXY:

PGW:

LGLY:

CFEL:

CCRN:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:	128989594 128989636

PHU:	Phum_PHUM575140

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_195061

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:	111701929 111713988

LSM:	121117693 121121772

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:	124492885 124494780

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

106457170 106465673 106466051

CEL:	CELE_R155.1(mboa-6)

CBR:

CBG_11740

CRQ:	GCK72_011592

NAI:	NECAME_06368 NECAME_16493

BMY:	BM_BM5438(Bma-mboa-6)

LOA:	LOAG_07382

HRO:	HELRODRAFT_167215

LGI:	LOTGIDRAFT_105367

PVUL:

PCAN:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

DPOL:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_169040

SHX:	MS3_00010784(LPCAT3)

OVI:	T265_05273

LLON:

135497172

NVE:	116621119 5501573

EPA:	110245373 110249007

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

HMG:

HSY:	130641959 130641960

TAD:	TRIADDRAFT_57452 TRIADDRAFT_57453

» show all

Reference

PMID:19351971

Authors

Jain S, Zhang X, Khandelwal PJ, Saunders AJ, Cummings BS, Oelkers P

Title

Characterization of human lysophospholipid acyltransferase 3.

Journal

J Lipid Res 50:1563-70 (2009)
DOI:10.1194/jlr.M800398-JLR200

Reference

PMID:18287005

Authors

Hishikawa D, Shindou H, Kobayashi S, Nakanishi H, Taguchi R, Shimizu T

Title

Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity.

Journal

Proc Natl Acad Sci U S A 105:2830-5 (2008)
DOI:10.1073/pnas.0712245105

Sequence

[mmu:14792]

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