KEGG ORTHOLOGY: K19477

ORTHOLOGY: K19477

Entry

K19477                      KO

Symbol

PRKG2

Name

cGMP-dependent protein kinase 2 [EC:2.7.11.12]

Pathway

map04022

cGMP-PKG signaling pathway

map04540

Gap junction

map04611

Platelet activation

map04713

Circadian entrainment

map04714

Thermogenesis

map04730

Long-term depression

map04740

Olfactory transduction

map04923

Regulation of lipolysis in adipocytes

map04924

Renin secretion

map04970

Salivary secretion

Disease

H02185

Spondylometaphyseal dysplasia

H02543

Acromesomelic dysplasia

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04022 cGMP-PKG signaling pathway
    K19477  PRKG2; cGMP-dependent protein kinase 2
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K19477  PRKG2; cGMP-dependent protein kinase 2
09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K19477  PRKG2; cGMP-dependent protein kinase 2
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    K19477  PRKG2; cGMP-dependent protein kinase 2
   04924 Renin secretion
    K19477  PRKG2; cGMP-dependent protein kinase 2
  09154 Digestive system
   04970 Salivary secretion
    K19477  PRKG2; cGMP-dependent protein kinase 2
  09156 Nervous system
   04730 Long-term depression
    K19477  PRKG2; cGMP-dependent protein kinase 2
  09157 Sensory system
   04740 Olfactory transduction
    K19477  PRKG2; cGMP-dependent protein kinase 2
  09159 Environmental adaptation
   04713 Circadian entrainment
    K19477  PRKG2; cGMP-dependent protein kinase 2
   04714 Thermogenesis
    K19477  PRKG2; cGMP-dependent protein kinase 2
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K19477  PRKG2; cGMP-dependent protein kinase 2
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.12  cGMP-dependent protein kinase
     K19477  PRKG2; cGMP-dependent protein kinase 2
Protein kinases [BR:ko01001]
Serine/threonine kinases: AGC group
  PKG family
   K19477  PRKG2; cGMP-dependent protein kinase 2

Other DBs

GO:

0004692

Genes

HSA:	5593(PRKG2)

PTR:	461217(PRKG2)

PPS:	100978260(PRKG2)

GGO:	101139285(PRKG2)

PON:	100438589(PRKG2)

NLE:	100584834(PRKG2)

HMH:	116466333(PRKG2)

MCC:	696308(PRKG2)

MCF:	102142098(PRKG2)

MTHB:

126954542

MNI:	105463319(PRKG2)

CSAB:

103235875(PRKG2)

CATY:

105576820(PRKG2)

PANU:

101021599(PRKG2)

TGE:	112624826(PRKG2)

MLEU:

105533621(PRKG2)

RRO:	104654813(PRKG2)

RBB:	108543451(PRKG2)

TFN:	117085403(PRKG2)

PTEH:

111549391(PRKG2)

CANG:

105511587(PRKG2)

CJC:	100384937(PRKG2)

SBQ:	101033123(PRKG2)

CIMI:

108305534(PRKG2)

CSYR:

103272881(PRKG2)

MMUR:

105880962(PRKG2)

LCAT:

123627373(PRKG2)

OGA:	100941256(PRKG2)

MMU:	19092(Prkg2)

MCAL:

110294464(Prkg2)

MPAH:

110330505(Prkg2)

RNO:	25523(Prkg2)

MCOC:

116067909(Prkg2)

ANU:	117699970(Prkg2)

MUN:	110562188(Prkg2)

CGE:	100765312(Prkg2)

MAUA:

101827998(Prkg2)

PROB:

127232334(Prkg2)

PLEU:

114695723(Prkg2)

MORG:

121460822(Prkg2)

MFOT:

126506457

AAMP:

119817224(Prkg2)

NGI:	103735969(Prkg2)

HGL:	101697843(Prkg2)

CPOC:

100724794(Prkg2)

CCAN:

109702659(Prkg2)

DORD:

105988515(Prkg2)

DSP:	122106688(Prkg2)

PLOP:

125364578(Prkg2)

MMMA:

107153695(Prkg2)

OCU:

100008781

OPI:	101534728(PRKG2)

TUP:	102489899(PRKG2)

GVR:	103596579(PRKG2)

CFA:	100855930(PRKG2)

CLUD:

112646510(PRKG2)

