KEGG ORTHOLOGY: K13547

ORTHOLOGY: K13547

Entry

K13547                      KO

Symbol

btrR, neoB, kanB

Name

L-glutamine:2-deoxy-scyllo-inosose/3-amino-2,3-dideoxy-scyllo-inosose aminotransferase [EC:2.6.1.100 2.6.1.101]

Pathway

map00524

Neomycin, kanamycin and gentamicin biosynthesis

map01110

Biosynthesis of secondary metabolites

Reaction

R08890

L-glutamine:2-deoxy-scyllo-inosose aminotransferase

R08891

L-glutamine:3-amino-2,3-dideoxy-scyllo-inosose aminotransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00524 Neomycin, kanamycin and gentamicin biosynthesis
    K13547  btrR, neoB, kanB; L-glutamine:2-deoxy-scyllo-inosose/3-amino-2,3-dideoxy-scyllo-inosose aminotransferase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01007 Amino acid related enzymes
    K13547  btrR, neoB, kanB; L-glutamine:2-deoxy-scyllo-inosose/3-amino-2,3-dideoxy-scyllo-inosose aminotransferase
Enzymes [BR:ko01000]
2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.100  L-glutamine:2-deoxy-scyllo-inosose aminotransferase
     K13547  btrR, neoB, kanB; L-glutamine:2-deoxy-scyllo-inosose/3-amino-2,3-dideoxy-scyllo-inosose aminotransferase
    2.6.1.101  L-glutamine:3-amino-2,3-dideoxy-scyllo-inosose aminotransferase
     K13547  btrR, neoB, kanB; L-glutamine:2-deoxy-scyllo-inosose/3-amino-2,3-dideoxy-scyllo-inosose aminotransferase
Amino acid related enzymes [BR:ko01007]
Aminotransferase (transaminase)
  Others
   K13547  btrR, neoB, kanB; L-glutamine:2-deoxy-scyllo-inosose/3-amino-2,3-dideoxy-scyllo-inosose aminotransferase

Genes

PMUY:

KSS95_17140

PCEL:

HUB94_17990

MOT:	LTS72_25990

NTC:	KHQ06_25020

NHU:	H0264_36130

NYA:	LTV02_00430

SRN:	A4G23_05129(neoB)

SFB:	CP974_27370

CWN:	NP075_08690

AGRA:

AGRA3207_003346

NFS:	OIE67_09805

MCHL:

PVK74_08590

MFEU:

H1D33_23865

GAW:	V144x_51670(btrR_2)

ACAF:

CA12_03720(btrR)

CCOS:

Pan44_41230(btrR_3)

PVAR:

SH412_001922

UAM:	UABAM_05678

AG:	BAD95819(neoB) BAE07061(btrR) CAE46938(kanB)

» show all

Reference

PMID:16156513 (btrR)

Authors

Kudo F, Numakura M, Tamegai H, Yamamoto H, Eguchi T, Kakinuma K

Title

Extended sequence and functional analysis of the butirosin biosynthetic gene cluster in Bacillus circulans SANK 72073.

Journal

J Antibiot (Tokyo) 58:373-9 (2005)
DOI:10.1038/ja.2005.47

Sequence

[ag:BAE07061]

Reference

PMID:16506694 (neoB)

Authors

Kudo F, Yamamoto Y, Yokoyama K, Eguchi T, Kakinuma K

Title

Biosynthesis of 2-deoxystreptamine by three crucial enzymes in Streptomyces fradiae NBRC 12773.

Journal

J Antibiot (Tokyo) 58:766-74 (2005)
DOI:10.1038/ja.2005.104

Sequence

[ag:BAD95819]

Reference

PMID:15313224 (kanB)

Authors

Kharel MK, Subba B, Basnet DB, Woo JS, Lee HC, Liou K, Sohng JK

Title

A gene cluster for biosynthesis of kanamycin from Streptomyces kanamyceticus: comparison with gentamicin biosynthetic gene cluster.

Journal

Arch Biochem Biophys 429:204-14 (2004)
DOI:10.1016/j.abb.2004.06.009

Sequence

[ag:CAE46938]

Reference

PMID:19362652

Authors

Kudo F, Eguchi T

Title

Biosynthetic enzymes for the aminoglycosides butirosin and neomycin.

Journal

Methods Enzymol 459:493-519 (2009)
DOI:10.1016/S0076-6879(09)04620-5

Reference

PMID:15839685

Authors

Yokoyama K, Kudo F, Kuwahara M, Inomata K, Tamegai H, Eguchi T, Kakinuma K

Title

Stereochemical recognition of doubly functional aminotransferase in 2-deoxystreptamine biosynthesis.

Journal

J Am Chem Soc 127:5869-74 (2005)
DOI:10.1021/ja0445948

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