KEGG   ORTHOLOGY: K19460
Entry
K19460                      KO                                     
Symbol
LMP2A
Name
Lymphocryptovirus latent membrane protein 2A
Pathway
map05169  Epstein-Barr virus infection
map05203  Viral carcinogenesis
Network
nt06165  Epstein-Barr virus (EBV)
nt06517  TLR signaling
nt06537  TCR/BCR signaling
  Element
N00266  EBV LMP2A to PI3K signaling pathway
N00471  EBV LMP2A/2B to IFN signaling pathway
N00488  EBV LMP2A to BCR signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K19460  LMP2A; Lymphocryptovirus latent membrane protein 2A
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    K19460  LMP2A; Lymphocryptovirus latent membrane protein 2A
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K19460  LMP2A; Lymphocryptovirus latent membrane protein 2A
Viral proteins [BR:ko03200]
 dsDNA viruses
  Epstein-Barr virus (Human herpesvirus 4)
   K19460  LMP2A; Lymphocryptovirus latent membrane protein 2A
Genes
VG: 3783751(LMP-2A) 5176182(HHV4tp2_gp01)
Reference
PMID:2536113
  Authors
Sample J, Liebowitz D, Kieff E
  Title
Two related Epstein-Barr virus membrane proteins are encoded by separate genes.
  Journal
J Virol 63:933-7 (1989)
DOI:10.1128/JVI.63.2.933-937.1989
  Sequence
[vg:3783751]
Reference
PMID:16490228
  Authors
Dolan A, Addison C, Gatherer D, Davison AJ, McGeoch DJ
  Title
The genome of Epstein-Barr virus type 2 strain AG876.
  Journal
Virology 350:164-70 (2006)
DOI:10.1016/j.virol.2006.01.015
  Sequence
[vg:5176182]
LinkDB

KEGG   Homo sapiens (human): 4734
Entry
4734              CDS       T01001                                 
Symbol
NEDD4, NEDD4-1, RPF1
Name
(RefSeq) NEDD4 E3 ubiquitin protein ligase
  KO
K10591  E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04120  Ubiquitin mediated proteolysis
hsa04144  Endocytosis
hsa04530  Tight junction
hsa05169  Epstein-Barr virus infection
Network
nt06165  Epstein-Barr virus (EBV)
nt06537  TCR/BCR signaling
  Element
N00488  EBV LMP2A to BCR signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    4734 (NEDD4)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    4734 (NEDD4)
  09144 Cellular community - eukaryotes
   04530 Tight junction
    4734 (NEDD4)
 09160 Human Diseases
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    4734 (NEDD4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    4734 (NEDD4)
   04121 Ubiquitin system [BR:hsa04121]
    4734 (NEDD4)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    4734 (NEDD4)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.26  HECT-type E3 ubiquitin transferase
     4734 (NEDD4)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Ubiquitin E3 ligases
    4734 (NEDD4)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  HECT type E3
   4734 (NEDD4)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitochondrial dynamics
   Morphogenesis factors
    4734 (NEDD4)
SSDB
Motif
Pfam: HECT WW
Other DBs
NCBI-GeneID: 4734
NCBI-ProteinID: NP_001271267
OMIM: 602278
HGNC: 7727
Ensembl: ENSG00000069869
UniProt: P46934
Structure
LinkDB
Position
15:complement(55826917..55993612)
AA seq 1319 aa
MAQSLRLHFAARRSNTYPLSETSGDDLDSHVHMCFKRPTRISTSNVVQMKLTPRQTALAP
LIKENVQSQERSSVPSSENVNKKSSCLQISLQPTRYSGYLQSSNVLADSDDASFTCILKD
GIYSSAVVDNELNAVNDGHLVSSPAICSGSLSNFSTSDNGSYSSNGSDFGSCASITSGGS
YTNSVISDSSSYTFPPSDDTFLGGNLPSDSTSNRSVPNRNTTPCEIFSRSTSTDPFVQDD
LEHGLEIMKLPVSRNTKIPLKRYSSLVIFPRSPSTTRPTSPTSLCTLLSKGSYQTSHQFI
ISPSEIAHNEDGTSAKGFLSTAVNGLRLSKTICTPGEVRDIRPLHRKGSLQKKIVLSNNT
PRQTVCEKSSEGYSCVSVHFTQRKAATLDCETTNGDCKPEMSEIKLNSDSEYIKLMHRTS
ACLPSSQNVDCQININGELERPHSQMNKNHGILRRSISLGGAYPNISCLSSLKHNCSKGG
PSQLLIKFASGNEGKVDNLSRDSNRDCTNELSNSCKTRDDFLGQVDVPLYPLPTENPRLE
RPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPDAA
CHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQAQ
RAFTTRRQISEETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSNLDVPTHLAEEL
NARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDER
GRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSEIEQG
FLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEE
RTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIPN
KFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMF
NPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFY
KMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGSE
IVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLG
DVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAEL
YGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFDGVD
NT seq 3960 nt   +upstreamnt  +downstreamnt
atggcacaaagcttacgattgcactttgcagccagaagaagcaatacttaccctttgtca
gaaacctccggagatgacttggatagccatgttcacatgtgcttcaaaagaccaacacgg
atttcaacgtctaacgttgttcaaatgaagctgactcccagacagactgcactagctccg
ttaataaaggaaaacgttcagtctcaagaaagatcatctgttccctcatctgaaaatgtt
aataaaaagagcagctgtctacagatttcactacagccaacaaggtacagtggatatctt
cagtctagcaatgtcttagctgatagtgatgatgcttcgtttacttgtatcttgaaggat
ggtatttacagtagtgctgtggtcgataatgaattgaatgctgtgaatgatggtcacctt
gtaagcagtccagccatttgtagtggtagccttagtaacttttcaaccagtgataatggg
tcttacagcagcaacggtagtgattttgggtcatgtgcaagtatcacaagtggaggttca
tatactaacagtgtcatcagtgacagtagtagttatacttttccaccaagtgatgatact
tttttgggtggaaacttaccttctgacagcacctccaatagaagtgtgccaaacaggaat
actactccttgtgaaattttttcaagaagtacaagtacagatccttttgtccaggatgac
ttggaacatggattagagattatgaaattgccagtgagcaggaacacaaaaattccacta
aaacgttactcctccttagtcatttttcctaggagtccttcaactacccgaccgacttct
ccaacaagtctgtgtactcttctgagcaaaggatcctatcaaacttcacaccagtttatt
atttctcctagtgaaattgcacataatgaggatggcactagtgctaaaggatttctttca
acagctgtcaatggacttcggttatctaaaacaatttgtacccccggagaagtaagagac
atacggccgcttcacaggaagggctcgttacagaagaaaattgttctttcgaataatact
cccagacagactgtctgtgaaaagtcatctgaaggatattcttgtgtttcagtgcatttc
acccaacgaaaagcagctacattagactgtgaaacaacaaatggtgattgtaaaccagaa
atgtcagaaattaagcttaattctgattcagagtatattaagctcatgcataggacatct
gcatgtttgccatcctcccaaaatgtagattgtcaaataaatatcaatggagaattggaa
agaccacattcacagatgaacaaaaaccatggtattttacgaagaagtatttcattggga
ggagcttatccaaatatttcctgtctatccagccttaagcacaattgttctaaaggggga
ccatctcagttactcataaagtttgcatctggaaatgaaggtaaagtggataatttatca
agagacagcaacagagattgcacaaatgaactgtctaattcttgcaagacaagagatgat
ttcctaggtcaagtggatgttccactttatccattaccgacagaaaatccaagattggag
agaccatatacatttaaggattttgttcttcatccaagaagtcacaaatcaagagttaaa
ggttatctgagactaaaaatgacttatttacctaaaaccagtggctcagaagatgataat
gcagaacaggctgaggaattagagcctggctgggttgttttggaccaaccagatgctgct
tgccatttgcagcaacaacaagaaccttctcctctacctccagggtgggaagagaggcag
gatatccttggaaggacctattatgtaaaccatgaatctagaagaacacagtggaaaaga
ccaacccctcaggacaacctaacagatgctgagaatggcaacattcaactgcaagcacaa
cgtgcatttaccaccaggcggcagatatccgaggaaacagaaagtgttgacaaccgagag
tcttccgagaactgggaaattataagagaagatgaagccaccatgtatagcaaccaggcc
ttcccatcacctccaccgtcaagtaacttggatgttccaactcatcttgcagaagaattg
aatgccagactcaccatttttggaaattcagccgtgagccagccagcatcgagctcaaat
cattccagcagaagaggcagcttacaagcctatacttttgaggaacaacctacacttcct
gtgcttttgcctacttcatctggattaccaccaggttgggaagaaaaacaagatgaaaga
ggaagatcatattatgtagatcacaattccagaacgactacttggacaaagcccactgta
caggccacagtggagaccagtcagctgacctcaagccagagttctgcaggccctcaatca
caagcctccaccagtgattcaggccagcaggtgacccagccatctgaaattgagcaagga
ttccttcctaaaggctgggaagtccggcatgcaccaaatgggaggcctttctttattgac
cacaacactaaaaccaccacctgggaagatccaagattgaaaattccagcccatctgaga
ggaaagacatcacttgatacttccaatgatctagggcctttacctccaggatgggaagag
agaactcacacagatggaagaatcttctacataaatcacaatataaaaagaacacaatgg
gaagatcctcggttggagaatgtagcaataactggaccagcagtgccctactccagggat
tacaaaagaaagtatgagttcttccgaagaaagttgaagaagcagaatgacattccaaac
aaatttgaaatgaaacttcgccgagcaactgttcttgaagactcttaccggagaattatg
ggtgtcaagagagcagacttcctgaaggctcgactgtggattgagtttgatggtgaaaag
ggattggattatggaggagttgccagagaatggttcttcctgatctcaaaggaaatgttt
aacccttattatgggttgtttgaatattctgctacggacaattataccctacagataaat
ccaaactctggattgtgtaacgaagatcacctctcttacttcaagtttattggtcgggta
gctggaatggcagtttatcatggcaaactgttggatggttttttcatccgcccattttac
aagatgatgcttcacaaaccaataacccttcatgatatggaatctgtggatagtgaatat
tacaattccctaagatggattcttgaaaatgacccaacagaattggacctcaggtttatc
atagatgaagaactttttggacagacacatcaacatgagctgaaaaatggtggatcagaa
atagttgtcaccaataagaacaaaaaggaatatatttatcttgtaatacaatggcgattt
gtaaaccgaatccagaagcaaatggctgcttttaaagagggattctttgaactaatacca
caggatctcatcaaaatttttgatgaaaatgaactagagcttcttatgtgtggactggga
gatgttgatgtgaatgactggagggaacatacaaagtataaaaatggctacagtgcaaat
catcaggttatacagtggttttggaaggctgttttaatgatggattcagaaaaaagaata
agattacttcagtttgtcactggcacatctcgggtgcctatgaatggatttgctgaacta
tacggttcaaatggaccacagtcatttacagttgaacagtggggtactcctgaaaagctg
ccaagagctcatacctgttttaatcgcctggacttgccaccttatgaatcatttgaagaa
ttatgggataaacttcagatggcaattgaaaacacccagggctttgatggagttgattag

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