VVP:	112919705(PRKG2)

VLG:	121493652(PRKG2)

NPO:	129501897(PRKG2)

AML:	100467892(PRKG2)

UMR:	103665352(PRKG2)

UAH:	113263226(PRKG2)

UAR:	123787502(PRKG2)

ELK:

111149130

LLV:

125093912

MPUF:

101673181(PRKG2)

MNP:	132007578(PRKG2)

MLK:	131819346(PRKG2)

NVS:	122889527(PRKG2)

ORO:	101381093(PRKG2)

EJU:	114224927(PRKG2)

ZCA:	113924739(PRKG2)

MLX:	118010403(PRKG2)

NSU:	110591456(PRKG2)

LWW:	102747285(PRKG2)

FCA:	101091618(PRKG2)

PYU:	121033641(PRKG2)

PCOO:

112858125(PRKG2)

PBG:	122478735(PRKG2)

PVIV:

125163996(PRKG2)

LRUF:

124520837

PTG:	102949245(PRKG2)

PPAD:

109276981(PRKG2)

PUC:

125922860

AJU:

106976911

HHV:	120222860(PRKG2)

BTA:	533330(PRKG2)

BOM:	102269763(PRKG2) 102270503

BIU:	109560622(PRKG2)

BBUB:

102405676(PRKG2)

BBIS:

104992909(PRKG2)

CHX:	102172135(PRKG2)

OAS:	101113758(PRKG2)

BTAX:

128049712(PRKG2)

ODA:	120861498(PRKG2)

CCAD:

122428219(PRKG2)

MBEZ:

129561781(PRKG2)

SSC:	100512796(PRKG2)

CFR:	102519263(PRKG2)

CBAI:

105084003(PRKG2)

CDK:	105091814(PRKG2)

VPC:	102525406(PRKG2)

BACU:

103013933(PRKG2)

BMUS:

118895587(PRKG2)

LVE:	103091057(PRKG2)

OOR:	101280012(PRKG2)

DLE:	111187663(PRKG2)

PCAD:

102985621(PRKG2)

PSIU:

116754313(PRKG2)

NASI:

112414514(PRKG2)

ECB:	100060358(PRKG2)

EPZ:	103549039(PRKG2)

EAI:	106828068(PRKG2)

MYB:	102258852(PRKG2)

MYD:	102770749(PRKG2)

MMYO:

118670506(PRKG2)

MLF:	102423140(PRKG2)

PKL:	118704664(PRKG2)

EFUS:

103287900(PRKG2)

MNA:	107537152(PRKG2)

DRO:	112319697(PRKG2)

SHON:

118990410(PRKG2)

AJM:	119056901(PRKG2)

PDIC:

114493410(PRKG2)

PHAS:

123831363(PRKG2)

MMF:	118635511(PRKG2)

PPAM:

129084129(PRKG2)

HAI:	109387927(PRKG2)

RFQ:	117021894(PRKG2)

PALE:

102894554(PRKG2)

PGIG:

120588263(PRKG2)

PVP:	105292433(PRKG2)

RAY:	107516479(PRKG2)

MJV:	108396587(PRKG2)

TOD:	119260972(PRKG2)

SARA:

101542063(PRKG2)

SETR:

126032201(PRKG2)

LAV:	100657163(PRKG2)

TMU:

101346076

ETF:	101646984(PRKG2)

DNM:	101439805(PRKG2)

MDO:	100014568(PRKG2)

GAS:	123252215(PRKG2)

SHR:	100927283(PRKG2)

AFZ:

127540897

PCW:	110209720(PRKG2)

OAA:	100082499(PRKG2)

GGA:	100859181(PRKACA) 428753(PRKG2)

PCOC:

116230675 116231090(PRKG2)

MGP:	100541294(PRKG2) 100544740

CJO:	107312321 107313465(PRKG2)

TPAI:

128080203(PRKG2) 128080602

LMUT:

125692001(PRKG2)

NMEL:

110396408 110397428(PRKG2)

APLA:

101790644(PRKG2)

ACYG:

106041906(PRKG2) 106049906

CATA:

118249551(PRKG2) 118259033

AFUL:

116488259 116489089(PRKG2)

TGU:	100232260(PRKG2)

LSR:	110480895(PRKG2)

SCAN:

103826056(PRKG2)

PMOA:

120502746(PRKG2)

