KEGG ORTHOLOGY: K17985

ORTHOLOGY: K17985

Entry

K17985                      KO

Symbol

AMBRA1

Name

activating molecule in BECN1-regulated autophagy protein 1

Pathway

map04137

Mitophagy - animal

map04140

Autophagy - animal

map05010

Alzheimer disease

map05014

Amyotrophic lateral sclerosis

map05016

Huntington disease

map05017

Spinocerebellar ataxia

map05022

Pathways of neurodegeneration - multiple diseases

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K17985  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1
   04137 Mitophagy - animal
    K17985  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1
09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K17985  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1
   05014 Amyotrophic lateral sclerosis
    K17985  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1
   05016 Huntington disease
    K17985  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1
   05017 Spinocerebellar ataxia
    K17985  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1
   05022 Pathways of neurodegeneration - multiple diseases
    K17985  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K17985  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1
   03029 Mitochondrial biogenesis
    K17985  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1
Membrane trafficking [BR:ko04131]
Autophagy
  Mitophagy
   PINK1-Parkin associated proteins
    K17985  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1
Mitochondrial biogenesis [BR:ko03029]
Mitochondrial quality control factors
  Mitophagy factors
   Parkin-dependent mechanism factors
    K17985  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1

Genes

HSA:	55626(AMBRA1)

PTR:	451154(AMBRA1)

PPS:	100976893(AMBRA1)

GGO:	101144271(AMBRA1)

PON:	100456410(AMBRA1)

NLE:	100595128(AMBRA1)

HMH:	116476298(AMBRA1)

MCC:	714434(AMBRA1)

MCF:	101925989(AMBRA1)

MTHB:

126935738

MNI:	105471664(AMBRA1)

CSAB:

103236448(AMBRA1)

CATY:

105592798(AMBRA1)

PANU:

101004741(AMBRA1)

TGE:	112606606(AMBRA1)

MLEU:

105554801(AMBRA1)

RRO:	104668391(AMBRA1)

TFN:	117079889(AMBRA1)

PTEH:

111544908(AMBRA1)

CANG:

105527115(AMBRA1)

CJC:	100385379(AMBRA1)

SBQ:	101046668(AMBRA1)

CIMI:

108304868(AMBRA1)

CSYR:

103267783(AMBRA1)

MMUR:

105885026(AMBRA1)

LCAT:

123642652(AMBRA1)

PCOQ:

105811088(AMBRA1)

OGA:	100957984(AMBRA1)

MMU:	228361(Ambra1)

MCAL:

110309853(Ambra1)

MPAH:

110317534(Ambra1)

RNO:	59319(Ambra1)

MCOC:

116090484(Ambra1)

ANU:	117702984(Ambra1)

MUN:	110549887(Ambra1)

CGE:	100753101(Ambra1)

MAUA:

101843441(Ambra1)

PROB:

127222235(Ambra1)

PLEU:

114699701(Ambra1)

MORG:

121437617(Ambra1)

MFOT:

126489749

AAMP:

119814136(Ambra1)

NGI:	103748789(Ambra1)

HGL:	101725050(Ambra1)

CPOC:

100716429(Ambra1)

CCAN:

109692005(Ambra1)

DORD:

105996026(Ambra1)

DSP:	122104920(Ambra1)

PLOP:

125361394(Ambra1)

NCAR:

124958674

MMMA:

107135795(Ambra1)

OCU:

100349558

OPI:	101529943(AMBRA1)

TUP:	102491780(AMBRA1)

GVR:

103603380

CFA:	483634(AMBRA1)

CLUD:

112663298(AMBRA1)

VVP:	112924090(AMBRA1)

VLG:	121501658(AMBRA1)

NPO:	129500433(AMBRA1)

AML:	100471614(AMBRA1)

UMR:	103672328(AMBRA1)

UAH:	113264983(AMBRA1)

UAR:	123799572(AMBRA1)

ELK:

111149427

LLV:

125079465

MPUF:

101680997(AMBRA1)

MNP:	132008252 132008462

MLK:	131812046(AMBRA1)

NVS:	122912882(AMBRA1)

ORO:	101383471(AMBRA1)

EJU:	114215381(AMBRA1)

ZCA:	113915368(AMBRA1)

MLX:	118015811(AMBRA1)

NSU:	110575761(AMBRA1)

LWW:	102746948(AMBRA1)

FCA:	101088613(AMBRA1)

PYU:	121043470(AMBRA1)

PCOO:

112865154(AMBRA1)

PBG:	122483756(AMBRA1)

PVIV:

125176272(AMBRA1)

LRUF:

124506277

PTG:	102950173(AMBRA1)

PPAD:

109245100(AMBRA1)

PUC:

125912665

AJU:

106978066

HHV:	120228409(AMBRA1)

BTA:	517263(AMBRA1)

BOM:	102269275(AMBRA1)

BIU:	109569559(AMBRA1)

BBUB:

102409652(AMBRA1)

BBIS:

104990387(AMBRA1)

CHX:	102184456(AMBRA1)

OAS:	101117963(AMBRA1)

BTAX:

128060116(AMBRA1)

ODA:	120876935(AMBRA1)

CCAD:

122450447(AMBRA1)

MBEZ:

129554797(AMBRA1)

SSC:	100519700(AMBRA1)

CFR:	102512599(AMBRA1)

CBAI:

105076466(AMBRA1)

CDK:	105106861(AMBRA1)

VPC:	102536199(AMBRA1)

BACU:

103009999(AMBRA1)

BMUS:

118898884(AMBRA1)

LVE:	103084043(AMBRA1)

OOR:	101287189(AMBRA1)

DLE:	111183981(AMBRA1)

PCAD:

102989160

PSIU:

116757500(AMBRA1)

NASI:

112402536(AMBRA1)

ECB:	100050652(AMBRA1)

EPZ:	103566525(AMBRA1)

EAI:	106843993(AMBRA1)

MYB:	102248838(AMBRA1)

MYD:	102768382(AMBRA1)

MMYO:

118665082(AMBRA1)

MLF:	102431271(AMBRA1)

PKL:	118713108(AMBRA1)

EFUS:

103291023(AMBRA1)

MNA:	107530323(AMBRA1)

DRO:	112303248(AMBRA1)

SHON:

118974506(AMBRA1)

AJM:	119064443(AMBRA1)

PDIC:

114499714(AMBRA1)

PHAS:

123810017(AMBRA1)

MMF:	118628767(AMBRA1)

PPAM:

129081447(AMBRA1)

HAI:	109390228(AMBRA1)

RFQ:	117029950(AMBRA1)

PALE:

102896507(AMBRA1)

PGIG:

120606809(AMBRA1)

PVP:	105290018(AMBRA1)

RAY:	107511862(AMBRA1)

MJV:	108406809(AMBRA1)

TOD:

119255314

SARA:

101544558(AMBRA1)

SETR:

126017587(AMBRA1)

LAV:	100676710(AMBRA1)

TMU:

101345407

ETF:	101642059(AMBRA1)

DNM:	101416247(AMBRA1)

MDO:

100015431

GAS:	123252025(AMBRA1)

SHR:	100914667(AMBRA1)

AFZ:

127539798

PCW:	110224007(AMBRA1)

OAA:	100093574(AMBRA1)

GGA:	423194(AMBRA1)

PCOC:

116229168(AMBRA1)

MGP:	100539246 104911101

CJO:	107314775(AMBRA1)

TPAI:

128086311(AMBRA1)

LMUT:

125695223(AMBRA1)

NMEL:

110400981(AMBRA1)

APLA:

101794362(AMBRA1)

ACYG:

106043506(AMBRA1)

CATA:

118244608(AMBRA1)

AFUL:

116490044(AMBRA1)

TGU:	100219120(AMBRA1)

LSR:	110472074(AMBRA1)

SCAN:

103826682(AMBRA1)

PMOA:

120500330(AMBRA1)

OTC:	121332623(AMBRA1)

PRUF:

121349473(AMBRA1)

GFR:	102033425(AMBRA1)

FAB:	101809327(AMBRA1)

OMA:	130253757(AMBRA1)

PHI:	102099944(AMBRA1)

PMAJ:

107206049(AMBRA1)

CCAE:

111930182(AMBRA1)

CCW:	104698116(AMBRA1)

CBRC:

103620926(AMBRA1)

ETL:	114059061(AMBRA1)

ZAB:	102065991(AMBRA1)

ZLE:	135448435(AMBRA1)

ACHL:

103800842(AMBRA1)

SVG:	106856490(AMBRA1)

MMEA:

130572997(AMBRA1)

HRT:	120754122(AMBRA1)

FPG:	101913027(AMBRA1)

FCH:	102046086(AMBRA1)

CLV:	102094839(AMBRA1)

EGZ:	104134079(AMBRA1)

NNI:	104020375(AMBRA1)

