KEGG ORTHOLOGY: K17902

ORTHOLOGY: K17902

Entry

K17902                      KO

Symbol

TBC1D4, AS160

Name

TBC1 domain family member 4

Pathway

map04919

Thyroid hormone signaling pathway

map04931

Insulin resistance

map05415

Diabetic cardiomyopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    K17902  TBC1D4, AS160; TBC1 domain family member 4
09160 Human Diseases
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    K17902  TBC1D4, AS160; TBC1 domain family member 4
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    K17902  TBC1D4, AS160; TBC1 domain family member 4
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K17902  TBC1D4, AS160; TBC1 domain family member 4
Membrane trafficking [BR:ko04131]
Exocytosis
  Small GTPases and associated proteins
   Rab associated proteins
    K17902  TBC1D4, AS160; TBC1 domain family member 4
Protein recycling
  Rab GTPases and associated proteins
   Other Rab GTPase associated proteins
    K17902  TBC1D4, AS160; TBC1 domain family member 4
Endoplasmic reticulum (ER) - Golgi transport
  Forward pathways
   Rab associated proteins
    K17902  TBC1D4, AS160; TBC1 domain family member 4

Other DBs

GO:	0005096 0017137

TC:	8.A.87.1.1

Genes

HSA:	9882(TBC1D4)

PTR:	467286(TBC1D4)

PPS:	100987740(TBC1D4)

GGO:	101135377(TBC1D4)

PON:	100172313(TBC1D4)

NLE:	100606378(TBC1D4)

HMH:	116467348(TBC1D4)

MCC:	696915(TBC1D4)

MCF:	102146743(TBC1D4)

MTHB:

126940500

MNI:	105481744(TBC1D4)

CSAB:

103214869(TBC1D4)

CATY:

105572026(TBC1D4)

PANU:

101004773(TBC1D4)

TGE:	112611011(TBC1D4)

MLEU:

105533533(TBC1D4)

RRO:	104673571(TBC1D4)

RBB:	108527181(TBC1D4)

TFN:	117063688(TBC1D4)

PTEH:

111522306(TBC1D4)

CANG:

105504641(TBC1D4)

CJC:	100391512(TBC1D4)

SBQ:	101027673(TBC1D4)

CIMI:

108300742(TBC1D4)

CSYR:

103266829(TBC1D4)

MMUR:

105855858(TBC1D4)

LCAT:

123649463(TBC1D4)

PCOQ:

105808501(TBC1D4)

OGA:	100966356(TBC1D4)

MMU:	210789(Tbc1d4)

MCAL:

110309142(Tbc1d4)

MPAH:

110325249(Tbc1d4)

RNO:	306117(Tbc1d4)

MCOC:

116085380(Tbc1d4)

ANU:	117706107(Tbc1d4)

MUN:	110554366(Tbc1d4)

CGE:	100755100(Tbc1d4)

MAUA:

101841445(Tbc1d4)

PROB:

127230130(Tbc1d4)

PLEU:

114690192(Tbc1d4)

MORG:

121460202(Tbc1d4)

MFOT:

126503120

AAMP:

119800356(Tbc1d4)

NGI:	103746258(Tbc1d4)

HGL:	101719700(Tbc1d4)

CPOC:

100730955(Tbc1d4)

CCAN:

109699229(Tbc1d4)

DORD:

105980580(Tbc1d4)

DSP:	122112565(Tbc1d4)

PLOP:

125348201(Tbc1d4)

NCAR:

124984719

MMMA:

107153213(Tbc1d4)

OCU:

100348990

OPI:	101524056(TBC1D4) 101531433

TUP:	102479749(TBC1D4)

GVR:	103590188(TBC1D4)

CFA:	485494(TBC1D4)

CLUD:

112655840(TBC1D4)

VVP:	112934285(TBC1D4)

VLG:	121477154(TBC1D4)

NPO:	129516557(TBC1D4)

AML:	100479445(TBC1D4)

