KEGG ORTHOLOGY: K13878

ORTHOLOGY: K13878

Entry

K13878                      KO

Symbol

BEST1, VMD2

Name

bestrophin-1

Disease

H00527

Retinitis pigmentosa

H00805

Vitreoretinal degeneration

H00814

Vitelliform macular dystrophy

H02078

Vitreoretinochoroidopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K13878  BEST1, VMD2; bestrophin-1
Transporters [BR:ko02000]
Other transporters
  Pores ion channels
   K13878  BEST1, VMD2; bestrophin-1

Other DBs

GO:

0005254

TC:	1.A.46.1.1

Genes

HSA:	7439(BEST1)

PTR:	466630(BEST1)

PPS:	100983849(BEST1)

GGO:	101147405(BEST1)

PON:	100434568(BEST1)

PPYG:

129007396(BEST1)

NLE:	100597804(BEST1)

HMH:	116468872(BEST1)

SSYN:

129485960(BEST1)

MCC:	718993(BEST1)

MCF:	101925702(BEST1)

MTHB:

126935467

MNI:	105469429(BEST1)

CSAB:

103234162(BEST1)

CATY:

105577571(BEST1)

PANU:

101021439(BEST1)

TGE:	112605687(BEST1)

MLEU:

105549027(BEST1)

RRO:	104679368(BEST1)

RBB:	108533595(BEST1)

TFN:	117081463(BEST1)

PTEH:

111524336(BEST1)

CANG:

105512283(BEST1)

CJC:	100391026(BEST1)

SBQ:	101028327(BEST1)

CIMI:

108286215(BEST1)

ANAN:

105718632(BEST1)

CSYR:

103269265(BEST1)

MMUR:

105878611(BEST1)

LCAT:

123641345(BEST1)

ERUF:

138384578(BEST1)

PCOQ:

105825042(BEST1)

OGA:	100952339(BEST1)

MMU:	24115(Best1)

MCAL:

110285517(Best1)

MPAH:

110330087(Best1)

RNO:	293735(Best1)

MCOC:

116103539(Best1)

ANU:	117718988(Best1)

ASYL:

127690727(Best1)

MUN:	110548085(Best1)

CGE:	100758040(Best1)

MAUA:

101829114(Best1)

PROB:

127227833(Best1)

PLEU:

114685691 114703463(Best1)

PMAV:

102928784(Best1)

MORG:

121454762(Best1)

MFOT:

126498618

AAMP:

119802811(Best1)

CNL:	130879856(Best1)

NGI:	103729155(Best1) 103738819

HGL:	101710606(Best1)

CPOC:

100723621(Best1)

CCAN:

109700914(Best1)

DORD:

105995275(Best1)

DSP:	122104838(Best1)

DMER:

138818122 138833516(Best1)

PLOP:

125362338(Best1)

NCAR:

124958824

MMMA:

107160157(Best1)

ITI:	101958872(Best1)

OCU:

100352203

OPI:	101524455(BEST1)

OCZ:	121157571(BEST1)

TUP:	102503121(BEST1)

GVR:	103604098(BEST1)

CFA:	483791(BEST1)

CLUD:

112659527(BEST1)

VVP:	112911075(BEST1)

VLG:	121472281(BEST1)

NPO:	129500983(BEST1)

AML:	100470710(BEST1)

UMR:	103678176(BEST1)

UAH:	113246991(BEST1)

UAR:	123785129(BEST1)

ELK:

111150025

LLV:

125079261

MPUF:

101673548(BEST1)

MNP:	132006940(BEST1)

MLK:	131813837(BEST1)

NVS:	122914546(BEST1)

ORO:	101363451(BEST1)

EJU:	114220373(BEST1)

ZCA:	113913509(BEST1)

MLX:	118015929(BEST1)

MANO:

123857079(BEST1)

NSU:	110575890(BEST1)

LWW:	102726979(BEST1)

FCA:	101084904(BEST1)

PYU:	121043309(BEST1)

PCOO:

112852096(BEST1)

PBG:	122483872(BEST1)

PVIV:

125176797(BEST1)

LRUF:

124505188

LGF:	123601807(BEST1)

AJU:

106986977

PTG:	102952198(BEST1)

PPAD:

109246564(BEST1)

PUC:

125932403

PLEZ:

122200063(BEST1)

HHV:	120246161(BEST1)

CCRU:

144218760(BEST1)

BTA:	508924(BEST1)

BOM:	102276660(BEST1)

BIU:	109554490(BEST1)

