KEGG   ORTHOLOGY: K15089
Entry
K15089            Tight     KO                                     
Symbol
CYP71D13_15_95
Name
(S)-limonene 3-monooxygenase [EC:1.14.14.99]
Pathway
map00902  Monoterpenoid biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R02469  (S)-limonene,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (3-hydroxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00902 Monoterpenoid biosynthesis
    K15089  CYP71D13_15_95; (S)-limonene 3-monooxygenase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K15089  CYP71D13_15_95; (S)-limonene 3-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.99  (S)-limonene 3-monooxygenase
     K15089  CYP71D13_15_95; (S)-limonene 3-monooxygenase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, plant type
  CYP71 family
   K15089  CYP71D13_15_95; (S)-limonene 3-monooxygenase
Other DBs
GO: 0018674
Genes
AG: AAD44151(CYP71D13) AAD44152(CYP71D15) AAQ18708(CYP71D95) AAT39473(CYP71D95)
Reference
PMID:11050228
  Authors
Schalk M, Croteau R
  Title
A single amino acid substitution (F363I) converts the regiochemistry of the spearmint (-)-limonene hydroxylase from a C6- to a C3-hydroxylase.
  Journal
Proc Natl Acad Sci U S A 97:11948-53 (2000)
DOI:10.1073/pnas.97.22.11948
Reference
PMID:11368174
  Authors
Wust M, Little DB, Schalk M, Croteau R
  Title
Hydroxylation of limonene enantiomers and analogs by recombinant (-)-limonene 3- and 6-hydroxylases from mint (Mentha) species: evidence for catalysis within sterically constrained active sites.
  Journal
Arch Biochem Biophys 387:125-36 (2001)
DOI:10.1006/abbi.2000.2248
Reference
PMID:15200648 (CYP71D95)
  Authors
Lucker J, Schwab W, Franssen MC, Van Der Plas LH, Bouwmeester HJ, Verhoeven HA
  Title
Metabolic engineering of monoterpene biosynthesis: two-step production of (+)-trans-isopiperitenol by tobacco.
  Journal
Plant J 39:135-45 (2004)
DOI:10.1111/j.1365-313X.2004.02113.x
  Sequence
[ag:AAT39473]
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