OTC:	121339894(PRKG2)

PRUF:

121354020(PRKG2)

GFR:	102042278(PRKG2)

FAB:	101813345(PRKG2)

OMA:	130252815(PRKG2)

PHI:	102108417(PRKG2)

PMAJ:

107203574(PRKG2)

CCAE:

111928808(PRKG2)

CCW:	104697218(PRKG2)

CBRC:

103622367(PRKG2)

ETL:	114059161(PRKG2)

ZAB:	102074710(PRKG2)

ZLE:	135446802(PRKG2)

ACHL:

103804902(PRKG2)

SVG:	106855679(PRKG2)

MMEA:

130584103(PRKG2)

HRT:	120753398(PRKG2)

FPG:	101916682 101918759(PRKG2)

FCH:	102055004(PRKG2) 106631485

CLV:	102089346(PRKG2)

EGZ:	104133983(PRKG2)

NNI:	104021251(PRKG2)

PCRI:

104036646(CNBD2)

ACUN:

113479638(PRKG2)

TALA:

104363723(PRKG2) 116959621

PADL:

103913713(PRKG2)

AFOR:

103897069(PRKG2)

ACHC:

115339981(PRKG2) 115351043

HLE:	104829891(PRKG2) 104830771

AGEN:

126044889 126046258

GCL:

127015633

CCRI:

104163515

MUI:	104545609(PRKG2)

BREG:

FGA:

GSTE:

LDI:

NNT:	104400050(PRKG2)

SHAB:

115610136 115610797(PRKG2)

DPUB:

104296890(PRKG2) 104308337

PGUU:

104471482(PRKG2)

ACAR:

104518127(PRKG2)

CVF:	104288698(PRKG2)

RTD:	128907544 128910017(PRKG2)

AAM:	106491038(PRKG2)

AROW:

112977374(PRKG2)

NPD:	112954775(PRKG2)

DNE:	112992291(PRKG2)

SCAM:

104146525(PRKG2)

ASN:	102372581 102375122(PRKG2)

AMJ:	102560332(PRKACA) 102570800(PRKG2)

CPOO:

109309532(PRKG2)

GGN:	109297118(PRKG2)

CMY:

114018938

CCAY:

125628886 125634824

DCC:

119853911

CPIC:

103305918(PRKG2)

ACS:	100561246(prkg2) 103282038

ASAO:

132777049(PRKG2) 132780148

PVT:	110084111(PRKG2) 110087006

SUND:

121919531 121931735(PRKG2)

PBI:	103050448(PRKG2) 103060529 103064237

PMUR:

107286453 107303184(PRKG2)

CTIG:

120309158 120311420(PRKG2)

TSR:	106545902 106547680(PRKG2)

PGUT:

117667640 117673681(PRKG2)

APRI:

131188965 131203062(PRKG2)

PTEX:

113441533 113448279(PRKG2)

NSS:	113414552 113417896(PRKG2)

VKO:	123018727 123022846(PRKG2)

PMUA:

114595005 114604385(PRKG2)

PRAF:

128411526 128421452(PRKG2)

ZVI:	118083662(PRKG2)

HCG:	128325226 128325630(PRKG2)

GJA:	107114871(PRKG2)

STOW:

125440352(PRKG2) 125443595

EMC:	129334647 129336712(PRKG2)

XLA:	108696263 108697216 444025(prkg2.L)

XTR:	100497736(prkg2) 100498055

NPR:	108789074(PRKG2)

RTEM:

120908941 120914409(PRKG2)

BBUF:

120991655(PRKG2) 121005082

BGAR:

122927516(PRKG2) 122941006

MUO:	115465137 115471206(PRKG2)

GSH:	117358256 117358630(PRKG2)

DRE:	100125912(prkg2) 326020(si:dkey-121j17.5) 556339

SRX:	107708387 107727357 107731507 107744862 107746786

SANH:

107660531 107661254 107663377(prkg2) 107680302 107699307

SGH:	107554918 107586507 107599184 107602032

CCAR:

109078441 109090195 109090782 109108300

CAUA:

113049125 113057217 113063503 113077808

CGIB:

127939021 127957131 127970459 128002983

PTET:

122325243(prkg3) 122345008(prkg2) 122356061

LROH:

127161762(prkg3) 127164833(prkg2) 127174824

OMC:	131527240(prkg3) 131540163(prkg2) 131552271

PPRM:

