KEGG   ORTHOLOGY: K14249
Entry
K14249            Tight     KO                                     
Symbol
oxyK
Name
bifunctional cyclase/aromatase [EC:4.2.1.-]
Pathway
map00253  Tetracycline biosynthesis
map01056  Biosynthesis of type II polyketide backbone
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00778  Type II polyketide backbone biosynthesis, acyl-CoA + malonyl-CoA => polyketide
Reaction
R09187  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01056 Biosynthesis of type II polyketide backbone
    K14249  oxyK; bifunctional cyclase/aromatase
   00253 Tetracycline biosynthesis
    K14249  oxyK; bifunctional cyclase/aromatase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K14249  oxyK; bifunctional cyclase/aromatase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Type II PKS
   C7-C14 cyclized polyketide type
    Nonaketide PKS
     K14249  oxyK; bifunctional cyclase/aromatase
Genes
SRIM: CP984_02420
AG: AAZ78334(oxyK)
Reference
PMID:16597959
  Authors
Zhang W, Ames BD, Tsai SC, Tang Y
  Title
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.
  Journal
Appl Environ Microbiol 72:2573-80 (2006)
DOI:10.1128/AEM.72.4.2573-2580.2006
  Sequence
[ag:AAZ78334]
Reference
PMID:20522541
  Authors
Pickens LB, Tang Y
  Title
Oxytetracycline biosynthesis.
  Journal
J Biol Chem 285:27509-15 (2010)
DOI:10.1074/jbc.R110.130419
Reference
PMID:10551844
  Authors
Petkovic H, Thamchaipenet A, Zhou LH, Hranueli D, Raspor P, Waterman PG, Hunter IS
  Title
Disruption of an aromatase/cyclase from the oxytetracycline gene cluster of Streptomyces rimosus results in production of novel polyketides with shorter chain lengths.
  Journal
J Biol Chem 274:32829-34 (1999)
DOI:10.1016/S0021-9258(17)46583-5
LinkDB

DBGET integrated database retrieval system