KEGG ORTHOLOGY: K19674

ORTHOLOGY: K19674

Entry

K19674                      KO

Symbol

WDR35, IFT121

Name

WD repeat-containing protein 35

Disease

H00511

Short rib-polydactyly syndrome

H00529

Cranioectodermal dysplasia

H02157

Short-rib thoracic dysplasia

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   03037 Cilium and associated proteins
    K19674  WDR35, IFT121; WD repeat-containing protein 35
Cilium and associated proteins [BR:ko03037]
Primary cilia and associated proteins
  Intraflagellar transport (IFT) complex A
   K19674  WDR35, IFT121; WD repeat-containing protein 35

Genes

HSA:	57539(WDR35)

PTR:	459049(WDR35)

PPS:	100983492(WDR35)

GGO:	101124525(WDR35)

PON:	100445910(WDR35)

NLE:	100602468(WDR35)

HMH:	116480357(WDR35)

MCC:	716638(WDR35)

MCF:	102129975(WDR35)

MTHB:

126933901

MNI:	105479879(WDR35)

CSAB:

103220730(WDR35)

CATY:

105578581(WDR35)

PANU:

101018979(WDR35)

TGE:	112605170(WDR35)

MLEU:

105533065(WDR35)

RRO:	104654309(WDR35) 104678996

RBB:	108543016(WDR35)

TFN:	117062865(WDR35) 117063069 117099702

PTEH:

111554424(WDR35)

CANG:

105511664 105518266(WDR35)

CJC:	100401811(WDR35)

SBQ:	101029599(WDR35)

CIMI:

108302652(WDR35)

CSYR:

103275333(WDR35)

MMUR:

105884042(WDR35)

LCAT:

123636625(WDR35)

PCOQ:

105817389(WDR35)

OGA:	100961096(WDR35)

MMU:	74682(Wdr35)

MCAL:

110306786(Wdr35)

MPAH:

110325010(Wdr35)

RNO:	503018(Wdr35)

MCOC:

116079812(Wdr35)

ANU:	117716922(Wdr35)

MUN:	110563630(Wdr35)

CGE:	100751359(Wdr35)

MAUA:

101836307(Wdr35)

PROB:

127220013(Wdr35)

PLEU:

114691987(Wdr35)

MORG:

121438895(Wdr35)

MFOT:

126501348

AAMP:

119808180(Wdr35)

NGI:	103726588(Wdr35)

HGL:	101721184(Wdr35)

CPOC:

100723470(Wdr35)

CCAN:

109681730(Wdr35)

DORD:

105983749(Wdr35)

DSP:	122108801(Wdr35)

PLOP:

125356699(Wdr35)

NCAR:

124963366

MMMA:

107137476(Wdr35)

OCU:

100358240

OPI:	101524547(WDR35)

TUP:	102497824(WDR35)

GVR:	103590904(WDR35)

CFA:	475677(WDR35)

CLUD:

112664765(WDR35)

VVP:	112932105(WDR35)

VLG:	121491150(WDR35)

NPO:	129511059(WDR35)

AML:	100470577(WDR35)

UMR:	103671701(WDR35)

UAH:	113270226(WDR35)

UAR:	123802611(WDR35)

ELK:

111154128

LLV:

125109402

MPUF:

101679235(WDR35)

MNP:	132021156(WDR35)

MLK:	131807332(WDR35)

NVS:	122915285(WDR35)

ORO:	101374512(WDR35)

EJU:	114205767(WDR35)

ZCA:	113937598(WDR35)

MLX:	118007622(WDR35)

NSU:	110587264(WDR35)

LWW:

102733052

FCA:	101083332(WDR35)

PYU:	121044161(WDR35)

PCOO:

112864060(WDR35)

PBG:	122497424(WDR35)

PVIV:

125162712(WDR35)

LRUF:

124504006

PTG:	102960914(WDR35)

PPAD:

109268048(WDR35)

PUC:

125937340

AJU:

106980369

HHV:	120222393(WDR35) 120224989

BTA:	100337107(WDR35)

BOM:	102274949(WDR35)

BBUB:

102399296(WDR35)

BBIS:

104989009(WDR35)

CHX:	102176432(WDR35)

OAS:	101103137(WDR35)

BTAX:

128056046(WDR35)

ODA:	120851912(WDR35)

CCAD:

122442034(WDR35)

MBEZ:

129539205(WDR35)

SSC:	100519954(WDR35)

CFR:	102503855(WDR35) 102507383

CBAI:

105062948(WDR35) 105074779

CDK:	105092991 105101162 116157416

VPC:	102529700(WDR35) 102532168

BACU:

103013369(WDR35)

BMUS:

