KEGG ORTHOLOGY: K17547

ORTHOLOGY: K17547

Entry

K17547                      KO

Symbol

SGK196

Name

glycoprotein-mannosyl O6-kinase [EC:2.7.1.183]

Pathway

map00515

Mannose type O-glycan biosynthesis

map01100

Metabolic pathways

Module

M00872

O-glycan biosynthesis, mannose type (core M3)

Reaction

R11400

ATP:3-O-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein] 6-phosphotransferase

R12293

Disease

H00120

Muscular dystrophy-dystroglycanopathy type A

H01959

Muscular dystrophy-dystroglycanopathy type C

H02307

Muscular dystrophy-dystroglycanopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00515 Mannose type O-glycan biosynthesis
    K17547  SGK196; glycoprotein-mannosyl O6-kinase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K17547  SGK196; glycoprotein-mannosyl O6-kinase
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.183  glycoprotein-mannosyl O6-kinase
     K17547  SGK196; glycoprotein-mannosyl O6-kinase
Protein kinases [BR:ko01001]
Serine/threonine kinases: Other
  Other
   K17547  SGK196; glycoprotein-mannosyl O6-kinase

Genes

HSA:	84197(POMK)

PTR:	464154(POMK)

PPS:	100985143(POMK)

GGO:	101148209(POMK)

PON:	100446965(POMK)

NLE:	100593922(POMK)

HMH:	116462137(POMK)

MCC:	706318(POMK)

MCF:	102126456(POMK)

MTHB:

126960764

CSAB:

103215702(POMK)

CATY:

105595742(POMK)

PANU:

101024701(POMK)

TGE:	112630262(POMK)

MLEU:

105554528(POMK)

RRO:	104668311(POMK)

RBB:	108534355(POMK)

TFN:	117095885(POMK)

PTEH:

111544084(POMK)

CANG:

105522557(POMK)

CJC:	100403123(POMK)

SBQ:	101052644(POMK)

CIMI:

108316203(POMK)

CSYR:

103274594

MMUR:

105878131(POMK)

LCAT:

123626595(POMK)

PCOQ:

105819683(POMK)

OGA:	100951684(POMK)

MMU:	74653(Pomk)

MCAL:

110299993(Pomk)

MPAH:

110336756(Pomk)

RNO:	306549(Pomk)

MCOC:

116069072(Pomk)

ANU:	117721873(Pomk)

MUN:	110566310(Pomk)

CGE:	100771074(Pomk)

MAUA:

101844716(Pomk)

PROB:

127220367(Pomk)

PLEU:

114681357(Pomk)

MORG:

121462112(Pomk)

MFOT:

126504439

AAMP:

119813639(Pomk)

NGI:	103728518(Pomk)

HGL:	101699969(Pomk)

CPOC:

100718330(Pomk)

CCAN:

109699825(Pomk)

DORD:

106002029(Pomk)

DSP:	122107682(Pomk)

PLOP:

125339266(Pomk)

NCAR:

124982626

MMMA:

107160925(Pomk)

OCU:

100346922

OPI:	101535715(POMK)

TUP:	102493452(POMK)

GVR:	103600541(POMK)

CFA:	482834(POMK)

CLUD:

112658415(POMK)

VVP:	112916169(POMK)

VLG:	121489599(POMK)

NPO:	129515948(POMK)

AML:	100469245(POMK)

UMR:	103677043(POMK)

UAH:	113245578(POMK)

UAR:	123780309(POMK)

ELK:

111144525

LLV:

125092814

MPUF:

101690834(POMK)

MNP:	132006623(POMK)

MLK:	131820447(POMK)

NVS:	122889846(POMK)

ORO:	101370967(POMK)

EJU:	114224858(POMK)

ZCA:	113925750(POMK)

MLX:	118009907(POMK)

NSU:	110573167(POMK)

LWW:	102740684(POMK)

FCA:	102902090(POMK)

PYU:	121010370(POMK)

PCOO:

112859012(POMK)

PBG:	122472821(POMK)

PVIV:

125164939(POMK)

LRUF:

124520839

PTG:	102958518(POMK)

