KEGG   ORTHOLOGY: K19650
Entry
K19650            Tight     KO                                     
Symbol
SDH
Name
secoisolariciresinol dehydrogenase [EC:1.1.1.331]
Pathway
map00999  Biosynthesis of various plant secondary metabolites
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00902  Podophyllotoxin biosynthesis, coniferyl alcohol => podophyllotoxin
Reaction
R10129  (-)-secoisolariciresinol:NAD+ oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00999 Biosynthesis of various plant secondary metabolites
    K19650  SDH; secoisolariciresinol dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.331  secoisolariciresinol dehydrogenase
     K19650  SDH; secoisolariciresinol dehydrogenase
Genes
AG: AAK38664(SDH) ABN14311(SDH)
Reference
PMID:11278426
  Authors
Xia ZQ, Costa MA, Pelissier HC, Davin LB, Lewis NG
  Title
Secoisolariciresinol dehydrogenase purification, cloning, and functional expression. Implications for human health protection.
  Journal
J Biol Chem 276:12614-23 (2001)
DOI:10.1074/jbc.M008622200
  Sequence
[ag:AAK38664]
Reference
PMID:26359402
  Authors
Lau W, Sattely ES
  Title
Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone.
  Journal
Science 349:1224-8 (2015)
DOI:10.1126/science.aac7202
  Sequence
[ag:ABN14311]
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