KEGG ORTHOLOGY: K14589

ORTHOLOGY: K14589

Entry

K14589                      KO

Symbol

CMTR1, FTSJD2, MTR1

Name

cap1 methyltransferase [EC:2.1.1.57]

Reaction

R03922

S-adenosyl-L-methionine:5-(N7-methyl 5-triphosphoguanosine)-(purine-ribonucleotide)-[mRNA] 2-O-methyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis
    K14589  CMTR1, FTSJD2, MTR1; cap1 methyltransferase
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.57  methyltransferase cap1
     K14589  CMTR1, FTSJD2, MTR1; cap1 methyltransferase
Messenger RNA biogenesis [BR:ko03019]
Eukaryotic type
  mRNA processing factors
   5' end processing
    Capping factors
     K14589  CMTR1, FTSJD2, MTR1; cap1 methyltransferase

Other DBs

GO:

0004483

Genes

HSA:	23070(CMTR1)

PTR:	471998(CMTR1)

PPS:	100973075(CMTR1)

GGO:	101137720(CMTR1)

PON:	100172922(CMTR1)

NLE:	100603379(CMTR1)

HMH:	116459678(CMTR1)

MCC:	719402(CMTR1)

MCF:	102122892(CMTR1)

MTHB:

126952723

MNI:	105474547(CMTR1)

CSAB:

103221567(CMTR1)

CATY:

105592372(CMTR1)

PANU:

101009175(CMTR1)

TGE:	112622499(CMTR1)

MLEU:

105544249(CMTR1)

RRO:	104682893(CMTR1)

RBB:	108528352(CMTR1)

TFN:	117087153(CMTR1)

PTEH:

111543000(CMTR1)

CANG:

105513580(CMTR1)

CJC:	100388430(CMTR1)

SBQ:	101048288(CMTR1)

CIMI:

108299963(CMTR1)

CSYR:

103268555(CMTR1)

MMUR:

105861413(CMTR1)

LCAT:

123631845(CMTR1)

PCOQ:

105812231(CMTR1)

OGA:	100949235(CMTR1)

MMU:	74157(Cmtr1)

MCAL:

110284181(Cmtr1)

MPAH:

110337841(Cmtr1)

RNO:	309656(Cmtr1)

MCOC:

116075446(Cmtr1)

ANU:	117724381(Cmtr1)

MUN:	110546567(Cmtr1)

CGE:	100755381(Cmtr1)

MAUA:

101832677(Cmtr1)

PROB:

127224183(Cmtr1)

PLEU:

114703984(Cmtr1) 114705719

MORG:

121435213(Cmtr1)

MFOT:

126499385

AAMP:

119822661(Cmtr1)

NGI:	103739641(Cmtr1)

HGL:	101702635(Cmtr1)

CPOC:

100725670(Cmtr1)

CCAN:

109694147(Cmtr1)

DORD:

105995784(Cmtr1)

DSP:	122111125(Cmtr1)

PLOP:

125352633(Cmtr1)

NCAR:

124988754

MMMA:

107143868(Cmtr1)

OCU:

100350011

OPI:	101524184(CMTR1)

TUP:	102486149(CMTR1)

GVR:	103587039(CMTR1)

CFA:	100683999(CMTR1)

CLUD:

112641518(CMTR1)

VVP:	112913952(CMTR1)

VLG:	121492710(CMTR1)

NPO:	129512518(CMTR1)

AML:	100464010(CMTR1)

UMR:	103665432(CMTR1)

UAH:	113243879(CMTR1)

UAR:	123784821(CMTR1)

ELK:

111147878

LLV:

125102253

MPUF:

101685828(CMTR1)

MNP:	132018092(CMTR1)

MLK:	131833904(CMTR1)

NVS:	122907475(CMTR1)

ORO:	101370834(CMTR1)

EJU:	114222124(CMTR1)

ZCA:	113926977(CMTR1)

MLX:	118000632(CMTR1)

NSU:	110575689(CMTR1)

LWW:

102730333

FCA:	101082907(CMTR1)

PYU:	121029380(CMTR1)

