KEGG ORTHOLOGY: K18086

ORTHOLOGY: K18086

Entry

K18086                      KO

Symbol

MTMR14

Name

myotubularin-related protein 14 [EC:3.1.3.64 3.1.3.95]

Pathway

map00562

Inositol phosphate metabolism

map01100

Metabolic pathways

map04070

Phosphatidylinositol signaling system

map04140

Autophagy - animal

Reaction

R10928

1-phosphatidyl-1D-myo-inositol-3,5-bisphosphate 3-phosphohydrolase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K18086  MTMR14; myotubularin-related protein 14
09130 Environmental Information Processing
  09132 Signal transduction
   04070 Phosphatidylinositol signaling system
    K18086  MTMR14; myotubularin-related protein 14
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K18086  MTMR14; myotubularin-related protein 14
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K18086  MTMR14; myotubularin-related protein 14
Enzymes [BR:ko01000]
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.64  phosphatidylinositol-3-phosphatase
     K18086  MTMR14; myotubularin-related protein 14
    3.1.3.95  phosphatidylinositol-3,5-bisphosphate 3-phosphatase
     K18086  MTMR14; myotubularin-related protein 14
Protein phosphatases and associated proteins [BR:ko01009]
Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Dual specificity phosphatases)
   Myotubularins
    K18086  MTMR14; myotubularin-related protein 14

Other DBs

GO:	0004438 0052629

Genes

HSA:	64419(MTMR14)

PTR:	460149(MTMR14)

PPS:	100991819(MTMR14)

GGO:	101134886(MTMR14)

PON:	100435473(MTMR14)

NLE:	100594364(MTMR14)

HMH:	116466705(MTMR14)

MCC:	703936(MTMR14)

MCF:	102143610(MTMR14)

MTHB:

126947695

MNI:	105477663(MTMR14)

CSAB:

103227971(MTMR14)

CATY:

105585754(MTMR14)

PANU:

101004740(MTMR14)

TGE:	112618577(MTMR14)

MLEU:

105552830(MTMR14)

RRO:	104667167(MTMR14)

RBB:	108534803(MTMR14)

TFN:	117083208(MTMR14)

PTEH:

111546956(MTMR14)

CANG:

105519057(MTMR14)

CJC:	100397575(MTMR14)

SBQ:	101045778(MTMR14)

CIMI:

108284687(MTMR14)

CSYR:

103270574(MTMR14)

MMUR:

105869056(MTMR14)

LCAT:

123623080(MTMR14)

PCOQ:

105812594(MTMR14)

OGA:	100956987(MTMR14)

MMU:	97287(Mtmr14)

MCAL:

110296023(Mtmr14)

MPAH:

110314623(Mtmr14)

RNO:	312634(Mtmr14)

MCOC:

116099386(Mtmr14)

ANU:	117714868(Mtmr14)

MUN:	110548928(Mtmr14)

CGE:	100754286(Mtmr14)

MAUA:

101831459(Mtmr14)

PROB:

127236256(Mtmr14)

PLEU:

114689597(Mtmr14)

MORG:

121435092(Mtmr14)

MFOT:

126505570

AAMP:

119806602(Mtmr14)

NGI:	103751415(Mtmr14)

HGL:	101724817(Mtmr14)

CPOC:

100731708(Mtmr14)

CCAN:

109686991(Mtmr14)

DORD:

105981369(Mtmr14)

DSP:	122107942(Mtmr14)

PLOP:

125358784(Mtmr14)

NCAR:

124971017

MMMA:

107150056(Mtmr14)

OCU:	100348191 127487216

OPI:	101527201(MTMR14)

TUP:	102488403(MTMR14)

GVR:	103594270(MTMR14)

CFA:	484668(MTMR14)

CLUD:

112662145(MTMR14)

VVP:	112933749(MTMR14)

VLG:	121495030(MTMR14)

NPO:	129521410(MTMR14)

AML:	100474479(MTMR14)

UMR:	103669649(MTMR14)

UAH:	113257139(MTMR14)

