KEGG   ORTHOLOGY: K13939
Entry
K13939                      KO                                     
Symbol
FOL1
Name
dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase [EC:4.1.2.25 2.7.6.3 2.5.1.15]
Pathway
map00790  Folate biosynthesis
map01100  Metabolic pathways
map01240  Biosynthesis of cofactors
Module
M00126  Tetrahydrofolate biosynthesis, GTP => THF
Reaction
R03066  6-(hydroxymethyl)-7,8-dihydropterin:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase
R03067  (7,8-dihydropterin-6-yl)methyl diphosphate:4-aminobenzoate 2-amino-4-hydroxy-7,8-dihydropteridine-6-methenyltransferase
R03503  ATP:6-hydroxymethyl-7,8-dihydropterin 6'-diphosphotransferase
R03504  7,8-dihydroneopterin glycolaldehyde-lyase [6-(hydroxymethyl)-7,8-dihydropterin-forming]
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    K13939  FOL1; dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.15  dihydropteroate synthase
     K13939  FOL1; dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase
  2.7  Transferring phosphorus-containing groups
   2.7.6  Diphosphotransferases
    2.7.6.3  2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
     K13939  FOL1; dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.2  Aldehyde-lyases
    4.1.2.25  dihydroneopterin aldolase
     K13939  FOL1; dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase
Other DBs
COG: COG1539 COG0801 COG0294
GO: 0004150 0003848 0004156
Genes
SCE: YNL256W(FOL1)
SEUB: DI49_4491
SPAO: SPAR_N00730
AGO: AGOS_AFR647C
ERC: Ecym_1119
KLA: KLLA0_C02783g
KMX: KLMA_10126(FOL1)
LTH: KLTH0F02882g
VPO: Kpol_2000p42
ZRO: ZYRO0F16170g
CGR: CAGL0J07920g
NCS: NCAS_0A00710(NCAS0A00710)
NDI: NDAI_0F04090(NDAI0F04090)
TPF: TPHA_0B04280(TPHA0B04280)
TBL: TBLA_0A05660(TBLA0A05660)
TGB: HG536_0B01220
TDL: TDEL_0C05970(TDEL0C05970)
KAF: KAFR_0D03830(KAFR0D03830)
KNG: KNAG_0F00590(KNAG0F00590)
ZMK: HG535_0A01220
PPA: PAS_chr2-2_0302
DHA: DEHA2E11704g
PIC: PICST_66087
PGU: PGUG_03380
SPAA: SPAPADRAFT_61089
LEL: PVL30_004597(FOL1)
CAL: CAALFM_C500770CA(FOL1)
CTP: CTRG_05355
COT: CORT_0E05530
CDU: CD36_51690
CTEN: CANTEDRAFT_124080
YLI: YALI0A02541g
CLU: CLUG_03386
CLUS: A9F13_01g08085
CAUR: CJI96_0001312
SLB: AWJ20_43(FOL1)
PKZ: C5L36_0B03380
BNN: FOA43_004472
BBRX: BRETT_002287
OPA: HPODL_02556
SLUD: SCDLUD_003916
TML: GSTUM_00011612001
SPO: SPBC1734.03
SOM: SOMG_01394(fol1)
CNE: CNC04040
CNB: CNBC3140
CNG: CNAG_02786
CGI: CGB_C6150C
CDEU: CNBG_3441
TMS: TREMEDRAFT_30738
TASA: A1Q1_04530
CCAC: CcaHIS019_0211600(FOL1)
TVS: TRAVEDRAFT_52553
DSQ: DICSQDRAFT_94022
SHS: STEHIDRAFT_96629
HIR: HETIRDRAFT_65517
PSQ: PUNSTDRAFT_140849
ADL: AURDEDRAFT_181441
FME: FOMMEDRAFT_156900
GTR: GLOTRDRAFT_80794 GLOTRDRAFT_96055
RSX: RhiXN_11025
CCI: CC1G_15556
ABP: AGABI1DRAFT115300(AGABI1DRAFT_115300)
ABV: AGABI2DRAFT208226(AGABI2DRAFT_208226)
MRR: Moror_15039
MORE: E1B28_006493
CPUT: CONPUDRAFT_166442
SLA: SERLADRAFT_414778
WIC: J056_003823
UMA: UMAG_05171
PFP: PFL1_03100
SGRA: EX895_004566
MRT: MRET_0826
MSYM: MSY001_3431
MLR: MELLADRAFT_94398
EHE: EHEL_050080
DDI: DDB_G0278283(fol1)
DPP: DICPUDRAFT_155477
DFA: DFA_08871(fol1)
 » show all
Reference
PMID:15826662
  Authors
Lawrence MC, Iliades P, Fernley RT, Berglez J, Pilling PA, Macreadie IG
  Title
The three-dimensional structure of the bifunctional 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase/dihydropteroate synthase of Saccharomyces cerevisiae.
  Journal
J Mol Biol 348:655-70 (2005)
DOI:10.1016/j.jmb.2005.03.021
Reference
PMID:15169867
  Authors
Guldener U, Koehler GJ, Haussmann C, Bacher A, Kricke J, Becher D, Hegemann JH
  Title
Characterization of the Saccharomyces cerevisiae Fol1 protein: starvation for C1 carrier induces pseudohyphal growth.
  Journal
Mol Biol Cell 15:3811-28 (2004)
DOI:10.1091/mbc.E03-09-0680
  Sequence
[sce:YNL256W]
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