PCOO:

112862229(CMTR1)

PBG:	122489463(CMTR1)

PVIV:

125165789(CMTR1)

LRUF:

124528057

PTG:	102959389(CMTR1)

PPAD:

109271551(CMTR1)

PUC:

125938286

AJU:

106972787

HHV:	120233800(CMTR1)

BTA:	509620(CMTR1)

BOM:	102286518(CMTR1)

BIU:	109577167(CMTR1)

BBUB:

102416543(CMTR1)

BBIS:

104994963(CMTR1)

CHX:	102183833(CMTR1)

OAS:	101123242(CMTR1)

BTAX:

128055826(CMTR1)

ODA:	120870176(CMTR1)

CCAD:

122429062(CMTR1)

MBEZ:

129543117(CMTR1)

SSC:	100154061(CMTR1)

CFR:	102519501(CMTR1)

CBAI:

105064154(CMTR1)

CDK:	105087036(CMTR1)

VPC:	102535476(CMTR1)

BACU:

102999368(CMTR1)

BMUS:

118903618(CMTR1)

LVE:	103084086(CMTR1)

OOR:	101285678(CMTR1)

DLE:	111178760(CMTR1)

PCAD:

102979678(CMTR1)

PSIU:

116761965(CMTR1)

NASI:

112413838(CMTR1)

ECB:	100064496(CMTR1)

EPZ:	103565234(CMTR1)

EAI:	106824556(CMTR1)

MYB:	102239315(CMTR1) 102261455(UBAC2)

MYD:	102752437(CMTR1)

MMYO:

118649597(UBAC2) 118659923(CMTR1)

MLF:	102416806(UBAC2) 102436523(CMTR1)

PKL:	118705176(CMTR1)

EFUS:

103295496(CMTR1)

MNA:	107545617(CMTR1)

DRO:	112302112(CMTR1)

SHON:

118998947(CMTR1)

AJM:	119050049(CMTR1)

PDIC:

114493973(CMTR1)

PHAS:

123821464(CMTR1)

MMF:	118621566(CMTR1)

PPAM:

129067426(CMTR1)

HAI:	109395523(CMTR1)

RFQ:	117020432(CMTR1)

PALE:

102890551(CMTR1)

PGIG:

120597626(CMTR1)

PVP:	105288393(CMTR1)

RAY:	107514694(CMTR1)

MJV:	108384511(CMTR1)

TOD:	119252409(CMTR1)

SARA:

101552226(CMTR1)

SETR:

125996528(CMTR1)

LAV:	100676382(CMTR1)

TMU:

101344306

ETF:	101638500(CMTR1)

DNM:	101430444(CMTR1)

MDO:	100029458(CMTR1)

GAS:	123245469(CMTR1)

SHR:	100932113(CMTR1)

AFZ:	127548545 127561332 127561619

PCW:	110217306(CMTR1)

OAA:	100080325(CMTR1)

GGA:	421434(CMTR1)

PCOC:

116229522(CMTR1)

MGP:	100550686(CMTR1)

CJO:	107311264(CMTR1)

TPAI:

128085237(CMTR1)

LMUT:

125688948(CMTR1)

NMEL:

110395644(CMTR1)

APLA:

101791717(CMTR1)

ACYG:

106029753(CMTR1)

CATA:

118254879(CMTR1)

AFUL:

116487582(CMTR1)

TGU:	100221592(CMTR1)

LSR:	110481715(CMTR1)

SCAN:

103817971(CMTR1)

PMOA:

120496965(CMTR1)

OTC:	121335844(CMTR1)

PRUF:

121358573(CMTR1)

GFR:	102034324(CMTR1)

FAB:	101813808(CMTR1)

OMA:	130251141(CMTR1)

PHI:	102100817(CMTR1)

PMAJ:

107201841(CMTR1)

CCAE:

111927547(CMTR1)

CCW:	104684420(CMTR1)

CBRC:

103621089(CMTR1)

ETL:	114059329(CMTR1)

ZAB:	102067083(CMTR1)

ZLE:	135445812(CMTR1)