UAR:	123799184(MTMR14)

ELK:

111143809

LLV:

125109056

MPUF:

101691252(MTMR14)

MNP:	132011532(MTMR14)

MLK:	131824191(MTMR14)

NVS:	122909231(MTMR14)

ORO:	101377447(MTMR14)

EJU:	114207796(MTMR14)

ZCA:	113917458(MTMR14)

MLX:	118005816(MTMR14)

NSU:	110584779(MTMR14)

LWW:	102737501(MTMR14)

FCA:	101083154(MTMR14)

PYU:	121041285(MTMR14)

PCOO:

112858579(MTMR14)

PBG:	122487475(MTMR14)

PVIV:

125160739(MTMR14)

LRUF:

124525107

PTG:	102971939(MTMR14)

PPAD:

109254380(MTMR14)

PUC:

125929608

AJU:

106972336

HHV:	120231346(MTMR14)

BTA:	514596(MTMR14)

BOM:	102269780(MTMR14)

BIU:	109576236(MTMR14)

BBUB:

102396026(MTMR14)

BBIS:

104990124(MTMR14)

CHX:	102184563(MTMR14)

OAS:	101102342(MTMR14)

BTAX:

128056325(MTMR14)

ODA:	120867719(MTMR14)

CCAD:

122424526(MTMR14)

MBEZ:

129548054(MTMR14)

SSC:	100157480(MTMR14)

CFR:	102519969(MTMR14)

CBAI:

105067430(MTMR14)

CDK:	105093140(MTMR14)

VPC:	102530025(MTMR14)

BACU:

103020754(MTMR14)

BMUS:

118904340(MTMR14)

LVE:	103073483(MTMR14)

OOR:	101287733(MTMR14)

DLE:	111169980(MTMR14)

PCAD:

102996901(MTMR14)

PSIU:

116761561(MTMR14)

NASI:

112412903(MTMR14)

ECB:	100058531(MTMR14)

EPZ:	103566623(MTMR14)

EAI:	106835605(MTMR14)

MYB:	102256907(MTMR14)

MYD:	102767087(MTMR14)

MMYO:

118668032(MTMR14)

MLF:	102423847(MTMR14)

PKL:	118715182(MTMR14)

EFUS:

103295341(MTMR14)

MNA:	107534762(MTMR14)

DRO:	112301138(MTMR14)

SHON:

118993354(MTMR14)

AJM:	119041408(MTMR14)

PDIC:

114501503(MTMR14)

PHAS:

123814552(MTMR14)

MMF:	118633007(MTMR14)

PPAM:

129088253(MTMR14)

HAI:	109387291(MTMR14)

RFQ:	117036826(MTMR14)

PALE:

102882988(MTMR14)

PGIG:

120621435(MTMR14)

PVP:	105299058(MTMR14)

RAY:	107504877(MTMR14)

MJV:	108407974(MTMR14)

TOD:	119255289(MTMR14)

SARA:

101540499(MTMR14)

SETR:

125998046(MTMR14)

LAV:	100658106(MTMR14)

TMU:

101347544

ETF:	101653650(MTMR14)

DNM:	101415058(MTMR14)

MDO:	100014047(MTMR14)

GAS:	123237174(MTMR14)

SHR:	100928957(MTMR14)

AFZ:

127551665

PCW:	110204845(MTMR14)

OAA:	100075535(MTMR14)

GGA:	416048(MTMR14)

PCOC:

116237710(MTMR14)

MGP:	100542441(MTMR14)

CJO:	107319801(MTMR14)

TPAI:

128078661(MTMR14)

LMUT:

125698595(MTMR14)

NMEL:

110404893(MTMR14)

APLA:

101800837(MTMR14)

ACYG:

106045072(MTMR14)

CATA:

118248147(MTMR14)

AFUL:

116493219(MTMR14)

TGU:	100224025(MTMR14)

LSR:	110471253(MTMR14)

SCAN:

103817175(MTMR14)

PMOA:

120513996(MTMR14)

OTC:	121347129(MTMR14)