UMR:	103659165(TBC1D4)

UAH:	113251422(TBC1D4)

UAR:	123801093(TBC1D4)

ELK:

111146968

LLV:

125094704

MPUF:

101683940(TBC1D4)

MNP:	132002763(TBC1D4)

MLK:	131813836(TBC1D4)

NVS:	122907150(TBC1D4)

ORO:	101362215(TBC1D4)

EJU:	114211505(TBC1D4)

ZCA:	113919745(TBC1D4)

MLX:	118009334(TBC1D4)

NSU:	110587615(TBC1D4)

LWW:	102749262(TBC1D4)

FCA:	101100706(TBC1D4)

PYU:	121037843(TBC1D4)

PCOO:

112860780(TBC1D4)

PBG:	122483485(TBC1D4)

PVIV:

125168913(TBC1D4)

LRUF:

124512991

PTG:	102967077(TBC1D4)

PPAD:

109264220(TBC1D4)

PUC:

125934140

AJU:

106965739

HHV:	120236971(TBC1D4)

BTA:	534649(TBC1D4)

BOM:	102264455(TBC1D4)

BIU:	109566880(TBC1D4)

BBUB:

102393694(TBC1D4)

BBIS:

104988366(TBC1D4)

CHX:	102180863(TBC1D4)

OAS:	101123311(TBC1D4)

BTAX:

128057561(TBC1D4)

ODA:	120883015(TBC1D4)

CCAD:

122447256(TBC1D4)

MBEZ:

129556423(TBC1D4)

SSC:	100523015(TBC1D4)

CFR:	102523063(TBC1D4)

CBAI:

105083640

CDK:	105101774(TBC1D4)

VPC:	102524883(TBC1D4)

BACU:

103000948(TBC1D4)

BMUS:

118884082(TBC1D4)

LVE:	103068751(TBC1D4)

OOR:	101287854(TBC1D4)

DLE:	111176487(TBC1D4)

PCAD:

102988788(TBC1D4)

PSIU:

116743187(TBC1D4)

NASI:

112405508(TBC1D4)

ECB:	100051815(TBC1D4)

EPZ:	103552111(TBC1D4)

EAI:	106843092(TBC1D4)

MYB:	102251725(TBC1D4)

MYD:	102751857(TBC1D4)

MMYO:

118651779(TBC1D4)

MLF:	102439723(TBC1D4)

PKL:	118728659(TBC1D4)

EFUS:

103288392(TBC1D4)

MNA:	107539841(TBC1D4)

DRO:	112312545(TBC1D4)

SHON:

118996113(TBC1D4)

AJM:	119055106(TBC1D4)

PDIC:

114508693(TBC1D4)

PHAS:

123818766(TBC1D4)

MMF:	118622694(TBC1D4)

PPAM:

129080916(TBC1D4)

HAI:	109374247(TBC1D4)

RFQ:	117021118(TBC1D4)

PALE:

102898844(TBC1D4)

PGIG:

120621509(TBC1D4)

PVP:	105298481(TBC1D4)

RAY:	107513086(TBC1D4)

MJV:	108385692(TBC1D4)

TOD:	119259923(TBC1D4)

SARA:

101545203(TBC1D4)

SETR:

126016345(TBC1D4)

LAV:	100675182(TBC1D4)

TMU:

101357612

ETF:	101655785(TBC1D4)

DNM:	101412937(TBC1D4)

MDO:	100012014(TBC1D4)

GAS:	123242665(TBC1D4)

SHR:	100925957(TBC1D4)

AFZ:

127553314

PCW:	110212440(TBC1D4)

OAA:	100077864(TBC1D4)

GGA:	428062(TBC1D4)

PCOC:

116237965(TBC1D4)

MGP:	100548326(TBC1D4)

CJO:	107308056(TBC1D4)

TPAI:

128092084(TBC1D4)

LMUT:

125687928(TBC1D4)

NMEL:

110408540(TBC1D4)

APLA:

101792746(TBC1D4)

ACYG:

106042322(TBC1D4)

CATA:

118255238(TBC1D4)

AFUL:

116488143(TBC1D4)

TGU:	100221429(TBC1D4)

LSR:	110480238(TBC1D4)

SCAN:

103812264(TBC1D4)

PMOA:

120504801(TBC1D4)

OTC:	121344197(TBC1D4)

PRUF:

121355654(TBC1D4)

GFR:	102045064(TBC1D4)

FAB:	101812735(TBC1D4)

OMA:	130254662(TBC1D4)

PHI:	102099858(TBC1D4)

PMAJ:

107201983(TBC1D4)

CCAE:

111930037(TBC1D4)

CCW:	104695871(TBC1D4)

CBRC:

103624425(TBC1D4)

ETL:	114062615(TBC1D4)

ZAB:	102067477(TBC1D4)

ZLE:	135447998(TBC1D4)

ACHL:

103808313(TBC1D4)

SVG:	106849986(TBC1D4)

MMEA:

130573778(TBC1D4)

HRT:	120748417(TBC1D4)

FPG:	101916918(TBC1D4)

FCH:	102046420(TBC1D4)

CLV:	102094838(TBC1D4)

EGZ:	104133581(TBC1D4)

NNI:	104010862(TBC1D4)

PLET:

104624939(TBC1D4)

EHS:	104516916(TBC1D4)

PCAO:

104053399(TBC1D4)

ACUN:

113482002(TBC1D4)

TALA:

104357326(TBC1D4)

PADL:

103913067(TBC1D4)

AFOR:

103900948

ACHC:

115350598(TBC1D4)

HLE:	104836589(TBC1D4)

AGEN:

126045272

GCL:

127017647

CCRI:

104164822(TBC1D4)

CSTI:

104554556

CMAC:

104477796(TBC1D4)

MUI:	104546845(TBC1D4)

BREG:

104632414(TBC1D4)

FGA:	104080345(TBC1D4)

GSTE:

104253365(TBC1D4)

LDI:

104354388

MNB:

103782534

OHA:	104336651(TBC1D4)

NNT:	104413572(TBC1D4)

SHAB:

115603927(TBC1D4)

DPUB:

104310311(TBC1D4)

PGUU:

104471121(TBC1D4)

ACAR:

104529137(TBC1D4)

CPEA:

104393965(TBC1D4)

CVF:	104289951(TBC1D4)

RTD:	128904556(TBC1D4)

CUCA:

104054964(TBC1D4)

TEO:	104377924(TBC1D4)

BRHI:

104498795(TBC1D4)

AAM:	106491691(TBC1D4)

AROW:

112975015(TBC1D4)

NPD:	112951759(TBC1D4)

TGT:	104576038(TBC1D4)

DNE:	112995710(TBC1D4)

SCAM:

104147461(TBC1D4)

ASN:	102388828(TBC1D4)

AMJ:	102566781(TBC1D4)

CPOO:

109306440(TBC1D4)

GGN:	109302735(TBC1D4)

PSS:	102451644(TBC1D4)

CMY:	102930228(TBC1D4)

CCAY:

125637620(TBC1D4)

DCC:	119850084(TBC1D4)

CPIC:

101943608(TBC1D4)

TST:	117870890(TBC1D4)

CABI:

116836333(TBC1D4)

MRV:	120402920(TBC1D4)

ACS:	100561881(tbc1d4)

ASAO:

132771427(TBC1D4)

PVT:	110073853(TBC1D4)

SUND:

121925045(TBC1D4)

PBI:	103053667(TBC1D4)

PMUR:

107303133(TBC1D4)

CTIG:

120318361(TBC1D4)

TSR:	106554018(TBC1D4)

PGUT:

117665255(TBC1D4)

APRI:

131200200(TBC1D4)

PTEX:

113439435(TBC1D4)

NSS:	113415893(TBC1D4)

