KEGG ORTHOLOGY: K16421

ORTHOLOGY: K16421

Entry

K16421                      KO

Symbol

hmaS, nocF

Name

4-hydroxymandelate synthase [EC:1.13.11.46]

Pathway

map00261

Monobactam biosynthesis

map01055

Biosynthesis of vancomycin group antibiotics

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Reaction

R06632

4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01055 Biosynthesis of vancomycin group antibiotics
    K16421  hmaS, nocF; 4-hydroxymandelate synthase
  09110 Biosynthesis of other secondary metabolites
   00261 Monobactam biosynthesis
    K16421  hmaS, nocF; 4-hydroxymandelate synthase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K16421  hmaS, nocF; 4-hydroxymandelate synthase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.46  4-hydroxymandelate synthase
     K16421  hmaS, nocF; 4-hydroxymandelate synthase
Polyketide biosynthesis proteins [BR:ko01008]
Nonribosomal peptide tailoring proteins
  Others
   K16421  hmaS, nocF; 4-hydroxymandelate synthase

Other DBs

GO:

0050585

Genes

BNU:	N3Z17_07100(hppD)

THAA:

CFI11_12525

MSD:	MYSTI_03600

MFB:	MFUL124B02_19465

AGE:	AA314_04078

CFUS:

CYFUS_002913

NTP:	CRH09_30890(hppD)

NHU:	H0264_30685(hppD)

SCO:	SCO3229(SCE63.04)

SVL:	Strvi_8789

SRC:	M271_09160 M271_27680

SBH:

SBI_01126

SLV:	SLIV_21545

SVT:	SVTN_32165 SVTN_32295

STRE:

GZL_08687

SLC:	SL103_26560

STRC:

AA958_31850

SAMB:

SAM23877_5652

SRW:	TUE45_06938

SPAV:

Spa2297_02915 Spa2297_26610 Spa2297_32985

STSI:

A4E84_04200 A4E84_32820

SKY:	D0C37_28235(hppD)

SALW:

CP975_31965(hppD)

SNR:	SNOUR_39385

SALU:

DC74_563

SALL:

SAZ_03310

SPLU:

LK06_002715 LK06_031630

SSIA:

A7J05_04105

SLAU:

SLA_6884

STRO:

STRMOE7_29130

SFK:	KY5_6265c KY5_6719 KY5_7437c

SCYA:

EJ357_01680(hppD)

SKA:	CP970_03010(hppD) CP970_07050(hppD) CP970_09760(hppD)

SRK:	FGW37_00515(hppD)

SGAL:

CP966_31740

SVR:	CP971_02370(hppD) CP971_08110(hppD)

SFY:	GFH48_02890(hppD) GFH48_36325(hppD)

SBY:	H7H31_03515(hppD)

SRIM:

CP984_06500(hppD)

SFUG:

CNQ36_25575(hppD)

STSU:

B7R87_00120 B7R87_00865

SCHA:

CP983_01445(hppD) CP983_10855(hppD)

SGX:	H4W23_38355(hppD)

SATA:

C5746_00990(hppD) C5746_42245(hppD)

SAUH:

SU9_002080(hppD)

SANU:

K7396_35155(hppD)

SINE:

KI385_01575(hppD) KI385_38530(hppD)

SDUR:

M4V62_39095(hppD)

SRUG:

F0345_27930(hppD)

SNIG:

HEK616_29510 HEK616_51390 HEK616_51650

SENG:

OJ254_30510(hppD) OJ254_30635(hppD)

SANT:

QR300_24025(hppD)

SYUN:

MOV08_40300(hppD)

SFIY:

F0344_35060(hppD)

SHAU:

K9S39_10855(hppD)

STRZ:

OYE22_03385(hppD)

KSK:	KSE_65080 KSE_67340

KAU:	B6264_28345

KIT:	CFP65_1222

KIS:	HUT16_30870 HUT16_31070(hppD) HUT16_31790(hppD)

STRH:

GXP74_15495(hppD) GXP74_26090(hppD)

ABRY:

NYE86_02870(hppD)

KFL:

Kfla_6066

KSL:	OG809_05925(hppD)

THAO:

NI17_008240(hppD)

NEC:	KGD82_24210(hppD)

AGRA:

AGRA3207_002325 AGRA3207_007458

AMAZ:

LUW76_44620(hppD)

SRO:

Sros_6970

NOA:	BKM31_54205

NCX:	Nocox_13265(noc2)

NGN:	LCN96_07790(hppD) LCN96_24325(hppD)

FRA:	Francci3_2454

AOI:	AORI_1495(hppD)

AJA:	AJAP_32040

AMYB:

BKN51_28930 BKN51_41520

AORI:

SD37_16610 SD37_33645

AROO:

NQK81_15410(hppD) NQK81_30300(hppD)

AMI:

Amir_4590

SSYI:

EKG83_29580(hppD) EKG83_30955(hppD)

KAL:

KALB_6132

KUT:	JJ691_47820 JJ691_70350

KBU:	Q4V64_04815(hppD)

ACTI:

UA75_15380

ACAD:

UA74_14810

ACTA:

C1701_23410(hppD)

STP:	Strop_2490 Strop_2727

SAQ:

Sare_2673

MAU:	Micau_3482

MIL:

ML5_4909

MICB:

MicB006_2537

MTUA:

CSH63_07635(hppD)

MICH:

FJK98_16440(hppD)

MTEM:

GCE86_13405(hppD)

MCAB:

HXZ27_18210(hppD)

MSAG:

GCM10017556_53780

VMA:	VAB18032_22230

MCHL:

PVK74_07655(hppD)

MFEU:

H1D33_22995(hppD) H1D33_24960(hppD)

MHAW:

RMN56_24450(hppD)

AOU:	ACTOB_006460(hppD)

PFLA:

Pflav_007570

PSUU:

Psuf_064610

ATL:	Athai_13960

PRY:	Prubr_36840 Prubr_65200

CATI:

CS0771_77170

DVC:	Dvina_13810(hppD) Dvina_18685(hppD)

DFU:	Dfulv_12455(hppD)

DAUR:

Daura_12945(hppD)

DMAT:

Dmats_13345(hppD)

CAI:

Caci_3256

HAU:

Haur_1888

AG:	AAT09803(nocF) CAA11761(hmaS)

» show all

Reference

PMID:11137816

Authors

Hubbard BK, Thomas MG, Walsh CT

Title

Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics.

Journal

Chem Biol 7:931-42 (2000)
DOI:10.1016/S1074-5521(00)00043-0

Sequence

[ag:CAA11761]

Reference

PMID:12445768

Authors

Hojati Z, Milne C, Harvey B, Gordon L, Borg M, Flett F, Wilkinson B, Sidebottom PJ, Rudd BA, Hayes MA, Smith CP, Micklefield J

Title

Structure, biosynthetic origin, and engineered biosynthesis of calcium-dependent antibiotics from Streptomyces coelicolor.

Journal

Chem Biol 9:1175-87 (2002)
DOI:10.1016/S1074-5521(02)00252-1

Sequence

[sco:SCO3229]

Reference

PMID:15271351

Authors

Gunsior M, Breazeale SD, Lind AJ, Ravel J, Janc JW, Townsend CA

Title

The biosynthetic gene cluster for a monocyclic beta-lactam antibiotic, nocardicin A.

Journal

Chem Biol 11:927-38 (2004)
DOI:10.1016/j.chembiol.2004.04.012

Sequence

[ag:AAT09803]

LinkDB

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