ACHL:

103799816(CMTR1)

SVG:	106854256(CMTR1)

MMEA:

130576313(CMTR1)

HRT:	120750139(CMTR1)

FPG:	101914346(CMTR1)

FCH:	102046764(CMTR1)

CLV:	102095138(CMTR1)

EGZ:	104124848(CMTR1)

NNI:	104021512(CMTR1)

PCRI:

104032104(CMTR1)

PLET:

104625646(CMTR1)

EHS:	104513900(CMTR1)

PCAO:

104051104

ACUN:

113477838(CMTR1)

TALA:

104357929(CMTR1)

PADL:

103922862(CMTR1)

AFOR:

103902667(CMTR1)

HALD:

104318970(CMTR1)

HLE:	104840307(CMTR1)

AGEN:

126051453

GCL:

127014500

CCRI:

104166905(CMTR1)

CSTI:

104559586(CMTR1)

CMAC:

104473479(CMTR1)

MUI:	104547945(CMTR1)

BREG:

104633287(CMTR1)

FGA:	104079102(CMTR1)

GSTE:

104262671(CMTR1)

LDI:	104349235(CMTR1)

MNB:	103773916(CMTR1)

OHA:	104326676(CMTR1)

NNT:	104412199(CMTR1)

SHAB:

115614029(CMTR1)

DPUB:

104302888(CMTR1)

PGUU:

104469127(CMTR1)

ACAR:

104518068(CMTR1)

CPEA:

104396212(CMTR1)

AVIT:

104275349(CMTR1)

CVF:	104282331(CMTR1)

RTD:	128907985(CMTR1)

CUCA:

104057689(CMTR1)

TEO:	104382768(CMTR1)

BRHI:

104499748(CMTR1)

AAM:	106485494(CMTR1)

AROW:

112973417(CMTR1)

NPD:	112957548(CMTR1)

TGT:	104578120(CMTR1)

DNE:	112997105(CMTR1)

SCAM:

104151706(CMTR1)

ASN:	102369625(CMTR1)

AMJ:	102558730(CMTR1)

CPOO:

109319841(CMTR1)

GGN:	109304277(CMTR1)

PSS:	102451122(CMTR1)

CMY:	102946212(CMTR1)

CCAY:

125633766(CMTR1)

DCC:	119853825(CMTR1)

CPIC:

101934896(CMTR1)

TST:	117874572(CMTR1)

CABI:

116819186(CMTR1)

MRV:	120400851(CMTR1)

ACS:	100553490(cmtr1)

ASAO:

132761312(CMTR1)

PVT:	110074654(CMTR1)

SUND:

121936626(CMTR1)

PBI:	103059677(CMTR1)

PMUR:

107294666(CMTR1)

CTIG:

120309627(CMTR1)

TSR:	106539335(CMTR1)

PGUT:

117671832(CMTR1)

APRI:

131198544(CMTR1)

PTEX:

113433176(CMTR1)

NSS:	113421103(CMTR1)

VKO:	123033758(CMTR1)

PMUA:

114594548(CMTR1)

PRAF:

128410994(CMTR1)

ZVI:	118081759(CMTR1)

HCG:	128348944(CMTR1)

GJA:	107115268(CMTR1)

STOW:

125446071(CMTR1)

EMC:	129328730(CMTR1)

XLA:	108716524(cmtr1.L) 443938(cmtr1.S)

XTR:	100170565(cmtr1)

NPR:	108801553(CMTR1)

RTEM:

120938096(CMTR1)

BBUF:

120999802(CMTR1)

BGAR:

122922300(CMTR1)

MUO:	115465340(CMTR1)

GSH:	117356319(CMTR1)

DRE:	393102(cmtr1)

SRX:	107707025 107715019

SANH:

107664240(cmtr1) 107697840

SGH:	107593988(cmtr1) 107599383

CCAR:

109113211

CAUA:

113041549 113065734 113072759

CGIB:

127944368 128011264

PTET:

122329024(cmtr1)

LROH:

127155033(cmtr1)

OMC:	131531928(cmtr1)

PPRM:

120463479(cmtr1)

RKG:	130090530(cmtr1)

MAMB:

125260024(cmtr1)

CIDE:

127505489

MASI:

127419900

TROS:

130544922(cmtr1)

TDW:	130409762(cmtr1)

MANU:

129430934(cmtr1)

IPU:

108275821

IFU:	128619210(cmtr1)

PHYP:

113545617(cmtr1)

SMEO:

124399064(cmtr1)

TFD:	113650702(cmtr1)

TVC:	132862058(cmtr1)

TRN:	134333120(cmtr1)

AMEX:

103047841(cmtr1)

CMAO:

118822313(cmtr1)

EEE:	113591183(cmtr1)

CHAR:

105889823(cmtr1)

TRU:	101074289(cmtr1)

TFS:	130516222(cmtr1)

TNG:	GSTEN00023025G001

LCO:	104921992(cmtr1)

NCC:	104941960(cmtr1)

TBEN:

117492785(cmtr1)

CGOB:

115003994(cmtr1)

PGEO:

117440109(cmtr1)

GACU:

117533819(cmtr1)

EMAC:

134877153(cmtr1)

ELY:	117271003(cmtr1)

EFO:	125897139(cmtr1)

PLEP:

121955970(cmtr1)

SLUC:

116066052(cmtr1)

ECRA:

117961526(cmtr1)

ESP:	116706397(cmtr1)

PFLV:

114573280(cmtr1)

GAT:	120807923(cmtr1)

PPUG:

119194981(cmtr1)

AFB:	129107024(cmtr1)

PSWI:

130202825(cmtr1)

MSAM:

119909259(cmtr1)

SCHU:

122862953(cmtr1)

CUD:	121521453(cmtr1)

ALAT:

119012902(cmtr1)

MZE:	101469980(cmtr1)

ONL:	100704706(cmtr1)

OAU:	116310725(cmtr1)

OLA:	101158070(cmtr1)

OML:	112158261(cmtr1)

CSAI:

133464561(cmtr1)

XMA:	102216684(cmtr1)

XCO:	114158805(cmtr1)

XHE:	116734391(cmtr1)

PRET:

103457551(cmtr1)

PFOR:

103138583(cmtr1)

PLAI:

106950156(cmtr1)

PMEI:

106904507(cmtr1)

GAF:	122825284(cmtr1)

PPRL:

129351213(cmtr1)

CVG:	107083924(cmtr1)

CTUL:

119773936(cmtr1)

GMU:	124881949(cmtr1)

NFU:	107377611(cmtr1)

KMR:	108240058(cmtr1)

ALIM:

106519759(cmtr1)

NWH:	119418205(cmtr1)

AOCE:

111587098(cmtr1)

MCEP:

124999393(cmtr1)

CSEM:

103380848(cmtr1)

POV:	109636200(cmtr1)

SSEN:

122784425(cmtr1)

HHIP:

117758660(cmtr1)

HSP:	118099357(cmtr1)

PPLT:

128459975(cmtr1)

SMAU:

118290055(cmtr1)

LCF:

108895626

SDU:	111235503(cmtr1)

SLAL:

111650577(cmtr1)

XGL:	120789209(cmtr1)

HCQ:	109518088(cmtr1)

SSCV:

125989828

SBIA:

133496220(cmtr1)

PEE:	133417247(cmtr1)

PTAO:

133468380(cmtr1)

BPEC:

110175704(cmtr1)

MALB:

109954305(cmtr1)

BSPL:

114849485(cmtr1)

SJO:	128377290(cmtr1)

SASA:

106608025(cmtr1)

STRU:

115208091(cmtr1)

OTW:	112217739(cmtr1)

OMY:	110522417(cmtr1)

OGO:	123995206(cmtr1)

ONE:	115139245(cmtr1)

OKI:	109866303(cmtr1)

OKE:	118387025(cmtr1)

SALP:

111972589(cmtr1)

SNH:	120019051(cmtr1)

CCLU:

121548799(cmtr1)

ELS:	105006028(cmtr1)

SFM:	108936559(cmtr1)

