Entry
Symbol
THI6
Name
thiamine-phosphate diphosphorylase / hydroxyethylthiazole kinase [EC:
2.5.1.3 2.7.1.50 ]
Pathway
Module
M00898 Thiamine biosynthesis, pyridoxal-5P => TMP/thiamine/TPP
Reaction
R03223 2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:4-methyl-5-(2-phosphoethyl)-thiazole 2-methyl-4-aminopyridine-5-methenyltransferase
R04448 ATP:4-methyl-5-(2-hydroxyethyl)thiazole 2-phosphotransferase
R10712 2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate 2-methyl-4-aminopyrimidine-5-methenyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00730 Thiamine metabolism
K14154 THI6; thiamine-phosphate diphosphorylase / hydroxyethylthiazole kinase
Enzymes [BR:ko01000 ]
2. Transferases
2.5 Transferring alkyl or aryl groups, other than methyl groups
2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
2.5.1.3 thiamine phosphate synthase
K14154 THI6; thiamine-phosphate diphosphorylase / hydroxyethylthiazole kinase
2.7 Transferring phosphorus-containing groups
2.7.1 Phosphotransferases with an alcohol group as acceptor
2.7.1.50 hydroxyethylthiazole kinase
K14154 THI6; thiamine-phosphate diphosphorylase / hydroxyethylthiazole kinase
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Taxonomy UniProt
Reference
Authors
Nosaka K, Nishimura H, Kawasaki Y, Tsujihara T, Iwashima A
Title
Isolation and characterization of the THI6 gene encoding a bifunctional thiamin-phosphate pyrophosphorylase/hydroxyethylthiazole kinase from Saccharomyces cerevisiae.
Journal
J Biol Chem 269:30510-6 (1994)
Sequence
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