PRUF:

121350604(MTMR14)

GFR:	102041338(MTMR14)

FAB:	101807592(MTMR14)

OMA:	130258393(MTMR14)

PHI:	102106615(MTMR14)

PMAJ:

107210220(MTMR14)

CCAE:

111935041(MTMR14)

CCW:	104683318(MTMR14)

CBRC:

103614429(MTMR14)

ETL:	114056773(MTMR14)

ZAB:	102071771(MTMR14)

ACHL:

103800158(MTMR14)

SVG:	106850842(MTMR14)

MMEA:

130589123(MTMR14)

HRT:	120758335(MTMR14)

FPG:	101911308(MTMR14)

FCH:	102059156(MTMR14)

CLV:	102095343(MTMR14)

EGZ:	104134774(MTMR14)

NNI:	104016971(MTMR14)

PCRI:

104036286(MTMR14)

PLET:

104623906(MTMR14)

PCAO:

104042896(MTMR14)

ACUN:

113484741(MTMR14)

TALA:

104363971(MTMR14)

PADL:

103921903(MTMR14)

AFOR:

103903349(MTMR14)

ACHC:

115353664(MTMR14)

HALD:

104321547(MTMR14)

HLE:	104835529(MTMR14)

AGEN:

126049647

CCRI:

104167219(MTMR14)

CSTI:

104555347(MTMR14)

CMAC:

104473012(MTMR14)

MUI:	104540068(MTMR14)

BREG:

104643286(MTMR14)

FGA:	104073000(MTMR14)

GSTE:

104261621(MTMR14)

LDI:	104347563(MTMR14)

MNB:	103775485(MTMR14)

OHA:	104329996(MTMR14)

NNT:	104409374(MTMR14)

SHAB:

115614903(MTMR14)

DPUB:

104305114(MTMR14)

PGUU:

104471474(MTMR14)

ACAR:

104530444(MTMR14)

CPEA:

104390210(MTMR14)

AVIT:

104267738(MTMR14)

CVF:	104290748(MTMR14)

RTD:	128915808(MTMR14)

CUCA:

104063664(MTMR14)

TEO:	104373539(MTMR14)

BRHI:

104494785(MTMR14)

AAM:	106498998(MTMR14)

AROW:

112976586(MTMR14)

NPD:	112958726(MTMR14)

TGT:	104570098(MTMR14)

DNE:	112979155(MTMR14)

SCAM:

104140525(MTMR14)

ASN:	102370505(MTMR14)

AMJ:	102568445(MTMR14)

CPOO:

109311391(MTMR14)

GGN:	109288843(MTMR14)

CMY:	102939454(MTMR14)

CCAY:

125639771(MTMR14)

DCC:	119858543(MTMR14)

CPIC:

101940028(MTMR14)

TST:	117880121(MTMR14)

CABI:

116835788(MTMR14)

MRV:	120409397(MTMR14)

ACS:	100554543(mtmr14)

ASAO:

132769481(MTMR14)

PVT:	110079925(MTMR14)

SUND:

121922287(MTMR14)

PBI:	103068280(MTMR14)

PMUR:

107290924(MTMR14)

CTIG:

120313341(MTMR14)

TSR:	106554353(MTMR14)

PGUT:

117673995(MTMR14)

APRI:

131190323(MTMR14)

PTEX:

113447631(MTMR14)

NSS:	113422217(MTMR14)

VKO:	123034442(MTMR14)

PMUA:

114591944(MTMR14)

PRAF:

128408558(MTMR14)

ZVI:	118080894(MTMR14)

HCG:	128345653(MTMR14)

GJA:

107111938

STOW:

125427747(MTMR14)

EMC:	129328542(MTMR14)

XLA:	734951(mtmr14.S)

XTR:	100036693(mtmr14)

NPR:	108788242(MTMR14)

RTEM:

120945149(MTMR14)

BBUF:

120978480(MTMR14)

BGAR:

122943079(MTMR14)

MUO:	115471874(MTMR14)