PCRI:

104036404

PLET:

104620083

EHS:

104509385

ACUN:

113480722(AMBRA1)

TALA:

104369062(AMBRA1)

PADL:

103921736(AMBRA1)

AFOR:

103897487(AMBRA1)

ACHC:

115333728(AMBRA1)

HALD:

104319772(AMBRA1)

HLE:	104839686(AMBRA1)

AGEN:

GCL:

CCRI:

CSTI:

CMAC:

MUI:	104538315(AMBRA1)

BREG:

104639568

FGA:

104080051

LDI:	104340707(AMBRA1)

MNB:	103777526(AMBRA1)

OHA:	104328148(AMBRA1)

NNT:	104405296(AMBRA1)

SHAB:

115606001(AMBRA1)

DPUB:

104297441(AMBRA1)

PGUU:

104467176(AMBRA1)

ACAR:

104525666

CPEA:

104390456(AMBRA1)

AVIT:

104271446

CVF:	104295862(AMBRA1)

RTD:	128908161(AMBRA1)

CUCA:

104067291(AMBRA1)

TEO:	104381684(AMBRA1)

AAM:	106498255(AMBRA1)

AROW:

112977825(AMBRA1)

NPD:	112943831(AMBRA1)

TGT:	104578852(AMBRA1)

DNE:	112979233(AMBRA1)

SCAM:

104150415(AMBRA1)

ASN:	102372892(AMBRA1)

AMJ:	102566830(AMBRA1)

CPOO:

109321173(AMBRA1)

GGN:	109298908(AMBRA1)

PSS:	102450852(AMBRA1)

CMY:	102938796(AMBRA1)

CCAY:

125637732(AMBRA1)

DCC:	119857221(AMBRA1)

CPIC:

101935107(AMBRA1)

TST:	117876939(AMBRA1)

CABI:

116821705(AMBRA1)

MRV:	120404310(AMBRA1)

ACS:	100553616(ambra1)

ASAO:

132768158(AMBRA1)

PVT:	110081812(AMBRA1)

SUND:

121919937(AMBRA1)

PBI:	103063553(AMBRA1)

CTIG:

120314875(AMBRA1)

TSR:	106552302(AMBRA1)

PGUT:

117665517(AMBRA1)

APRI:

131187462(AMBRA1)

PTEX:

113440979(AMBRA1)

NSS:	113414354(AMBRA1)

VKO:	123026362(AMBRA1)

PMUA:

114595975(AMBRA1)

PRAF:

128413082(AMBRA1)

ZVI:	118085057(AMBRA1)

HCG:	128336144(AMBRA1)

STOW:

125426658(AMBRA1)

EMC:	129324368(AMBRA1)

XLA:	108715245(ambra1.S) 121402910

XTR:	100497158(ambra1)

NPR:	108797317(AMBRA1)

RTEM:

120917130(AMBRA1)

BBUF:

120980213(AMBRA1)

BGAR:

122920472(AMBRA1)

MUO:	115468831(AMBRA1)

GSH:	117352181(AMBRA1)

DRE:	100332642(ambra1a) 559106(ambra1b)

SRX:	107720791 107722385 107740878

SANH:

107656180 107670191 107673272

SGH:	107560119 107569709

CCAR:

109050618

CAUA:

113043689 113051449 113066685 113106111

CGIB:

127946973 127961558 128014580 128016804

PTET:

122331159(ambra1b) 122347951 122348819(ambra1a)

LROH:

127156379(ambra1b) 127168061(ambra1a)

OMC:	131534055(ambra1b) 131543561

PPRM:

120475358(ambra1b) 120490984(ambra1a)

RKG:	130073646(ambra1b) 130078259(ambra1a)

MAMB:

125246792(ambra1b) 125265002(ambra1a)

CIDE:

127507470 127516839

MASI:

127416633 127432968 127436085 127437586

TROS:

130551955(ambra1b)

TDW:	130414300(ambra1b)

MANU:

129433588(ambra1b) 129445548(ambra1a)

IPU:	108274968(ambra1b)

IFU:	128617889(ambra1b)

PHYP:

113529725(ambra1)

SMEO:

124392492(ambra1b)

TFD:	113653942(ambra1b)

TVC:	132856559(ambra1b)

TRN:	134311589(ambra1b)

AMEX:

103040690(ambra1)

CMAO:

118811891(ambra1b) 118817358(ambra1a)

EEE:	113584511(ambra1)

CHAR:

105892364(ambra1b)

TRU:	101071809(ambra1)

TFS:	130535751(ambra1b)

LCO:

104936096

TBEN:

117476183

PGEO:

117441308

EMAC:

134878896(ambra1b)

ELY:	117262006(ambra1b)

EFO:	125887109(ambra1b)

PLEP:

121938078

SLUC:

116055787(ambra1b)

PFLV:

114560402(ambra1)

GAT:	120808843(ambra1b) 120812637

PPUG:

119196052(ambra1b)

AFB:	129108083(ambra1b)

CLUM:

117731889(ambra1b)

PSWI:

130195018(ambra1b)

MSAM:

119893203(ambra1b)

SCHU:

122874399(ambra1b)

CUD:	121514944(ambra1b)

ALAT:

119024226(ambra1b)

MZE:	101473599(ambra1)

ONL:	100691687(ambra1)

OAU:	116329709(ambra1b)

OLA:	101170429(ambra1)

OML:	112151863(ambra1b)

CSAI:

133444077(ambra1b)

XMA:	102237588(ambra1)

XCO:	114154499(ambra1)

XHE:	116732838(ambra1)

PRET:

103466795(ambra1)

PFOR:

103148673(ambra1)

PLAI:

106955221(ambra1)

PMEI:

106921946(ambra1)

GAF:	122836173(ambra1b)

PPRL:

129361652(ambra1b)

CVG:	107100530(ambra1)

CTUL:

119781637(ambra1b)

GMU:	124883760(ambra1b)

NFU:	107389120(ambra1)

KMR:	108250131(ambra1b)

ALIM:

106527974(ambra1)

NWH:	119416111(ambra1b)

AOCE:

111578061(ambra1)

MCEP:

125014878(ambra1b)

CSEM:

103379694(ambra1)

SSEN:

122775778(ambra1b)

HHIP:

117762638(ambra1b)

HSP:	118109278(ambra1b)

PPLT:

128444629(ambra1b)

SMAU:

118314785(ambra1b)

LCF:	108885219(ambra1b)

SDU:	111233714(ambra1)

SLAL:

111666039

XGL:	120793063(ambra1b)

HCQ:	109518196(ambra1)

SSCV:

125970081

SBIA:

133512300(ambra1b)

PEE:	133402543(ambra1b)

PTAO:

133478737(ambra1b)

MALB:

109969085(ambra1)

BSPL:

114857683(ambra1b)

SJO:	128358736(ambra1b)

SASA:

106560763 106561945 106587104

STRU:

115152423 115167530 115197139 115202872

OTW:	112218296(ambra1b) 112249007 112263501

OMY:	110491728(ambra1b) 110506316 110525355 110526195

OGO:	124004917 124033924 124035894 124039975(ambra1b)

ONE:	115109730 115112072 115113487 115134554

OKI:	109866810 109885326 109889691

OKE:	118357857 118393678 118396372(ambra1b) 118400925

SALP:

111962079 111969216 111974722

SNH:	120024941 120045763(ambra1a) 120054202 120066077(ambra1b)

CCLU:

121532101(ambra1b) 121555272 121573308 123481595

ELS:	105018664 105027321

SFM:	108929067(ambra1)

PKI:	111846697(ambra1)

AANG:

118227463

LOC:	102693859(ambra1)

PSPA:

121294603 121330411

ARUT:

117432245 117435053

PSEX:

120530385(ambra1a)

LCM:	102357663(AMBRA1)

CMK:

CPLA:

HOC:

LERI:

BFO:

BBEL:

CIN:

SCLV:

SPU:	115918760 592522

LPIC:

APLC:

AJC:

SKO:

AME:

ALAB:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BPYO:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

TCA:

SOY:

AGRG:

ATD:

CSET:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_211108

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

LGLY:

HHAL:

PHU:	Phum_PHUM148290 Phum_PHUM148300

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

DPX:	DAPPUDRAFT_313380

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

ESN:

LSM:

RSAN:

RMP:

VDE:

VJA:

LPOL:

GAE:

HRF:

HRJ:

PMAX:

MMER:

LAK:

SMM:	Smp_156350

NVE:	116618097 5512038

EPA:

ATEN:

AMIL:

PDAM:

SPIS:

DGT:

HMG:

ATH:	AT1G04140 AT5G43930

ALY:

9325557

CRB:	17874903 17896952

CSAT:

104725057 104738926 104754538 104760557 104761706 104771546

EUS:	EUTSA_v10006848mg

BRP:	103836591 103843670

BNA:	106400443 106405833 125577216 125591571

BOE:	106309666 106311575

RSZ:	108822168 108822170 108862767

THJ:

104826055

CPAP:

110811523

CIT:

102630449

CIC:	CICLE_v10018910mg

PVY:	116142501 116142505

MINC:

123216802 123223713

TCC:

18613025

GRA:

105798577

GHI:	107952744 121219041

GAB:

HSYR:

DZI:

EGR:

GMX:

GSJ:

PVU:	PHAVU_001G1674000

VRA:

VAR:

VUN:

VUM:

CCAJ:

APRC:

MTR:

TPRA:

CAM:	101507891 101511532

PSAT:

127091640 127125959

VVO:	131610045 131622325 131644503

LJA:	Lj1g3v4528630.1(Lj1g3v4528630.1)

ADU:

107491704

AIP:

107647863

AHF:	112695141 112758815

LANG:

109334428 109348438

PCIN:

129305634

QSA:	O6P43_010435 O6P43_022091

FVE:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:	103402369 103445452 103453501

MSYL:

126595638 126606242

PXB:	103933638 103941624 103960067

ZJU:	107422615 107426465

MNT:	21394628 21398979

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

JCU:

HBR:	110660097 110666270

MESC:

110630094

POP:	7461479 7464413

PEU:	105114033 105125661 105133364

PALZ:

JRE:

CILL:

CAVE:

QSU:	111988041 111990014

QLO:	115959778 115994075

TWL:	120001213 120007553

VVI:	100246400 100263178

VRI:	117914342 117918348

SLY:	101245950 101247260

SPEN:

107020573 107031074

SOT:	102584562 102599622

SSTN:

125851232 125866620

SDUL:

129880919 129883209

CANN:

107864542 107871242

LBB:	132610352 132640307

NTA:	107776350 107822349

NSY:	104226875 104238476

NTO:	104085667 104102657

NAU:	109229400 109229447

INI:

ITR:

SIND:

OEU:

EGT:

SSPL:

121773545 121792039 121804815 121808534

SMIL:

130991784 131001255 131021533

SHIS:

125194452 125212310 125221640

APAN:

ECAD:

CCAV:

DCR:

CSIN:

RVL:	131313226 131316331

AEW:	130760201 130767531 130770251

BVG:

104884073

SOE:

110777756

CQI:	110692503 110727338

ATRI:

130817969

MOF:	131151071 131155156

NNU:

MING:

TSS:

PSOM:

OSA:	4329056 4346650

DOSA:

Os02t0290300-01(Os02g0290300) Os09t0296900-01(Os09g0296900)

OBR:	102702593 102705977

OGL:	127761661 127784875

BDI:

100829808

ATS:

109743723

TDC:	119287341 119312918

TAES:

123087553 123114386 123123889

TUA:

LPER:

LRD:

SBI:

ZMA:

SITA:

SVS:

PVIR:

120660268 120674483 120675307 120707649

PHAI:

PDA:

EGU:

MUS:

ZOF:

DCT:

PEQ:

MSIN:

NCOL:

ATR:

SMO:	SELMODRAFT_445918

CSL:	COCSUDRAFT_44461

CVR:	CHLNCDRAFT_144506

OLU:	OSTLU_88419

MIS:	MICPUN_101389

MPP:	MICPUCDRAFT_46303(JGI:MicpuC2_46303)

GSL:	Gasu_35820

CCP:	CHC_T00002489001

PTI:	PHATRDRAFT_42687

TPS:	THAPSDRAFT_261472

PIF:	PITG_05623

GTT:	GUITHDRAFT_48381

» show all

Reference

PMID:21921694

Authors

Van Humbeeck C, Cornelissen T, Vandenberghe W

Title

Ambra1: a Parkin-binding protein involved in mitophagy.

Journal

Autophagy 7:1555-6 (2011)
DOI:10.4161/auto.7.12.17893

Reference

PMID:17589504

Authors

Fimia GM, Stoykova A, Romagnoli A, Giunta L, Di Bartolomeo S, Nardacci R, Corazzari M, Fuoco C, Ucar A, Schwartz P, Gruss P, Piacentini M, Chowdhury K, Cecconi F

Title

Ambra1 regulates autophagy and development of the nervous system.

Journal

Nature 447:1121-5 (2007)
DOI:10.1038/nature05925

Sequence

[mmu:228361]

LinkDB

DBGET integrated database retrieval system