VKO:	123027266(TBC1D4)

PMUA:

114596601(TBC1D4)

PRAF:

128411977(TBC1D4)

ZVI:	118084625(TBC1D4)

HCG:	128350007(TBC1D4)

GJA:	107108799(TBC1D4)

STOW:

125430788(TBC1D4)

EMC:	129325771(TBC1D4)

XLA:	108709775(tbc1d4.S) 444449(tbc1d4.L)

XTR:	100379738(tbc1d4)

NPR:	108794921(TBC1D4)

RTEM:

120929688(TBC1D4)

BBUF:

120995880(TBC1D4)

BGAR:

122931698(TBC1D4)

MUO:	115468694(TBC1D4)

GSH:	117362420(TBC1D4)

DRE:	321065(tbc1d4)

SRX:	107720111 107741985

SANH:

107655530 107668890

SGH:	107569953 107600383

CCAR:

109065842

CAUA:

113053171 113108540 113108655

CGIB:

127965221 128019898

PTET:

122352029(tbc1d4)

LROH:

127170657(tbc1d4)

OMC:	131546980(tbc1d4)

PPRM:

120466847(tbc1d4)

RKG:	130094407(tbc1d4)

MAMB:

125270337(tbc1d4)

CIDE:

127518266

MASI:

127447029 127447701

TROS:

130555521(tbc1d4)

TDW:	130427824(tbc1d4)

MANU:

129451821(tbc1d4)

IPU:

108266625

IFU:	128609246(tbc1d4)

PHYP:

113547624(tbc1d4)

SMEO:

124382633(tbc1d4)

TFD:	113655455(tbc1d4)

TVC:	132850025(tbc1d4)

TRN:	134323865(tbc1d4)

AMEX:

103023482(tbc1d4)

CMAO:

118814873(tbc1d4)

EEE:

113574361

CHAR:

105905943(tbc1d4)

TRU:	101064612(tbc1d4)

TFS:	130537737(tbc1d4)

TNG:	GSTEN00027930G001

LCO:	104921466(tbc1d4)

NCC:	104962222(tbc1d4)

TBEN:

117481055(tbc1d4)

CGOB:

115026071(tbc1d4)

PGEO:

117466598(tbc1d4)

GACU:

117544484(tbc1d4)

EMAC:

134866951(tbc1d4)

ELY:	117251183(tbc1d4)

EFO:	125899350(tbc1d4)

PLEP:

121948698(tbc1d4)

SLUC:

116041930(tbc1d4)

ECRA:

117952451(tbc1d4)

ESP:	116698303(tbc1d4)

PFLV:

114564610(tbc1d4)

GAT:	120833905(tbc1d4)

PPUG:

119228703(tbc1d4)

AFB:	129104211(tbc1d4)

CLUM:

117750816(tbc1d4)

PSWI:

130201009(tbc1d4)

MSAM:

119904354(tbc1d4)

SCHU:

122885037(tbc1d4)

CUD:	121522278(tbc1d4)

ALAT:

119025682(tbc1d4)

MZE:	101480160(tbc1d4)

ONL:	100712298(tbc1d4)

OAU:	116316036(tbc1d4)

OLA:	101168582(tbc1d4)

OML:	112155074(tbc1d4)

CSAI:

133446231(tbc1d4)

XMA:	102236823(tbc1d4)

XCO:	114147907(tbc1d4)

XHE:	116722691(tbc1d4)

PRET:

103479242(tbc1d4)

PFOR:

103134740(tbc1d4)

PLAI:

106962564(tbc1d4)

PMEI:

106927937(tbc1d4)

GAF:	122840328(tbc1d4)

PPRL:

129361108(tbc1d4)

CVG:

107092952

CTUL:

119794750(tbc1d4)

GMU:	124871123(tbc1d4)

NFU:	107389729(tbc1d4)

KMR:	108232415(tbc1d4)

ALIM:

106528119(tbc1d4)

