KEGG   ORTHOLOGY: K17746
Entry
K17746                      KO                                     
Symbol
ChaDH
Name
chanoclavine-I dehydrogenase [EC:1.1.1.332]
Pathway
map00901  Indole alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00963  Chanoclavine aldehyde biosynthesis, tryptophan => chanoclavine-I aldehyde
Reaction
R10128  chanoclavine-I:NAD+ oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00901 Indole alkaloid biosynthesis
    K17746  ChaDH; chanoclavine-I dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.332  chanoclavine-I dehydrogenase
     K17746  ChaDH; chanoclavine-I dehydrogenase
Genes
MGR: MGG_02225 MGG_09087
PPEI: PpBr36_06906
PGRI: PgNI_05463
NHE: NECHADRAFT_80607
FFC: NCS54_00718400
FKR: NCS57_00758700
MAW: MAC_06985
MAJ: MAA_06739
CFJ: CFIO01_09989
GLZ: GLAREA_05925
AFM: AFUA_2G18000
ABE: ARB_04646
TVE: TRV_01860
 » show all
Reference
PMID:20039019
  Authors
Wallwey C, Matuschek M, Li SM
  Title
Ergot alkaloid biosynthesis in Aspergillus fumigatus: conversion of chanoclavine-I to chanoclavine-I aldehyde catalyzed by a short-chain alcohol dehydrogenase FgaDH.
  Journal
Arch Microbiol 192:127-34 (2010)
DOI:10.1007/s00203-009-0536-1
  Sequence
[afm:AFUA_2G18000]
Reference
PMID:22403186
  Authors
Wallwey C, Heddergott C, Xie X, Brakhage AA, Li SM
  Title
Genome mining reveals the presence of a conserved gene cluster for the biosynthesis of ergot alkaloid precursors in the fungal family Arthrodermataceae.
  Journal
Microbiology 158:1634-44 (2012)
DOI:10.1099/mic.0.056796-0
  Sequence
[abe:ARB_04646]
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