120461784(prkg2) 120479266(prkg3) 120479323

RKG:	130083165 130083865(prkg3) 130085017(prkg2)

MAMB:

125266993(prkg2) 125276687 125277724(prkg3)

CIDE:

127502574 127513552 127525555

MASI:

127412142 127415805 127438549

TROS:

130559144 130565999(prkg3) 130571236(prkg2)

TDW:	130419270(prkg2) 130431575 130434728(prkg3)

MANU:

129415953 129440528(prkg2)

IPU:	108255985 108261320(prkg3) 108263686

IFU:	128605587 128619504(prkg3) 128625602(prkg2)

PHYP:

113529209 113537052(prkg2) 113538666

SMEO:

124380680(prkg2) 124394485 124401374(prkg3)

TFD:	113637633(prkg2) 113639764 113654820(prkg3)

TVC:	132846676 132854519(prkg2) 132854543(prkg3)

TRN:	134314537 134320450(prkg3) 134335306(prkg2)

AMEX:

103022723 103030142(prkg2) 103041230

CMAO:

118800224(prkg3) 118810379 118827230(prkg2)

EEE:	113585394 113589804 113591915

CHAR:

105890865 105892148 105906881(prkg2)

TRU:	101071377 101074431(prkg2) 105419048

TFS:	130515973(prkg3) 130525533(prkg2) 130533403

TNG:	GSTEN00030356G001

LCO:	104921979 104929951(prkg2) 104939827

NCC:	104947339 104954051 104955882

TBEN:

117472906(prkg2) 117492035 117492241(prkg3)

CGOB:

115003587 115013763(prkg2) 115019815

PGEO:

117439546(prkg3) 117453172(prkg2) 117459933

GACU:

117533757(prkg3) 117546443(prkg2) 117546495

EMAC:

134858881 134873673(prkg2) 134877219

ELY:	117252905(prkg2) 117270421(prkg3)

EFO:	125890075(prkg2) 125897510(prkg3)

PLEP:

121944718(prkg2) 121954433 121956012(prkg3)

SLUC:

116050373 116054106(prkg2) 116066486(prkg3)

ECRA:

117945406(prkg2) 117960788 117961240(prkg3)

ESP:	116690309(prkg2) 116705633 116706636

PFLV:

114555686(prkg2) 114572507

GAT:	120807891(prkg3) 120813110

PPUG:

119195391(prkg3) 119224835(prkg2)

AFB:	129092173 129100726(prkg2) 129107225(prkg3)

CLUM:

117727574(prkg3) 117735803(prkg2) 117744101

PSWI:

130196964(prkg2) 130202649(prkg3) 130206760

MSAM:

119892004(prkg2) 119908424(prkg3)

SCHU:

122863525(prkg3) 122876944(prkg2)

CUD:	121510051(prkg2) 121511336 121521080(prkg3)

ALAT:

119012153(prkg3) 119020289(prkg2) 119033457

MZE:	101471197(prkg2) 101479945

ONL:	100699113(prkg2) 100708987

OAU:	116310793(prkg3) 116333376(prkg2)

OLA:	101158535(prkg2) 101165996 101173830

OML:	112137683(prkg2) 112158429(prkg3) 112161926

CSAI:

133418477(prkg3) 133451539(prkg2) 133463233

XMA:	102216397 102230306(prkg2)

XCO:	114153990(prkg2) 114158207

XHE:	116729132(prkg2) 116733691

PRET:

103457572 103469805(prkg2)

PFOR:

103134891(prkg2) 103134980 103138603

PLAI:

106934820(prkg2) 106957396

PMEI:

106922336(prkg2) 106928310

GAF:	122825526(prkg3) 122828661(prkg2)

PPRL:

129351243(prkg3) 129365933(prkg2)

CVG:	107083363 107083975(prkg2)

CTUL:

119785128(prkg3) 119785444(prkg2)

GMU:	124877400(prkg2) 124882369(prkg3)

NFU:	107375493 107377464 107386061(prkg2)

KMR:	108239119 108240136(prkg3) 108244533(prkg2)

ALIM:

106513735 106516936 106525434(prkg2)

NWH:	119407520 119413136(prkg2) 119418541(prkg3)

AOCE:

111565792(prkg2) 111568230 111586601

MCEP:

124999409(prkg3) 125012623(prkg2) 125018728

CSEM:

103380827 103386981 103397539(prkg2)

POV:

109629155

SSEN:

122762998(prkg2) 122764933 122782184 122783714(prkg3)

HHIP:

117758431(prkg3) 117767429(prkg2) 117775114

HSP:	118099599(prkg3) 118115516(prkg2) 118119160

PPLT:

128438591(prkg2) 128453603 128460151(prkg3)

SMAU:

118284063 118290569(prkg3) 118313955(prkg2)

LCF:	108887140 108895314 108895629(prkg3)

SDU:	111216303 111228005(prkg2)

SLAL:

111650595 111653026 111654602 111660882(prkg2)

XGL:	120789174(prkg3) 120796544 120805415(prkg2)

HCQ:	109516694 109520050 109526918(prkg2)

SSCV:

125978603 125989832 125994013

SBIA:

133496305(prkg3) 133499621(prkg2) 133509353

PEE:	133400268(prkg2) 133409600 133416923(prkg3)

PTAO:

133468513(prkg3) 133474835(prkg2) 133485896

BPEC:

110155390 110158150 110160457

MALB:

109952723 109957341(prkg2)

BSPL:

114850179(prkg3) 114862959(prkg2)

SJO:	128365498(prkg2) 128373173 128377123(prkg3)

SASA:

106571758 106576682 106607930 106608672

STRU:

115153151 115174456 115189308 115193847

OTW:	112217699 112232971 112253523 112253870

OMY:	110502406 110522345 110527939 110529892

OGO:	123991020 123995194 124037210 124040785

ONE:	115108024 115113268 115135178 115139298

OKI:	109866123 109888778 109899093 109900319

OKE:	118361806 118369645 118387011 118398382

SALP:

111951584 111954366 111973400 111977420

SNH:	120017414 120024381 120045866

CCLU:

121548817(prkg3) 121553733 121580925

ELS:	105006031 105007647(prkg2) 105010732

SFM:	108924066 108938469(prkg2) 108942712

PKI:	111839266 111841262

AANG:

118217808 118229259(prkg3) 118237345(prkg2)

LOC:	102694398(prkg2) 102697784 102698203

PSPA:

121300010(prkg2) 121317145(prkg3) 121318794 121325426

ARUT:

117410442(prkg3) 117417630 117962943

PSEX:

120525826(prkg3) 120532132(prkg2)

LCM:	102345412 102361824(PRKG2)

CMK:	103180874(prkg2) 103181471

CPLA:

122541939 122552933(prkg2)

HOC:	132820182(prkg2) 132835099

LERI:

129693307(prkg2) 129712974

PMRN:

116940188 116946601

LRJ:	133350692 133352864

BBEL:

109478278

CIN:	100176673 100179064

CSET:

123317286

DVV:

114326942

BGT:

106067606

VCN:	VOLCADRAFT_81219 VOLCADRAFT_97912

CSL:	COCSUDRAFT_35741

CVR:	CHLNCDRAFT_49225

APRO:

F751_6750

OTA:	OT_ostta13g01130

BPG:	Bathy04g01910

MIS:	MICPUN_104866(CL-PK2)

MPP:	MICPUCDRAFT_33413(JGI:MicpuC2_33413)

PFD:	PFDG_01207

PFH:	PFHG_04513

PTM:	GSPATT00017822001 GSPATT00038158001

FCY:	FRACYDRAFT_263989

AAF:	AURANDRAFT_19287 AURANDRAFT_63526

SMAG:

SMAZ:

SPHU:

Reference

PMID:9788971

Authors

Wagner C, Pfeifer A, Ruth P, Hofmann F, Kurtz A

Title

Role of cGMP-kinase II in the control of renin secretion and renin expression.

Journal

J Clin Invest 102:1576-82 (1998)
DOI:10.1172/JCI4044

Reference

PMID:8607838

Authors

Orstavik S, Solberg R, Tasken K, Nordahl M, Altherr MR, Hansson V, Jahnsen T, Sandberg M

Title

Molecular cloning, cDNA structure, and chromosomal localization of the human type II cGMP-dependent protein kinase.

Journal

Biochem Biophys Res Commun 220:759-65 (1996)
DOI:10.1006/bbrc.1996.0477

Sequence

[hsa:5593]

LinkDB

DBGET integrated database retrieval system