PPAD:

109262248(POMK)

PUC:

125923848

AJU:

106990023

HHV:	120234023(POMK)

BTA:	514490(POMK)

BOM:	102270881(POMK)

BIU:	109553500(POMK)

BBUB:

102404277(POMK)

BBIS:

104993268(POMK)

CHX:	102191304(POMK)

OAS:	105605250(POMK)

BTAX:

128068221(POMK)

ODA:	120865868(POMK)

CCAD:

122426731 122432247(POMK)

MBEZ:

129549442(POMK)

CFR:	116660062(POMK)

CBAI:

105071098(POMK)

VPC:	102525840(POMK)

BACU:

103009793(POMK)

BMUS:

118887963(POMK)

LVE:	103085701(POMK)

OOR:	101288878(POMK)

DLE:	111173564(POMK)

PCAD:

102996084(POMK)

PSIU:

116746716(POMK)

NASI:

112413160(POMK)

ECB:	100053457(POMK)

EPZ:	103541353(POMK)

EAI:	106828970(POMK)

MYB:	102242789(POMK)

MYD:	102769516(POMK)

MMYO:

118651705(POMK)

MLF:	102436905(POMK)

PKL:	118729222(POMK)

EFUS:

103288192(POMK)

MNA:	107523904(POMK)

DRO:	112321487(POMK)

SHON:

118993222(POMK)

AJM:	119063071(POMK)

PDIC:

114508520(POMK)

PHAS:

123807632(POMK)

MMF:	118622665(POMK)

PPAM:

129064779(POMK)

HAI:	109386257(POMK)

RFQ:	117021646(POMK)

PALE:

102890250(POMK)

PGIG:

120595664(POMK)

PVP:	105300659(POMK)

RAY:	107501363(POMK)

MJV:	108396029(POMK)

TOD:	119257864(POMK)

SETR:

126006447(POMK)

LAV:	100654599(POMK)

TMU:

101344402

ETF:	101644690(POMK)

DNM:	101440148(POMK)

MDO:	100030275(POMK)

GAS:	123234842(POMK)

SHR:	100924613(POMK)

AFZ:

127548287

PCW:	110196409(POMK)

OAA:	100082420(POMK)

GGA:	422491(POMK)

PCOC:

116238088(POMK)

MGP:	100538885(POMK)

CJO:	107313218(POMK)

LMUT:

125692141(POMK)

NMEL:

110397665(POMK)

APLA:

101801929(POMK)

ACYG:

106035193(POMK)

CATA:

118246662(POMK)

AFUL:

116489168(POMK)

TGU:	100231168(POMK)

LSR:	110471717(POMK)

SCAN:

103825994(POMK)

PMOA:

120502697(POMK)

OTC:	121331452(POMK)

PRUF:

121360190(POMK)

GFR:	102033758(POMK)

FAB:	101811138(POMK)

OMA:	130252747(POMK)

PHI:	102112849(POMK)

PMAJ:

107202634(POMK)

CCAE:

111927790(POMK)

CCW:	104697134(POMK)

CBRC:

103617338(POMK)

ETL:	114062190(POMK)

ZAB:	102063824(POMK)

ZLE:	135446746(POMK)

ACHL:

103806002(POMK)

SVG:	106854411(POMK)

MMEA:

130576238(POMK)

HRT:	120753521(POMK)

FPG:	101910645(POMK)

FCH:	102059878(POMK)

CLV:	102088245(POMK)

EGZ:	104135539(POMK)

NNI:	104021153(POMK)

PCRI:

104025085(POMK)

PLET:

104627328(POMK)

EHS:	104503411(POMK)

PCAO:

104051535(POMK)

ACUN:

113479861(POMK)

TALA:

104368531(POMK)

PADL:

103925419(POMK)

AFOR:

103894248(POMK)

ACHC:

115339485(POMK)

HALD:

104317846(POMK)

HLE:	104843357(POMK)

AGEN:

126044972

GCL:

127015625

CCRI:

104161231(POMK)

CSTI:

104549119(POMK)

CMAC:

104472956(POMK)

