KEGG   ORTHOLOGY: K18827
Entry
K18827                      KO                                     
Symbol
wbdD
Name
O-antigen chain-terminating bifunctional methyltransferase/kinase [EC:2.1.1.- 2.1.1.294 2.7.1.181]
Reaction
R10657  ATP:alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)]n-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol 3-phosphotransferase
R10658  S-adenosyl-L-methionine:3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)]n-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-alpha-diphospho-ditrans,octacis-undecaprenol 3-phospho-methyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01005 Lipopolysaccharide biosynthesis proteins
    K18827  wbdD; O-antigen chain-terminating bifunctional methyltransferase/kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.294  3-O-phospho-polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol 3-phospho-methyltransferase
     K18827  wbdD; O-antigen chain-terminating bifunctional methyltransferase/kinase
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.181  polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol kinase
     K18827  wbdD; O-antigen chain-terminating bifunctional methyltransferase/kinase
Lipopolysaccharide biosynthesis proteins [BR:ko01005]
 O-antigen repeat unit
  K18827  wbdD; O-antigen chain-terminating bifunctional methyltransferase/kinase
Genes
ECX: EcHS_A2169
SBG: SBG_0615(wbdD)
SBZ: A464_688
SBV: N643_03100
KPJ: N559_1771
KVA: Kvar_1569
KPE: KPK_1679
KVD: KR75_26285
KVQ: SP68_06430
KQU: AVR78_21675
PGE: LG71_13030
ASUB: NLZ15_07780
TCI: A7K98_13155
PPI: YSA_02210
PTAI: ICN73_13155
AG: AFQ31610(wbdD)
 » show all
Reference
PMID:15184370
  Authors
Clarke BR, Cuthbertson L, Whitfield C
  Title
Nonreducing terminal modifications determine the chain length of polymannose O antigens of Escherichia coli and couple chain termination to polymer export via an ATP-binding cassette transporter.
  Journal
J Biol Chem 279:35709-18 (2004)
DOI:10.1074/jbc.M404738200
  Sequence
[ag:AFQ31610] [ecx:EcHS_A2169]
Reference
PMID:21990359
  Authors
Clarke BR, Richards MR, Greenfield LK, Hou D, Lowary TL, Whitfield C
  Title
In vitro reconstruction of the chain termination reaction in biosynthesis of the Escherichia coli O9a O-polysaccharide: the chain-length regulator, WbdD, catalyzes the addition of methyl phosphate to the non-reducing terminus of the growing glycan.
  Journal
J Biol Chem 286:41391-401 (2011)
DOI:10.1074/jbc.M111.295857
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