BJV:	133241306(BEST1)

BBUB:

102409001(BEST1)

BKE:	129652438(BEST1)

BBIS:

104998701(BEST1)

CHX:	102179639(BEST1)

OAS:	101109837(BEST1)

OCAN:

138426921(BEST1)

BTAX:

128068919(BEST1)

CSUM:

138084036(BEST1)

ODA:	120874552(BEST1)

CCAD:

122430683(BEST1)

MREE:

136168997(BEST1)

OVR:	110152995(BEST1)

MBEZ:

129548878(BEST1)

SSC:	397169(BEST1)

CFR:	102507466(BEST1)

CBAI:

105070116(BEST1)

CDK:	116147058(BEST1)

VPC:	102542506(BEST1)

BACU:

103007247(BEST1)

BMUS:

118899784(BEST1)

LVE:	103081523(BEST1)

OOR:	101277067(BEST1)

LALB:

132525132(BEST1)

GMF:	115840657(BEST1)

DDP:	132429975(BEST1)

SCOO:

307190890(BEST1)

DLE:	111183879(BEST1)

PCAD:

102976630(BEST1)

PSIU:

116758407(BEST1)

PPHC:

136126556(BEST1)

NASI:

112402366(BEST1)

ECB:	100059901(BEST1)

EPZ:	103567041(BEST1)

EAI:	106847585(BEST1)

MYB:	102263119(BEST1)

MYD:	102774033(BEST1)

MMYO:

118648939(BEST1)

MLF:

102441102

MDT:	132241697(BEST1)

EFUS:

103303313(BEST1)

POTS:

308257771(BEST1)

MNA:	107527568(BEST1)

DRO:	112317200(BEST1)

SHON:

118996921(BEST1)

AJM:	119043678(BEST1)

PDIC:

114499126(BEST1)

PHAS:

123829530(BEST1)

MMF:	118628070(BEST1)

PPAM:

129062747(BEST1)

HAI:	109389977(BEST1)

RFQ:	117030976(BEST1)

PALE:

102886491(BEST1)

PGIG:

120600671(BEST1)

PVP:	105297979(BEST1)

RAY:	107501605(BEST1)

TOD:

119250120

LAV:	100676645(BEST1)

TMU:

101350327

ETF:	101651423(BEST1)

DNM:	101424682(BEST1)

MDO:	100010557(BEST1)

GAS:	123252766(BEST1)

SHR:	100929267(BEST1)

AFZ:

127539897

PCW:	110195461(BEST1)

TVP:	118853785(BEST1)

PBRV:

138177364(BEST1)

MLAO:

141518916(BEST1)

OAA:	100089896(BEST1)

TACU:

119944121(BEST1)

GGA:	423124(BEST1)

PCOC:

116238982

MGP:	100550132(BEST1)

CJO:	107314459(BEST1)

TPAI:

128085479(BEST1)

LMUT:

125695403(BEST1)

NMEL:

110401444(BEST1)

APLA:

101800834

AACU:

137857826

OJA:	118167418(BEST1)

ACYG:

106033829(BEST1)

CATA:

118249732(BEST1)

AFUL:

116490124

TGU:

100229562

LSR:

110485024

VMC:	128808317(BEST1)

VCHA:

128790319(BEST1)

AIB:

SCAN:

PMOA:

OTC:

PRUF:

ATRC:

MATE:

118687460(BEST1)

MAEN:

136558000(BEST1)

GFR:	102031342(BEST1)

FAB:	101810801 101810994(BEST1)

OMA:

PHI:

PMAJ:

CCAE:

CCW:	104697622(BEST1)

CBRC:

103614729

ACOE:

138111131

ETL:	114067855(BEST1)

ZAB:	102069780(BEST1)

ZLE:

ACHL:

SVG:

MMEA:

HRT:	120753707(BEST1)

SATI:

136362061

CFAI:

136292062(BEST1)

CCIC:

134045139(BEST1)

NNT:

104405859

SHAB:

115606146

POCC:

134165311(BEST1)

FPG:	101912179(BEST1)

FCH:

102049927

FRS:

119154414

CCRI:

104155597

ACUN:

113481282(BEST1)

ANOC:

141965845(BEST1)

SURA:

141950026(BEST1)

TALA:

104357030(BEST1)

ACHC:

HALD:

HLE:

AGEN:

HHAR:

128152953(BEST1)

BBUT:

GCL:

CSTI:

LDI:

MNB:

DPUB:

104304442(BEST1)

