KEGG   ORTHOLOGY: K16033
Entry
K16033                      KO                                     
Symbol
asm12
Name
FADH2-dependent halogenase
Pathway
map01051  Biosynthesis of ansamycins
map01052  Type I polyketide structures
map01110  Biosynthesis of secondary metabolites
Reaction
R09851  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K16033  asm12; FADH2-dependent halogenase
   01051 Biosynthesis of ansamycins
    K16033  asm12; FADH2-dependent halogenase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K16033  asm12; FADH2-dependent halogenase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Halogenase
   K16033  asm12; FADH2-dependent halogenase
Genes
SRW: TUE45_00076(lodB)
SPAV: Spa2297_32570
SCYG: S1361_33970(lodB3)
SDD: D9753_04195
FRA: Francci3_2065
AORI: SD37_10910
APRE: CNX65_16200
AMI: Amir_3184
UME: RM788_15195
Reference
PMID:12060743
  Authors
Yu TW, Bai L, Clade D, Hoffmann D, Toelzer S, Trinh KQ, Xu J, Moss SJ, Leistner E, Floss HG
  Title
The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum.
  Journal
Proc Natl Acad Sci U S A 99:7968-73 (2002)
DOI:10.1073/pnas.092697199
  Sequence
[apre:CNX65_16200]
Reference
PMID:21614382
  Authors
Wu Y, Kang Q, Shen Y, Su W, Bai L
  Title
Cloning and functional analysis of the naphthomycin biosynthetic gene cluster in Streptomyces sp. CS.
  Journal
Mol Biosyst 7:2459-69 (2011)
DOI:10.1039/c1mb05036b
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