GSH:	117351349(MTMR14)

DRE:	323929(mtmr14)

SRX:	107710166 107716897

SANH:

107688805(mtmr14) 107691493

SGH:	107569464 107586366

CCAR:

109092397 109092399

CAUA:

113049902 113097391

CGIB:

127959632 128015472

PTET:

122346784(mtmr14)

LROH:

127166731(mtmr14)

OMC:	131542417(mtmr14)

PPRM:

120466940(mtmr14)

MAMB:

125278116(mtmr14)

CIDE:

127513885

IPU:

108272090

IFU:	128615217(mtmr14)

PHYP:

113528267(mtmr14)

SMEO:

124399868(mtmr14)

TFD:	113642867(mtmr14)

TVC:	132844523(mtmr14)

TRN:	134316874(mtmr14)

AMEX:

103023723(mtmr14)

CMAO:

118808398(mtmr14)

EEE:	113581550(mtmr14)

CHAR:

105901893(mtmr14)

TRU:	101077753(mtmr14)

TFS:	130524719(mtmr14)

TNG:	GSTEN00004651G001

LCO:	104934550(mtmr14)

NCC:	104945404(mtmr14)

TBEN:

117493111(mtmr14)

CGOB:

115008815(mtmr14)

PGEO:

117446141(mtmr14)

GACU:

117549120(mtmr14)

EMAC:

134882589(mtmr14)

ELY:	117257186(mtmr14)

EFO:	125885481(mtmr14)

PLEP:

121952229(mtmr14)

SLUC:

116059778(mtmr14)

ECRA:

117943510(mtmr14)

ESP:	116687892(mtmr14)

PFLV:

114553586(mtmr14)

GAT:	120834922(mtmr14)

PPUG:

119230140(mtmr14)

AFB:	129105237(mtmr14)

CLUM:

117730321(mtmr14)

PSWI:

130208068(mtmr14)

MSAM:

119885675(mtmr14)

SCHU:

122885013(mtmr14)

CUD:	121504426(mtmr14)

ALAT:

119020916(mtmr14)

MZE:	101477870(mtmr14)

ONL:	100712197(mtmr14)

OAU:	116326301(mtmr14)

OLA:	105354120(mtmr14)

OML:	112145144(mtmr14)

CSAI:

133448966(mtmr14)

XMA:	102221740(mtmr14)

XCO:	114135172(mtmr14)

XHE:	116710231(mtmr14)

PRET:

103465500(mtmr14)

PFOR:

103152719(mtmr14)

PLAI:

106959690(mtmr14)

PMEI:

106929319(mtmr14)

GAF:	122833821(mtmr14)

PPRL:

129357138(mtmr14)

CVG:	107102233(mtmr14)

CTUL:

119777692(mtmr14)

GMU:	124856493(mtmr14)

NFU:	107395059(mtmr14)

KMR:	108248376(mtmr14)

ALIM:

106519064(mtmr14)

NWH:	119412090(mtmr14)

AOCE:

111584396(mtmr14)

MCEP:

125006240(mtmr14)

CSEM:

103386626(mtmr14)

POV:	109629009(mtmr14)

SSEN:

122767941(mtmr14)

HHIP:

117760921(mtmr14)

HSP:	118103314(mtmr14)

PPLT:

128446986(mtmr14)

SMAU:

118309131(mtmr14)

LCF:	108877482 108879963 108880075

SDU:	111221688(mtmr14)

SLAL:

111668632(mtmr14)

XGL:	120787531(mtmr14)

HCQ:	109514829(mtmr14)

SBIA:

133507890(mtmr14)

PEE:	133408554(mtmr14)

PTAO:

133483123(mtmr14)

BPEC:

110170198(mtmr14)

MALB:

109960052(mtmr14)

BSPL:

114855535(mtmr14)

SJO:	128356302(mtmr14)

SASA:

106565250(mtmr14) 106583633

STRU:

115150142 115208333

OTW:	112246236 112267540(mtmr14)

