KEGG   ORTHOLOGY: K18028
Entry
K18028                      KO                                     
Symbol
nicX
Name
2,5-dihydroxypyridine 5,6-dioxygenase [EC:1.13.11.9]
Pathway
map00760  Nicotinate and nicotinamide metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Module
M00622  Nicotinate degradation, nicotinate => fumarate
Reaction
R09125  2,5-dihydroxypyridine:oxygen 5,6-oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00760 Nicotinate and nicotinamide metabolism
    K18028  nicX; 2,5-dihydroxypyridine 5,6-dioxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.9  2,5-dihydroxypyridine 5,6-dioxygenase
     K18028  nicX; 2,5-dihydroxypyridine 5,6-dioxygenase
Other DBs
GO: 0047075
Genes
SMAR: SM39_1771
SMAC: SMDB11_1584
SMW: SMWW4_v1c23260
SPE: Spro_2312
SRR: SerAS9_2269
SRL: SOD_c21420(nicX)
SRY: M621_11735
SPLY: Q5A_011870(nicX)
SRS: SerAS12_2269
SRA: SerAS13_2270
SLQ: M495_11505
SERF: L085_17115
SQU: E4343_04630
SFJ: SAMEA4384070_2381
SOF: NCTC11214_04488
SURI: J0X03_12365
SNEM: NLX84_11780
SNEV: OI978_19650
GQU: AWC35_02975
PAO: Pat9b_5175
PPHO: CTZ24_20570
TCI: A7K98_12095
TPTY: NCTC11468_02202
PPU: PP_3945(nicX)
PPF: Pput_1892
PPG: PputGB1_3580
PPW: PputW619_2138
PPT: PPS_4058
PPB: PPUBIRD1_1863
PPI: YSA_08963
PPX: T1E_5122
PPUT: L483_21715
PPUN: PP4_17770
PALD: LU682_010740
PFS: PFLU_2800
PFB: VO64_0127
PAZO: AYR47_21620
PMED: E3Z27_20705
PTOL: I7845_13265
PFW: PF1751_v1c24710
PFF: PFLUOLIPICF724375
PFX: A7318_11825
PLUL: FOB45_03920
PSK: U771_14860
PFZ: AV641_08730
PANR: A7J50_2717
PSIL: PMA3_12570
PYM: AK972_2676
PGG: FX982_03129
PVK: EPZ47_21845
PEZ: HWQ56_12835
PWY: HU734_022660
PTAE: NCTC10697_01684
PPEG: KUA23_13470
PNB: NK667_12115
PTAI: ICN73_23205
PPAO: K3169_11260
PSJY: AA098_03900 AA098_17790 AA098_21325
AWU: BEN71_18360
AGU: AS4_40080
HAM: HALO0548
HAXI: HAALTHF_14370n
HSV: HNO53_05730
HPRO: LMS44_20650
HASO: B2G49_16060
HVN: EI420_02005
HOL: HORIV_64960
HNP: SR894_18970
HTT: HZS52_07580
HTX: EKK97_06015
ADI: B5T_02297
MARS: A8C75_16295
MRZ: KDW95_18750
RPJ: N234_04330 N234_15835 N234_24890
REH: H16_A0925(h16_A0925) H16_A2810(h16_A2810) H16_B0813(h16_B0813)
CNC: CNE_1c08750 CNE_1c27100 CNE_2c07610
CUH: BJN34_04910 BJN34_15135 BJN34_29420
REU: Reut_A2512 Reut_B3788
CTI: RALTA_A0870 RALTA_A2299
CBW: RR42_m3126 RR42_s0171 RR42_s1172
CGD: CR3_0579(ampS) CR3_0803(ampS) CR3_3007(nicX)
CCUP: BKK81_07370 BKK81_15650