PPUS:

IIN:

AVIT:

BRHI:

EGZ:	104129640(BEST1)

NNI:

104009482

PCRI:

104025060

PCAO:

104053926

PARX:

142058011(BEST1)

PADL:

103925829(BEST1)

AFOR:

103907205(BEST1)

FGA:

104078004

CBOR:

142088253

GSTE:

104251513(BEST1)

CBOY:

140653072

MAME:

142410060

CLV:

102097484

CNIC:

135989017(BEST1)

MUI:	104536467(BEST1)

PGUU:

PLET:

EHS:

CMAC:

CUCA:

104062557(BEST1)

PCUR:

138720918

TEO:	104382328(BEST1)

BREG:

104630167(BEST1)

GAME:

129206575(BEST1)

OHA:	104339409(BEST1)

ACAR:

104523890

CEUR:

306725238(LOC306725238)

CPEA:

104397497(BEST1)

CVF:

104287565

RTD:

128908394

CRID:

134515564

LMIC:

141742893(BEST1)

NARQ:

141465578

AAM:	106490043(BEST1)

AROW:

112978033(BEST1)

NPD:

TGT:

DNE:

SCAM:

ASN:

AMJ:	102572275(BEST1)

CPOO:

109318154

PSS:

102459271

CIZ:

142014832

CMY:	102935016(BEST1)

CCAY:

125637827(BEST1)

LKP:	140912495(BEST1)

NDS:	141989943(BEST1)

DCC:	119857288(BEST1)

CPIC:

101949198

TST:	117876628(BEST1)

EOB:	135878091(BEST1)

CABI:

116824561(BEST1)

MRV:	120403990(BEST1)

EMQ:	137148578(BEST1)

ACS:	100556328(best1)

ASAO:

132771935(BEST1)

PVT:	110086195(BEST1)

SUND:

121923224

PBI:

103051256

PMUR:

107294249

CTIG:

120312453(BEST1)

TSR:

PGUT:

PCAE:

APRI:

PTEX:

NSS:

VKO:	123021349(BEST1)

PMUA:

114600510(BEST1)

PRAF:

128417676(BEST1)

ZVI:	118088981(BEST1)

HCG:	128340844(BEST1)

GJA:

107108844

STOW:

125427419

EMC:	129324503(BEST1)

XLA:	108713834(best1.L) 108714934(best1.S)

XTR:	100302038(best1)

NPR:	108794186(BEST1)

RTEM:

120917255(BEST1)

ACAT:

141112130

PADS:

140337914(BEST1)

BBUF:

120980664(BEST1)

BGAR:

122920921(BEST1)

DTC:	141088137(BEST1)

PWL:	138284452(BEST1)

MUO:	115468976(BEST1)

GSH:	117351980(BEST1)

DRE:	560608(best1)

DAES:

130219701(best1)

SRX:

107724651

SANH:

107669042

SGH:

107572318

CCAR:

109098860 109099143(best1)

CAUA:

113042866 113042941

CGIB:

128013964

PTET:

122330638(best1)

LROH:

127156651(best1)

GRF:	141301561(best1)

OMC:	131534615(best1)

PPRM:

120472207(best1)

RKG:	130106458(best1)

SCEP:

307151086(best1)

MAMB:

125248015(best1)

CIDE:

127506541

CERY:

137015243(best1)

MASI:

127436049 127437645

TROS:

130550091(best1)

TDW:	130414090(best1)

MANU:

129433473(best1)

PDAB:

135768214(best1)

IPU:	108274989(best1)

IFU:	128618673(best1)

PHYP:

113529681

SMEO:

124392947(best1)

TFD:	113653923(best1)

TVC:	132856996(best1)

CGAR:

128540784(best1)

NGRA:

132869667(best1)

TRN:	134321616(best1)

AMEX:

103045999(best1)

CMAO:

118811864(best1)

EEE:

113583563

CHAR:

105892419(best1)

SPIL:

134094129(best1)

ASAD:

121724107(best1)

TRU:	101062542(best1)

TFS:	130536012(best1)

TNG:	GSTEN00029869G001

NCC:

104944636

TBEN:

117491936(best1)

CGOB:

115009404

PGEO:

117448488(best1)

GACU:

117538818(best1)

EMAC:

134858540(best1)

ELY:	117262617(best1)

EFO:	125886854(best1)

PLEP:

121950674(best1)

SLUC:

116038498(best1)

SVIT:

144522221(best1)

ECRA:

117949682(best1)