118906303(WDR35)

LVE:	103071137(WDR35)

OOR:	101282993(WDR35)

DLE:	111175041(WDR35)

PCAD:

102989169(WDR35)

PSIU:

116764515(WDR35)

NASI:

112401520(WDR35)

ECB:	100056455(WDR35)

EPZ:	103556437(WDR35)

EAI:	106835582(WDR35)

MYB:	102239620(WDR35)

MYD:	102766361(WDR35)

MMYO:

118669248(WDR35)

MLF:	102425446(WDR35)

PKL:	118717069(WDR35)

EFUS:

103305567(WDR35)

MNA:	107546366(WDR35)

DRO:	112297734(WDR35)

SHON:

118979389(WDR35)

AJM:	119053985(WDR35)

PDIC:

114499457(WDR35)

PHAS:

123822539(WDR35)

MMF:	118630673(WDR35)

PPAM:

129067459(WDR35)

HAI:	109388682(WDR35)

RFQ:	117033423(WDR35)

PALE:

102880845(WDR35)

PGIG:

120621925(WDR35)

PVP:	105289823(WDR35)

RAY:	107510837(WDR35)

MJV:	108403784(WDR35)

TOD:	119259522(WDR35)

SARA:

101555897(WDR35)

SETR:

126024401(WDR35)

LAV:	100670900(WDR35)

TMU:

101346176

ETF:	101664483(WDR35)

DNM:	101424704(WDR35)

MDO:	100016539(WDR35)

GAS:	123236641(WDR35)

SHR:	100921746(WDR35)

AFZ:

127547293

PCW:	110194848(WDR35) 110204520

OAA:	100080585(WDR35)

GGA:	421958(WDR35)

PCOC:

116240484(WDR35)

MGP:	100542060(WDR35)

CJO:	107312243(WDR35)

TPAI:

128083125(WDR35)

LMUT:

125688719(WDR35)

NMEL:

110395382(WDR35)

APLA:

101798126(WDR35)

ACYG:

106047366(WDR35)

CATA:

118254678(WDR35)

AFUL:

116487779(WDR35)

TGU:	100224634(WDR35)

LSR:	110467923(WDR35)

SCAN:

103820780(WDR35)

PMOA:

120508216(WDR35)

OTC:	121345079(WDR35)

PRUF:

121360789(WDR35)

GFR:	102036415(WDR35)

FAB:	101816444(WDR35)

OMA:	130250552(WDR35)

PHI:	102100529(WDR35)

PMAJ:

107202232(WDR35)

CCAE:

111925994(WDR35)

CCW:	104685498(WDR35)

CBRC:

103622864(WDR35)

ETL:	114065065(WDR35)

ZAB:	102064797(WDR35)

ZLE:	135445388(WDR35)

ACHL:

103800506(WDR35)

SVG:	106865084(WDR35)

MMEA:

130589212(WDR35)

HRT:	120750735(WDR35)

FPG:	101922147(WDR35)

FCH:	102051451(WDR35)

CLV:	102088136(WDR35)

EGZ:	104130029(WDR35)

NNI:	104011899(WDR35)

PCRI:

104032218(WDR35)

PLET:

104616793(WDR35)

EHS:	104515536(WDR35)

PCAO:

104044981(WDR35)

ACUN:

113478211(WDR35)

TALA:

104364530(WDR35)

PADL:

103915540(WDR35)

AFOR:

103908332(WDR35)

ACHC:

115350908(WDR35)

HALD:

104318754(WDR35)

HLE:	104831218(WDR35)

AGEN:

126046515

GCL:

127014547

CCRI:

104169416(WDR35)

CSTI:

104558807(WDR35)

CMAC:

104486884(WDR35)

MUI:	104538721(WDR35)

FGA:	104075137(WDR35)

LDI:	104352732(WDR35)

MNB:	103774746(WDR35)

OHA:	104332040(WDR35)

NNT:	104411505(WDR35)

SHAB:

115609664(WDR35)

DPUB:

104308280(WDR35)

ACAR:

104518040(WDR35)

CPEA:

104392932(WDR35)

AVIT:

104278835(WDR35)

CVF:	104286699(WDR35)

RTD:	128906721(WDR35)

CUCA:

104056986(WDR35)

BRHI:

104496296(WDR35)

AAM:	106494770(WDR35)

AROW:

112977498(WDR35)

NPD:	112952110(WDR35)

TGT:	104573481(WDR35)

DNE:	112985072(WDR35)

SCAM:

104149994(WDR35)

ASN:	102380759(WDR35)

AMJ:	102567020(WDR35)

CPOO:

109311616(WDR35)

GGN:	109300187(WDR35)

PSS:	102460732(WDR35)