CUP: BKK80_06670 BKK80_16605
CUU: BKK79_05480 BKK79_16350
CPAU: EHF44_27015
COX: E0W60_08960 E0W60_14770 E0W60_23265
CCAM: M5D45_06905
CCAX: KZ686_07225 KZ686_20175
CUK: KB879_04570 KB879_08785 KB879_26000
CNAN: A2G96_05375 A2G96_17625
BSAV: WS86_30280
BCM: Bcenmc03_3486
BCH: Bcen2424_4039
BCJ: BCAM1142
BCEN: DM39_3879
BCEO: I35_4989
BMJ: BMULJ_03960
BMU: Bmul_4550
BMK: DM80_3720
BMUL: NP80_4069
BCED: DM42_3948
BCON: NL30_06920
BSEM: WJ12_25610
BPSL: WS57_08415
BMEC: WJ16_24240
BSTG: WT74_20825
BANN: JFN94_22955 JFN94_25175
BARI: NLX30_32985 NLX30_38905
BAEN: L3V59_37165
BGD: bgla_1g12670
BGO: BM43_2599
BYI: BYI23_D006280 BYI23_D011200
BUE: BRPE67_DCDS08100 BRPE67_DCDS13330
BGP: BGL_1c11600
BPLA: bpln_1g11120
BUM: AXG89_36965
BUI: AX768_15625
BURK: DM992_20105
BXE: Bxe_C0216
BXB: DR64_8215
BFN: OI25_6799
BCAI: K788_0007381
PTER: C2L65_30585
PTRO: G5S35_31885
PPAI: E1956_29580
PPK: U875_06205
PPNO: DA70_23280
PPNM: LV28_07430
PRB: X636_03370
PPUL: RO07_01615
PSPU: NA29_10040 NA29_11640 NA29_13055
PAPI: SG18_01755
PVE: UC34_12640 UC34_17850
POX: MB84_21140 MB84_22640
PTX: ABW99_20545
PFG: AB870_04880
PNR: AT302_14240 AT302_20395
PAND: DRB87_16370
PFIB: PI93_010200
PCOM: NTU39_19585
CABA: SBC2_37490(nicX_1) SBC2_53530(nicX_2)
BUO: BRPE64_DCDS05940 BRPE64_DCDS10990
CABK: NK8_47380 NK8_58470
BPE: BP0581 BP1957
BPC: BPTD_0590 BPTD_1929
BPER: BN118_0957 BN118_3486
BPET: B1917_3473
BPEU: Q425_15030 Q425_35680
BPAR: BN117_0269 BN117_1484
BPA: BPP0271 BPP2330
BBH: BN112_1734 BN112_3143
BBR: BB0274 BB1781
BBM: BN115_0259 BN115_1683
BBX: BBS798_0269 BBS798_1682
BAV: BAV1529 BAV2742
BBRO: BAU06_10300 BAU06_12295 BAU06_25035
BFZ: BAU07_14190 BAU07_23450 BAU07_25070
BPDZ: BBN53_17720
BOH: AKI39_11515
BGM: CAL15_11470 CAL15_12490
BGV: CAL12_01120 CAL12_10370 CAL12_12830
AXY: AXYL_02466
AXO: NH44784_051911
AXN: AX27061_3327
AXX: ERS451415_03307
ADT: APT56_16400
AIS: BUW96_02610 BUW96_28750
ASW: CVS48_09645
ACHR: C2U31_23370
ACHB: DVB37_25110
APES: FOC84_00570
AAEG: RA224_20485
PUD: G9Q38_03255 G9Q38_04180 G9Q38_04670
AKA: TKWG_00615 TKWG_01105 TKWG_19790
AMIM: MIM_c02050 MIM_c31080
AFA: UZ73_03775 UZ73_10785 UZ73_14565 UZ73_14765
AFQ: AFA_13575 AFA_14965(nicX) AFA_15135(picD) AFA_18565(hpaX)
AAQU: D3M96_14525 D3M96_15895 D3M96_16075
AAMM: FE795_12525 FE795_13825 FE795_14000
PHN: PAEH1_03580
ODI: ODI_R3898
PIG: EGT29_00800 EGT29_02745 EGT29_03390