NWH:	119419685(tbc1d4)

AOCE:

111572803(tbc1d4)

MCEP:

125017608(tbc1d4)

CSEM:

103391926(tbc1d4)

SSEN:

122758615(tbc1d4)

HHIP:

117755443(tbc1d4)

HSP:	118120459(tbc1d4)

PPLT:

128455623(tbc1d4)

SMAU:

118320329(tbc1d4)

LCF:

108901259

SDU:	111218219(tbc1d4)

SLAL:

111673029(tbc1d4)

XGL:	120801188(tbc1d4)

HCQ:	109523298(tbc1d4)

SSCV:

125973840

SBIA:

133512420(tbc1d4)

PEE:	133410252(tbc1d4)

PTAO:

133486461(tbc1d4)

BPEC:

110170565(tbc1d4)

MALB:

109965419(tbc1d4)

BSPL:

114847072(tbc1d4)

SJO:	128367633(tbc1d4)

SASA:

106581617(tbc1d4)

STRU:

115156242(tbc1d4)

OTW:	112225052(tbc1d4)

OMY:	110501243(tbc1d4)

OGO:	124041518(tbc1d4)

ONE:	115133193(tbc1d4)

OKI:	109871419(tbc1d4)

OKE:	118385896(tbc1d4)

SALP:

111959944(tbc1d4)

SNH:	120064478(tbc1d4)

CCLU:

121536603 121546305

ELS:	105008379(tbc1d4)

SFM:	108920465 108930208(tbc1d4)

PKI:	111844615(tbc1d4) 111852765

AANG:

118213906(tbc1d4)

LOC:	102691902(tbc1d4)

PSPA:

121320938 121327734

ARUT:

117405857 117406908

PSEX:

120523757(tbc1d4)

LCM:	102361698(TBC1D4)

CMK:	103176892(tbc1d4)

CPLA:

122550526(tbc1d4)

HOC:	132816393(tbc1d4)

LERI:

129697962(tbc1d4)

PMRN:

116943469

LRJ:	133349944(TBC1D4)

BFO:

BBEL:

CIN:

SCLV:

SPU:

APLC:

SKO:

DME:	Dmel_CG42612(plx)

DER:

6552835

DSE:

6614013

DSI:	Dsimw501_GD19813(Dsim_GD19813)

DYA:	Dyak_GE10157

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI23777

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ001401

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_205122

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PGW:

LGLY:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM569740

FOC:

TPAL:

ZNE:

CSEC:

BROR:

IEL:

DPX:	DAPPUDRAFT_232154

DMK:

DPZ:

PVM:

PJA:

PCHN:

PCLA:

PTRU:

ESN:

MNZ:

HAZT:

LSM:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

SDM:

PVUL:

PCAN:

GAE:

HRF:

HRJ:

CVN:

CANU:

OED:

MYI:

PMAX:

OBI:

OSN:

LJP:

LAK:

NVE:

EPA:

ATEN:

AMIL:

PDAM:

SPIS:

HMG:

RES:

AQU:

SRE:	PTSG_07431

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Reference

PMID:18771725

Authors

Baus D, Heermeier K, De Hoop M, Metz-Weidmann C, Gassenhuber J, Dittrich W, Welte S, Tennagels N

Title

Identification of a novel AS160 splice variant that regulates GLUT4 translocation and glucose-uptake in rat muscle cells.

Journal

Cell Signal 20:2237-46 (2008)
DOI:10.1016/j.cellsig.2008.08.010

Sequence

[hsa:9882]

Reference

PMID:19252894

Authors

Treebak JT, Frosig C, Pehmoller C, Chen S, Maarbjerg SJ, Brandt N, MacKintosh C, Zierath JR, Hardie DG, Kiens B, Richter EA, Pilegaard H, Wojtaszewski JF

Title

Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle.

Journal

Diabetologia 52:891-900 (2009)
DOI:10.1007/s00125-009-1294-y

LinkDB

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