CMY:	102929578(WDR35)

CCAY:

125634604(WDR35)

DCC:	119853600(WDR35)

CPIC:

101942932(WDR35)

TST:	117875329(WDR35)

CABI:

116821177(WDR35)

MRV:	120401325(WDR35)

ACS:	100557271(wdr35)

ASAO:

132782464(WDR35)

PVT:	110074247(WDR35)

SUND:

121919555(WDR35)

PBI:	103065622(WDR35)

PMUR:

107284924(WDR35)

CTIG:

120306011(WDR35)

TSR:	106549657(WDR35)

PGUT:

117674257(WDR35)

APRI:

131196391(WDR35)

PTEX:

113432997(WDR35)

NSS:	113417270(WDR35)

VKO:	123030895(WDR35)

PMUA:

114593694(WDR35)

PRAF:

128410134(WDR35)

ZVI:	118082469(WDR35)

HCG:	128340324(WDR35)

GJA:	107114264(WDR35)

STOW:

125433983(WDR35)

EMC:	129328683(WDR35)

XLA:	108718257(wdr35.S)

XTR:	100496375(wdr35)

NPR:	108789786(WDR35)

RTEM:

120936303(WDR35)

BBUF:

120997331(WDR35)

BGAR:

122934273(WDR35)

MUO:	115467120(WDR35)

GSH:	117356966(WDR35)

DRE:	565515(wdr35)

SRX:

107707974

SANH:

107681549(wdr35)

SGH:	107588590(wdr35)

CCAR:

109101106 109101109(wdr35)

CAUA:

113056695 113056908

CGIB:

127970701

PTET:

122356083(wdr35)

LROH:

127175076(wdr35)

OMC:	131552710(wdr35)

PPRM:

120479818(wdr35)

MAMB:

125277093(wdr35)

CIDE:

127525414

MASI:

127412512 127413977

TROS:

130559095(wdr35)

TDW:	130432268(wdr35)

MANU:

129416129(wdr35)

IPU:

108263857

IFU:	128605096(wdr35)

PHYP:

113541931(wdr35)

SMEO:

124396725(wdr35)

TFD:	113656869(wdr35)

TVC:	132846859(wdr35)

TRN:	134314893(wdr35)

AMEX:

103045945(wdr35)

CMAO:

118811016(wdr35)

EEE:	113576277(wdr35)

CHAR:

105896808(wdr35)

TRU:	101065274(wdr35)

TFS:	130540266(wdr35)

TNG:	GSTEN00034750G001

LCO:	109140532(wdr35)

TBEN:

117478378(wdr35)

CGOB:

115027830(wdr35)

PGEO:

117468072(wdr35)

GACU:

117539749(wdr35)

EMAC:

134881591(wdr35)

ELY:	117266623(wdr35)

EFO:	125901313(wdr35)

PLEP:

121953631(wdr35)

SLUC:

116065760(wdr35)

ECRA:

117935310(wdr35)

ESP:	116670318(wdr35)

PFLV:

114546653(wdr35)

GAT:	120832751(wdr35)

PPUG:

119228019(wdr35)

AFB:	129103250(wdr35)

CLUM:

117725394(wdr35)

PSWI:

130201562(wdr35)

MSAM:

119910637(wdr35)

SCHU:

122861472(wdr35)

CUD:	121525867(wdr35)

ALAT:

119005042(wdr35)

MZE:	101467717(wdr35)

ONL:	100689840(wdr35)

OAU:	116315210(wdr35)

OLA:	101161686(wdr35)

OML:	112144540(wdr35)

CSAI:

133462387(wdr35)

XMA:	102231674(wdr35)

XCO:	114133982(wdr35)

XHE:	116709446(wdr35)

PRET:

103458678(wdr35)

PFOR:

103154104 103154156

PLAI:

106942007 106942012

PMEI:

106921222 106929499

GAF:	122845610(wdr35)

PPRL:

129365591(wdr35)

CVG:	107091115(wdr35)

CTUL:

119783578(wdr35)

GMU:	124856054(wdr35)

NFU:	107395955(wdr35)

KMR:	108245065(wdr35)

ALIM:

106518704(wdr35)

NWH:	119427427(wdr35)

AOCE:

111571129(wdr35)

MCEP:

125024166(wdr35)

CSEM:

103387708(wdr35)

POV:	109627875(wdr35)

SSEN:

122783029(wdr35)

HHIP:

117756176(wdr35)

HSP:	118116929(wdr35)

PPLT:

128451511(wdr35)

SMAU:

118285971(wdr35)

LCF:	108886930 108896122

SDU:	111225457(wdr35)

SLAL:

111645509(wdr35)