PACR: FXN63_06615
NARM: N7E01_07645 N7E01_09560 N7E01_09865
RHF: EUB48_20920
ACK: C380_17105
AAV: Aave_3930
AAA: Acav_3827
DAC: Daci_1850
DEL: DelCs14_4788
DTS: BI380_15400
DHK: BO996_08760
DLA: I6G47_15030
VAP: Vapar_4293
VAM: C4F17_28025
CTES: O987_23190
CRJ: QMY55_00795
LIM: L103DPR2_00582(nicX)
LIH: L63ED372_00060(nicX)
HYB: Q5W_22175
HYL: LPB072_00950
HYC: E5678_16815
HPSE: HPF_00905(nicX)
HYN: F9K07_01290 F9K07_02925 F9K07_21765
HTN: KI616_00800
HCZ: G9Q37_17660
HSE: Hsero_1325
HSZ: ACP92_06630
HEE: hmeg3_19265
HFR: G5S34_06840
MTIM: DIR46_21155
XYK: GT347_17965
XYG: R9X41_15970
AZR: CJ010_02410 CJ010_22080
MLN: A9174_33965
MAMO: A6B35_09700
MESP: C1M53_21410
MESR: FGU64_17615
AAK: AA2016_6001 AA2016_6584
SIX: BSY16_4976
ATA: AWN88_01320
RLG: Rleg_6046
RTR: RTCIAT899_PC08580
RAD: CO657_35880
RII: FFM53_028515
RRG: J3P73_36855
RAW: NE851_01760
RSUL: N2599_21415
RRHO: PR018_21730
RTU: PR017_19735
RBW: RLCC275e_26400
SHZ: shn_30285
SSUM: Q9314_24280
HOE: IMCC20628_03533
OCH: CES85_3503(nicX)
BJA: bll6088(bll6088)
BJU: BJ6T_36210
BJP: RN69_17555
BRA: BRADO2312
BRS: S23_21870
AOL: S58_52840
BRC: BCCGELA001_25855
BRAD: BF49_5545
BRO: BRAD285_5030
BRK: CWS35_28865
BOT: CIT37_06750 CIT37_23840
BRQ: CIT40_22420
BGQ: X265_12340 X265_13550
BGZ: XH91_11115
BSYM: CIT39_21615
BBET: F8237_26010
BARH: WN72_34005 WN72_44280
BVZ: BRAD3257_3041
BEL: BE61_17030
BDG: LPJ38_32260
BQB: J4P68_0007725
BSEI: KMZ68_19940
BBAN: J4G43_036475
BCAN: BcanWSM471_26940
BBRA: QA636_11880
BGK: IC762_04975
BCOU: IC761_11300
BPAH: QA639_37430
BXN: I3J27_26420
BRAZ: LRP30_27995
RBK: E0H22_02850 E0H22_16390
TRB: HB776_11430
TALZ: RPMA_17200
HMC: HYPMC_0203
RHZ: RHPLAN_69100
PHL: KKY_3788
PLEO: OHA_1_03169(nicX)
HDI: HDIA_0234(nicX)
AUB: LXB15_07185
PSIN: CAK95_12375 CAK95_14180 CAK95_27070
PPHR: APZ00_25430
SIW: GH266_12020
OAR: OA238_c08170
CID: P73_3892
CEH: CEW89_08860
CON: TQ29_12570 TQ29_12770 TQ29_16070
PABY: Ga0080574_TMP31
SAGU: CDO87_22440
MALU: KU6B_06560
FYT: QF092_07150
PYE: A6J80_00020 A6J80_23200
PSEW: JHW44_20155
PFIS: JHX87_02950
DAA: AKL17_3241
LVS: LOKVESSMR4R_03232(nicX)
PALW: PSAL_024210(nicX)
FAP: GR316_10985
GCE: KYE46_03215
NSM: JO391_01895
SNJ: A7E77_04545
SMY: BJP26_14900
SNAP: PQ455_05085
SBAR: H5V43_21650(ndpE)
SLAA: EUU25_06890(ndpE)
ELQ: Ga0102493_111595
NTD: EGO55_05275
GOY: GLS_c14230
GAL: A0U94_10315
GTI: FXF46_02575
