KEGG   ORTHOLOGY: K18976
Entry
K18976            Tight     KO                                     
Symbol
blaOXA-48
Name
beta-lactamase class D OXA-48 [EC:3.5.2.6]
Pathway
map01501  beta-Lactam resistance
Module
M00851  Carbapenem resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K18976  blaOXA-48; beta-lactamase class D OXA-48
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K18976  blaOXA-48; beta-lactamase class D OXA-48
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K18976  blaOXA-48; beta-lactamase class D OXA-48
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class D [MT]
    K18976  blaOXA-48; beta-lactamase class D OXA-48
Antimicrobial resistance: KEGG signatures [br01600.html]
 Signature KOs for antimicrobial resistance
  K18976
Other DBs
COG: COG2602
GO: 0008800 0008658
Genes
SON: SO_0837(blaA)
SHE: Shewmr4_0694
SHM: Shewmr7_3328
SHN: Shewana3_3440
SHF: CEQ32_12270(blaOXA)
SBJ: CF168_03605
SXM: MKD32_17140(blaOXA)
SSEH: N7V09_06040(blaOXA)
SDEO: D0436_18660(blaOXA)
SMAY: K0H60_17220(blaOXA)
AG: AAP70012(OXA-48) AAR89917(OXA-54) ADG27454(OXA-162) ADY06444(OXA-163) AEP16366(OXA-181) AFC95894(OXA-199) AFU91598(OXA-204) AGC60012(OXA-244) AGC60013(OXA-245) AGC70814(OXA-247) AGD91915(OXA-232) AHF71363(OXA-370) AJA30430(OXA-405) AKH90740(OXA-416) AMN85820(OXA-514) AMN85821(OXA-515)
 » show all
Reference
PMID:14693513
  Authors
Poirel L, Heritier C, Tolun V, Nordmann P
  Title
Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae.
  Journal
Antimicrob Agents Chemother 48:15-22 (2004)
DOI:10.1128/AAC.48.1.15-22.2004
  Sequence
[ag:AAP70012]
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