XGL:	120795837(wdr35)

HCQ:	109524332(wdr35)

SSCV:

125980514

SBIA:

133513509(wdr35)

PEE:	133412871(wdr35)

PTAO:

133487493(wdr35)

BPEC:

110155484(wdr35)

MALB:

109964960(wdr35)

BSPL:

114848591(wdr35)

SJO:	128374817(wdr35)

SASA:

106607832(wdr35)

STRU:

115172935(wdr35)

OTW:	112262229(wdr35)

OMY:	110498213(wdr35)

OGO:	124001910(wdr35)

ONE:	115146476(wdr35)

OKI:	109893821(wdr35)

OKE:	118362226(wdr35)

SALP:

112070213(wdr35)

SNH:	120060146(wdr35)

CCLU:

121539045(wdr35)

ELS:	105015959(wdr35)

SFM:	108923606(wdr35)

PKI:	111855567(wdr35)

AANG:

118213657(wdr35)

LOC:	102698464(wdr35)

PSPA:

121315601(wdr35)

ARUT:

117403295(wdr35)

PSEX:

120525676(wdr35)

LCM:	102353296(WDR35)

CMK:	103183121(wdr35)

CPLA:

122540592(wdr35)

HOC:	132834818(wdr35)

LERI:

129697149(wdr35)

PMRN:

116946478(WDR35)

LRJ:	133352846(WDR35)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG2069(Oseg4)

DER:

6545851

DSE:

6610389

DSI:	Dsimw501_GD13444(Dsim_GD13444)

DYA:	Dyak_GE20921

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI12779

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ012945

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:	124366649 124367026

MQU:	129002378 129004091

PHU:	Phum_PHUM077910

FOC:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:	110850928 110853095

DPX:	DAPPUDRAFT_187411

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

PCLA:

CQD:

PTRU:

ESN:	126994526 127004856

MNZ:	135210062 135210063

HAZT:

EAF:

LSM:

TCF:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_C54G7.4(ifta-1)

CBR:	CBG_14804(Cbr-ifta-1)

CRQ:	GCK72_011693

LOA:	LOAG_18471

TSP:

Tsp_04214

HRO:	HELRODRAFT_86462

LGI:	LOTGIDRAFT_197584

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:	106175854 106181695

SMM:	Smp_124350

SHX:	MS3_00002017(WDR35)

OVI:	T265_02113

EGL:

EGR_07444

LLON:

135502868

NVE:	116608300 5518407

EPA:

110234460

ATEN:

116302564

ADF:	107344727 107351188

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_50569

AQU:

100634432

SMO:	SELMODRAFT_449576(FAP2-2)

PPP:

112277948

CRE:	CHLRE_11g475000v5

VCN:	VOLCADRAFT_108602(fap118)

MNG:

MNEG_2248

MIS:	MICPUN_107345(WDR35)

MPP:	MICPUCDRAFT_55377(JGI:MicpuC2_55377) MICPUCDRAFT_55378(JGI:MicpuC2_55378)

MBR:	MONBRDRAFT_34149

SRE:	PTSG_05546

TGO:	TGME49_256865

TET:	TTHERM_00261950

PTM:	GSPATT00000495001 GSPATT00003792001 PTMB.56

SMIN:

v1.2.014207.t1(symbB.v1.2.014207.t1) v1.2.014211.t1(symbB.v1.2.014211.t1) v1.2.014211.t2(symbB.v1.2.014211.t2)

AAF:	AURANDRAFT_51986

PIF:	PITG_13766

PSOJ:

PHYSODRAFT_314992

SPAR:

SPRG_02455

GTT:	GUITHDRAFT_118819

TBR:	Tb927.5.3030

TBG:	TbgDal_V4230

TCR:

510173.60

LMA:	LMJF_08_1190

LIF:	LINJ_08_1100

LDO:	LDBPK_081100

LMI:	LMXM_08_1190

LBZ:	LBRM_08_0960

LPAN:

LPMP_080990

NGR:	NAEGRDRAFT_32701

TVA:	TVAG_2v0339530 TVAG_2v0380580 TVAG_2v0811180 TVAG_2v0966720

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Reference

PMID:20193664

Authors

Feng GG, Li C, Huang L, Tsunekawa K, Sato Y, Fujiwara Y, Komatsu T, Honda T, Fan JH, Goto H, Koide T, Hasegawa T, Ishikawa N

Title

Naofen, a novel WD40-repeat protein, mediates spontaneous and tumor necrosis factor-induced apoptosis.

Journal

Biochem Biophys Res Commun 394:153-7 (2010)
DOI:10.1016/j.bbrc.2010.02.133

Sequence

[hsa:57539]

LinkDB

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