OMY:	110493932(mtmr14) 110528513

OGO:	124002548(mtmr14) 124026852

ONE:	115142811 115143757

OKI:	109891401 109891575(mtmr14)

OKE:	118388968(mtmr14) 118399711

SALP:

111962102 111970754

SNH:	120064300 120065419

CCLU:

121566622 121578437

ELS:	105024794(mtmr14)

SFM:	108918301(mtmr14)

PKI:	111851709(mtmr14)

AANG:

118211071(mtmr14)

LOC:	102687345(mtmr14)

PSPA:

121298193 121328686

ARUT:

117412205(mtmr14)

PSEX:

120540386(mtmr14)

LCM:	102360413(MTMR14)

CMK:	103176603(mtmr14)

RTP:	109912378(mtmr14)

CPLA:

122547610

HOC:	132822271(mtmr14)

LERI:

129704767(mtmr14)

PMRN:

116951288(MTMR14)

LRJ:	133356391(MTMR14)

BFO:

BBEL:

CIN:

SCLV:

SPU:	115919259 577354

LPIC:

129256982

APLC:

110984892

SKO:

102808735

DME:	Dmel_CG6542(EDTP)

DER:

6548147

DSE:

6609593

DSI:	Dsimw501_GD25480(Dsim_GD25480)

DYA:	Dyak_GE14194

DAN:

6494646

DSR:	110176787 110189297

DPO:

4803925

DPE:

6591090

DMN:	108159296 117194952

DWI:

6652318

DGR:

6560795

DMO:	Dmoj_GI21030

DAZ:

108615004

DNV:

108654496

DHE:	111600571 115482818

DVI:

CCAT:

BDR:

RZE:

AOQ:

TDA:	119679430 119679501

MDE:	101901021 131804707

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

109409322 109419104 115258948

CQU:	CpipJ_CPIJ000895

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

DPA:

SOY:

AGRG:

CSET:

AGB:

LDC:	111503116 111503502

NVL:

APLN:

PPYR:

OTU:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

NLU:

MQU:

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

IEL:

FCD:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

HAZT:

PPOI:

DSV:	119432019 119442487

RSAN:

119396067 119396068 119397994 119407251

RMP:	119161925 119163618

DPTE:

113791165

DFR:

124498375

CSCU:

111621344

PTEP:

107438727 107443501 107447676

ABRU:

129988467

UDV:

129222880

SDM:	118180740 118181031 118184436 118186969 118187983 118193521 118193525 118200259 118200261 118200564 118202564 118204252

LPOL:

106457342

HRO:	HELRODRAFT_190283

LGI:	LOTGIDRAFT_173287

PVUL:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:	106152589 106178913

SMM:	Smp_075440.1

SHX:	MS3_00004284(MTMR14_1)

OVI:	T265_08371

NVE:

5507666

EPA:

110239476

ATEN:

116306063

ADF:	107330431 107342002

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HSY:

TAD:	TRIADDRAFT_52465

AQU:

100641184

MBR:	MONBRDRAFT_21963

SRE:	PTSG_05869

DDI:	DDB_G0289807

DPP:	DICPUDRAFT_153793

DFA:

DFA_02288

ACAN:

ACA1_389600

» show all

Reference

PMID:20595810

Authors

Gibbs EM, Feldman EL, Dowling JJ

Title

The role of MTMR14 in autophagy and in muscle disease.

Journal

Autophagy 6:819-20 (2010)
DOI:10.4161/auto.6.6.12624

Sequence

[hsa:64419] [dre:323929]

Reference

PMID:17008356

Authors

Tosch V, Rohde HM, Tronchere H, Zanoteli E, Monroy N, Kretz C, Dondaine N, Payrastre B, Mandel JL, Laporte J

Title

A novel PtdIns3P and PtdIns(3,5)P2 phosphatase with an inactivating variant in centronuclear myopathy.

Journal

Hum Mol Genet 15:3098-106 (2006)
DOI:10.1093/hmg/ddl250

Sequence

[hsa:64419]

LinkDB

DBGET integrated database retrieval system