KEGG ORTHOLOGY: K14252

ORTHOLOGY: K14252

Entry

K14252                      KO

Symbol

oxyL

Name

6-methylpretetramide 4-monooxygenase / 4-hydroxy-6-methylpretetramide 12a-monooxygenase [EC:1.14.13.232 1.14.13.233]

Pathway

map00253

Tetracycline biosynthesis

map01057

Biosynthesis of type II polyketide products

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00780

Tetracycline/oxytetracycline biosynthesis, pretetramide => tetracycline/oxytetracycline

M00823

Chlortetracycline biosynthesis, pretetramide => chlortetracycline

Reaction

R05462

4-hydroxy-6-methylpretetramide,NADPH:oxygen oxidoreductase (12a-hydroxylating)

R09190

6-methylpretetramide,NADPH:oxygen oxidoreductase (4,12a-hydroxylating)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K14252  oxyL; 6-methylpretetramide 4-monooxygenase / 4-hydroxy-6-methylpretetramide 12a-monooxygenase
   00253 Tetracycline biosynthesis
    K14252  oxyL; 6-methylpretetramide 4-monooxygenase / 4-hydroxy-6-methylpretetramide 12a-monooxygenase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K14252  oxyL; 6-methylpretetramide 4-monooxygenase / 4-hydroxy-6-methylpretetramide 12a-monooxygenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.232  6-methylpretetramide 4-monooxygenase
     K14252  oxyL; 6-methylpretetramide 4-monooxygenase / 4-hydroxy-6-methylpretetramide 12a-monooxygenase
    1.14.13.233  4-hydroxy-6-methylpretetramide 12a-monooxygenase
     K14252  oxyL; 6-methylpretetramide 4-monooxygenase / 4-hydroxy-6-methylpretetramide 12a-monooxygenase
Polyketide biosynthesis proteins [BR:ko01008]
Polyketide tailoring proteins
  Oxygenase
   K14252  oxyL; 6-methylpretetramide 4-monooxygenase / 4-hydroxy-6-methylpretetramide 12a-monooxygenase

Other DBs

COG:

COG0654

Genes

NAH:	F5544_10695

SHY:

SHJG_1193

SHO:	SHJGH_1028

SBH:

SBI_06866

SCI:	B446_13470

SPRI:

SPRI_0201 SPRI_7152

SPAV:

Spa2297_32760

SGS:	AVL59_46185

SGM:	GCM10017557_73940

SPHW:

NFX46_25010

SGZ:	C0216_31875

SVR:	CP971_24005

SGF:	HEP81_07938

SRIM:

CP984_02425

SPLA:

CP981_34475

SHUN:

DWB77_05143(pcpB_4)

SXN:	IAG42_36430

SINE:

SYAN:

SVIO:

SSPN:

SDRZ:

SHAU:

KAU:	B6264_18580

KIS:	HUT16_23740

MIK:	FOE78_19175

AORI:

SD37_34185

ARHD:

VSH64_28950

KAL:

KALB_7834

KUT:	JJ691_15620

ACTU:

Actkin_02482(pcpB_1)

CROS:

N8J89_20350

PLK:	CIK06_11100

DAUR:

Daura_37895

CCAZ:

COUCH_15955

KBB:	ccbrp13_21970

AG:	AAZ78335(oxyL)

» show all

Reference

PMID:16597959

Authors

Zhang W, Ames BD, Tsai SC, Tang Y

Title

Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.

Journal

Appl Environ Microbiol 72:2573-80 (2006)
DOI:10.1128/AEM.72.4.2573-2580.2006

Sequence

[ag:AAZ78335]

Reference

PMID:18422316

Authors

Zhang W, Watanabe K, Cai X, Jung ME, Tang Y, Zhan J

Title

Identifying the minimal enzymes required for anhydrotetracycline biosynthesis.

Journal

J Am Chem Soc 130:6068-9 (2008)
DOI:10.1021/ja800951e

Reference

PMID:19472250

Authors

Wang P, Zhang W, Zhan J, Tang Y

Title

Identification of OxyE as an ancillary oxygenase during tetracycline biosynthesis.

Journal

Chembiochem 10:1544-50 (2009)
DOI:10.1002/cbic.200900122

LinkDB

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