GSP: IGS75_12410
GXL: H845_1042
KEU: S101446_01672(nicX)
KSC: CD178_02878(nicX)
KRE: GWK63_12515
APT: APA01_23760
APW: APA42C_23760
APF: APA03_23760
APU: APA07_23760
APG: APA12_23760
APQ: APA22_23760
APX: APA26_23760
APZ: APA32_23760
APK: APA386B_1210
ASV: WG31_11905
APOM: CPF11_08775
ATO: CIW82_09425
AASC: A4S02_13830
ACET: DS739_11635
ROS: CTJ15_00290
RMUC: FOB66_01435
KHA: IFJ82_11095
SRF: LHU95_20255
NGU: QN315_14015
ALI: AZOLI_p20433
ABS: AZOBR_p480011
ABQ: ABAZ39_30180
ABF: AMK58_25905
ATI: AL072_30665
AZT: TSH58p_19530
AZM: DM194_20100 DM194_21870
AOZ: HUE56_08300
AARE: D3093_29340
AZS: E6C72_22660
HTQ: FRZ44_18690
HADH: FRZ61_39250 FRZ61_46310
APB: SAR116_0287
BACA: FAY30_11695
PARH: I5S86_12070
MVQ: MYVA_3797
ROA: Pd630_LPD07329
RFA: A3L23_03312(nicX)
RHS: A3Q41_00020(nicX)
RCR: NCTC10994_03415
SVL: Strvi_4768
SRC: M271_44585
SMAL: SMALA_0613
SSOI: I1A49_06645
STRE: GZL_07763
SNR: SNOUR_35470
SALU: DC74_1449
SALL: SAZ_07780
SAUO: BV401_06895
SBAT: G4Z16_06625
SINE: KI385_04355
SDUR: M4V62_06910
SLON: LGI35_43460
SANT: QR300_41505
SYUN: MOV08_36035
JME: EEW87_000025
SAIU: J4H86_13115
NFS: OIE67_08645
FAL: FRAAL6169
AOI: AORI_4776
AJA: AJAP_15760(nicX)
AMQ: AMETH_3951
AMYC: CU254_15755
AMYY: YIM_29130(nicX)
AACD: LWP59_17615
AROO: NQK81_43040
ATHM: L1857_21475
PSEA: WY02_22100
PSEE: FRP1_20590
PSEH: XF36_05315
PSEQ: AD006_28010
PECQ: AD017_07605
PHH: AFB00_17850
PAUT: Pdca_13590
PBRO: HOP40_05480
ACTY: OG774_13255
PSUU: Psuf_015390
SBAE: DSM104329_02297(nicX_1) DSM104329_02308(nicX_2) DSM104329_02367(nicX_3) DSM104329_02480(nicX_4) DSM104329_03697(nicX_5) DSM104329_03708(nicX_6)
HAAD: MW046_15080
HLS: KU306_03805
SRUB: C2R22_21800
MJN: MjAS7_2157
 » show all
Reference
PMID:5578917
  Authors
Gauthier JJ, Rittenberg SC
  Title
The metabolism of nicotinic acid. I. Purification and properties of 2,5-dihydroxypyridine oxygenase from Pseudomonas putida N-9.
  Journal
J Biol Chem 246:3737-42 (1971)
  Sequence
[ppu:PP_3945]
Reference
PMID:18678916
  Authors
Jimenez JI, Canales A, Jimenez-Barbero J, Ginalski K, Rychlewski L, Garcia JL, Diaz E
  Title
Deciphering the genetic determinants for aerobic nicotinic acid degradation: the nic cluster from Pseudomonas putida KT2440.
  Journal
Proc Natl Acad Sci U S A 105:11329-34 (2008)
DOI:10.1073/pnas.0802273105
  Sequence
[ppu:PP_3945]
LinkDB

DBGET integrated database retrieval system