ESP:

116694342

PFLV:

114560066

PFLT:

120564108(best1)

GAT:	120808686(best1)

PPUG:

119196270(best1)

AFB:	129108876(best1)

CLUM:

117731998(best1)

PSWI:

130195440(best1)

CANA:

137803731(best1)

CVE:	137881479(best1)

AMIR:

142948048(best1)

MSAM:

119893889(best1)

SCHU:

122875392(best1)

EARM:

139286737(best1)

CUD:	121515753(best1)

SPUL:

138613271(best1)

LMIX:

132972586(best1)

HTC:	141796905(best1)

ALAT:

119024342(best1)

ASTR:

137594324(best1)

PKLU:

139201189(best1)

LCO:

104928855

MZE:	101467590(best1)

ONL:

100691977

OAU:	116326152(best1)

OLA:

101167866

OML:	112152861(best1)

CSAI:

133444128(best1)

XMA:

102229874

XCO:

114151159

XHE:

116707726

PRET:

103466497(best1)

PFOR:

103141316

PLAI:

106964664

PMEI:

106933101

GAF:	122835557(best1)

PPRL:

129369833(best1)

CVG:

107100638

CTUL:

119787413(best1)

GMU:	124859631(best1)

NFU:

107388672

KMR:	108229990(best1)

ALIM:

106521175(best1)

NWH:	119415791(best1)

LTU:	140307192(best1)

MCEP:

125015101(best1)

AOCE:

111584100(best1)

EJA:	138205952(best1)

BFRE:

138626445(best1)

LCF:

108887003

CSEM:

103380298

POV:

109624076

SSEN:

122776539(best1)

SSOE:

131469426(best1)

HHIP:

117762922(best1)

HSP:	118109764(best1)

PPLT:

128443914(best1)

SMAU:

118315250(best1)

SDU:

111229743

SLAL:

111667034

XGL:	120793540(best1)

HCQ:

109507507

SSCV:

125970102(best1)

SBIA:

133501711(best1)

PEE:	133402802(best1)

PTAO:

133478509(best1)

BPEC:

110169708

ENY:	140349349(best1)

MALB:

109972457

BSPL:

114857077(best1)

SJO:	128359349(best1)

SSCO:

133982503(best1)

TTY:	137183149(best1)

GMH:

115550865

SASA:

106561822

STRU:

115197716(best1)

OTW:	112238655(best1)

OMY:	110502656(best1)

OGO:	124031721(best1)

ONE:

115123986

OKI:

109884800

OKE:	118379868 127919908

OMM:	135508881(best1)

OCLA:

139378606

SALP:

112071752

SNH:	120065980(best1)

SFON:

129861861(best1)

CCLU:

121531592 121540757 123488241

ELS:

105029692

OEP:	134021576(best1)

SFM:

108940923

PKI:

111848019

AANG:

118215389(best1)

AROT:

135242094(best1)

CCOG:

133111133(best1)

PSPA:

121294672(best1)

ARUT:

117432324

PSEX:

120535990

LCM:	102351537(BEST1)

CMK:	103174856 121850337

RTP:

CPLA:

CPUN:

HOC:

SCAU:

LERI:

HAKA:

BFO:	118427812 118427923

BBEL:

CIN:

SCLV:

CLEP:

SPU:

LPIC:

LVG:

AJJ:

APLC:

AAMU:

AFIL:

AJC:

SKO:	100369861 100372449

PFLL:

139137919 139147831 139147840 139149641

TCF:

CQD:

MRJ:

PORN:

DALB:

CVS:

ABRU:

129960658 129987797 129988101 129989364

UDV:	129229358 129229882 129231250

AIRR:

138317827

» show all

Reference

PMID:19262692

Authors

Kranjc A, Grillo FW, Rievaj J, Boccaccio A, Pietrucci F, Menini A, Carloni P, Anselmi C

Title

Regulation of bestrophins by Ca2+: a theoretical and experimental study.

Journal

PLoS One 4:e4672 (2009)
DOI:10.1371/journal.pone.0004672

Sequence

[hsa:7439]

Reference

PMID:19375515

Authors

Boon CJ, Klevering BJ, Leroy BP, Hoyng CB, Keunen JE, den Hollander AI

Title

The spectrum of ocular phenotypes caused by mutations in the BEST1 gene.

Journal

Prog Retin Eye Res 28:187-205 (2009)
DOI:10.1016/j.preteyeres.2009.04.002

LinkDB

DBGET integrated database retrieval system