MUI:	104546321(POMK)

BREG:

104628989(POMK)

FGA:	104074713(POMK)

GSTE:

104256305(POMK)

LDI:	104352380(POMK)

MNB:	103775806(POMK)

OHA:	104329196(POMK)

NNT:	104413156(POMK)

SHAB:

115610317(POMK)

DPUB:

104304152(POMK)

PGUU:

104465858(POMK)

ACAR:

104521295(POMK)

CPEA:

104398867(POMK)

AVIT:

104266994(POMK)

CVF:	104282997(POMK)

RTD:	128910105(POMK)

CUCA:

104064683(POMK)

TEO:	104381077(POMK)

BRHI:

104490289(POMK)

AAM:	106484357(POMK)

AROW:

112972166(POMK)

NPD:	112953460(POMK)

TGT:	104564852(POMK)

DNE:	112993247(POMK)

SCAM:

104152069(POMK)

ASN:	102374161(POMK)

AMJ:	102567007(POMK)

CPOO:

109309428(POMK)

GGN:	109301227(POMK)

PSS:	102445972(POMK)

CMY:	102947718(POMK)

CCAY:

125635903(POMK)

DCC:	119854448(POMK)

CPIC:

101949171(POMK)

TST:	117877944(POMK)

CABI:

116834477(POMK)

MRV:	120406732(POMK)

ACS:	100560387(pomk)

ASAO:

132778438(POMK)

PVT:	110086322(POMK)

SUND:

121917884 121932988(POMK)

PBI:	103068088(POMK)

PMUR:

107302375(POMK)

CTIG:

120302759(POMK)

TSR:	106550224(POMK)

PGUT:

117664778(POMK)

APRI:

131196946(POMK)

PTEX:

113447253(POMK)

NSS:	113428985 113428986

VKO:	123031849(POMK)

PMUA:

114581527 114581529

PRAF:

128400669(POMK)

ZVI:	118079270 118094855(POMK)

HCG:	128328733(POMK)

GJA:	107107431(POMK)

EMC:	129337466(POMK)

XLA:	496338(pomk.L)

XTR:	100497421(pomk)

NPR:	108804921(POMK)

RTEM:

120914558(POMK)

BBUF:

120989665(POMK)

BGAR:

122945703(POMK)

MUO:	115458898 115463782(POMK)

GSH:	117346093(POMK)

DRE:	492773(pomk)

SRX:	107708470 107733691

SANH:

107678554

SGH:	107567859 107582561

CCAR:

109061611 109065618

CAUA:

113057034 113078215

CGIB:

127969639

PTET:

122356741(pomk)

LROH:

127174682(pomk)

OMC:	131552254(pomk)

PPRM:

120479678(pomk)

RKG:	130083084(pomk)

MAMB:

125276601(pomk)

CIDE:

127524656

MASI:

127414245

TROS:

130558850(pomk)

TDW:	130431705(pomk)

MANU:

129416640(pomk)

IPU:

108263618

IFU:	128605509(pomk)

PHYP:

113542784(pomk)

SMEO:

124394813(pomk)

TFD:	113639743(pomk)

TVC:	132847208(pomk)

TRN:	134314501(pomk)

AMEX:

103039966(pomk)

CMAO:

118810311(pomk)

EEE:	113585802(pomk)

CHAR:

105899654(pomk)

TRU:	101062833(pomk)

TFS:	130516851(pomk)

TNG:	GSTEN00000504G001 GSTEN00013652G001

NCC:	104947920(pomk)

TBEN:

117474462(pomk)

PGEO:

117455733(pomk)

GACU:

117557431(pomk)

EMAC:

134868394(pomk)

ELY:	117269211(pomk)

EFO:	125905840(pomk)

PLEP:

121960031(pomk)

SLUC:

116041376(pomk)

ECRA:

117958862(pomk)

PFLV:

114571045(pomk)

GAT:	120831507(pomk)

PPUG:

119226242(pomk)

AFB:	129102661(pomk)

CLUM:

117740492(pomk)

PSWI:

130205501(pomk)

MSAM:

119914310(pomk)

SCHU:

122865871(pomk)

CUD:	121525343(pomk)

ALAT:

119030297(pomk)

MZE:	101481202(pomk)

ONL:	100700536(pomk)

OAU:	116319162(pomk)

OLA:	101164276(pomk)

OML:	112140349(pomk)

CSAI:

133454794(pomk)

XMA:	106700026(pomk)

XCO:	114150255(pomk)

XHE:	116724754(pomk)

PRET:

103473164(pomk)

PFOR:

103152298(pomk)

PLAI:

106947027(pomk)

PMEI:

106922492(pomk)

GAF:	122847279(pomk)

PPRL:

129379778(pomk)

CVG:	107098491(pomk)

CTUL:

119797753(pomk)

GMU:	124872308(pomk)

NFU:	107395076(pomk)

KMR:	108246453(pomk)

ALIM:

106522200(pomk)

NWH:	119424393(pomk)

AOCE:

111579159(pomk)

MCEP:

124996365(pomK)

CSEM:

103389221(pomk)

POV:	109637637(pomk)

SSEN:

122761047(pomk)

HHIP:

117771427(pomk)

HSP:	118098074(pomk)

PPLT:

128424791(pomk)

SMAU:

118284802(pomk)

LCF:

108877752

SDU:	111221209(pomk)

SLAL:

111659623(pomk)

XGL:	120806638(pomk)

HCQ:	109530012(pomk)

SSCV:

125979835

SBIA:

133490941(pomk)

PEE:	133414067(pomk)

PTAO:

133465266(pomk)

BPEC:

110161849(pomk)

MALB:

109960745(pomk)

BSPL:

114867242(pomk)

SJO:	128380283(pomk)

SASA:

100306734(pomk)

STRU:

115172928(pomk)

OTW:	112262119(pomk)

OMY:	110498207(pomk)

OGO:	124001569(pomk)

ONE:	115146469(pomk)

OKI:	109894713(pomk)

OKE:	118362233(pomk)

SALP:

111968961(pomk)

SNH:	120059807(pomk)

CCLU:

121538738(pomk)

ELS:	105015966(pomk)

SFM:	108920894(pomk)

PKI:	111833170(pomk)

AANG:

118226785(pomk)

LOC:	102694538(pomk)

PSPA:

121294710(pomk)

ARUT:

117408772(pomk) 117420431

PSEX:

120532342(pomk)

LCM:	102349350(POMK)

CMK:	103191503(pomk)

RTP:	109935288(pomk)

CPLA:

122539287(pomk)

HOC:	132833395(pomk)

LERI:

129701228(pomk)

PMRN:

116950423(POMK)

LRJ:	133352471(POMK)

BFO:	118412857 118413332 118426113

BBEL:

109462232 109462249 109462276 109463158 109463207 109466369 109469120 109475484 109475485

CIN:	100180020 100180094

SCLV:

120335512 120336072 120336720

APLC:

110983381

SKO:

100366379

BTAB:

109043533

NLU:	111056326 120350971

HVI:

MQU:

FOC:

TPAL:

BROR:

PVM:

PJA:

PCHN:

PMOO:

HAME:

MNZ:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

LGI:	LOTGIDRAFT_123453

PVUL:

PCAN:

BGT:

GAE:

CRG:	105333495 105333837 105333838 105343841 117690447

CVN:	111101602 111102115 111136424

CANU:

128179273 128179332 128179340 128179403 128179567 128181641 128181778 128181924 128182065 128182296 128182372 128182407 128182425 128182451

OED:	125658888 125659771

MYI:

PMAX:

OBI:

OSN:

LAK:	106159752 106164523

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

TAD:	TRIADDRAFT_32494

SRE:	PTSG_04862

» show all

Reference

PMID:23929950

Authors

Yoshida-Moriguchi T, Willer T, Anderson ME, Venzke D, Whyte T, Muntoni F, Lee H, Nelson SF, Yu L, Campbell KP

Title

SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function.

Journal

Science 341:896-9 (2013)
DOI:10.1126/science.1239951

Sequence

[hsa:84197]

LinkDB

DBGET integrated database retrieval system