KEGG ORTHOLOGY: K14592

ORTHOLOGY: K14592

Entry

K14592                      KO

Symbol

FOLH1, GCPII

Name

glutamate carboxypeptidase II (folate hydrolase 1) [EC:3.4.17.21]

Pathway

map00250

Alanine, aspartate and glutamate metabolism

map01100

Metabolic pathways

map04977

Vitamin digestion and absorption

Reaction

R10687

R10688

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00250 Alanine, aspartate and glutamate metabolism
    K14592  FOLH1, GCPII; glutamate carboxypeptidase II (folate hydrolase 1)
09150 Organismal Systems
  09154 Digestive system
   04977 Vitamin digestion and absorption
    K14592  FOLH1, GCPII; glutamate carboxypeptidase II (folate hydrolase 1)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K14592  FOLH1, GCPII; glutamate carboxypeptidase II (folate hydrolase 1)
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.17  Metallocarboxypeptidases
    3.4.17.21  glutamate carboxypeptidase II
     K14592  FOLH1, GCPII; glutamate carboxypeptidase II (folate hydrolase 1)
Peptidases and inhibitors [BR:ko01002]
Metallo peptidases
  Family M28: aminopeptidase Y family
   K14592  FOLH1, GCPII; glutamate carboxypeptidase II (folate hydrolase 1)

Genes

HSA:	2346(FOLH1)

PTR:	451185 451475(FOLH1B)

PPS:	100970802 100980316

GGO:	101147888 101149915

PON:	100453848(FOLH1B)

NLE:	100589099(FOLH1B)

HMH:

116476797

MCC:	707714(FOLH1B)

MCF:	101866140(FOLH1B)

MTHB:

126934744

MNI:	105468899(FOLH1B)

CSAB:

103248197(FOLH1B)

CATY:

105592968(FOLH1B)

PANU:

101022396

TGE:	112606075(FOLH1B)

MLEU:

105543123(FOLH1B)

RRO:	104678909(FOLH1B)

RBB:	108539153(FOLH1B)

TFN:	117080629(FOLH1B)

PTEH:

111540744(FOLH1B)

CANG:

105509294(FOLH1B)

CJC:

100396945

SBQ:	101044541(FOLH1B)

CIMI:

108290544(FOLH1B)

CSYR:

103271409

MMUR:

105865102 105865103

LCAT:

123642235(FOLH1B)

PCOQ:

105808218(FOLH1B)

OGA:	100962089(FOLH1B)

MMU:	53320(Folh1)

MCAL:

110297451(Folh1b)

MPAH:

110325375(Folh1b)

RNO:	85309(Folh1)

MCOC:

116100637(Folh1b)

ANU:

117710848

MUN:	110562303(Folh1)

CGE:

100768684

MAUA:

101841671(Folh1b)

PROB:

127227228

PLEU:

114682738(Folh1b)

MORG:

121444201(Folh1b)

MFOT:

126509015

AAMP:

119802635(Folh1b)

NGI:	103750517(Folh1)

HGL:	101725016(Folh1b)

CPOC:

100712916(Folh1b)

CCAN:

109696834

DORD:

106000547(Folh1b)

DSP:	122115932(Folh1b)

PLOP:

125361794(Folh1b)

NCAR:

124960251

MMMA:

107135437

OCU:

100358060

OPI:	101520191(FOLH1B)

TUP:	102487205(FOLH1B)

CFA:	476775(FOLH1)

CLUD:

112642038(FOLH1B)

VVP:

112915749

VLG:

121476478

NPO:	129506820(FOLH1)

AML:

100472805

UMR:	103675371(FOLH1B)

UAH:	113269424(FOLH1B)

UAR:

123803814

ELK:

111154494

LLV:

125078783

MPUF:

101694251(FOLH1B)

MNP:	132025348(FOLH1)

MLK:	131839422(FOLH1)

NVS:	122912501(FOLH1B)

EJU:	114199711(FOLH1B)

ZCA:	113913704(FOLH1B)

MLX:	118013456(FOLH1B)

NSU:	110570994(FOLH1B)

LWW:

102741119

FCA:	101089641(FOLH1B)

PYU:	121039399(FOLH1B)

PCOO:

112864913(FOLH1B)

PBG:	122483225(FOLH1B)

PVIV:

125146981

LRUF:

124505601

PTG:	102957765(FOLH1B)

PPAD:

109267331(FOLH1B)

PUC:

125938240

AJU:

106983063

HHV:	120246246(FOLH1B)

BTA:	505865(FOLH1B)

BOM:	102272952(FOLH1B) 106700854

BIU:	109554596(FOLH1B)

BBUB:

102406997(FOLH1B)

BBIS:

104999134

CHX:	102190665(FOLH1B)

OAS:	101121723(FOLH1)

BTAX:

128068851

ODA:	120874817(FOLH1B)

CCAD:

122431256(FOLH1B)

MBEZ:

129549083(FOLH1)

SSC:	397677(FOLH1B)

CFR:	102510657(FOLH1B)

CBAI:

105083514(FOLH1B)

CDK:	105088594(FOLH1B)

VPC:	102545019(FOLH1B)

BACU:

103001153

BMUS:

118900165

LVE:

103089873

OOR:	101280978 125960271

DLE:

111170975

PCAD:

102979651(FOLH1)

PSIU:

116758197

NASI:

112397891

ECB:	100060132(FOLH1B)

EPZ:	103547857(FOLH1B)

EAI:	106822677(FOLH1B)

MYB:	102258767(FOLH1B)

MYD:	102761189(FOLH1B)

MMYO:

118664536(FOLH1B)

MLF:

102429206

PKL:	118712526(FOLH1B)

EFUS:

103296988

MNA:

107532373

DRO:	112315970(FOLH1B)

SHON:

118984760

AJM:

119044483

PDIC:

114499474(FOLH1B)

PHAS:

123805618(FOLH1B)

MMF:	118627580(FOLH1B)

PPAM:

129072829(FOLH1)

HAI:	109374041(FOLH1B)

RFQ:	117031190(FOLH1B)

PALE:

102895068

PGIG:

120590541(FOLH1B)

PVP:	105294194(FOLH1B)

RAY:	107514943(FOLH1B)

MJV:

108390597

SETR:

126019133

LAV:	100660135(FOLH1B)

TMU:

101357352

ETF:

101664149

DNM:

101438576

MDO:	100009990(FOLH1B)

GAS:	123240544(FOLH1B)

SHR:	100918727(FOLH1B)

AFZ:

127555168

PCW:	110213435(FOLH1B)

OAA:

100081512

GGA:	419011(FOLH1)

PCOC:

116241925

MGP:	100550377 100550836

CJO:

TPAI:

LMUT:

NMEL:

APLA:

ACYG:

CATA:

AFUL:

TGU:

LSR:

SCAN:

PMOA:

OTC:	121341016(FOLH1B)

PRUF:

121362303

GFR:	102034877(FOLH1B)

FAB:	101814982(FOLH1)

OMA:

PHI:

PMAJ:

CCAE:

CCW:	104690325(FOLH1B)

CBRC:

103616750

ETL:	114063504(FOLH1B)

ZAB:

ZLE:

ACHL:

SVG:

MMEA:

HRT:

FPG:

FCH:

CLV:

EGZ:

NNI:	104017386(FOLH1B)

PCRI:

PLET:

EHS:

PCAO:

ACUN:

TALA:

PADL:

AFOR:

ACHC:

HALD:

HLE:

AGEN:

GCL:

CCRI:

CSTI:

CMAC:

BREG:

FGA:

GSTE:

LDI:

MNB:

OHA:	104327662(FOLH1B)

NNT:

SHAB:

DPUB:

PGUU:

ACAR:

CPEA:

104393155(FOLH1B)

AVIT:

104280449

CVF:	104283096(FOLH1B)

RTD:

128904104

CUCA:

104064197(FOLH1B)

BRHI:

104496468

AAM:

106495541

AROW:

112973711(FOLH1B)

NPD:

112949989

TGT:	104574279 104574282

DNE:

112988580

SCAM:

104153277

ASN:

102387587

AMJ:	102569346(FOLH1B)

CPOO:

109306785

GGN:	109302806(FOLH1B)

PSS:	102455710(FOLH1B)

CMY:

102934118

CCAY:

125632972

DCC:

119858063

CPIC:

101934265(FOLH1B)

TST:	117871229(FOLH1B)

CABI:

116818087

MRV:	120389099(FOLH1B)

ACS:

ASAO:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

APRI:

PTEX:

113440430(FOLH1B)

NSS:	113420130(FOLH1B)

VKO:

123029330

PMUA:

114595614(FOLH1B)

PRAF:

128412531

ZVI:	118085476(FOLH1B)

HCG:

GJA:

STOW:

EMC:

XLA:

XTR:	100485577(folh1)

NPR:	108794765(FOLH1B)

RTEM:

120920234 120928971

BBUF:

120981848 120996449

BGAR:

122922105 122922106 122932891(FOLH1B)

MUO:	115468445(FOLH1B) 115477350

GSH:	117362999(FOLH1B) 117363922

LOC:

102692081

CPLA:

122550585(naalad2)

HOC:	132816415(naalad2)

LERI:

129698253(naalad2)

PMRN:

116956822

BBEL:

109464534 109471333 109473230 109474109 109486674 109487965

LPIC:

129261389

AJC:	117106697 117106699 117107591 117122546

BROR:

134535859

DMK:	116924614 116932392

DPZ:

PCHN:

PCLA:

PTRU:

ESN:	126983983 126987991 127008952

MNZ:	135219145 135222629

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

PMEO:

PVUL:

BGT:	106066523 106072574 106079826

GAE:	121383708 121384810

HRF:	124140941 124140945 124142882

HRJ:	124262084 124275188 124276111

CRG:

105349101

CVN:	111104084 111127797 111131441 111136594

CANU:

128183672

MMER:

123527538 123555773

RPHI:

132744588

OSN:	115216731 115218023

EPA:

110233909

ATEN:

116287417 116299244 116299245 116299362 116303584 116304238 116305801

AMIL:

114956456

PDAM:

113679020

SPIS:

111322624

XEN:	124438437 124439058

HSY:	130630584 130635978 130649188

» show all

Reference

PMID:9685395

Authors

Halsted CH, Ling EH, Luthi-Carter R, Villanueva JA, Gardner JM, Coyle JT

Title

Folylpoly-gamma-glutamate carboxypeptidase from pig jejunum. Molecular characterization and relation to glutamate carboxypeptidase II.

Journal

J Biol Chem 273:20417-24 (1998)
DOI:10.1074/jbc.273.32.20417

Sequence

[ssc:397677]

Reference

PMID:22918695

Authors

Guo J, Xie H, Wang J, Zhao H, Wang F, Liu C, Wang L, Lu X, Bao Y, Zou J, Wang G, Niu B, Zhang T

Title

The maternal folate hydrolase gene polymorphism is associated with neural tube defects in a high-risk Chinese population.

Journal

Genes Nutr 8:191-7 (2013)
DOI:10.1007/s12263-012-0309-3

LinkDB

DBGET integrated database retrieval system