PKI:	111834731(cmtr1)

AANG:

118230001(cmtr1)

LOC:	102688838(cmtr1)

PSPA:

121316190 121317323

ARUT:

117403072 117410581

PSEX:

120525774(cmtr1)

LCM:	102345363(CMTR1)

CMK:	103177927(cmtr1)

RTP:	109933378(cmtr1)

HOC:	132836100(cmtr1)

LERI:

129697551(cmtr1)

PMRN:

116939571(CMTR1)

LRJ:	133347203(CMTR1)

BFO:

BBEL:

CIN:

SCLV:

SPU:	580281 752380

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG6379(Cmtr1)

DER:

6551111

DSE:

6612543

DSI:	Dsimw501_GD16313(Dsim_GD16313)

DYA:	Dyak_GE16874

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI16152

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

AOQ:

TDA:	119662804 119665875

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:	5568541 5578704

AALB:

109405510 109428513 109430091

ASUA:

134205283 134207668

CQU:	CpipJ_CPIJ006982 CpipJ_CPIJ015411

CPII:

120413355 120429010

CNS:	116340373 116343796 116344118

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

122565973 122569899 122577500

BPAS:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:	115235527 115235528

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

122415877 122416389 122416390 122416624

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_207794

BANY:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

LSIN:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

PXY:

PGW:

LGLY:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:	111046709 111060322

HVI:

124356575

MQU:	128986054 128986579

PHU:	Phum_PHUM390510

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:	110843640 110843758 110852909 110860647 110861994

DPX:	DAPPUDRAFT_307206

DMK:

116929684

DPZ:

124311801

PVM:	113811849 113819146

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:	119458317 119459037

RSAN:

RMP:

CSCU:

ABRU:

UDV:

SDM:

PMEO:

CEL:	CELE_Y53F4B.13(cmtr-1)

CBR:	CBG_20906 CBG_20907

CRQ:	GCK72_006648

NAI:	NECAME_06045

BMY:	BM_BM6757(Bm6757)

LOA:	LOAG_08398

TSP:	Tsp_03060 Tsp_12519a

HRO:	HELRODRAFT_192823

LGI:	LOTGIDRAFT_161337

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:	110441033 110456294

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_122730

OVI:	T265_01277

EGL:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

TAD:	TRIADDRAFT_51728

AQU:	100635482 109581720

DDI:	DDB_G0279593

DPP:	DICPUDRAFT_150730

DFA:

DFA_05394

SMIN:

v1.2.011137.t1(symbB.v1.2.011137.t1)

PTI:	PHATRDRAFT_49487

TPS:	THAPSDRAFT_23316

NGD:	NGA_2039600

PIF:	PITG_06930

PSOJ:

PHYSODRAFT_485723

SPAR:

SPRG_13665 SPRG_15961

EHX:	EMIHUDRAFT_451680

TBR:	Tb10.6k15.2610

TBG:	TbgDal_X9720

TCR:	506247.320

LMA:	LMJF_36_6660

LIF:	LINJ_36_6970

LDO:	LDBPK_366970

LMI:	LMXM_36_6660

LBZ:	LBRM_35_7020

LPAN:

LPMP_356850

NGR:	NAEGRDRAFT_46720 NAEGRDRAFT_65760

TVA:	TVAG_2v0211980

GLA:	GL50803_00103058

» show all

Reference

PMID:18533109

Authors

Haline-Vaz T, Silva TC, Zanchin NI

Title

The human interferon-regulated ISG95 protein interacts with RNA polymerase II and shows methyltransferase activity.

Journal

Biochem Biophys Res Commun 372:719-24 (2008)
DOI:10.1016/j.bbrc.2008.05.137

Sequence

[hsa:23070]

Reference

PMID:20713356

Authors

Belanger F, Stepinski J, Darzynkiewicz E, Pelletier J

Title

Characterization of hMTr1, a human Cap1 2'-O-ribose methyltransferase.

Journal

J Biol Chem 285:33037-44 (2010)
DOI:10.1074/jbc.M110.155283

Sequence

[hsa:23070]

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